KEGG   PATHWAY: sbq05205
Entry
sbq05205                    Pathway                                
Name
Proteoglycans in cancer - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
sbq05205  Proteoglycans in cancer
sbq05205

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101028425  CD44; CD44 antigen isoform X2 [KO:K06256]
101051959  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101041507  CTTN; src substrate cortactin [KO:K06106]
101041938  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
101043415  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101038666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101054437  VAV1; proto-oncogene vav [KO:K05730]
101037400  guanine nucleotide exchange factor VAV3 [KO:K05730]
101038097  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
104652250  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101047035  KRAS; GTPase KRas isoform X1 [KO:K07827]
101036877  NRAS; GTPase NRas [KO:K07828]
101032806  RRAS; ras-related protein R-Ras [KO:K07829]
101034979  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101053335  MRAS; ras-related protein M-Ras [KO:K07831]
101052142  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101043605  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101030045  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101050895  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101045005  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101034130  estrogen receptor [KO:K08550]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
101037287  ACTB; actin, cytoplasmic 1 [KO:K05692]
101050060  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
101049910  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104651678  actin, cytoplasmic 1-like [KO:K05692]
101038946  FLNA; filamin-A isoform X1 [KO:K04437]
101042666  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101042162  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101043419  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
101052068  RHOA; transforming protein RhoA [KO:K04513]
104650592  ras-like GTP-binding protein O-RHO [KO:K04513]
104652261  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
101051787  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101028677  LOW QUALITY PROTEIN: rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
101039371  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101047554  ANK1; ankyrin-1 isoform X1 [KO:K10380]
101039279  ANK2; ankyrin-2 [KO:K09255]
101048966  ANK3; ankyrin-3 [KO:K09259]
101040995  GAB1; GRB2-associated-binding protein 1 isoform X4 [KO:K09593]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101042099  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101030626  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101050671  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101048497  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101048398  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101034840  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101053159  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X4 [KO:K12329]
101046107  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
101040423  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101043700  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101029556  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101049881  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101048916  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101031635  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101041452  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101052251  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101041781  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II delta chain-like [KO:K04515] [EC:2.7.11.17]
101038342  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X10 [KO:K04515] [EC:2.7.11.17]
101030424  homeobox protein NANOG-like [KO:K10164]
101044489  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
101043470  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
101049662  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
101031010  twist-related protein 1 [KO:K09069]
101035928  TWIST2; twist-related protein 2 [KO:K09069]
101034056  HOXD10; homeobox protein Hox-D10 [KO:K09295]
101051601  DCN; decorin [KO:K04660]
101036963  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
101039763  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101047083  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101032521  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101033758  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101038541  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101051237  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
101038852  RPS6; 40S ribosomal protein S6 [KO:K02991]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101039198  CAV1; caveolin-1 isoform X1 [KO:K06278]
101039961  CAV2; caveolin-2 [KO:K12958]
101051489  CAV3; caveolin-3 [KO:K12959]
101051238  CD63; CD63 antigen [KO:K06497]
101041919  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101029697  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101047980  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
101045472  TLR2; toll-like receptor 2 [KO:K10159]
101043935  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101033740  PDCD4; programmed cell death protein 4 [KO:K16865]
101031357  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101049311  IL12B; interleukin-12 subunit beta [KO:K05425]
101030064  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101049355  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
101043327  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101044689  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
101043319  TFAP4; LOW QUALITY PROTEIN: transcription factor AP-4 [KO:K09108]
101032691  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101036336  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101038696  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
101053489  CBL; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101042704  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
101029602  THBS1; thrombospondin-1 [KO:K16857]
101042210  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
101036569  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101051281  LUM; lumican [KO:K08122]
101035660  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101035635  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101036938  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101043647  TP53; cellular tumor antigen p53 [KO:K04451]
101044624  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
101040653  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
101043067  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
101048909  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
101050992  SDC1; syndecan-1 [KO:K06257]
101045946  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
101041224  PLAUR; urokinase plasminogen activator surface receptor [KO:K03985]
101051510  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101045518  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101041311  ITGA2; integrin alpha-2 [KO:K06481]
101040620  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101045891  VTN; vitronectin [KO:K06251]
101032614  ITGAV; integrin alpha-V [KO:K06487]
101049562  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
101045340  FN1; fibronectin isoform X10 [KO:K05717]
101029859  ITGB5; integrin beta-5 [KO:K06588]
101045517  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101044133  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101030044  FZD1; frizzled-1 [KO:K02432]
101049451  FZD7; frizzled-7 [KO:K02432]
101046720  FZD2; frizzled-2 [KO:K02235]
101037304  FZD3; frizzled-3 [KO:K02329]
101054300  FZD4; frizzled-4 [KO:K02354]
101036058  FZD5; frizzled-5 [KO:K02375]
101047742  FZD6; frizzled-6 [KO:K02376]
101030134  FZD9; frizzled-9 [KO:K02842]
101032028  FZD10; frizzled-10 [KO:K02842]
101043820  ITGA5; integrin alpha-5 [KO:K06484]
101032460  SDC2; syndecan-2 [KO:K16336]
101050249  EZR; ezrin isoform X1 [KO:K08007]
101037449  RDX; radixin isoform X1 [KO:K05762]
101031642  MSN; moesin [KO:K05763]
101051749  SDC4; syndecan-4 [KO:K16338]
101030554  FGF2; fibroblast growth factor 2 [KO:K18497]
101033213  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101043538  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
101031381  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101033019  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
101036943  SOS1; son of sevenless homolog 1 [KO:K03099]
101046427  SOS2; son of sevenless homolog 2 [KO:K03099]
101046976  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101030999  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101046010  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101039384  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101032613  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101044941  NUDT16L1; protein syndesmos [KO:K16867]
101054286  PXN; paxillin isoform X1 [KO:K05760]
101052217  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101029484  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
101036895  GPC1; glypican-1 [KO:K08107]
101036519  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
101049389  GPC3; glypican-3 [KO:K08109]
101037307  WNT2; protein Wnt-2 [KO:K00182]
101051098  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
101035500  WNT3A; protein Wnt-3a [KO:K00312]
101048838  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
101050255  WNT4; protein Wnt-4 [KO:K00408]
101038250  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
101040063  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
101028364  WNT6; protein Wnt-6 [KO:K00445]
101027644  WNT7A; protein Wnt-7a [KO:K00572]
101041057  WNT8B; protein Wnt-8b [KO:K00714]
101037830  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
104650180  WNT9B; protein Wnt-9b [KO:K01064]
101029432  WNT10A; protein Wnt-10a [KO:K01357]
101043819  WNT10B; protein Wnt-10b [KO:K01357]
101050295  WNT11; protein Wnt-11 [KO:K01384]
101032778  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
101034605  SHH; sonic hedgehog protein [KO:K11988]
101027525  IHH; indian hedgehog protein [KO:K11989]
101048276  PTCH1; protein patched homolog 1 [KO:K06225]
101028873  SMO; smoothened homolog [KO:K06226]
101035920  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
101030077  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
101051131  LOW QUALITY PROTEIN: putative cathepsin L-like protein 6 [KO:K01365] [EC:3.4.22.15]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101037444  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101044137  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101040899  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101052690  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101030267  HSPB2; heat shock protein beta-2 [KO:K09543]
101032306  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X4 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
sbq04010  MAPK signaling pathway
sbq04020  Calcium signaling pathway
sbq04066  HIF-1 signaling pathway
sbq04150  mTOR signaling pathway
sbq04151  PI3K-Akt signaling pathway
sbq04210  Apoptosis
sbq04310  Wnt signaling pathway
sbq04340  Hedgehog signaling pathway
sbq04350  TGF-beta signaling pathway
sbq04370  VEGF signaling pathway
sbq04510  Focal adhesion
sbq04520  Adherens junction
sbq04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
LinkDB

DBGET integrated database retrieval system