KEGG   PATHWAY: shr05208
Entry
shr05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Sarcophilus harrisii (Tasmanian devil)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
shr05208  Chemical carcinogenesis - reactive oxygen species
shr05208

Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100928482  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100929215  GSTT2B; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100924507  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100926836  LOW QUALITY PROTEIN: glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100935165  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100913363  glutathione S-transferase omega-1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
100927430  glutathione S-transferase Mu 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
100927692  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
100927944  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100929408  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100926310  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100926572  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
100927091  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
13826446  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
13826439  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
13826438  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
13826443  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
13826441  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
13826442  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
13826444  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100934645  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100928428  NDUFV2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100919401  LOW QUALITY PROTEIN: uncharacterized protein LOC100919401 [KO:K03944]
100919666  uncharacterized protein LOC100919666 [KO:K03944]
100933088  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100929783  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100929856  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
116419640  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100924322  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
100919967  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100918785  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100913375  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100933750  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100915617  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
100924549  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100927317  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100927182  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100922703  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100922855  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100930539  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100927339  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100918876  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100934778  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
111719323  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100913747  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100926601  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
116420693  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100917145  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100915928  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100914378  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
100922998  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
111721451  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100930936  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
100932609  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100933792  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100922533  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
100918238  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100929004  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100928800  NDUFC2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100931806  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
100924299  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100918297  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100916627  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
100920165  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
13826445  CYTB; cytochrome b [KO:K00412]
100923048  cytochrome c1, heme protein, mitochondrial [KO:K00413]
100919227  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100935369  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100933846  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
100928777  cytochrome b-c1 complex subunit 7 [KO:K00417]
100934825  cytochrome b-c1 complex subunit 8 [KO:K00418]
100933375  cytochrome b-c1 complex subunit 9 [KO:K00419]
100931111  cytochrome b-c1 complex subunit 10 [KO:K00420]
13826436  COX3; cytochrome c oxidase subunit III [KO:K02262]
13826440  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
13826435  COX2; cytochrome c oxidase subunit II [KO:K02261]
100924710  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
100922691  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X5 [KO:K02263]
100928744  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100919989  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100918528  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
111719270  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100922461  cytochrome c oxidase subunit 6B1 [KO:K02267]
100934493  cytochrome c oxidase subunit 6C [KO:K02268]
100921435  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100930775  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100928083  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100922983  cytochrome c oxidase subunit 7A1, mitochondrial-like [KO:K02270]
100932664  cytochrome c oxidase subunit 7B, mitochondrial isoform X1 [KO:K02271]
100933884  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100932575  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100921543  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100920745  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100934419  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100930145  ATP5F1E; LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial [KO:K02135]
13826434  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100916300  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100926225  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100914229  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
100915508  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100930357  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100923940  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100931914  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
13826437  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100922476  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
100927813  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100920408  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100923123  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
100920060  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100929945  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
116422319  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100925120  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100920450  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
100921016  CAT; catalase [KO:K03781] [EC:1.11.1.6]
105750931  SLC26A1; sulfate anion transporter 1 isoform X2 [KO:K14700]
100916422  SLC26A2; sulfate transporter [KO:K14701]
105749570  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
100933737  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
116421952  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
100923691  cytochrome P450 2F2 [KO:K07416] [EC:1.14.14.1]
100927711  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
100935353  cytochrome P450 1B1 isoform X2 [KO:K07410] [EC:1.14.14.1]
100925093  EPHX1; epoxide hydrolase 1 isoform X2 [KO:K01253] [EC:3.3.2.9]
100931196  bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100931720  LOW QUALITY PROTEIN: bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100931457  LOW QUALITY PROTEIN: bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100927232  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
100925348  EPHX4; epoxide hydrolase 4 isoform X1 [KO:K22369] [EC:3.3.-.-]
100933920  AKR1A1; aldo-keto reductase family 1 member A1 isoform X3 [KO:K00002] [EC:1.1.1.2]
100916256  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
100920969  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100933338  AHR; aryl hydrocarbon receptor [KO:K09093]
100916736  uncharacterized protein LOC100916736 [KO:K09093]
116423505  aryl hydrocarbon receptor-like [KO:K09093]
100918549  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
100934509  NOX4; NADPH oxidase 4 isoform X3 [KO:K21423] [EC:1.6.3.-]
100932491  cytochrome b-245 light chain isoform X1 [KO:K08009]
100920650  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100922051  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100933169  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100915696  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100917007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100927252  ras-related protein Rab-26-like [KO:K07827]
100929426  ras protein let-60-like [KO:K07827]
100928986  NRAS; GTPase NRas [KO:K07828]
100913901  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100917439  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100931587  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100926110  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100930815  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100928480  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100924267  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100928729  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100928990  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100925013  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100925447  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116423739  JUN; transcription factor AP-1 [KO:K04448]
100924435  FOS; proto-oncogene c-Fos [KO:K04379]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100919657  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100917568  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100917083  FOXO3; forkhead box protein O3 [KO:K09408]
100923199  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116421513  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
100927199  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100913624  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100928932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100926701  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
100919027  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
100932473  RELA; transcription factor p65 [KO:K04735]
100917619  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100925245  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
100919624  PTPRJ; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
100915295  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
100930062  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100915682  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100926529  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
100930047  ABL1; tyrosine-protein kinase ABL1 isoform X2 [KO:K06619] [EC:2.7.10.2]
100934520  ABL2; tyrosine-protein kinase ABL2 isoform X2 [KO:K08887] [EC:2.7.10.2]
100918841  PRKD1; serine/threonine-protein kinase D1 isoform X2 [KO:K06070] [EC:2.7.11.13]
100913910  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
100920206  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
100933019  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
100926651  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100914579  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100918124  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100931887  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
100917700  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
100913423  VEGFA; vascular endothelial growth factor A [KO:K05448]
100927230  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
100915496  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
100925365  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
shr00190  Oxidative phosphorylation
shr00980  Metabolism of xenobiotics by cytochrome P450
shr04010  MAPK signaling pathway
shr04064  NF-kappa B signaling pathway
shr04066  HIF-1 signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04370  VEGF signaling pathway
shr05207  Chemical carcinogenesis - receptor activation
shr05211  Renal cell carcinoma
shr05215  Prostate cancer
shr05219  Bladder cancer
shr05221  Acute myeloid leukemia
shr05222  Small cell lung cancer
shr05223  Non-small cell lung cancer
shr05224  Breast cancer
shr05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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