KEGG   PATHWAY: ssc04360
Entry
ssc04360                    Pathway                                
Name
Axon guidance - Sus scrofa (pig)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
ssc04360  Axon guidance
ssc04360

Other DBs
GO: 0007411
Organism
Sus scrofa (pig) [GN:ssc]
Gene
100152257  NTNG1; netrin-G1 isoform X1 [KO:K07522]
100512264  NTNG2; LOW QUALITY PROTEIN: netrin-G2 [KO:K16359]
106509370  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
100521592  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
733599  NTN1; netrin-1 precursor [KO:K06843]
100622906  NTN3; LOW QUALITY PROTEIN: netrin-3 [KO:K06844]
100516554  NTN4; netrin-4 isoform X2 [KO:K06845]
100152102  DCC; netrin receptor DCC isoform X4 [KO:K06765]
100152497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100518663  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100156938  TRPC1; short transient receptor potential channel 1 [KO:K04964]
397210  TRPC3; short transient receptor potential channel 3 [KO:K04966]
100157635  TRPC4; short transient receptor potential channel 4 [KO:K04967]
100037962  TRPC5; short transient receptor potential channel 5 [KO:K04968]
100271728  TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969]
397241  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100158082  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
396603  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
100625117  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100627903  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100134969  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
100739450  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100154469  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
102167153  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
791125  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
100154503  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
100627149  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100621675  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
110255928  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
780428  CDC42; cell division control protein 42 homolog [KO:K04393]
100154343  ABLIM1; actin-binding LIM protein 1 isoform X21 [KO:K07520]
100522624  ABLIM2; LOW QUALITY PROTEIN: actin-binding LIM protein 2 [KO:K07520]
100515194  ABLIM3; actin-binding LIM protein 3 isoform X1 [KO:K07520]
100192438  NCK1; cytoplasmic protein NCK1 [KO:K07365]
100525766  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100511837  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100624533  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
100627936  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
100152316  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
100153981  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
396849  RHOA; transforming protein RhoA [KO:K04513]
397447  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
397445  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
733600  UNC5B; netrin receptor UNC5B precursor [KO:K07521]
100156454  UNC5D; netrin receptor UNC5D isoform X1 [KO:K07521]
100525154  UNC5A; netrin receptor UNC5A isoform X1 [KO:K07521]
100621284  UNC5C; netrin receptor UNC5C isoform X1 [KO:K07521]
100170851  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100620540  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100156429  RGMA; repulsive guidance molecule A isoform X2 [KO:K23096]
100510914  NEO1; neogenin isoform X1 [KO:K06766]
100625329  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
100157760  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
733637  myosin regulatory light chain 2 protein isoform 1 [KO:K12757]
414399  MRLC2; myosin regulatory light chain 12B [KO:K12757]
100523324  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X5 [KO:K07532]
100154795  LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609]
100144501  EFNA1; ephrin-A1 precursor [KO:K05462]
100154710  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100512036  EFNA2; ephrin-A2 isoform X2 [KO:K05462]
100513721  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100155923  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
100135672  EFNB3; ephrin-B3 precursor [KO:K05463]
100135673  EFNB2; ephrin-B2 [KO:K05463]
100624619  EFNB1; ephrin-B1 isoform X1 [KO:K05463]
100519989  EPHA1; ephrin type-A receptor 1 [KO:K05102] [EC:2.7.10.1]
100522873  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100337658  EPHA3; ephrin type-A receptor 3 precursor [KO:K05104] [EC:2.7.10.1]
100188979  EPHA4; ephrin type-A receptor 4 precursor [KO:K05105] [EC:2.7.10.1]
100511463  EPHA5; ephrin type-A receptor 5 isoform X1 [KO:K05106] [EC:2.7.10.1]
100156650  EPHA6; ephrin type-A receptor 6 isoform X1 [KO:K05107] [EC:2.7.10.1]
100154222  EPHA7; ephrin type-A receptor 7 isoform X1 [KO:K05108] [EC:2.7.10.1]
100518378  EPHA8; LOW QUALITY PROTEIN: ephrin type-A receptor 8 [KO:K05109] [EC:2.7.10.1]
100524585  EPHB1; ephrin type-B receptor 1 [KO:K05110] [EC:2.7.10.1]
100519549  EPHB2; ephrin type-B receptor 2 isoform X3 [KO:K05111] [EC:2.7.10.1]
100337659  EPHB3; ephrin type-B receptor 3 isoform X1 [KO:K05112] [EC:2.7.10.1]
100517028  EPHB4; ephrin type-B receptor 4 [KO:K05113] [EC:2.7.10.1]
100511727  EPHB6; ephrin type-B receptor 6 isoform X1 [KO:K05114] [EC:2.7.10.1]
100524544  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100525245  ENAH; protein enabled homolog isoform X1 [KO:K05746]
100627579  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
100153801  NGEF; ephexin-1 isoform X1 [KO:K07525]
110259208  HRAS; GTPase HRas isoform X1 [KO:K02833]
100518251  KRAS; GTPase KRas isoform X2 [KO:K07827]
100739349  NRAS; GTPase NRas precursor [KO:K07828]
100153927  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
445013  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100192439  NCK2; cytoplasmic protein NCK2 [KO:K19862]
100517994  RGS3; LOW QUALITY PROTEIN: regulator of G-protein signaling 3 [KO:K07524]
494460  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
396659  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100144421  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100144419  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
397523  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100627880  SLIT1; slit homolog 1 protein [KO:K06838]
100620577  SLIT2; LOW QUALITY PROTEIN: slit homolog 2 protein [KO:K06839]
100513444  SLIT3; slit homolog 3 protein isoform X1 [KO:K06850]
100517310  ROBO1; roundabout homolog 1 isoform X9 [KO:K06753]
100517681  ROBO2; roundabout homolog 2 isoform X1 [KO:K06754]
100524637  ROBO3; roundabout homolog 3 [KO:K06755]
100518625  SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X5 [KO:K07526]
100623414  SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X2 [KO:K07526]
102167373  SRGAP3; LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526]
100153200  SEMA3B; semaphorin-3B isoform X1 [KO:K06840]
100157653  SEMA3G; semaphorin-3G [KO:K06840]
100153225  SEMA3F; semaphorin-3F isoform X1 [KO:K06840]
100523915  SEMA3D; semaphorin-3D [KO:K06840]
100524100  SEMA3E; semaphorin-3E isoform X1 [KO:K06840]
100624508  SEMA3C; semaphorin-3C isoform X1 [KO:K06840]
100620398  SEMA3A; semaphorin-3A isoform X1 [KO:K06840]
100620243  PLXNA4; plexin-A4 [KO:K06820]
100624579  PLXNA1; plexin-A1 isoform X1 [KO:K06820]
100620331  PLXNA3; LOW QUALITY PROTEIN: plexin-A3 [KO:K06820]
100624791  PLXNA2; LOW QUALITY PROTEIN: plexin-A2 [KO:K06820]
100286859  NRP1; neuropilin-1 isoform X2 [KO:K06724]
100525324  L1CAM; LOW QUALITY PROTEIN: neural cell adhesion molecule L1 [KO:K06550]
100627618  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
100156359  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
445532  CFL1; cofilin-1 [KO:K05765]
497233  CFL2; cofilin-2 [KO:K05765]
100625773  RHOD; rho-related GTP-binding protein RhoD [KO:K07530]
100737739  RND1; rho-related GTP-binding protein Rho6 [KO:K07531]
100155631  FES; tyrosine-protein kinase Fes/Fps isoform X2 [KO:K07527] [EC:2.7.10.2]
100511810  DPYSL5; dihydropyrimidinase-related protein 5 [KO:K07529]
100151886  DPYSL2; dihydropyrimidinase-related protein 2 isoform X3 [KO:K07528]
733700  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
100126852  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100152598  SEMA4D; semaphorin-4D isoform X1 [KO:K06521]
100157147  SEMA4A; semaphorin-4A isoform X1 [KO:K06521]
100512275  SEMA4F; semaphorin-4F isoform X1 [KO:K06521]
100525283  SEMA4C; semaphorin-4C isoform X2 [KO:K06521]
100625712  SEMA4G; semaphorin-4G [KO:K06521]
110261555  SEMA4B; semaphorin-4B [KO:K06521]
100737194  SEMA5A; LOW QUALITY PROTEIN: semaphorin-5A [KO:K06841]
100519925  SEMA5B; semaphorin-5B isoform X1 [KO:K06841]
100153477  SEMA6C; semaphorin-6C isoform X4 [KO:K06842]
100511850  SEMA6D; semaphorin-6D isoform X1 [KO:K06842]
100522008  SEMA6A; semaphorin-6A isoform X2 [KO:K06842]
110259360  SEMA6B; semaphorin-6B isoform X1 [KO:K06842]
100522643  PLXNB1; LOW QUALITY PROTEIN: plexin-B1 [KO:K06821]
100525146  PLXNB3; plexin-B3 [KO:K06821]
110260603  PLXNB2; plexin-B2 isoform X1 [KO:K06821]
654328  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100737448  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100516558  RRAS; ras-related protein R-Ras [KO:K07829]
100623369  SEMA7A; semaphorin-7A isoform X1 [KO:K06529]
100519487  PLXNC1; plexin-C1 isoform X1 [KO:K06572]
397019  ITGB1; integrin beta-1 precursor [KO:K05719]
100512749  SHH; sonic hedgehog protein preproprotein [KO:K11988]
100627504  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
100515110  SMO; smoothened homolog [KO:K06226]
397184  PRKCA; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100623256  ILK; integrin-linked protein kinase isoform X2 [KO:K06272] [EC:2.7.11.1]
100626085  BOC; brother of CDO isoform X2 [KO:K20020]
100516268  WNT5B; LOW QUALITY PROTEIN: protein Wnt-5b [KO:K00444]
100627056  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100153078  FZD3; frizzled-3 isoform X1 [KO:K02329]
100523513  RYK; LOW QUALITY PROTEIN: tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
397674  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
397394  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100626014  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X7 [KO:K04515] [EC:2.7.11.17]
100516166  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100327037  WNT4; protein Wnt-4 [KO:K00408]
100518131  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100621789  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100622559  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100511937  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100739510  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100623707  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100192445  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100512009  PARD3; LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
100533200  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100151957  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100522059  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100623575  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100520864  SSH2; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100157825  SSH1; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
106504157  SSH3; protein phosphatase Slingshot homolog 3 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
492315  BMP7; bone morphogenetic protein 7 precursor [KO:K16621]
100624534  GDF7; growth/differentiation factor 7 isoform X1 [KO:K20013]
100127483  BMPR2; bone morphogenetic protein receptor type-2 precursor [KO:K04671] [EC:2.7.11.30]
396691  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
ssc04010  MAPK signaling pathway
ssc04060  Cytokine-cytokine receptor interaction
ssc04310  Wnt signaling pathway
ssc04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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