KEGG   PATHWAY: thj03015
Entry
thj03015                    Pathway                                
Name
mRNA surveillance pathway - Tarenaya hassleriana (spider flower)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
thj03015  mRNA surveillance pathway
thj03015

Other DBs
GO: 0071028
Organism
Tarenaya hassleriana (spider flower) [GN:thj]
Gene
104800443  nuclear cap-binding protein subunit 1 [KO:K12882]
104801162  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
104806760  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
104815973  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
104817916  RNA-binding protein 8A-B-like [KO:K12876]
104816872  RNA-binding protein 8A-B isoform X1 [KO:K12876]
104811180  RNA-binding protein 8A-B-like [KO:K12876]
104801496  protein mago nashi homolog [KO:K12877]
104816996  protein mago nashi homolog [KO:K12877]
104814107  LOW QUALITY PROTEIN: protein mago nashi homolog [KO:K12877]
104826525  DEAD-box ATP-dependent RNA helicase 2 [KO:K13025] [EC:5.6.2.7]
104815234  LOW QUALITY PROTEIN: DEAD-box ATP-dependent RNA helicase 2-like [KO:K13025] [EC:5.6.2.7]
104802003  histone deacetylase complex subunit SAP18 [KO:K14324]
104805935  pinin [KO:K13114]
104807709  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
104824862  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
104813616  serine/arginine-rich splicing factor SR45-like isoform X1 [KO:K14325]
104827008  THO complex subunit 4B-like [KO:K12881]
104822306  THO complex subunit 4D isoform X1 [KO:K12881]
104823255  LOW QUALITY PROTEIN: THO complex subunit 4B-like [KO:K12881]
104823841  THO complex subunit 4D-like [KO:K12881]
104816286  THO complex subunit 4B [KO:K12881]
104805142  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:5.6.2.7]
104805269  protein GLE1 isoform X1 [KO:K18723]
104799232  DEAD-box ATP-dependent RNA helicase 56 [KO:K12812] [EC:5.6.2.7]
104798662  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
104825180  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
104809537  partner of Y14 and mago [KO:K14294]
104800686  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
104816222  mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
104823280  mRNA-capping enzyme-like isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
104827039  mRNA-capping enzyme-like isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
104806007  mRNA cap guanine-N7 methyltransferase 2 [KO:K00565] [EC:2.1.1.56]
104817889  mRNA cap guanine-N7 methyltransferase 1 [KO:K00565] [EC:2.1.1.56]
104814919  transcription initiation factor TFIID subunit 15b [KO:K13098]
104801673  polyadenylate-binding protein 3 [KO:K14396]
104798864  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
104814766  polyadenylate-binding protein 2-like isoform X1 [KO:K14396]
104825048  polyadenylate-binding protein 1-like [KO:K14396]
104811544  polyadenylate-binding protein 1 [KO:K14396]
104800254  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
104811985  pre-mRNA cleavage factor Im 25 kDa subunit 2-like [KO:K14397]
104820017  pre-mRNA cleavage factor Im 25 kDa subunit 1 [KO:K14397]
104827596  pre-mRNA cleavage factor Im 25 kDa subunit 2-like [KO:K14397]
104825098  pre-mRNA cleavage factor Im 25 kDa subunit 2-like [KO:K14397]
104813448  cleavage and polyadenylation specificity factor subunit 6-like [KO:K14398]
104825680  RNA-binding motif protein, X-linked-like-2 [KO:K14398]
104824017  cleavage and polyadenylation specificity factor subunit CG7185-like [KO:K14398]
104818108  spidroin-1-like [KO:K14398]
104803745  nuclear poly(A) polymerase 4 isoform X1 [KO:K14376] [EC:2.7.7.19]
104803802  nuclear poly(A) polymerase 4-like isoform X1 [KO:K14376] [EC:2.7.7.19]
104811261  nuclear poly(A) polymerase 4-like [KO:K14376] [EC:2.7.7.19]
104818875  nuclear poly(A) polymerase 3 [KO:K14376] [EC:2.7.7.19]
104812155  nuclear poly(A) polymerase 1 isoform X1 [KO:K14376] [EC:2.7.7.19]
104811064  protein CLP1 homolog isoform X1 [KO:K14399] [EC:2.7.1.78]
104805097  polyadenylation and cleavage factor homolog 4-like [KO:K14400]
104812944  polyadenylation and cleavage factor homolog 4 isoform X1 [KO:K14400]
104822429  polyadenylation and cleavage factor homolog 1-like [KO:K14400]
104824534  polyadenylation and cleavage factor homolog 4 [KO:K14400]
104825074  cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
104821393  cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
104819173  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
104798605  30-kDa cleavage and polyadenylation specificity factor 30 [KO:K14404]
104811338  putative uncharacterized protein DDB_G0274405 [KO:K14404]
104824416  uncharacterized protein LOC104824416 [KO:K14404]
104826724  flowering time control protein FY-like [KO:K15542]
104819128  flowering time control protein FY-like [KO:K15542]
104821325  WD repeat-containing protein 82-B isoform X1 [KO:K14962]
104822400  WD repeat-containing protein 82 [KO:K14962]
104809362  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1 isozyme 3 [KO:K06269] [EC:3.1.3.16]
104810065  serine/threonine-protein phosphatase PP1 isozyme 4 [KO:K06269] [EC:3.1.3.16]
104802792  serine/threonine-protein phosphatase PP1 isozyme 9 [KO:K06269] [EC:3.1.3.16]
104810749  serine/threonine-protein phosphatase PP1 isozyme 2 [KO:K06269] [EC:3.1.3.16]
104815772  serine/threonine-protein phosphatase PP1 isozyme 1 [KO:K06269] [EC:3.1.3.16]
104826079  serine/threonine-protein phosphatase PP1 isozyme 7 [KO:K06269] [EC:3.1.3.16]
104823766  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
104815993  serine/threonine-protein phosphatase PP1 isozyme 7-like isoform X1 [KO:K06269] [EC:3.1.3.16]
104814760  serine/threonine-protein phosphatase PP1 isozyme 6-like isoform X1 [KO:K06269] [EC:3.1.3.16]
104814889  serine/threonine-protein phosphatase PP1 isozyme 2-like [KO:K06269] [EC:3.1.3.16]
104818727  serine/threonine-protein phosphatase PP1 isozyme 9 isoform X1 [KO:K06269] [EC:3.1.3.16]
104821300  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
104813029  serine/threonine-protein phosphatase PP1 isozyme 6 [KO:K06269] [EC:3.1.3.16]
104812146  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
104818519  LOW QUALITY PROTEIN: cleavage stimulation factor subunit 50 [KO:K14406]
104800099  cleavage stimulating factor 64 [KO:K14407]
104800222  cleavage stimulating factor 64-like [KO:K14407]
104812205  cleavage stimulation factor subunit 77 [KO:K14408]
104799842  uncharacterized protein LOC104799842 isoform X1 [KO:K06100]
104825811  uncharacterized protein LOC104825811 [KO:K06100]
104816196  uncharacterized protein LOC104816196 isoform X1 [KO:K06100]
104808854  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
104806733  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
104808655  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
104807586  RNA-binding protein Musashi homolog 2 [KO:K14411]
104801074  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
104802622  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
104816766  RNA-binding protein 1 [KO:K14411]
104813442  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
104826617  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
104817697  heterogeneous nuclear ribonucleoprotein 1-like isoform X1 [KO:K14411]
104812800  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
104826659  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
104811651  heterogeneous nuclear ribonucleoprotein 1 isoform X1 [KO:K14411]
104798793  polyadenylate-binding protein 8-like [KO:K13126]
104800094  polyadenylate-binding protein 3 isoform X1 [KO:K13126]
104804379  polyadenylate-binding protein 2-like [KO:K13126]
104804545  polyadenylate-binding protein 4-like [KO:K13126]
104810539  polyadenylate-binding protein 6-like [KO:K13126]
104807261  LOW QUALITY PROTEIN: polyadenylate-binding protein 2 [KO:K13126]
104807595  polyadenylate-binding protein 4 [KO:K13126]
104823023  30S ribosomal protein 2, chloroplastic [KO:K13126]
104817957  polyadenylate-binding protein 6 [KO:K13126]
104825367  polyadenylate-binding protein 8 isoform X2 [KO:K13126]
104820493  polyadenylate-binding protein 8-like isoform X1 [KO:K13126]
104814171  polyadenylate-binding protein 2-like [KO:K13126]
104827503  polyadenylate-binding protein 7 isoform X1 [KO:K13126]
104807188  eukaryotic peptide chain release factor subunit 1-1 [KO:K03265]
104799994  eukaryotic peptide chain release factor subunit 1-1-like [KO:K03265]
104805291  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
104807998  eukaryotic peptide chain release factor subunit 1-1-like [KO:K03265]
104813913  eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
104812160  eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like [KO:K03267]
104798343  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104806689  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104809987  regulator of nonsense transcripts UPF2 [KO:K14327]
104807342  uncharacterized protein LOC104807342 [KO:K08873] [EC:2.7.11.1]
104799125  protein SMG7-like [KO:K14409]
104811190  protein SMG7 [KO:K14409]
104802239  serine/threonine-protein phosphatase PP2A-3 catalytic subunit [KO:K04382] [EC:3.1.3.16]
104802782  serine/threonine-protein phosphatase PP2A-3 catalytic subunit [KO:K04382] [EC:3.1.3.16]
104808798  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like isoform X1 [KO:K04382] [EC:3.1.3.16]
104822943  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
104821037  serine/threonine-protein phosphatase PP2A-3 catalytic subunit isoform X1 [KO:K04382] [EC:3.1.3.16]
104819719  serine/threonine-protein phosphatase PP2A-2 catalytic subunit isoform X1 [KO:K04382] [EC:3.1.3.16]
104822079  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
104805249  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
104821949  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
104824034  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
104805916  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
104798709  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
104812210  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104813945  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104817931  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
104801146  serine/threonine protein phosphatase 2A regulatory subunit B''alpha isoform X1 [KO:K11583]
104805784  probable serine/threonine protein phosphatase 2A regulatory subunit B''delta isoform X1 [KO:K11583]
104801728  serine/threonine protein phosphatase 2A regulatory subunit B''beta-like [KO:K11583]
104802847  serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583]
104821241  probable serine/threonine protein phosphatase 2A regulatory subunit B''delta [KO:K11583]
104818847  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
104807730  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
104809975  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform isoform X1 [KO:K11584]
104809018  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584]
104826920  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
104812226  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
104816360  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
104820217  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform-like [KO:K11584]
104815041  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform [KO:K11584]
104821755  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform-like [KO:K11584]
104824020  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform [KO:K11584]
104824023  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform [KO:K11584]
104825528  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
104803321  HBS1-like protein isoform X1 [KO:K14416]
104814967  HBS1-like protein isoform X1 [KO:K14416]
104821795  protein PELOTA 1 [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
thj03013  Nucleocytoplasmic transport
thj03018  RNA degradation
thj03040  Spliceosome
KO pathway
ko03015   
LinkDB

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