KEGG   PATHWAY: tpai04510
Entry
tpai04510                   Pathway                                
Name
Focal adhesion - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tpai04510  Focal adhesion
tpai04510

Other DBs
GO: 0005925
Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128074711  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
128085258  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
128073653  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
128082202  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
128082252  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
128075833  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
128075834  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
128092204  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
128092205  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
128076632  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
128076731  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
128077145  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
128085639  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
128080890  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
128088277  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
128076078  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
128074842  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
128090816  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
128080826  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
128091449  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
128078412  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
128079677  LAMB1; laminin subunit beta-1 [KO:K05636]
128078355  laminin subunit beta-2-like [KO:K06243]
128078357  laminin subunit beta-2-like [KO:K06243]
128088067  LAMB3; laminin subunit beta-3 [KO:K06244]
128079500  LAMB4; laminin subunit beta-4 [KO:K06245]
128072150  LAMC1; laminin subunit gamma-1 [KO:K05635]
128072153  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
128073887  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
128083127  CHAD; chondroadherin isoform X1 [KO:K06248]
128079544  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
128086613  THBS1; thrombospondin-1 [KO:K16857]
128086523  THBS2; thrombospondin-2 [KO:K04659]
128074425  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
128088837  COMP; cartilage oligomeric matrix protein [KO:K04659]
128076844  FN1; fibronectin isoform X1 [KO:K05717]
128080437  SPP1; osteopontin [KO:K06250]
128083687  VTN; vitronectin [KO:K06251]
128074111  TNC; tenascin isoform X1 [KO:K06252]
128074274  tenascin-X-like isoform X1 [KO:K06252]
128072404  TNR; tenascin-R isoform X1 [KO:K06252]
128072406  TNN; tenascin-N isoform X1 [KO:K06252]
128084459  VWF; von Willebrand factor isoform X1 [KO:K03900]
128080495  IBSP; bone sialoprotein 2 [KO:K06253]
128074412  ITGA1; integrin alpha-1 [KO:K06480]
128074410  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
128088819  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
128074721  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
128076949  ITGA4; integrin alpha-4 [KO:K06483]
128076685  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
128090472  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
128086382  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
128085591  ITGA9; integrin alpha-9 [KO:K06585]
128072021  ITGA10; integrin alpha-10 [KO:K06586]
128075272  ITGA11; integrin alpha-11 [KO:K06587]
128076982  ITGAV; integrin alpha-V [KO:K06487]
128085455  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128088725  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
128083052  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
128077229  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
128076937  ITGB6; integrin beta-6 [KO:K06589]
128085800  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
128079334  EMP2; epithelial membrane protein 2 [KO:K26256]
128079041  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128073591  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128074814  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
128084384  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
128080350  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
128073537  IGF1; insulin-like growth factor I [KO:K05459]
128076240  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
128086972  PGF; placenta growth factor isoform X1 [KO:K16859]
128080166  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
128076448  VEGFD; vascular endothelial growth factor D [KO:K05449]
128079558  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
128080542  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
128081597  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
128075328  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
128080541  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128088438  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128074996  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128075754  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
128081503  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
128073475  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128089037  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
128074024  EMP1; epithelial membrane protein 1 [KO:K26255]
128081145  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
128085675  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
128078777  RHOA; transforming protein RhoA [KO:K04513]
128091426  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
128084251  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
128084726  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
128080912  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
128083521  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
128090813  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
128090814  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
128086790  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
128076356  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
128084646  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
128074109  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
128090296  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
128080942  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
128087741  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
128081886  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
128088754  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
128076624  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
128089356  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
128090138  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
128071911  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
128075170  actin, cytoplasmic type 5 [KO:K05692]
128083066  ACTG1; actin, cytoplasmic 2 [KO:K05692]
128079246  ACTB; actin, cytoplasmic 1 [KO:K05692]
128075443  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
128076189  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
128073380  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
128085527  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
128074581  TLN1; talin-1 isoform X1 [KO:K06271]
128075126  TLN2; talin-2 [KO:K06271]
128078718  FLNB; filamin-B isoform X1 [KO:K27392]
128084073  PXN; paxillin isoform X1 [KO:K05760]
128088605  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
128089828  ZYX; LOW QUALITY PROTEIN: zyxin [KO:K06273]
128078209  VCL; vinculin isoform X1 [KO:K05700]
128084540  PARVB; beta-parvin isoform X1 [KO:K06275]
128084541  PARVG; gamma-parvin isoform X1 [KO:K06275]
128085613  PARVA; LOW QUALITY PROTEIN: alpha-parvin [KO:K06275]
128078925  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
128086784  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128085876  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128072414  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
128086077  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
128083108  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128078963  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
128090859  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
128082424  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128082641  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128084838  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128074427  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
128088982  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128072383  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
128077925  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128077425  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
128072818  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
128073308  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
128079308  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
128073655  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
128083202  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128074235  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
128082135  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
128075839  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
128073126  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
128087861  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
128086573  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
128085113  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128081724  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
128083660  CRK; adapter molecule crk isoform X1 [KO:K04438]
128084151  CRKL; crk-like protein [KO:K04438]
128077582  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
128073957  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
128088024  RAP1A; ras-related protein Rap-1A [KO:K04353]
128073883  RAP1B; ras-related protein Rap-1b [KO:K07836]
128079966  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
128083876  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128077983  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128072448  JUN; transcription factor Jun [KO:K04448]
128073173  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128073483  CAV1; caveolin-1 [KO:K06278]
128073484  CAV2; caveolin-2 [KO:K12958]
128078310  CAV3; caveolin-3 [KO:K12959]
128078435  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
128078804  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
128090392  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
128089591  SHC3; SHC-transforming protein 3 [KO:K17448]
128075375  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
128083026  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
128086826  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
128087173  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
128086364  HRAS; GTPase HRas [KO:K02833]
128078363  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128075267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128084585  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128086508  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
128084476  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
128087997  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
128074803  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
128076243  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
128087755  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
tpai04010  MAPK signaling pathway
tpai04060  Cytokine-cytokine receptor interaction
tpai04070  Phosphatidylinositol signaling system
tpai04110  Cell cycle
tpai04310  Wnt signaling pathway
tpai04512  ECM-receptor interaction
tpai04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

DBGET integrated database retrieval system