KEGG   ORTHOLOGY: K05361
Entry
K05361                      KO                                     

Name
GPX4
Definition
phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
ko04216  Ferroptosis
Disease
H01825  Spondylometaphyseal dysplasia, Sedaghatian type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.12  phospholipid-hydroperoxide glutathione peroxidase
     K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
Other DBs
RN: R03167
GO: 0047066
Genes
HSA: 2879(GPX4)
PTR: 741876(GPX4)
PPS: 100990361(GPX4)
PON: 100458624(GPX4)
NLE: 100601223(GPX4)
MCC: 705333(GPX4)
MCF: 102142580(GPX4)
CSAB: 103233593(GPX4)
RRO: 104671424(GPX4)
RBB: 108537892(GPX4)
CJC: 100391793(GPX4) 103790339
SBQ: 101053315(GPX4)
MMU: 625249(Gpx4)
MCAL: 110303889(Gpx4)
MPAH: 110326696(Gpx4)
RNO: 29328(Gpx4)
MUN: 110551358(Gpx4)
CGE: 100765235(Gpx4)
NGI: 103737339(Gpx4)
HGL: 101708875(Gpx4)
CCAN: 109681876(Gpx4)
TUP: 102483947(GPX4)
AML: 100464258
UMR: 103681777(GPX4)
UAH: 113242720(GPX4)
ORO: 101377930(GPX4)
ELK: 111161740
FCA: 101095956(GPX4)
PTG: 102949955(GPX4)
PPAD: 109257691(GPX4)
AJU: 106978096(GPX4)
BTA: 286809(GPX4)
BOM: 102284111(GPX4)
BIU: 109561977(GPX4)
BBUB: 102404388(GPX4)
CHX: 100860867(GPX4)
OAS: 101113149(GPX4)
SSC: 399537(GPX4)
CFR: 102515650(GPX4)
CDK: 105104118(GPX4)
BACU: 103000913(GPX4)
LVE: 103071491(GPX4)
OOR: 101270118(GPX4)
DLE: 111170533(GPX4)
PCAD: 102992869(GPX4)
ECB: 102147383(GPX4)
EAI: 106834230(GPX4)
MYB: 102247160 102257806(GPX4)
MYD: 102758267(GPX4)
MNA: 107534552(GPX4)
HAI: 109390605
DRO: 112312403(GPX4)
PALE: 102878189(GPX4)
RAY: 107500914(GPX4)
MJV: 108388787(GPX4)
LAV: 100675152(GPX4)
TMU: 101355012
MDO: 100015749(GPX4)
SHR: 100930158(GPX4)
PCW: 110223406(GPX4)
OAA: 100088643(GPX4)
GGA: 374056(GPX4)
MGP: 100379155(GPX4)
CJO: 107325473(GPX4)
NMEL: 110389092(GPX4)
APLA: 101796330(GPX4)
ACYG: 106048194(GPX4)
TGU: 100190423(GPX4)
LSR: 110479113(GPX4)
SCAN: 115483836(GPX4)
GFR: 102045367(GPX4)
FAB: 101817765(GPX4)
PHI: 102113402(GPX4)
PMAJ: 107215549(GPX4)
CCAE: 111940246(GPX4)
CCW: 104697013(GPX4)
ETL: 114066400(GPX4)
FPG: 101916317(GPX4)
FCH: 102055857(GPX4)
CLV: 102092188(GPX4)
EGZ: 104127393(GPX4)
NNI: 104016300(GPX4)
PADL: 103922946(GPX4)
AAM: 106493531(GPX4)
ASN: 102386897(GPX4)
AMJ: 102570581(GPX4)
PSS: 102460999(GPX4)
CMY: 102948400(GPX4)
CPIC: 101944764(GPX4)
ACS: 100563257(gpx4)
PVT: 110079257(GPX4)
PBI: 103065827(GPX4)
PMUR: 107295211(GPX4)
TSR: 106550757(GPX4)
PMUA: 114588449(GPX4)
GJA: 107107351(GPX4)
XLA: 100036920(gpx4.L) 734888(gpx4.S)
XTR: 100496541(gpx4)
NPR: 108789489(GPX4)
DRE: 352928(gpx4a) 352929(gpx4b)
SANH: 107660382
SGH: 107552704
IPU: 100528418(gpx4)
PHYP: 113533158(gpx4)
AMEX: 103026361(gpx4)
EEE: 113585970(gpx4)
NCC: 104958153(gpx4)
MZE: 101475014 101481366(gpx4)
XMA: 102218769 102219707(gpx4)
XCO: 114147031 114150819(gpx4)
PRET: 103463715(gpx4) 103479268
CVG: 107091856 107095297(gpx4)
NFU: 107384121 107393348(gpx4)
KMR: 108230562(gpx4) 108239424
ALIM: 106526245(gpx4)
CSEM: 103376758(gpx4) 103395914
SLAL: 111653742(gpx4) 111658891
BPEC: 110157283 110174007(gpx4)
MALB: 109966994(gpx4) 109969232
SASA: 100194734(gpx4b) 106573579
PKI: 111836622(gpx4) 111860199
CMK: 103189927(gpx4)
RTP: 109931453(gpx4)
BFO: 118421311
CIN: 100175675(gpx_e)
APLC: 110989974
SKO: 102807044
AGA: AgaP_AGAP004248(GPXH3)
AALB: 109401758
AME: 726269
BIM: 100743362
BTER: 100648859
CCAL: 108626755
OBB: 114877693
SOC: 105193617
MPHA: 105837252
ACEP: 105625818
PBAR: 105425460
VEM: 105566065
HST: 105183432
DQU: 106745051
CFO: 105248391
LHU: 105668639
PGC: 109853223
PCF: 106790095
CSOL: 105366802
MDL: 106693859
TCA: 658307(GLEAN_10355)
DPA: 109546481
BMOR: 101744684
TNL: 113505368
AGS: 114123314
ZNE: 110827342
PVM: 113800343
TUT: 107368679
DPTE: 113797481
PTEP: 107457231
CRG: 105330305
MYI: 110445160
EGL: EGR_06748
NVE: 116621178
ADF: 107353881
AMIL: 114973227
SPIS: 111325528
DGT: 114528108
HMG: 100212361 100215761(GPx)
SPAR: SPRG_01802
 » show all
Reference
PMID:8323565
  Authors
Sunde RA, Dyer JA, Moran TV, Evenson JK, Sugimoto M
  Title
Phospholipid hydroperoxide glutathione peroxidase: full-length pig blastocyst cDNA sequence and regulation by selenium status.
  Journal
Biochem Biophys Res Commun 193:905-11 (1993)
DOI:10.1006/bbrc.1993.1711
  Sequence
[ssc:399537]
LinkDB

KEGG   ENZYME: 1.11.1.12
Entry
EC 1.11.1.12                Enzyme                                 

Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O [RN:R03167]
Reaction(KEGG)
R03167
Substrate
glutathione [CPD:C00051];
hydroperoxy-fatty-acyl-[lipid]
Product
glutathione disulfide [CPD:C00127];
hydroxy-fatty-acyl-[lipid];
H2O [CPD:C00001]
Comment
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).
History
EC 1.11.1.12 created 1989, modified 2015
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K05361  phospholipid-hydroperoxide glutathione peroxidase
Genes
HSA: 2879(GPX4)
PTR: 741876(GPX4)
PPS: 100990361(GPX4)
PON: 100458624(GPX4)
NLE: 100601223(GPX4)
MCC: 705333(GPX4)
MCF: 102142580(GPX4)
CSAB: 103233593(GPX4)
RRO: 104671424(GPX4)
RBB: 108537892(GPX4)
CJC: 100391793(GPX4) 103790339
SBQ: 101053315(GPX4)
MMU: 625249(Gpx4)
MCAL: 110303889(Gpx4)
MPAH: 110326696(Gpx4)
RNO: 29328(Gpx4)
MUN: 110551358(Gpx4)
CGE: 100765235(Gpx4)
NGI: 103737339(Gpx4)
HGL: 101708875(Gpx4)
CCAN: 109681876(Gpx4)
TUP: 102483947(GPX4)
AML: 100464258
UMR: 103681777(GPX4)
UAH: 113242720(GPX4)
ORO: 101377930(GPX4)
ELK: 111161740
FCA: 101095956(GPX4)
PTG: 102949955(GPX4)
PPAD: 109257691(GPX4)
AJU: 106978096(GPX4)
BTA: 286809(GPX4)
BOM: 102284111(GPX4)
BIU: 109561977(GPX4)
BBUB: 102404388(GPX4)
CHX: 100860867(GPX4)
OAS: 101113149(GPX4)
SSC: 399537(GPX4)
CFR: 102515650(GPX4)
CDK: 105104118(GPX4)
BACU: 103000913(GPX4)
LVE: 103071491(GPX4)
OOR: 101270118(GPX4)
DLE: 111170533(GPX4)
PCAD: 102992869(GPX4)
ECB: 102147383(GPX4)
EAI: 106834230(GPX4)
MYB: 102247160 102257806(GPX4)
MYD: 102758267(GPX4)
MNA: 107534552(GPX4)
HAI: 109390605
DRO: 112312403(GPX4)
PALE: 102878189(GPX4)
RAY: 107500914(GPX4)
MJV: 108388787(GPX4)
LAV: 100675152(GPX4)
TMU: 101355012
MDO: 100015749(GPX4)
SHR: 100930158(GPX4)
PCW: 110223406(GPX4)
OAA: 100088643(GPX4)
GGA: 374056(GPX4)
MGP: 100379155(GPX4)
CJO: 107325473(GPX4)
NMEL: 110389092(GPX4)
APLA: 101796330(GPX4)
ACYG: 106048194(GPX4)
TGU: 100190423(GPX4)
LSR: 110479113(GPX4)
SCAN: 115483836(GPX4)
GFR: 102045367(GPX4)
FAB: 101817765(GPX4)
PHI: 102113402(GPX4)
PMAJ: 107215549(GPX4)
CCAE: 111940246(GPX4)
CCW: 104697013(GPX4)
ETL: 114066400(GPX4)
FPG: 101916317(GPX4)
FCH: 102055857(GPX4)
CLV: 102092188(GPX4)
EGZ: 104127393(GPX4)
NNI: 104016300(GPX4)
PADL: 103922946(GPX4)
AAM: 106493531(GPX4)
ASN: 102386897(GPX4)
AMJ: 102570581(GPX4)
PSS: 102460999(GPX4)
CMY: 102948400(GPX4)
CPIC: 101944764(GPX4)
ACS: 100563257(gpx4)
PVT: 110079257(GPX4)
PBI: 103065827(GPX4)
PMUR: 107295211(GPX4)
TSR: 106550757(GPX4)
PMUA: 114588449(GPX4)
GJA: 107107351(GPX4)
XLA: 100036920(gpx4.L) 734888(gpx4.S)
XTR: 100496541(gpx4)
NPR: 108789489(GPX4)
DRE: 352928(gpx4a) 352929(gpx4b)
SANH: 107660382
SGH: 107552704
IPU: 100528418(gpx4)
PHYP: 113533158(gpx4)
AMEX: 103026361(gpx4)
EEE: 113585970(gpx4)
NCC: 104958153(gpx4)
MZE: 101475014 101481366(gpx4)
XMA: 102218769 102219707(gpx4)
XCO: 114147031 114150819(gpx4)
PRET: 103463715(gpx4) 103479268
CVG: 107091856 107095297(gpx4)
NFU: 107384121 107393348(gpx4)
KMR: 108230562(gpx4) 108239424
ALIM: 106526245(gpx4)
CSEM: 103376758(gpx4) 103395914
SLAL: 111653742(gpx4) 111658891
BPEC: 110157283 110174007(gpx4)
MALB: 109966994(gpx4) 109969232
SASA: 100194734(gpx4b) 106573579
PKI: 111836622(gpx4) 111860199
CMK: 103189927(gpx4)
RTP: 109931453(gpx4)
BFO: 118421311
CIN: 100175675(gpx_e)
APLC: 110989974
SKO: 102807044
AGA: AgaP_AGAP004248(GPXH3)
AALB: 109401758
AME: 726269
BIM: 100743362
BTER: 100648859
CCAL: 108626755
OBB: 114877693
SOC: 105193617
MPHA: 105837252
ACEP: 105625818
PBAR: 105425460
VEM: 105566065
HST: 105183432
DQU: 106745051
CFO: 105248391
LHU: 105668639
PGC: 109853223
PCF: 106790095
CSOL: 105366802
MDL: 106693859
TCA: 658307(GLEAN_10355)
DPA: 109546481
BMOR: 101744684
TNL: 113505368
AGS: 114123314
ZNE: 110827342
PVM: 113800343
TUT: 107368679
DPTE: 113797481
PTEP: 107457231
CRG: 105330305
MYI: 110445160
EGL: EGR_06748
NVE: 116621178
ADF: 107353881
AMIL: 114973227
SPIS: 111325528
DGT: 114528108
HMG: 100212361 100215761(GPx)
SPAR: SPRG_01802
 » show all
Reference
1  [PMID:3978121]
  Authors
Ursini F, Maiorino M, Gregolin C.
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
  Journal
Biochim Biophys Acta 839:62-70 (1985)
DOI:10.1016/0304-4165(85)90182-5
Reference
2  [PMID:8617728]
  Authors
Schnurr K, Belkner J, Ursini F, Schewe T, Kuhn H
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.
  Journal
J Biol Chem 271:4653-8 (1996)
DOI:10.1074/jbc.271.9.4653
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.12
IUBMB Enzyme Nomenclature: 1.11.1.12
ExPASy - ENZYME nomenclature database: 1.11.1.12
BRENDA, the Enzyme Database: 1.11.1.12
CAS: 97089-70-8
LinkDB

KEGG   REACTION: R03167
Entry
R03167                      Reaction                               

Name
glutathione:lipid-hydroperoxide oxidoreductase
Definition
Lipid hydroperoxide + 2 Glutathione <=> Lipid + Glutathione disulfide + 2 H2O
Equation
Comment
unclear reaction
Reaction class
RC00011  C00051_C00127
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K05361  phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
Other DBs
RHEA: 19060
LinkDB

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