KEGG   ORTHOLOGY: K05361
Entry
K05361                      KO                                     
Symbol
GPX4
Name
phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
Pathway
map00480  Glutathione metabolism
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map04216  Ferroptosis
Reaction
R03167  glutathione:lipid-hydroperoxide oxidoreductase
R07034  glutathione: 5-HPETE oxidoreductase
R07035  glutathione: 15-HPETE oxidoreductase
R13043  glutathione:12(S)-HPETE oxidoreductase
Disease
H01825  Spondylometaphyseal dysplasia, Sedaghatian type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.12  phospholipid-hydroperoxide glutathione peroxidase
     K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
Other DBs
GO: 0047066
Genes
HSA: 2879(GPX4)
PTR: 741876(GPX4)
PPS: 100990361(GPX4)
GGO: 129528812(GPX4)
PON: 100458624(GPX4)
PPYG: 129021026(GPX4)
NLE: 100601223(GPX4)
HMH: 116484117(GPX4)
SSYN: 129465760(GPX4)
MCC: 705333(GPX4)
MCF: 102142580(GPX4)
MNI: 105486305(GPX4)
CSAB: 103233593(GPX4)
CATY: 105591702(GPX4)
TGE: 112613047(GPX4)
MLEU: 105551983(GPX4)
RRO: 104671424(GPX4)
RBB: 108537892(GPX4)
TFN: 117075813(GPX4)
PTEH: 111526799(GPX4)
CANG: 105527614(GPX4)
CJC: 100391793(GPX4)
SBQ: 101053315(GPX4)
CIMI: 108293158(GPX4)
ANAN: 105705965(GPX4)
CSYR: 103262147(GPX4)
MMUR: 105860773(GPX4)
LCAT: 123632821(GPX4)
PCOQ: 105811258(GPX4)
OGA: 100963823(GPX4)
MMU: 625249(Gpx4)
MCAL: 110303889(Gpx4)
MPAH: 110326696(Gpx4)
RNO: 29328(Gpx4)
MCOC: 116075700(Gpx4)
ANU: 117696848(Gpx4)
ASYL: 127671174(Gpx4)
MUN: 110551358(Gpx4)
CGE: 100765235(Gpx4)
MAUA: 101837194(Gpx4)
PROB: 127216642(Gpx4)
PLEU: 114684123(Gpx4)
MORG: 121459510(Gpx4)
MFOT: 126489253
AAMP: 119820907(Gpx4)
NGI: 103737339(Gpx4)
HGL: 101708875(Gpx4)
CPOC: 100730119(Gpx4)
CCAN: 109681876(Gpx4)
DORD: 105990480(Gpx4)
DSP: 122122854(Gpx4)
PLOP: 125348520(Gpx4)
NCAR: 124968734
MMMA: 107157240(Gpx4)
ITI: 101974858(Gpx4)
OPI: 101530962(GPX4)
TUP: 102483947(GPX4)
GVR: 103603492
CFA: 119864793(GPX4)
CLUD: 112666172(GPX4)
VLG: 121494565(GPX4)
NPO: 129521530(GPX4)
AML: 100464258
UMR: 103681777(GPX4)
UAH: 113242720(GPX4)
UAR: 123794043(GPX4)
ELK: 111161740
LLV: 125087255
MPUF: 101678371(GPX4)
MNP: 132009636(GPX4)
MLK: 131823181(GPX4)
NVS: 122909965(GPX4)
ORO: 101377930(GPX4)
EJU: 114226343(GPX4)
ZCA: 113916983(GPX4)
MLX: 118005304(GPX4)
NSU: 110594093(GPX4)
LWW: 102731580(GPX4)
FCA: 101095956(GPX4)
PYU: 121021417(GPX4)
PCOO: 112852674(GPX4)
PBG: 122488586(GPX4)
PVIV: 125159712(GPX4)
LRUF: 124527695
LGF: 123604984(GPX4)
AJU: 106978096
PTG: 102949955(GPX4)
PPAD: 109257691(GPX4)
PUC: 125928788
PLEZ: 122213671(GPX4)
HHV: 120242414(GPX4)
BTA: 286809(GPX4)
BOM: 102284111(GPX4)
BIU: 109561977(GPX4)
BBUB: 102404388(GPX4)
BBIS: 104991950(GPX4)
CHX: 100860867(GPX4)
OAS: 101113149(GPX4)
BTAX: 128051158(GPX4)
CSUM: 138085822(GPX4)
ODA: 120863712(GPX4)
CCAD: 122439865(GPX4)
MREE: 136156068(GPX4)
OVR: 110135331(GPX4)
MBEZ: 129558181(GPX4)
SSC: 399537(GPX4)
CFR: 102515650(GPX4)
CBAI: 105078123(GPX4)
CDK: 105104118(GPX4)
VPC: 102544950(GPX4)
BACU: 103000913(GPX4)
BMUS: 118893604(GPX4)
LVE: 103071491(GPX4)
OOR: 101270118(GPX4)
LALB: 132518766(GPX4)
GMF: 115846709(GPX4)
DDP: 132421706(GPX4)
DLE: 111170533(GPX4)
PCAD: 102992869(GPX4)
PSIU: 116750457(GPX4)
PPHC: 136120013(GPX4)
NASI: 112396387(GPX4)
ECB: 102147383(GPX4)
EPZ: 139083746(GPX4)
EAI: 106834230(GPX4)
MYB: 102247160 102257806(GPX4)
MYD: 102758267(GPX4)
MMYO: 118659354(GPX4)
MLF: 102424448(GPX4) 106697200
MDT: 132235286(GPX4)
MYUM: 139010766(GPX4)
PKL: 118711787(GPX4)
EFUS: 103294305(GPX4)
MNA: 107534552(GPX4)
DRO: 112312403(GPX4)
SHON: 118984402(GPX4)
AJM: 119044584(GPX4)
PDIC: 114503559(GPX4) 114515394
PHAS: 123813806(GPX4)
MMF: 118616188(GPX4)
PPAM: 129080073(GPX4)
HAI: 109390605
RFQ: 117037754(GPX4)
PALE: 102878189(GPX4)
PGIG: 120583686(GPX4)
PVP: 105302263(GPX4)
RAY: 107500914(GPX4)
MJV: 108388787(GPX4)
TOD: 119240497(GPX4)
SARA: 101549194 101556647(GPX4)
SFUM: 130022076(GPX4)
SETR: 126029646(GPX4)
LAV: 100675152(GPX4)
TMU: 101355012
ETF: 101650828(GPX4)
DNM: 101428069
MDO: 100015749(GPX4)
GAS: 123232218(GPX4)
SHR: 100930158(GPX4)
AFZ: 127545099
PCW: 110223406(GPX4)
TVP: 118846557(GPX4)
PBRV: 138172311(GPX4)
MLAO: 141500934(GPX4)
OAA: 100088643(GPX4)
TACU: 119950249(GPX4)
GGA: 374056(GPX4)
PCOC: 116235806(GPX4)
MGP: 100379155(GPX4)
CJO: 107325473(GPX4)
TPAI: 128072038(GPX4)
LMUT: 125684976(GPX4)
NMEL: 110389092(GPX4)
APLA: 101796330(GPX4)
ACYG: 136787006(GPX4)
CATA: 118260068(GPX4)
AFUL: 116499031(GPX4)
TGU: 100190423(GPX4)
LSR: 110479113(GPX4)
SCAN: 115483836(GPX4)
PMOA: 120495770(GPX4)
OTC: 121342529(GPX4)
PRUF: 121360999(GPX4)
ATRC: 139602157(GPX4)
GFR: 102045367(GPX4)
FAB: 101817765(GPX4)
OMA: 130264347(GPX4)
PHI: 102113402(GPX4)
PMAJ: 107215549(GPX4)
CCAE: 111940246(GPX4)
CCW: 104697013(GPX4)
CBRC: 103622134(GPX4)
ACOE: 138099554(GPX4)
ETL: 114066400(GPX4)
ZAB: 102072687(GPX4)
ZLE: 135458770(GPX4)
SVG: 106857097(GPX4)
MMEA: 130580173(GPX4)
HRT: 120763542(GPX4)
SATI: 136371894(GPX4)
CCIC: 134054521(GPX4)
FPG: 101916317(GPX4)
FCH: 102055857(GPX4)
CCRI: 104159269(GPX4)
SHAB: 115618028(GPX4)
TALA: 116961654(GPX4)
ACHC: 115349084(GPX4)
HALD: 104314809(GPX4)
HLE: 104829163(GPX4)
AGEN: 126041774
HHAR: 128148515(GPX4)
GCL: 127025524
CSTI: 104557679(GPX4)
DPUB: 104300525(GPX4)
PPUS: 135192083(GPX4)
BRHI: 104497570(GPX4)
EGZ: 104127393(GPX4)
NNI: 104016300(GPX4)
PCRI: 104031556(GPX4)
PADL: 103922946(GPX4)
AFOR: 103899414(GPX4)
CBOY: 140643476(GPX4)
CLV: 102092188(GPX4)
CNIC: 135999137(GPX4)
MUI: 104535977(GPX4)
PLET: 104626575(GPX4)
EHS: 104514689(GPX4)
CUCA: 104065785(GPX4)
BREG: 104631930(GPX4)
CPEA: 104392460(GPX4)
CVF: 104287163(GPX4)
RTD: 128900479(GPX4)
CRID: 134526208(GPX4)
AAM: 106493531(GPX4)
AROW: 112965676(GPX4)
NPD: 112946817(GPX4)
TGT: 104577742(GPX4)
DNE: 112988049(GPX4)
SCAM: 104139528(GPX4)
ASN: 102386897(GPX4)
AMJ: 102570581(GPX4)
CPOO: 109312300(GPX4)
GGN: 109294939(GPX4)
PSS: 102460999(GPX4)
CMY: 102948400(GPX4)
CCAY: 125627096(GPX4)
DCC: 119848363(GPX4)
CPIC: 101944764(GPX4)
TST: 117869003(GPX4)
CABI: 116828925(GPX4)
MRV: 120391529(GPX4)
ACS: 100563257(gpx4)
ASAO: 132781105(GPX4)
PVT: 110079257(GPX4)
SUND: 121936901(GPX4)
PBI: 103065827(GPX4)
PMUR: 107295211(GPX4)
CTIG: 120297082(GPX4)
TSR: 106550757(GPX4)
PGUT: 117668634(GPX4)
PCAE: 139308351(GPX4)
APRI: 131188331(GPX4)
PTEX: 113452253(GPX4)
NSS: 113429770(GPX4)
VKO: 123036606(GPX4)
PMUA: 114588449(GPX4)
PRAF: 128405825(GPX4)
ZVI: 118087571(GPX4)
HCG: 128347864(GPX4)
GJA: 107107351(GPX4)
STOW: 125433909(GPX4)
EMC: 129331415(GPX4)
XLA: 100036920(gpx4.L) 734888(gpx4.S)
XTR: 100496541(gpx4)
NPR: 108789489(GPX4)
RTEM: 120913798(GPX4)
ACAT: 141106402(GPX4)
BBUF: 120989460(GPX4)
BGAR: 122920161(GPX4)
DTC: 141050274(GPX4)
PWL: 138267518(GPX4)
MUO: 115480885(GPX4)
GSH: 117365837(GPX4)
DRE: 352928(gpx4a) 352929(gpx4b)
SANH: 107660382
SGH: 107552704
CCAR: 109071199 109095832(gpx4b)
PTET: 122328086(gpx4a) 122335633(gpx4b)
LROH: 127154036(gpx4a) 127178548(gpx4b)
GRF: 141339116(gpx4a) 141343981(gpx4b)
OMC: 131522086 131530650(gpx4a)
PPRM: 120471296(gpx4b) 120486531(gpx4a)
RKG: 130075349(gpx4b) 130089248(gpx4a)
MAMB: 125251077(gpx4b) 125252116(gpx4a)
CERY: 137003417(gpx4b) 137027722(gpx4a)
TROS: 130548448(gpx4a) 130555007(gpx4b)
TDW: 130418275(gpx4b) 130430621(gpx4a)
PDAB: 135744321(gpx4b)
IPU: 100528418(gpx4b)
IFU: 128613432(gpx4a) 128624279(gpx4b)
PHYP: 113533158(gpx4)
SMEO: 124390796(gpx4a) 124403356(gpx4b)
TFD: 113645121(gpx4b)
CGAR: 128513257(gpx4b)
NGRA: 132871792(gpx4b)
TRN: 134302451(gpx4b) 134331354(gpx4a)
AMEX: 103026361(gpx4b) 103047294(gpx4a)
CMAO: 118797289(gpx4b) 118818681(gpx4a)
EEE: 113585970(gpx4)
CHAR: 105889685(gpx4a) 122131805
TFS: 130529177(gpx4a) 130539092
NCC: 104958153(gpx4)
TBEN: 117488934 117496016(gpx4a)
PGEO: 117445429(gpx4a) 117462837
GACU: 117532617 117555205(gpx4a)
EMAC: 134865874 134869266(gpx4a)
ELY: 117254152(gpx4a) 117272200
EFO: 125895672(gpx4a) 125902182
PLEP: 121939387(gpx4a) 121951193
SLUC: 116037299 116063394(gpx4a)
ECRA: 117950202(gpx4a) 117953870
ESP: 116696111(gpx4) 116699145
PFLV: 114561982(gpx4) 114565634
GAT: 120815942
CLUM: 117730040(gpx4a) 117746743
PSWI: 130193447(gpx4a) 130198386
CANA: 137779359 137795521(gpx4a)
CVE: 137866484(gpx4a) 137892401
SCHU: 122878234(gpx4a) 122886314
CUD: 121512726(gpx4a) 121520718
SPUL: 138607030(gpx4a) 138611338
LMIX: 132972047(gpx4a) 132979002
ALAT: 119011833 119029309(gpx4a)
ASTR: 137599206(gpx4a) 137611999
MZE: 101475014 101481366(gpx4)
OAU: 116319194 116327902(gpx4a)
OML: 112147668 112150257(gpx4a)
CSAI: 133451920 133458162(gpx4a)
XMA: 102218769 102219707(gpx4)
XCO: 114147031 114150819(gpx4)
XHE: 116722172 116725535(gpx4)
PRET: 103463715(gpx4) 103479268
PLAI: 106949670(gpx4) 106961711
GAF: 122838806(gpx4a) 122840802
PPRL: 129361645 129371536(gpx4a)
CVG: 107091856 107095297(gpx4)
CTUL: 119773700 119790048(gpx4a)
GMU: 124869953 124873595(gpx4a)
NFU: 107384121 107393348(gpx4)
KMR: 108230562(gpx4a) 108239424
ALIM: 106526245(gpx4)
NWH: 119407986(gpx4a) 119414633
AOCE: 111563473(gpx4a) 111571007
EJA: 138198621(gpx4a) 138202810
BFRE: 138618847(gpx4a) 138625275
MCEP: 125009873(gpx4a) 125011311
CSEM: 103376758(gpx4) 103395914
SSEN: 122780472(gpx4a) 122781861(gpx4b)
SSOE: 131465842 131466215(gpx4a)
HHIP: 117760019(gpx4a) 117778055
HSP: 118118007 124854676(gpx4a)
PPLT: 128448346(gpx4a) 128455032
SMAU: 118311442 118318584(gpx4a)
SLAL: 111653742(gpx4) 111658891
XGL: 120790974(gpx4a) 120799459
SSCV: 125972914(gpx4a) 125985250
SBIA: 133503717(gpx4a) 133511306
PEE: 133406844(gpx4a) 133411661
PTAO: 133480984(gpx4a) 133489082
BPEC: 110157283 110174007(gpx4)
ENY: 140353768(gpx4a) 140356385
MALB: 109966994(gpx4) 109969232
BSPL: 114845018 114853090(gpx4a)
SJO: 128361533(gpx4a) 128368581
SSCO: 133984601(gpx4a) 133990330
SASA: 100194734(gpx4b) 106573579
OMY: 110506115(gpx4a)
OGO: 123999099(gpx4a)
ONE: 115114709
OKI: 109889213
OKE: 118373929(gpx4a) 118389079
OMM: 135524567(gpx4a)
SNH: 120056116
CCLU: 121535669 121576785(gpx4a)
OEP: 134010936(gpx4a) 134036191
PKI: 111836622(gpx4) 111860199
AANG: 118224614(gpx4a) 118230010(gpx4b)
AROT: 135251323(gpx4b) 135253006(gpx4a)
LOC: 102683270(gpx4)
PSPA: 121301423
PSEX: 120537631
CMK: 103189927
RTP: 109931453(gpx4b)
CPLA: 122565353
HOC: 132829173
LERI: 129711308
HAKA: 140739760
PMRN: 116951847
LRJ: 133349064(GPX4)
BFO: 118421311
CIN: 100175675(gpx_e)
SCLV: 120327570
AJJ: 139957565
APLC: 110989974
AFIL: 140145797
AJC: 117112402
SKO: 102807044
PFLL: 139138618
AGA: 1274093
ACOZ: 120952681
ASTE: 118517422
AMAP: 126559242
AFUN: 125765397
AMOU: 128306964
AMRS: 128707985
AALI: 118462734
ACOS: 131259216
AALB: 109401758
AME: 726269
ACER: 107994450
ALAB: 122714729
ADR: 102674260
AFLR: 100869880
BIM: 100743362
BBIF: 117207632
BVK: 117231056
BVAN: 117156330
BHUN: 126872068
BTER: 100648859
BAFF: 126921778
BPYO: 122567717
BPAS: 132912831
FVI: 122531333
CCAL: 108626755
OBB: 114877693
OLG: 117602899
MGEN: 117219236
NMEA: 116432653
CGIG: 122399219
SOC: 105193617
MPHA: 105837252
ACEP: 105625818
ACOC: 108692160
MZT: 108729786
CCOA: 108780400
PBAR: 105425460
VEM: 105566065
COBS: 139105234
TLN: 139822348
HST: 105183432
DQU: 106745051
CFO: 105248391
FEX: 115245404
LHU: 105668639
PGC: 109853223
PCF: 106790095
PFUC: 122519916
VPS: 122631076
VCRB: 124422329
VVE: 124957163
CSOL: 105366802
TPRE: 106652294
LHT: 122504735
LBD: 127284921
MDL: 106693859
CGLO: 123265503
FAS: 105269323
DAM: 107040528
CINS: 118068406
CCIN: 107269072
DSM: 124414050
NPT: 124223814
NFB: 124186366
NLO: 107223532
NVG: 124309201
AROA: 105685353
TCA: 658307(GLEAN_10355)
DPA: 109546481
ESIM: 136412196
EFOR: 136341089
DVV: 114329379
NVL: 108566482
VCD: 124543819
PPOT: 106100013
PXU: 106121901
ZCE: 119833957
CCRC: 123696978
HZE: 124634171
TNL: 113505368
OFU: 114360488
AGS: 114123314
ACOO: 126846384
DVT: 126896888
ZNE: 110827342
CSEC: 111863272
IEL: 124157339
AFRA: 136034938
PVM: 113800343(Gtpx)
PJA: 122265622
PCHN: 125030356
PMOO: 119576094
HAME: 121860142
PTRU: 123511450
ESN: 127008367
MNZ: 135220005
MRJ: 136852611(Gtpx)
PORN: 139764824
HAZT: 108680142
TCF: 131877241
PPOI: 119099814
VDE: 111254008
TUT: 107368679
DPTE: 113797481
DFR: 124494483
PTEP: 107457231
ABRU: 129963237
UDV: 129228176
SDM: 118191819
LPOL: 106470024
PMEO: 129588880
PVUL: 126818474
BGT: 106061375
GAE: 121376352
HRF: 124116706
HASI: 137291257
CRG: 105330305
CANU: 128165689
OED: 125668418
MYI: 110445160
PMAX: 117325643
AIRR: 138325876
MCAF: 127714052
MMER: 123524341
RPHI: 132750097
DPOL: 127855281
LJP: 135469897
EGL: EGR_06748
LLON: 135487124
NVE: 116621178
ATEN: 116303299
ADF: 107353881
AMIL: 114973227
MFOO: 137982975
SPIS: 111325528
DGT: 114528108
HSY: 130630656
SPAR: SPRG_01802
 » show all
Reference
PMID:8323565
  Authors
Sunde RA, Dyer JA, Moran TV, Evenson JK, Sugimoto M
  Title
Phospholipid hydroperoxide glutathione peroxidase: full-length pig blastocyst cDNA sequence and regulation by selenium status.
  Journal
Biochem Biophys Res Commun 193:905-11 (1993)
DOI:10.1006/bbrc.1993.1711
  Sequence
[ssc:399537]
LinkDB

KEGG   ENZYME: 1.11.1.12
Entry
EC 1.11.1.12                Enzyme                                 
Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O [RN:R03167]
Reaction(KEGG)
R03167;
(other) R07034 R07035 R13043
Substrate
glutathione [CPD:C00051];
hydroperoxy-fatty-acyl-[lipid]
Product
glutathione disulfide [CPD:C00127];
hydroxy-fatty-acyl-[lipid];
H2O [CPD:C00001]
Comment
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).
History
EC 1.11.1.12 created 1989, modified 2015
Pathway
ec00480  Glutathione metabolism
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K05361  phospholipid-hydroperoxide glutathione peroxidase
Genes
HSA2879(GPX4)
PTR741876(GPX4)
PPS100990361(GPX4)
GGO129528812(GPX4)
PON100458624(GPX4)
PPYG129021026(GPX4)
NLE100601223(GPX4)
HMH116484117(GPX4)
SSYN129465760(GPX4)
MCC705333(GPX4)
MCF102142580(GPX4)
MNI105486305(GPX4)
CSAB103233593(GPX4)
CATY105591702(GPX4)
TGE112613047(GPX4)
MLEU105551983(GPX4)
RRO104671424(GPX4)
RBB108537892(GPX4)
TFN117075813(GPX4)
PTEH111526799(GPX4)
CANG105527614(GPX4)
CJC100391793(GPX4)
SBQ101053315(GPX4)
CIMI108293158(GPX4)
ANAN105705965(GPX4)
CSYR103262147(GPX4)
MMUR105860773(GPX4)
LCAT123632821(GPX4)
PCOQ105811258(GPX4)
OGA100963823(GPX4)
MMU625249(Gpx4)
MCAL110303889(Gpx4)
MPAH110326696(Gpx4)
RNO29328(Gpx4)
MCOC116075700(Gpx4)
ANU117696848(Gpx4)
ASYL127671174(Gpx4)
MUN110551358(Gpx4)
CGE100765235(Gpx4)
MAUA101837194(Gpx4)
PROB127216642(Gpx4)
PLEU114684123(Gpx4)
MORG121459510(Gpx4)
MFOT126489253
AAMP119820907(Gpx4)
NGI103737339(Gpx4)
HGL101708875(Gpx4)
CPOC100730119(Gpx4)
CCAN109681876(Gpx4)
DORD105990480(Gpx4)
DSP122122854(Gpx4)
PLOP125348520(Gpx4)
NCAR124968734
MMMA107157240(Gpx4)
ITI101974858(Gpx4)
OPI101530962(GPX4)
TUP102483947(GPX4)
GVR103603492
CFA119864793(GPX4)
CLUD112666172(GPX4)
VLG121494565(GPX4)
NPO129521530(GPX4)
AML100464258
UMR103681777(GPX4)
UAH113242720(GPX4)
UAR123794043(GPX4)
ELK111161740
LLV125087255
MPUF101678371(GPX4)
MNP132009636(GPX4)
MLK131823181(GPX4)
NVS122909965(GPX4)
ORO101377930(GPX4)
EJU114226343(GPX4)
ZCA113916983(GPX4)
MLX118005304(GPX4)
NSU110594093(GPX4)
LWW102731580(GPX4)
FCA101095956(GPX4)
PYU121021417(GPX4)
PCOO112852674(GPX4)
PBG122488586(GPX4)
PVIV125159712(GPX4)
LRUF124527695
LGF123604984(GPX4)
AJU106978096
PTG102949955(GPX4)
PPAD109257691(GPX4)
PUC125928788
PLEZ122213671(GPX4)
HHV120242414(GPX4)
BTA286809(GPX4)
BOM102284111(GPX4)
BIU109561977(GPX4)
BBUB102404388(GPX4)
BBIS104991950(GPX4)
CHX100860867(GPX4)
OAS101113149(GPX4)
BTAX128051158(GPX4)
CSUM138085822(GPX4)
ODA120863712(GPX4)
CCAD122439865(GPX4)
MREE136156068(GPX4)
OVR110135331(GPX4)
MBEZ129558181(GPX4)
SSC399537(GPX4)
CFR102515650(GPX4)
CBAI105078123(GPX4)
CDK105104118(GPX4)
VPC102544950(GPX4)
BACU103000913(GPX4)
BMUS118893604(GPX4)
LVE103071491(GPX4)
OOR101270118(GPX4)
LALB132518766(GPX4)
GMF115846709(GPX4)
DDP132421706(GPX4)
DLE111170533(GPX4)
PCAD102992869(GPX4)
PSIU116750457(GPX4)
PPHC136120013(GPX4)
NASI112396387(GPX4)
ECB102147383(GPX4)
EPZ139083746(GPX4)
EAI106834230(GPX4)
MYB102247160 102257806(GPX4)
MYD102758267(GPX4)
MMYO118659354(GPX4)
MLF102424448(GPX4) 106697200
MDT132235286(GPX4)
MYUM139010766(GPX4)
PKL118711787(GPX4)
EFUS103294305(GPX4)
MNA107534552(GPX4)
DRO112312403(GPX4)
SHON118984402(GPX4)
AJM119044584(GPX4)
PDIC114503559(GPX4) 114515394
PHAS123813806(GPX4)
MMF118616188(GPX4)
PPAM129080073(GPX4)
HAI109390605
RFQ117037754(GPX4)
PALE102878189(GPX4)
PGIG120583686(GPX4)
PVP105302263(GPX4)
RAY107500914(GPX4)
MJV108388787(GPX4)
TOD119240497(GPX4)
SARA101549194 101556647(GPX4)
SFUM130022076(GPX4)
SETR126029646(GPX4)
LAV100675152(GPX4)
TMU101355012
ETF101650828(GPX4)
DNM101428069
MDO100015749(GPX4)
GAS123232218(GPX4)
SHR100930158(GPX4)
AFZ127545099
PCW110223406(GPX4)
TVP118846557(GPX4)
PBRV138172311(GPX4)
MLAO141500934(GPX4)
OAA100088643(GPX4)
TACU119950249(GPX4)
GGA374056(GPX4)
PCOC116235806(GPX4)
MGP100379155(GPX4)
CJO107325473(GPX4)
TPAI128072038(GPX4)
LMUT125684976(GPX4)
NMEL110389092(GPX4)
APLA101796330(GPX4)
ACYG136787006(GPX4)
CATA118260068(GPX4)
AFUL116499031(GPX4)
TGU100190423(GPX4)
LSR110479113(GPX4)
SCAN115483836(GPX4)
PMOA120495770(GPX4)
OTC121342529(GPX4)
PRUF121360999(GPX4)
ATRC139602157(GPX4)
GFR102045367(GPX4)
FAB101817765(GPX4)
OMA130264347(GPX4)
PHI102113402(GPX4)
PMAJ107215549(GPX4)
CCAE111940246(GPX4)
CCW104697013(GPX4)
CBRC103622134(GPX4)
ACOE138099554(GPX4)
ETL114066400(GPX4)
ZAB102072687(GPX4)
ZLE135458770(GPX4)
SVG106857097(GPX4)
MMEA130580173(GPX4)
HRT120763542(GPX4)
SATI136371894(GPX4)
CCIC134054521(GPX4)
FPG101916317(GPX4)
FCH102055857(GPX4)
CCRI104159269(GPX4)
SHAB115618028(GPX4)
TALA116961654(GPX4)
ACHC115349084(GPX4)
HALD104314809(GPX4)
HLE104829163(GPX4)
AGEN126041774
HHAR128148515(GPX4)
GCL127025524
CSTI104557679(GPX4)
DPUB104300525(GPX4)
PPUS135192083(GPX4)
BRHI104497570(GPX4)
EGZ104127393(GPX4)
NNI104016300(GPX4)
PCRI104031556(GPX4)
PADL103922946(GPX4)
AFOR103899414(GPX4)
CBOY140643476(GPX4)
CLV102092188(GPX4)
CNIC135999137(GPX4)
MUI104535977(GPX4)
PLET104626575(GPX4)
EHS104514689(GPX4)
CUCA104065785(GPX4)
BREG104631930(GPX4)
CPEA104392460(GPX4)
CVF104287163(GPX4)
RTD128900479(GPX4)
CRID134526208(GPX4)
AAM106493531(GPX4)
AROW112965676(GPX4)
NPD112946817(GPX4)
TGT104577742(GPX4)
DNE112988049(GPX4)
SCAM104139528(GPX4)
ASN102386897(GPX4)
AMJ102570581(GPX4)
CPOO109312300(GPX4)
GGN109294939(GPX4)
PSS102460999(GPX4)
CMY102948400(GPX4)
CCAY125627096(GPX4)
DCC119848363(GPX4)
CPIC101944764(GPX4)
TST117869003(GPX4)
CABI116828925(GPX4)
MRV120391529(GPX4)
ACS100563257(gpx4)
ASAO132781105(GPX4)
PVT110079257(GPX4)
SUND121936901(GPX4)
PBI103065827(GPX4)
PMUR107295211(GPX4)
CTIG120297082(GPX4)
TSR106550757(GPX4)
PGUT117668634(GPX4)
PCAE139308351(GPX4)
APRI131188331(GPX4)
PTEX113452253(GPX4)
NSS113429770(GPX4)
VKO123036606(GPX4)
PMUA114588449(GPX4)
PRAF128405825(GPX4)
ZVI118087571(GPX4)
HCG128347864(GPX4)
GJA107107351(GPX4)
STOW125433909(GPX4)
EMC129331415(GPX4)
XLA100036920(gpx4.L) 734888(gpx4.S)
XTR100496541(gpx4)
NPR108789489(GPX4)
RTEM120913798(GPX4)
ACAT141106402(GPX4)
BBUF120989460(GPX4)
BGAR122920161(GPX4)
DTC141050274(GPX4)
PWL138267518(GPX4)
MUO115480885(GPX4)
GSH117365837(GPX4)
DRE352928(gpx4a) 352929(gpx4b)
SRX107723219 107739954
SANH107660382
SGH107552704
CCAR109071199 109095832(gpx4b)
CGIB127938347 127943422 127951669
PTET122328086(gpx4a) 122335633(gpx4b)
LROH127154036(gpx4a) 127178548(gpx4b)
GRF141339116(gpx4a) 141343981(gpx4b)
OMC131522086 131530650(gpx4a)
PPRM120471296(gpx4b) 120486531(gpx4a)
RKG130075349(gpx4b) 130089248(gpx4a)
MAMB125251077(gpx4b) 125252116(gpx4a)
CIDE127519981 127522684
CERY137003417(gpx4b) 137027722(gpx4a)
MASI127438863 127443054
TROS130548448(gpx4a) 130555007(gpx4b)
TDW130418275(gpx4b) 130430621(gpx4a)
MANU129443230 129453119 141362386
PDAB135744321(gpx4b)
IPU100528418(gpx4b)
IFU128613432(gpx4a) 128624279(gpx4b)
PHYP113533158(gpx4)
SMEO124390796(gpx4a) 124403356(gpx4b)
TFD113645121(gpx4b)
TVC132845451(gpx4b) 132852631(gpx4a) 132852639 132852660
CGAR128513257(gpx4b)
NGRA132871792(gpx4b)
TRN134302451(gpx4b) 134331354(gpx4a)
AMEX103026361(gpx4b) 103047294(gpx4a)
CMAO118797289(gpx4b) 118818681(gpx4a)
EEE113585970(gpx4)
CHAR105889685(gpx4a) 122131805
SPIL134068608 134102740
TRU101066389 101070699
TFS130529177(gpx4a) 130539092
TNGGSTEN00024700G001 GSTEN00028551G001
LCO104929635 104930512
NCC104958153(gpx4)
TBEN117488934 117496016(gpx4a)
CGOB115006643 115023020
PGEO117445429(gpx4a) 117462837
GACU117532617 117555205(gpx4a)
EMAC134865874 134869266(gpx4a)
ELY117254152(gpx4a) 117272200
EFO125895672(gpx4a) 125902182
PLEP121939387(gpx4a) 121951193
SLUC116037299 116063394(gpx4a)
ECRA117950202(gpx4a) 117953870
ESP116696111(gpx4) 116699145
PFLV114561982(gpx4) 114565634
GAT120815942
PPUG119209805 119216983 119216984
AFB129094762 129112261
CLUM117730040(gpx4a) 117746743
PSWI130193447(gpx4a) 130198386
CANA137779359 137795521(gpx4a)
CVE137866484(gpx4a) 137892401
MSAM119884432 119900945(gpx4a) 119902192
SCHU122878234(gpx4a) 122886314
CUD121512726(gpx4a) 121520718
SPUL138607030(gpx4a) 138611338
LMIX132972047(gpx4a) 132979002
ALAT119011833 119029309(gpx4a)
ASTR137599206(gpx4a) 137611999
MZE101475014 101481366(gpx4)
ONL100696691 100711165
OAU116319194 116327902(gpx4a)
OLA101160642 101160762 111946273
OML112147668 112150257(gpx4a)
CSAI133451920 133458162(gpx4a)
XMA102218769 102219707(gpx4)
XCO114147031 114150819(gpx4)
XHE116722172 116725535(gpx4)
PRET103463715(gpx4) 103479268
PFOR103151222 103151223 103155162(gpx4)
PLAI106949670(gpx4) 106961711
PMEI106917758(gpx4) 106918624 106926317
GAF122838806(gpx4a) 122840802
PPRL129361645 129371536(gpx4a)
CVG107091856 107095297(gpx4)
CTUL119773700 119790048(gpx4a)
GMU124869953 124873595(gpx4a)
NFU107384121 107393348(gpx4)
KMR108230562(gpx4a) 108239424
ALIM106526245(gpx4)
NWH119407986(gpx4a) 119414633
AOCE111563473(gpx4a) 111571007
EJA138198621(gpx4a) 138202810
BFRE138618847(gpx4a) 138625275
MCEP125009873(gpx4a) 125011311
CSEM103376758(gpx4) 103395914
POV109625825 109647764
SSEN122780472(gpx4a) 122781861(gpx4b)
SSOE131465842 131466215(gpx4a)
HHIP117760019(gpx4a) 117778055
HSP118118007 124854676(gpx4a)
PPLT128448346(gpx4a) 128455032
SMAU118311442 118318584(gpx4a)
LCF108879022 108883623
SDU111229087 111231965
SLAL111653742(gpx4) 111658891
XGL120790974(gpx4a) 120799459
HCQ109507458 109532270
SSCV125972914(gpx4a) 125985250
SBIA133503717(gpx4a) 133511306
PEE133406844(gpx4a) 133411661
PTAO133480984(gpx4a) 133489082
BPEC110157283 110174007(gpx4)
ENY140353768(gpx4a) 140356385
MALB109966994(gpx4) 109969232
BSPL114845018 114853090(gpx4a)
SJO128361533(gpx4a) 128368581
SSCO133984601(gpx4a) 133990330
GMH115549464 115555184
SASA100194734(gpx4b) 106573579
STRU115157354 115158193
OTW112250826 112252227(gpx4a) 112260797
OMY110506115(gpx4a)
OGO123999099(gpx4a)
ONE115114709
OKI109889213
OKE118373929(gpx4a) 118389079
OMM135524567(gpx4a)
SALP111952959 111957159 111975698
SNH120056116
CCLU121535669 121576785(gpx4a)
ELS105011502 105022279
OEP134010936(gpx4a) 134036191
SFM108919780 108921631
PKI111836622(gpx4) 111860199
AANG118224614(gpx4a) 118230010(gpx4b)
AROT135251323(gpx4b) 135253006(gpx4a)
CCOG133126770 133129392
LOC102683270(gpx4)
PSPA121301423
ARUT117428936 117966230
PSEX120537631
LCM102346539 102365140
CMK103189927
RTP109931453(gpx4b)
CPLA122565353
HOC132829173
LERI129711308
HAKA140739760
PMRN116951847
LRJ133349064(GPX4)
BFO118421311
BBEL109478343 109484469
CIN100175675(gpx_e)
SCLV120327570
LPIC129270906 129270920
AJJ139957565
APLC110989974
AFIL140145797
AJC117112402
SKO102807044
PFLL139138618
RZE108377947 108381437 108381438
AGA1274093
ACOZ120952681
ASTE118517422
AMAP126559242
AFUN125765397
AMOU128306964
AMRS128707985
AALI118462734
ACOS131259216
AALB109401758
CQUCpipJ_CPIJ006047 CpipJ_CPIJ010637
AME726269
ACER107994450
ALAB122714729
ADR102674260
AFLR100869880
BIM100743362
BBIF117207632
BVK117231056
BVAN117156330
BHUN126872068
BTER100648859
BAFF126921778
BPYO122567717
BPAS132912831
FVI122531333
CCAL108626755
OBB114877693
OLG117602899
MGEN117219236
NMEA116432653
CGIG122399219
SOC105193617
MPHA105837252
ACEP105625818
ACOC108692160
MZT108729786
CCOA108780400
PBAR105425460
VEM105566065
COBS139105234
TLN139822348
HST105183432
DQU106745051
CFO105248391
FEX115245404
LHU105668639
PGC109853223
PCF106790095
PFUC122519916
VPS122631076
VCRB124422329
VVE124957163
NVI100114603 100123141
CSOL105366802
TPRE106652294
LHT122504735
LBD127284921
MDL106693859
CGLO123265503
FAS105269323
DAM107040528
AGIF122849604 122855894
CINS118068406
VCAN122417172 122417219 122417221 122417335 122417342 122417361
CCIN107269072
DSM124414050
NPT124223814
NFB124186366
NLO107223532
NVG124309201
AROA105685353
TCA658307(GLEAN_10355)
DPA109546481
ESIM136412196
EFOR136341089
SOY115874706 115877136 115880649 115880650
AGRG126741086 126742075 126742196 126750027
ATD109596245 109596246 109596247
CSET123306794 123307673 123308152 123309141 123322658
AGB108907641 108907642 108907643
LDC111504102 111512566 111512567
DVV114329379
NVL108566482
APLN108732800 108737053 108737061 108737077 112906260
PPYR116180501 116180502
OTU111413348 111413361 111413391
DPLKGM_202360 KGM_212277
VCD124543819
PPOT106100013
PXU106121901
ZCE119833957
CCRC123696978
HAW110372557 110372599
HZE124634171
TNL113505368
SLIU111357572 111357612
OFU114360488
CFEL113364132 113364133
AGS114123314
ACOO126846384
DVT126896888
BTAB109035151 109036432
ZNE110827342
CSEC111863272
SGRE126272591 126352401 126352417
IEL124157339
FCD110842172 110852997
DPXDAPPUDRAFT_220769 DAPPUDRAFT_233749 DAPPUDRAFT_310801
DMK116916349 116916352
DPZ124340674 124340676
AFRA136034938
PVM113800343(Gtpx)
PJA122265622
PCHN125030356
PMOO119576094
HAME121860142
PCLA123746973 138349823
PTRU123511450
ESN127008367
MNZ135220005
MRJ136852611(Gtpx)
PORN139764824
HAZT108680142
EAF111699065 111712316
LSM121114086 121131904
TCF131877241
PPOI119099814
DSV119432506 119433848
RSAN119374760 119404627
RMP119176173 119181298
VDE111254008
VJA111259647 111267629 111267630
GOE100898975 100906621
TUT107368679
DPTE113797481
DFR124494483
CSCU111620010 111620011 111620045
CVS136984032 136984085
PTEP107457231
ABRU129963237
UDV129228176
SDM118191819
LPOL106470024
PMEO129588880
TSPTsp_02268 Tsp_02272
LGILOTGIDRAFT_208098
PVUL126818474
PCAN112554193 112573590
BGT106061375
GAE121376352
HRF124116706
HRJ124255688 124255701
HASI137291257
CRG105330305
CANU128165689
CVN111120183 111120666
OED125668418
MYI110445160
PMAX117325643
AIRR138325876
MCAF127714052
MMER123524341
RPHI132750097
DPOL127855281
OBI106869007 106874999
OSN115223566 115223910
LJP135469897
LAK106176459 106176464
SMMSmp_058690 Smp_058700 Smp_124360
EGLEGR_06748
LLON135487124
NVE116621178
EPA110238768 110242483
ATEN116303299
ADF107353881
AMIL114973227
MFOO137982975
PDAM113682059 113683366
SPIS111325528
DGT114528108
XEN124445385 124447112
HMG100212361 100215761
HSY130630656
PSOJPHYSODRAFT_317624
SPARSPRG_01802
EHXEMIHUDRAFT_61670 EMIHUDRAFT_67177
 » show all
Reference
1  [PMID:3978121]
  Authors
Ursini F, Maiorino M, Gregolin C.
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
  Journal
Biochim Biophys Acta 839:62-70 (1985)
DOI:10.1016/0304-4165(85)90182-5
Reference
2  [PMID:8617728]
  Authors
Schnurr K, Belkner J, Ursini F, Schewe T, Kuhn H
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.
  Journal
J Biol Chem 271:4653-8 (1996)
DOI:10.1074/jbc.271.9.4653
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.12
IUBMB Enzyme Nomenclature: 1.11.1.12
ExPASy - ENZYME nomenclature database: 1.11.1.12
BRENDA, the Enzyme Database: 1.11.1.12
CAS: 97089-70-8
LinkDB

KEGG   REACTION: R03167
Entry
R03167                      Reaction                               
Name
glutathione:lipid-hydroperoxide oxidoreductase
Definition
Lipid hydroperoxide + 2 Glutathione <=> Lipid + Glutathione disulfide + 2 H2O
Equation
Comment
unclear reaction
Reaction class
RC00011  C00051_C00127
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.12
     R03167  Lipid hydroperoxide + 2 Glutathione <=> Lipid + Glutathione disulfide + 2 H2O
Orthology
K05361  phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
Other DBs
RHEA: 19060
LinkDB

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