KEGG ORTHOLOGY: K05361

ORTHOLOGY: K05361

Entry

K05361 KO

Name

GPX4

Definition

phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]

Pathway

ko00480

Glutathione metabolism

ko01100

Metabolic pathways

ko04216

Ferroptosis

Disease

H01825

Spondylometaphyseal dysplasia, Sedaghatian type

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.12  phospholipid-hydroperoxide glutathione peroxidase
     K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase

Other DBs

RN:

R03167

GO:

0047066

Genes

HSA:	2879(GPX4)

PTR:	741876(GPX4)

PPS:	100990361(GPX4)

PON:	100458624(GPX4)

NLE:	100601223(GPX4)

MCC:	705333(GPX4)

MCF:	102142580(GPX4)

CSAB:

103233593(GPX4)

RRO:	104671424(GPX4)

RBB:	108537892(GPX4)

CJC:	100391793(GPX4) 103790339

SBQ:	101053315(GPX4)

MMU:	625249(Gpx4)

MCAL:

110303889(Gpx4)

MPAH:

110326696(Gpx4)

RNO:	29328(Gpx4)

MUN:	110551358(Gpx4)

CGE:	100765235(Gpx4)

NGI:	103737339(Gpx4)

HGL:	101708875(Gpx4)

CCAN:

109681876(Gpx4)

TUP:	102483947(GPX4)

AML:

100464258

UMR:	103681777(GPX4)

UAH:	113242720(GPX4)

ORO:	101377930(GPX4)

ELK:

111161740

FCA:	101095956(GPX4)

PTG:	102949955(GPX4)

PPAD:

109257691(GPX4)

AJU:	106978096(GPX4)

BTA:	286809(GPX4)

BOM:	102284111(GPX4)

BIU:	109561977(GPX4)

BBUB:

102404388(GPX4)

CHX:	100860867(GPX4)

OAS:	101113149(GPX4)

SSC:	399537(GPX4)

CFR:	102515650(GPX4)

CDK:	105104118(GPX4)

BACU:

103000913(GPX4)

LVE:	103071491(GPX4)

OOR:	101270118(GPX4)

DLE:	111170533(GPX4)

PCAD:

102992869(GPX4)

ECB:	102147383(GPX4)

EAI:	106834230(GPX4)

MYB:	102247160 102257806(GPX4)

MYD:	102758267(GPX4)

MNA:	107534552(GPX4)

HAI:

109390605

DRO:	112312403(GPX4)

PALE:

102878189(GPX4)

RAY:	107500914(GPX4)

MJV:	108388787(GPX4)

LAV:	100675152(GPX4)

TMU:

101355012

MDO:	100015749(GPX4)

SHR:	100930158(GPX4)

PCW:	110223406(GPX4)

OAA:	100088643(GPX4)

GGA:	374056(GPX4)

MGP:	100379155(GPX4)

CJO:	107325473(GPX4)

NMEL:

110389092(GPX4)

APLA:

101796330(GPX4)

ACYG:

106048194(GPX4)

TGU:	100190423(GPX4)

LSR:	110479113(GPX4)

SCAN:

115483836(GPX4)

GFR:	102045367(GPX4)

FAB:	101817765(GPX4)

PHI:	102113402(GPX4)

PMAJ:

107215549(GPX4)

CCAE:

111940246(GPX4)

CCW:	104697013(GPX4)

ETL:	114066400(GPX4)

FPG:	101916317(GPX4)

FCH:	102055857(GPX4)

CLV:	102092188(GPX4)

EGZ:	104127393(GPX4)

NNI:	104016300(GPX4)

PADL:

103922946(GPX4)

AAM:	106493531(GPX4)

ASN:	102386897(GPX4)

AMJ:	102570581(GPX4)

PSS:	102460999(GPX4)

CMY:	102948400(GPX4)

CPIC:

101944764(GPX4)

ACS:	100563257(gpx4)

PVT:	110079257(GPX4)

PBI:	103065827(GPX4)

PMUR:

107295211(GPX4)

TSR:	106550757(GPX4)

PMUA:

114588449(GPX4)

GJA:	107107351(GPX4)

XLA:	100036920(gpx4.L) 734888(gpx4.S)

XTR:	100496541(gpx4)

NPR:	108789489(GPX4)

DRE:	352928(gpx4a) 352929(gpx4b)

SRX:	107723219 107739954

SANH:

107660382

SGH:

107552704

CCAR:

109071199 109095832

IPU:	100528418(gpx4)

PHYP:

113533158(gpx4)

AMEX:

103026361(gpx4)

EEE:	113585970(gpx4)

TRU:	101066389 101070699

TNG:	GSTEN00024700G001 GSTEN00028551G001

LCO:	104929635 104930512

NCC:	104958153(gpx4)

MZE:	101475014 101481366(gpx4)

ONL:	100696691 100711165

OLA:	101160642 101160762 111946273

XMA:	102218769 102219707(gpx4)

XCO:	114147031 114150819(gpx4)

PRET:

103463715(gpx4) 103479268

CVG:	107091856 107095297(gpx4)

NFU:	107384121 107393348(gpx4)

KMR:	108230562(gpx4) 108239424

ALIM:

106526245(gpx4)

AOCE:

111563473 111571007

CSEM:

103376758(gpx4) 103395914

POV:	109625825 109647764

LCF:	108879022 108883623

SDU:	111229087 111231965

SLAL:

111653742(gpx4) 111658891

HCQ:	109507458 109532270

BPEC:

110157283 110174007(gpx4)

MALB:

109966994(gpx4) 109969232

SASA:

100194734(gpx4b) 106573579

OTW:	112250826 112260797

SALP:

111952959 111957159 111975698

ELS:	105011502 105022279

SFM:	108919780 108921631

PKI:	111836622(gpx4) 111860199

LCM:	102346539 102365140

CMK:	103189927(gpx4)

RTP:	109931453(gpx4)

BFO:

118421311

CIN:	100175675(gpx_e)

APLC:

110989974

SKO:

102807044

AGA:	AgaP_AGAP004248(GPXH3)

AALB:

109401758

CQU:	CpipJ_CPIJ006047 CpipJ_CPIJ010637

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

PCF:

NVI:	100114603 100123141

CSOL:

105366802

MDL:

106693859

TCA:	658307(GLEAN_10355)

DPA:

109546481

ATD:	109596245 109596246 109596247

NVL:	108566482 108566483

BMOR:

101744684

DPL:	KGM_202360 KGM_212277

HAW:	110372557 110372599

TNL:

AGS:

BTAB:

ZNE:

FCD:	110842172 110852997

DPX:	DAPPUDRAFT_220769 DAPPUDRAFT_233749 DAPPUDRAFT_310801

PVM:

113800343

ISC:	IscW_ISCW015098 IscW_ISCW019584 IscW_ISCW022517

TUT:

107368679

DPTE:

113797481

CSCU:

111620010 111620011 111620045

PTEP:

107457231

TSP:	Tsp_02268 Tsp_02272

LGI:	LOTGIDRAFT_208098

PCAN:

112554193 112573590

CRG:

105330305

MYI:

110445160

OBI:	106869007 106874999

LAK:	106176459 106176464

SMM:	Smp_058690 Smp_058700 Smp_124360

EGL:

EGR_06748

NVE:

116621178

EPA:	110238768 110242483

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:	100212361 100215761(GPx)

PSOJ:

PHYSODRAFT_317624

SPAR:

SPRG_01802

EHX:	EMIHUDRAFT_61670 EMIHUDRAFT_67177

» show all

Reference

PMID:8323565

Authors

Sunde RA, Dyer JA, Moran TV, Evenson JK, Sugimoto M

Title

Phospholipid hydroperoxide glutathione peroxidase: full-length pig blastocyst cDNA sequence and regulation by selenium status.

Journal

Biochem Biophys Res Commun 193:905-11 (1993)
DOI:10.1006/bbrc.1993.1711

Sequence

[ssc:399537]

LinkDB

ENZYME: 1.11.1.12

Entry

EC 1.11.1.12 Enzyme

Name

phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase

Class

Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases

Sysname

glutathione:lipid-hydroperoxide oxidoreductase

Reaction(IUBMB)

2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O [RN:R03167]

Reaction(KEGG)

R03167

Substrate

glutathione [CPD:C00051];
hydroperoxy-fatty-acyl-[lipid]

Product

glutathione disulfide [CPD:C00127];
hydroxy-fatty-acyl-[lipid];
H2O [CPD:C00001]

Comment

A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).

History

EC 1.11.1.12 created 1989, modified 2015

Pathway

ec00480

Glutathione metabolism

ec01100

Metabolic pathways

Orthology

K05361

phospholipid-hydroperoxide glutathione peroxidase

Genes

HSA:	2879(GPX4)

PTR:	741876(GPX4)

PPS:	100990361(GPX4)

PON:	100458624(GPX4)

NLE:	100601223(GPX4)

MCC:	705333(GPX4)

MCF:	102142580(GPX4)

CSAB:

103233593(GPX4)

RRO:	104671424(GPX4)

RBB:	108537892(GPX4)

CJC:	100391793(GPX4) 103790339

SBQ:	101053315(GPX4)

MMU:	625249(Gpx4)

MCAL:

110303889(Gpx4)

MPAH:

110326696(Gpx4)

RNO:	29328(Gpx4)

MUN:	110551358(Gpx4)

CGE:	100765235(Gpx4)

NGI:	103737339(Gpx4)

HGL:	101708875(Gpx4)

CCAN:

109681876(Gpx4)

TUP:	102483947(GPX4)

AML:

100464258

UMR:	103681777(GPX4)

UAH:	113242720(GPX4)

ORO:	101377930(GPX4)

ELK:

111161740

FCA:	101095956(GPX4)

PTG:	102949955(GPX4)

PPAD:

109257691(GPX4)

AJU:	106978096(GPX4)

BTA:	286809(GPX4)

BOM:	102284111(GPX4)

BIU:	109561977(GPX4)

BBUB:

102404388(GPX4)

CHX:	100860867(GPX4)

OAS:	101113149(GPX4)

SSC:	399537(GPX4)

CFR:	102515650(GPX4)

CDK:	105104118(GPX4)

BACU:

103000913(GPX4)

LVE:	103071491(GPX4)

OOR:	101270118(GPX4)

DLE:	111170533(GPX4)

PCAD:

102992869(GPX4)

ECB:	102147383(GPX4)

EAI:	106834230(GPX4)

MYB:	102247160 102257806(GPX4)

MYD:	102758267(GPX4)

MNA:	107534552(GPX4)

HAI:

109390605

DRO:	112312403(GPX4)

PALE:

102878189(GPX4)

RAY:	107500914(GPX4)

MJV:	108388787(GPX4)

LAV:	100675152(GPX4)

TMU:

101355012

MDO:	100015749(GPX4)

SHR:	100930158(GPX4)

PCW:	110223406(GPX4)

OAA:	100088643(GPX4)

GGA:	374056(GPX4)

MGP:	100379155(GPX4)

CJO:	107325473(GPX4)

NMEL:

110389092(GPX4)

APLA:

101796330(GPX4)

ACYG:

106048194(GPX4)

TGU:	100190423(GPX4)

LSR:	110479113(GPX4)

SCAN:

115483836(GPX4)

GFR:	102045367(GPX4)

FAB:	101817765(GPX4)

PHI:	102113402(GPX4)

PMAJ:

107215549(GPX4)

CCAE:

111940246(GPX4)

CCW:	104697013(GPX4)

ETL:	114066400(GPX4)

FPG:	101916317(GPX4)

FCH:	102055857(GPX4)

CLV:	102092188(GPX4)

EGZ:	104127393(GPX4)

NNI:	104016300(GPX4)

PADL:

103922946(GPX4)

AAM:	106493531(GPX4)

ASN:	102386897(GPX4)

AMJ:	102570581(GPX4)

PSS:	102460999(GPX4)

CMY:	102948400(GPX4)

CPIC:

101944764(GPX4)

ACS:	100563257(gpx4)

PVT:	110079257(GPX4)

PBI:	103065827(GPX4)

PMUR:

107295211(GPX4)

TSR:	106550757(GPX4)

PMUA:

114588449(GPX4)

GJA:	107107351(GPX4)

XLA:	100036920(gpx4.L) 734888(gpx4.S)

XTR:	100496541(gpx4)

NPR:	108789489(GPX4)

DRE:	352928(gpx4a) 352929(gpx4b)

SRX:	107723219 107739954

SANH:

107660382

SGH:

107552704

CCAR:

109071199 109095832

IPU:	100528418(gpx4)

PHYP:

113533158(gpx4)

AMEX:

103026361(gpx4)

EEE:	113585970(gpx4)

TRU:	101066389 101070699

TNG:	GSTEN00024700G001 GSTEN00028551G001

LCO:	104929635 104930512

NCC:	104958153(gpx4)

MZE:	101475014 101481366(gpx4)

ONL:	100696691 100711165

OLA:	101160642 101160762 111946273

XMA:	102218769 102219707(gpx4)

XCO:	114147031 114150819(gpx4)

PRET:

103463715(gpx4) 103479268

CVG:	107091856 107095297(gpx4)

NFU:	107384121 107393348(gpx4)

KMR:	108230562(gpx4) 108239424

ALIM:

106526245(gpx4)

AOCE:

111563473 111571007

CSEM:

103376758(gpx4) 103395914

POV:	109625825 109647764

LCF:	108879022 108883623

SDU:	111229087 111231965

SLAL:

111653742(gpx4) 111658891

HCQ:	109507458 109532270

BPEC:

110157283 110174007(gpx4)

MALB:

109966994(gpx4) 109969232

SASA:

100194734(gpx4b) 106573579

OTW:	112250826 112260797

SALP:

111952959 111957159 111975698

ELS:	105011502 105022279

SFM:	108919780 108921631

PKI:	111836622(gpx4) 111860199

LCM:	102346539 102365140

CMK:	103189927(gpx4)

RTP:	109931453(gpx4)

BFO:

118421311

CIN:	100175675(gpx_e)

APLC:

110989974

SKO:

102807044

AGA:	AgaP_AGAP004248(GPXH3)

AALB:

109401758

CQU:	CpipJ_CPIJ006047 CpipJ_CPIJ010637

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

PCF:

NVI:	100114603 100123141

CSOL:

105366802

MDL:

106693859

TCA:	658307(GLEAN_10355)

DPA:

109546481

ATD:	109596245 109596246 109596247

NVL:	108566482 108566483

BMOR:

101744684

DPL:	KGM_202360 KGM_212277

HAW:	110372557 110372599

TNL:

AGS:

BTAB:

ZNE:

FCD:	110842172 110852997

DPX:	DAPPUDRAFT_220769 DAPPUDRAFT_233749 DAPPUDRAFT_310801

PVM:

113800343

ISC:	IscW_ISCW015098 IscW_ISCW019584 IscW_ISCW022517

TUT:

107368679

DPTE:

113797481

CSCU:

111620010 111620011 111620045

PTEP:

107457231

TSP:	Tsp_02268 Tsp_02272

LGI:	LOTGIDRAFT_208098

PCAN:

112554193 112573590

CRG:

105330305

MYI:

110445160

OBI:	106869007 106874999

LAK:	106176459 106176464

SMM:	Smp_058690 Smp_058700 Smp_124360

EGL:

EGR_06748

NVE:

116621178

EPA:	110238768 110242483

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:	100212361 100215761(GPx)

PSOJ:

PHYSODRAFT_317624

SPAR:

SPRG_01802

EHX:	EMIHUDRAFT_61670 EMIHUDRAFT_67177

» show all

Reference

1 [PMID:3978121]

Authors

Ursini F, Maiorino M, Gregolin C.

Title

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.

Journal

Biochim Biophys Acta 839:62-70 (1985)
DOI:10.1016/0304-4165(85)90182-5

Reference

2 [PMID:8617728]

Authors

Schnurr K, Belkner J, Ursini F, Schewe T, Kuhn H

Title

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.

Journal

J Biol Chem 271:4653-8 (1996)
DOI:10.1074/jbc.271.9.4653

Other DBs

ExplorEnz - The Enzyme Database:

1.11.1.12

IUBMB Enzyme Nomenclature:

1.11.1.12

ExPASy - ENZYME nomenclature database:

1.11.1.12

BRENDA, the Enzyme Database:

1.11.1.12