KEGG   ENZYME: 1.1.1.51
Entry
EC 1.1.1.51                 Enzyme                                 

Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3
K05296  3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3) 100612887 746545
PPS: 100971300 100986388(AKR1C3) 100987632 100988315
GGO: 101144878 101147265 101152195
PON: 100174617(AKR1C3) 100432652 100461633 100462259
NLE: 100593325 100604844 100606512
MCC: 100430336 722485 722496
MCF: 102116465(AKR1C2) 102143072 102144231
CSAB: 103237812 103237813 103237816
RRO: 104674747
MCAL: 110308148
RNO: 361267(Akr1cl)
MUN: 110560700
HGL: 101702106
CFA: 497070(AKR1C3)
VVP: 112933725
AML: 100483758
UMR: 103676234
UAH: 113241124
ELK: 111158636
FCA: 100510801(AKR1C3)
PTG: 102963188
PPAD: 109273789
AJU: 106988139
BTA: 100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
SSC: 654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
LVE: 103069218
PCAD: 102978533
HAI: 109378613
CMY: 102946053
GJA: 107108026
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
PKC: PKB_4320
PSET: THL1_4408
PSIL: PMA3_11580
PALI: A3K91_2273
SPL: Spea_2173
SHL: Shal_2144
ASIP: AQUSIP_13610(cpnA_2)
LCJ: NCTC11976_00397(phaB_1)
FPH: Fphi_0049
FPT: BZ13_56
FPI: BF30_220
FPM: LA56_250
FPX: KU46_1333
FPZ: LA55_1285
FPJ: LA02_1545
REH: H16_B0642(h16_B0642) H16_B0649(h16_B0649)
BCT: GEM_4149
BCON: NL30_04370
BTEI: WS51_05535
BFN: OI25_4612
CABA: SBC2_48780
CTES: O987_11065
MPT: Mpe_A0884
GME: Gmet_2217
SMAZ: LH19_04035
SWI: Swit_2259
SPHI: TS85_08785
SINB: SIDU_16905
BLAS: BSY18_620
GDI: GDI2584
GDJ: Gdia_0818
SHUM: STHU_19500
RCE: RC1_0549
TXI: TH3_02810
OOE: OEOE_0242
PUV: PUV_09390
 » show all
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe Seylers Z Physiol Chem 336:63-8 (1964)
DOI:10.1515/bchm2.1964.336.1.63
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J Biol Chem 232:1015-30 (1958)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J Biol Chem 252:3775-83 (1977)
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J Biol Chem 205:823-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.51
IUBMB Enzyme Nomenclature: 1.1.1.51
ExPASy - ENZYME nomenclature database: 1.1.1.51
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.51
BRENDA, the Enzyme Database: 1.1.1.51
CAS: 9015-81-0
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