Homo sapiens (human): 10013 Entry 10013             CDS       T01001                                  Gene name HDAC6, CPBHM, HD6, JM21, PPP1R90 Definition (RefSeq) histone deacetylase 6   KO K11407   histone deacetylase 6 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis Disease H02260   Chondrodysplasia Chassaing-Lacombe type Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Citarinostat:  D10918 Entinostat:  D09338 Fimepinostat:  D11319 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Ricolinostat:  D10661 Romidepsin:  D06637 Tinostamustine:  D11182 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     10013 (HDAC6)   09165 Substance dependence    05034 Alcoholism     10013 (HDAC6)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:hsa01009]     10013 (HDAC6)   09182 Protein families: genetic information processing    03019 Messenger RNA biogenesis [BR:hsa03019]     10013 (HDAC6)    04131 Membrane trafficking [BR:hsa04131]     10013 (HDAC6)    03036 Chromosome and associated proteins [BR:hsa03036]     10013 (HDAC6) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      10013 (HDAC6) Protein phosphatases and associated proteins [BR:hsa01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      10013 (HDAC6) Messenger RNA biogenesis [BR:hsa03019]  Eukaryotic type   mRNA surveillance and transport factors    mRNA cycle factors     Stress granule specific factors      10013 (HDAC6) Membrane trafficking [BR:hsa04131]  Autophagy   Aggrephagy    Other aggrephagy associated proteins     10013 (HDAC6) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class II HDACs      10013 (HDAC6) SSDB Motif Pfam:  Hist_deacetyl zf-UBP zf-UBP_var Other DBs NCBI-GeneID:  10013 NCBI-ProteinID:  NP_001308155 OMIM:  300272 HGNC:  14064 Ensembl:  ENSG00000094631 Vega:  OTTHUMG00000034496 Pharos:  Q9UBN7(Tclin) UniProt:  Q9UBN7 A0A024QZ26 LinkDB Structure PDB:  5B8D 5KH9 6CE8 6CEC 6CEE 5WPB 3C5K 6CE6 6CEA 5KH3 5WBN 6CED 5KH7 3GV4 6CEF 3PHD Position Xp11.23 AA seq 1215 aa MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLG QAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLI QEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNS YSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQ KHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQG QGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATP AGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSA QASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSR TGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCH SAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLN GAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMF EDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWH RLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEG GYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVE DREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSET AVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGA ILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQ TPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEA AGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQ ENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKN IAHQNKFGEDMPHPH NT seq 3648 nt   +upstreamnt  +downstreamnt atgacctcaaccggccaggattccaccacaaccaggcagcgaagaagtaggcagaacccc cagtcgccccctcaggactccagtgtcacttcgaagcgaaatattaaaaagggagccgtt ccccgctctatccccaatctagcggaggtaaagaagaaaggcaaaatgaagaagctcggc caagcaatggaagaagacctaatcgtgggactgcaagggatggatctgaaccttgaggct gaagcactggctggcactggcttggtgttggatgagcagttaaatgaattccattgcctc tgggatgacagcttcccggaaggccctgagcggctccatgccatcaaggagcaactgatc caggagggcctcctagatcgctgcgtgtcctttcaggcccggtttgctgaaaaggaagag ctgatgttggttcacagcctagaatatattgatctgatggaaacaacccagtacatgaat gagggagaactccgtgtcctagcagacacctacgactcagtttatctgcatccgaactca tactcctgtgcctgcctggcctcaggctctgtcctcaggctggtggatgcggtcctgggg gctgagatccggaatggcatggccatcattaggcctcctggacatcacgcccagcacagt cttatggatggctattgcatgttcaaccacgtggctgtggcagcccgctatgctcaacag aaacaccgcatccggagggtccttatcgtagattgggatgtgcaccacggtcaaggaaca cagttcaccttcgaccaggaccccagtgtcctctatttctccatccaccgctacgagcag ggtaggttctggccccacctgaaggcctctaactggtccaccacaggtttcggccaaggc caaggatataccatcaatgtgccttggaaccaggtggggatgcgggatgctgactacatt gctgctttcctgcacgtcctgctgccagtcgccctcgagttccagcctcagctggtcctg gtggctgctggatttgatgccctgcaaggggaccccaagggtgagatggccgccactccg gcagggttcgcccagctaacccacctgctcatgggtctggcaggaggcaagctgatcctg tctctggagggtggctacaacctccgcgccctggctgaaggcgtcagtgcttcgctccac acccttctgggagacccttgccccatgctggagtcacctggtgccccctgccggagtgcc caggcttcagtttcctgtgctctggaagcccttgagcccttctgggaggttcttgtgaga tcaactgagaccgtggagagggacaacatggaggaggacaatgtagaggagagcgaggag gaaggaccctgggagccccctgtgctcccaatcctgacatggccagtgctacagtctcgc acagggctggtctatgaccaaaatatgatgaatcactgcaacttgtgggacagccaccac cctgaggtaccccagcgcatcttgcggatcatgtgccgtctggaggagctgggccttgcc gggcgctgcctcaccctgacaccgcgccctgccacagaggctgagctgctcacctgtcac agtgctgagtacgtgggtcatctccgggccacagagaaaatgaaaacccgggagctgcac cgtgagagttccaactttgactccatctatatctgccccagtaccttcgcctgtgcacag cttgccactggcgctgcctgccgcctggtggaggctgtgctctcaggagaggttctgaat ggtgctgctgtggtgcgtcccccaggacaccacgcagagcaggatgcagcttgcggtttt tgctttttcaactctgtggctgtggctgctcgccatgcccagactatcagtgggcatgcc ctacggatcctgattgtggattgggatgtccaccacggtaatggaactcagcacatgttt gaggatgaccccagtgtgctatatgtgtccctgcaccgctatgatcatggcaccttcttc cccatgggggatgagggtgccagcagccagatcggccgggctgcgggcacaggcttcacc gtcaacgtggcatggaacgggccccgcatgggtgatgctgactacctagctgcctggcat cgcctggtgcttcccattgcctacgagtttaacccagaactggtgctggtctcagctggc tttgatgctgcacggggggatccgctggggggctgccaggtgtcacctgagggttatgcc cacctcacccacctgctgatgggccttgccagtggccgcattatccttatcctagagggt ggctataacctgacatccatctcagagtccatggctgcctgcactcgctccctccttgga gacccaccacccctgctgaccctgccacggcccccactatcaggggccctggcctcaatc actgagaccatccaagtccatcgcagatactggcgcagcttacgggtcatgaaggtagaa gacagagaaggaccctccagttctaagttggtcaccaagaaggcaccccaaccagccaaa cctaggttagctgagcggatgaccacacgagaaaagaaggttctggaagcaggcatgggg aaagtcacctcggcatcatttggggaagagtccactccaggccagactaactcagagaca gctgtggtggccctcactcaggaccagccctcagaggcagccacagggggagccactctg gcccagaccatttctgaggcagccattgggggagccatgctgggccagaccacctcagag gaggctgtcgggggagccactccggaccagaccacctcagaggagactgtgggaggagcc attctggaccagaccacctcagaggatgctgttgggggagccacgctgggccagactacc tcagaggaggctgtaggaggagctacactggcccagaccacctcggaggcagccatggag ggagccacactggaccagactacgtcagaggaggctccagggggcaccgagctgatccaa actcctctagcctcgagcacagaccaccagacccccccaacctcacctgtgcagggaact acaccccagatatctcccagtacactgattgggagtctcaggaccttggagctaggcagc gaatctcagggggcctcagaatctcaggccccaggagaggagaacctactaggagaggca gctggaggtcaggacatggctgattcgatgctgatgcagggatctaggggcctcactgat caggccatattttatgctgtgacaccactgccctggtgtccccatttggtggcagtatgc cccatacctgcagcaggcctagacgtgacccaaccttgtggggactgtggaacaatccaa gagaattgggtgtgtctctcttgctatcaggtctactgtggtcgttacatcaatggccac atgctccaacaccatggaaattctggacacccgctggtcctcagctacatcgacctgtca gcctggtgttactactgtcaggcctatgtccaccaccaggctctcctagatgtgaagaac atcgcccaccagaacaagtttggggaggatatgccccacccacactaa

Homo sapiens (human): 10014 Entry 10014             CDS       T01001                                  Gene name HDAC5, HD5, NY-CO-9 Definition (RefSeq) histone deacetylase 5   KO K11406   histone deacetylase 4/5 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa04371   Apelin signaling pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis hsa05206   MicroRNAs in cancer Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     10014 (HDAC5)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     10014 (HDAC5)    05203 Viral carcinogenesis     10014 (HDAC5)   09165 Substance dependence    05034 Alcoholism     10014 (HDAC5)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     10014 (HDAC5) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      10014 (HDAC5) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class II HDACs      10014 (HDAC5) SSDB Motif Pfam:  Hist_deacetyl HDAC4_Gln Other DBs NCBI-GeneID:  10014 NCBI-ProteinID:  NP_005465 OMIM:  605315 HGNC:  14068 Ensembl:  ENSG00000108840 Vega:  OTTHUMG00000181806 Pharos:  Q9UQL6(Tclin) UniProt:  Q9UQL6 LinkDB Position 17q21.31 AA seq 1122 aa MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELR GALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ QEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKL PLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEI TGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMST SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATS MRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEED CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQ SSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLP CGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAM GFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVS AGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVS ALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET EEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL NT seq 3369 nt   +upstreamnt  +downstreamnt atgaactctcccaacgagtcggatgggatgtcaggtcgggaaccatccttggaaatcctg ccgcggacttctctgcacagcatccctgtgacagtggaggtgaagccggtgctgccaaga gccatgcccagttccatggggggtgggggtggaggcagccccagccctgtggagctacgg ggggctctggtgggctctgtggaccccacactgcgggagcagcaactgcagcaggagctc ctggcgctcaagcagcagcagcagctgcagaagcagctcctgttcgctgagttccagaaa cagcatgaccacctgacaaggcagcatgaggtccagctgcagaagcacctcaagcagcag caggagatgctggcagccaagcagcagcaggagatgctggcagccaagcggcagcaggag ctggagcagcagcggcagcgggagcagcagcggcaggaagagctggagaagcagcggctg gagcagcagctgctcatcctgcggaacaaggagaagagcaaagagagtgccattgccagc actgaggtaaagctgaggctccaggaattcctcttgtcgaagtcaaaggagcccacacca ggcggcctcaaccattccctcccacagcaccccaaatgctggggagcccaccatgcttct ttggaccagagttcccctccccagagcggcccccctgggacgcctccctcctacaaactg cctttgcctgggccctacgacagtcgagacgacttccccctccgcaaaacagcctctgaa cccaacttgaaagtgcgttcaaggctaaaacagaaggtggctgagcggagaagcagtccc ctcctgcgtcgcaaggatgggactgttattagcacctttaagaagagagctgttgagatc acaggtgccgggcctggggcgtcgtccgtgtgtaacagcgcacccggctccggccccagc tctcccaacagctcccacagcaccatcgctgagaatggctttactggctcagtccccaac atccccactgagatgctccctcagcaccgagccctccctctggacagctcccccaaccag ttcagcctctacacgtctccttctctgcccaacatctccctagggctgcaggccacggtc actgtcaccaactcacacctcactgcctccccgaagctgtcgacacagcaggaggccgag aggcaggccctccagtccctgcggcagggtggcacgctgaccggcaagttcatgagcaca tcctctattcctggctgcctgctgggcgtggcactggagggcgacgggagcccccacggg catgcctccctgctgcagcatgtgctgttgctggagcaggcccggcagcagagcaccctc attgctgtgccactccacgggcagtccccactagtgacgggtgaacgtgtggccaccagc atgcggacggtaggcaagctcccgcggcatcggcccctgagccgcactcagtcctcaccg ctgccgcagagtccccaggccctgcagcagctggtcatgcaacaacagcaccagcagttc ctggagaagcagaagcagcagcagctacagctgggcaagatcctcaccaagacaggggag ctgcccaggcagcccaccacccaccctgaggagacagaggaggagctgacggagcagcag gaggtcttgctgggggagggagccctgaccatgccccgggagggctccacagagagtgag agcacacaggaagacctggaggaggaggacgaggaagacgatggggaggaggaggaggat tgcatccaggttaaggacgaggagggcgagagtggtgctgaggaggggcccgacttggag gagcctggtgctggatacaaaaaactgttctcagatgcccagccgctgcagcctttgcag gtgtaccaggcgcccctcagcctggccactgtgccccaccaggccctgggccgtacccag tcctcccctgctgcccctgggggcatgaagagccccccagaccagcccgtcaagcacctc ttcaccacaggtgtggtctacgacacgttcatgctaaagcaccagtgcatgtgcgggaac acacacgtgcaccctgagcatgctggccggatccagagcatctggtcccggctgcaggag acaggcctgcttagcaagtgcgagcggatccgaggtcgcaaagccacgctagatgagatc cagacagtgcactctgaataccacaccctgctctatgggaccagtcccctcaaccggcag aagctagacagcaagaagttgctcggccccatcagccagaagatgtatgctgtgctgcct tgtgggggcatcggggtggacagtgacaccgtgtggaatgagatgcactcctccagtgct gtgcgcatggcagtgggctgcctgctggagctggccttcaaggtggctgcaggagagctc aagaatggatttgccatcatccggcccccaggacaccacgccgaggaatccacagccatg ggattctgcttcttcaactctgtagccatcaccgcaaaactcctacagcagaagttgaac gtgggcaaggtcctcatcgtggactgggacattcaccatggcaatggcacccagcaggcg ttctacaatgacccctctgtgctctacatctctctgcatcgctatgacaacgggaacttc tttccaggctctggggctcctgaagaggttggtggaggaccaggcgtggggtacaatgtg aacgtggcatggacaggaggtgtggacccccccattggagacgtggagtaccttacagcc ttcaggacagtggtgatgcccattgcccacgagttctcacctgatgtggtcctagtctcc gccgggtttgatgctgttgaaggacatctgtctcctctgggtggctactctgtcaccgcc agatgttttggccacttgaccaggcagctgatgaccctggcagggggccgggtggtgctg gccctggagggaggccatgacttgaccgccatctgtgatgcctctgaggcttgtgtctcg gctctgctcagtgtagagctgcagcccttggatgaggcagtcttgcagcaaaagcccaac atcaacgcagtggccacgctagagaaagtcatcgagatccagagcaaacactggagctgt gtgcagaagttcgccgctggtctgggccggtccctgcgagaggcccaagcaggtgagacc gaggaggccgagactgtgagcgccatggccttgctgtcggtgggggccgagcaggcccag gctgcggcagcccgggaacacagccccaggccggcagaggagcccatggagcaggagcct gccctgtga

Homo sapiens (human): 3065 Entry 3065              CDS       T01001                                  Gene name HDAC1, GON-10, HD1, KDAC1, RPD3, RPD3L1 Definition (RefSeq) histone deacetylase 1   KO K06067   histone deacetylase 1/2 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa04110   Cell cycle hsa04213   Longevity regulating pathway - multiple species hsa04330   Notch signaling pathway hsa04919   Thyroid hormone signaling pathway hsa05016   Huntington disease hsa05031   Amphetamine addiction hsa05034   Alcoholism hsa05165   Human papillomavirus infection hsa05169   Epstein-Barr virus infection hsa05200   Pathways in cancer hsa05202   Transcriptional misregulation in cancer hsa05203   Viral carcinogenesis hsa05206   MicroRNAs in cancer hsa05220   Chronic myeloid leukemia Network nt06123  TNF signaling (viruses) nt06166  Human papillomavirus (HPV) nt06240  Transcription   Element N00118   TEL-AML1 fusion to transcriptional repression N00375   HPV E7 to TNF-IRF1 signaling pathway Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Mocetinostat (DG01404):  D09357 D09641 Nanatinostat:  D11442 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Tacedinaline:  D05988 Tinostamustine:  D11182 Tucidinostat:  D10993 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     3065 (HDAC1)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     3065 (HDAC1)  09150 Organismal Systems   09152 Endocrine system    04919 Thyroid hormone signaling pathway     3065 (HDAC1)   09149 Aging    04213 Longevity regulating pathway - multiple species     3065 (HDAC1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     3065 (HDAC1)    05202 Transcriptional misregulation in cancer     3065 (HDAC1)    05206 MicroRNAs in cancer     3065 (HDAC1)    05203 Viral carcinogenesis     3065 (HDAC1)   09162 Cancer: specific types    05220 Chronic myeloid leukemia     3065 (HDAC1)   09164 Neurodegenerative disease    05016 Huntington disease     3065 (HDAC1)   09165 Substance dependence    05031 Amphetamine addiction     3065 (HDAC1)    05034 Alcoholism     3065 (HDAC1)   09172 Infectious disease: viral    05169 Epstein-Barr virus infection     3065 (HDAC1)    05165 Human papillomavirus infection     3065 (HDAC1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     3065 (HDAC1) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      3065 (HDAC1) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class I HDACs      3065 (HDAC1)    HDAC complexes     Sin3A-HDAC complex      3065 (HDAC1)   Heterochromatin formation proteins    Other heterochromatin formation proteins     3065 (HDAC1)   Chromatin remodeling factors    NuRD complex     3065 (HDAC1) SSDB Motif Pfam:  Hist_deacetyl Other DBs NCBI-GeneID:  3065 NCBI-ProteinID:  NP_004955 OMIM:  601241 HGNC:  4852 Ensembl:  ENSG00000116478 Vega:  OTTHUMG00000007529 Pharos:  Q13547(Tclin) UniProt:  Q13547 Q6IT96 LinkDB Structure PDB:  4BKX 5ICN Position 1p35.2-p35.1 AA seq 482 aa MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK LA NT seq 1449 nt   +upstreamnt  +downstreamnt atggcgcagacgcagggcacccggaggaaagtctgttactactacgacggggatgttgga aattactattatggacaaggccacccaatgaagcctcaccgaatccgcatgactcataat ttgctgctcaactatggtctctaccgaaaaatggaaatctatcgccctcacaaagccaat gctgaggagatgaccaagtaccacagcgatgactacattaaattcttgcgctccatccgt ccagataacatgtcggagtacagcaagcagatgcagagattcaacgttggtgaggactgt ccagtattcgatggcctgtttgagttctgtcagttgtctactggtggttctgtggcaagt gctgtgaaacttaataagcagcagacggacatcgctgtgaattgggctgggggcctgcac catgcaaagaagtccgaggcatctggcttctgttacgtcaatgatatcgtcttggccatc ctggaactgctaaagtatcaccagagggtgctgtacattgacattgatattcaccatggt gacggcgtggaagaggccttctacaccacggaccgggtcatgactgtgtcctttcataag tatggagagtacttcccaggaactggggacctacgggatatcggggctggcaaaggcaag tattatgctgttaactacccgctccgagacgggattgatgacgagtcctatgaggccatt ttcaagccggtcatgtccaaagtaatggagatgttccagcctagtgcggtggtcttacag tgtggctcagactccctatctggggatcggttaggttgcttcaatctaactatcaaagga cacgccaagtgtgtggaatttgtcaagagctttaacctgcctatgctgatgctgggaggc ggtggttacaccattcgtaacgttgcccggtgctggacatatgagacagctgtggccctg gatacggagatccctaatgagcttccatacaatgactactttgaatactttggaccagat ttcaagctccacatcagtccttccaatatgactaaccagaacacgaatgagtacctggag aagatcaaacagcgactgtttgagaaccttagaatgctgccgcacgcacctggggtccaa atgcaggcgattcctgaggacgccatccctgaggagagtggcgatgaggacgaagacgac cctgacaagcgcatctcgatctgctcctctgacaaacgaattgcctgtgaggaagagttc tccgattctgaagaggagggagaggggggccgcaagaactcttccaacttcaaaaaagcc aagagagtcaaaacagaggatgaaaaagagaaagacccagaggagaagaaagaagtcacc gaagaggagaaaaccaaggaggagaagccagaagccaaaggggtcaaggaggaggtcaag ttggcctga

Homo sapiens (human): 3066 Entry 3066              CDS       T01001                                  Gene name HDAC2, HD2, KDAC2, RPD3, YAF1 Definition (RefSeq) histone deacetylase 2   KO K06067   histone deacetylase 1/2 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa04110   Cell cycle hsa04213   Longevity regulating pathway - multiple species hsa04330   Notch signaling pathway hsa04919   Thyroid hormone signaling pathway hsa05016   Huntington disease hsa05034   Alcoholism hsa05165   Human papillomavirus infection hsa05169   Epstein-Barr virus infection hsa05200   Pathways in cancer hsa05202   Transcriptional misregulation in cancer hsa05203   Viral carcinogenesis hsa05206   MicroRNAs in cancer hsa05220   Chronic myeloid leukemia Network nt06123  TNF signaling (viruses) nt06166  Human papillomavirus (HPV) nt06240  Transcription   Element N00118   TEL-AML1 fusion to transcriptional repression N00375   HPV E7 to TNF-IRF1 signaling pathway Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Mocetinostat (DG01404):  D09357 D09641 Nanatinostat:  D11442 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Tinostamustine:  D11182 Tucidinostat:  D10993 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     3066 (HDAC2)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     3066 (HDAC2)  09150 Organismal Systems   09152 Endocrine system    04919 Thyroid hormone signaling pathway     3066 (HDAC2)   09149 Aging    04213 Longevity regulating pathway - multiple species     3066 (HDAC2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     3066 (HDAC2)    05202 Transcriptional misregulation in cancer     3066 (HDAC2)    05206 MicroRNAs in cancer     3066 (HDAC2)    05203 Viral carcinogenesis     3066 (HDAC2)   09162 Cancer: specific types    05220 Chronic myeloid leukemia     3066 (HDAC2)   09164 Neurodegenerative disease    05016 Huntington disease     3066 (HDAC2)   09165 Substance dependence    05034 Alcoholism     3066 (HDAC2)   09172 Infectious disease: viral    05169 Epstein-Barr virus infection     3066 (HDAC2)    05165 Human papillomavirus infection     3066 (HDAC2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     3066 (HDAC2) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      3066 (HDAC2) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class I HDACs      3066 (HDAC2)    HDAC complexes     Sin3A-HDAC complex      3066 (HDAC2)   Heterochromatin formation proteins    Other heterochromatin formation proteins     3066 (HDAC2)   Chromatin remodeling factors    NuRD complex     3066 (HDAC2) SSDB Motif Pfam:  Hist_deacetyl Other DBs NCBI-GeneID:  3066 NCBI-ProteinID:  NP_001518 OMIM:  605164 HGNC:  4853 Ensembl:  ENSG00000196591 Vega:  OTTHUMG00000015411 Pharos:  Q92769(Tclin) UniProt:  Q92769 LinkDB Structure PDB:  4LY1 5IWG 5IX0 4LXZ 3MAX 6G3O Position 6q21 AA seq 488 aa MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT KSEQLSNP NT seq 1467 nt   +upstreamnt  +downstreamnt atggcgtacagtcaaggaggcggcaaaaaaaaagtctgctactactacgacggtgatatt ggaaattattattatggacagggtcatcccatgaagcctcatagaatccgcatgacccat aacttgctgttaaattatggcttatacagaaaaatggaaatatataggccccataaagcc actgccgaagaaatgacaaaatatcacagtgatgagtatatcaaatttctacggtcaata agaccagataacatgtctgagtatagtaagcagatgcagagatttaatgttggagaagat tgtccagtgtttgatggactctttgagttttgtcagctctcaactggcggttcagttgct ggagctgtgaagttaaaccgacaacagactgatatggctgttaattgggctggaggatta catcatgctaagaaatcagaagcatcaggattctgttacgttaatgatattgtgcttgcc atccttgaattactaaagtatcatcagagagtcttatatattgatatagatattcatcat ggtgatggtgttgaagaagctttttatacaacagatcgtgtaatgacggtatcattccat aaatatggggaatactttcctggcacaggagacttgagggatattggtgctggaaaaggc aaatactatgctgtcaattttccaatgagagatggtatagatgatgagtcatatgggcag atatttaagcctattatctcaaaggtgatggagatgtatcaacctagtgctgtggtatta cagtgtggtgcagactcattatctggtgatagactgggttgtttcaatctaacagtcaaa ggtcatgctaaatgtgtagaagttgtaaaaacttttaacttaccattactgatgcttgga ggaggtggctacacaatccgtaatgttgctcgatgttggacatatgagactgcagttgcc cttgattgtgagattcccaatgagttgccatataatgattactttgagtattttggacca gacttcaaactgcatattagtccttcaaacatgacaaaccagaacactccagaatatatg gaaaagataaaacagcgtttgtttgaaaatttgcgcatgttacctcatgcacctggtgtc cagatgcaagctattccagaagatgctgttcatgaagacagtggagatgaagatggagaa gatccagacaagagaatttctattcgagcatcagacaagcggatagcttgtgatgaagaa ttctcagattctgaggatgaaggagaaggaggtcgaagaaatgtggctgatcataagaaa ggagcaaagaaagctagaattgaagaagataagaaagaaacagaggacaaaaaaacagac gttaaggaagaagataaatccaaggacaacagtggtgaaaaaacagataccaaaggaacc aaatcagaacagctcagcaacccctga

Homo sapiens (human): 51564 Entry 51564             CDS       T01001                                  Gene name HDAC7, HD7, HD7A, HDAC7A Definition (RefSeq) histone deacetylase 7   KO K11408   histone deacetylase 7 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     51564 (HDAC7)   09165 Substance dependence    05034 Alcoholism     51564 (HDAC7)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     51564 (HDAC7) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      51564 (HDAC7) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class II HDACs      51564 (HDAC7) SSDB Motif Pfam:  Hist_deacetyl Other DBs NCBI-GeneID:  51564 NCBI-ProteinID:  NP_001091886 OMIM:  606542 HGNC:  14067 Ensembl:  ENSG00000061273 Vega:  OTTHUMG00000152968 Pharos:  Q8WUI4(Tclin) UniProt:  Q8WUI4 LinkDB Structure PDB:  3C10 3C0Y 3C0Z 3ZNR 3ZNS Position 12q13.11 AA seq 954 aa MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS SSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEA GGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRS EPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQ VVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGH RPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDN SRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLK LDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTF YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLA LEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCM QRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL NT seq 2865 nt   +upstreamnt  +downstreamnt atgcacagccccggcgctgatgggacccaggtgagcccgggtgcccactactgcagcccc actggcgcaggctgccccaggccctgtgcagacacaccaggccctcagccgcagcccatg gacctgcgggtgggccagcggcccccagtggagcccccaccagagcccacattgctggcc ctgcagcgtccccagcgcctgcaccaccacctcttcctagcaggcctgcagcagcagcgc tcggtggagcccatgaggctctccatggacacgccgatgcccgagttgcaggtgggaccc caggaacaagagctgcggcagcttctccacaaggacaagagcaagcgaagtgctgtagcc agcagcgtggtcaagcagaagctagcggaggtgattctgaaaaaacagcaggcggcccta gaaagaacagtccatcccaacagccccggcattccctacagaaccctggagcccctggag acggaaggagccacccgctccatgctcagcagctttttgcctcctgttcccagcctgccc agtgaccccccagagcacttccctctgcgcaagacagtctctgagcccaacctgaagctg cgctataagcccaagaagtccctggagcggaggaagaatccactgctccgaaaggagagt gcgccccccagcctccggcggcggcccgcagagaccctcggagactcctccccaagtagt agcagcacgcccgcatcagggtgcagctcccccaatgacagcgagcacggccccaatccc atcctgggctcggaggctgacagtgaccgcaggacccatccgactctgggccctcggggg ccaatcctggggagcccccacactcccctcttcctgccccatggcttggagcccgaggct gggggcaccttgccctctcgcctgcagcccattctcctcctggacccctcaggctctcat gccccgctgctgactgtgcccgggcttgggcccttgcccttccactttgcccagtcctta atgaccaccgagcggctctctgggtcaggcctccactggccactgagccggactcgctca gagcccctgccccccagtgccaccgctcccccaccgccgggccccatgcagccccgcctg gagcagctcaaaactcacgtccaggtgatcaagaggtcagccaagccgagtgagaagccc cggctgcggcagataccctcggctgaagacctggagacagatggcgggggaccgggccag gtggtggacgatggcctggagcacagggagctgggccatgggcagcctgaggccagaggc cccgctcctctccagcagcaccctcaggtgttgctctgggaacagcagcgactggctggg cggctcccccggggcagcaccggggacactgtgctgcttcctctggcccagggtgggcac cggcctctgtcccgggctcagtcttccccagccgcacctgcctcactgtcagccccagag cctgccagccaggcccgagtcctctccagctcagagacccctgccaggaccctgcccttc accacagggctgatctatgactcggtcatgctgaagcaccagtgctcctgcggtgacaac agcaggcacccggagcacgccggccgcatccagagcatctggtcccggctgcaggagcgg gggctccggagccagtgtgagtgtctccgaggccggaaggcctccctggaagagctgcag tcggtccactctgagcggcacgtgctcctctacggcaccaacccgctcagccgcctcaaa ctggacaacgggaagctggcagggctcctggcacagcggatgtttgtgatgctgccctgt ggtggggttggggtggacactgacaccatctggaatgagcttcattcctccaatgcagcc cgctgggccgctggcagtgtcactgacctcgccttcaaagtggcttctcgtgagctaaag aatggtttcgctgtggtgcggcccccaggacaccatgcagatcattcaacagccatgggc ttctgcttcttcaactcagtggccatcgcctgccggcagctgcaacagcagagcaaggcc agcaagatcctcattgtagactgggacgtgcaccatggcaacggcacccagcaaaccttc taccaagaccccagtgtgctctacatctccctgcatcgccatgacgacggcaacttcttc ccggggagtggggctgtggatgaggtaggggctggcagcggtgagggcttcaatgtcaat gtggcctgggctggaggtctggacccccccatgggggatcctgagtacctggctgctttc aggatagtcgtgatgcccatcgcccgagagttctctccagacctagtcctggtgtctgct ggatttgatgctgctgagggtcacccggccccactgggtggctaccatgtttctgccaaa tgttttggatacatgacgcagcaactgatgaacctggcaggaggcgcagtggtgctggcc ttggagggtggccatgacctcacagccatctgtgacgcctctgaggcctgtgtggctgct cttctgggtaacagggtggatcccctttcagaagaaggctggaaacagaaacccaacctc aatgccatccgctctctggaggccgtgatccgggtgcacagtaaatactggggctgcatg cagcgcctggcctcctgtccagactcctgggtgcctagagtgccaggggctgacaaagaa gaagtggaggcagtgaccgcactggcgtccctctctgtgggcatcctggctgaagatagg ccctcggagcagctggtggaggaggaagaacctatgaatctctaa

Homo sapiens (human): 55869 Entry 55869             CDS       T01001                                  Gene name HDAC8, CDA07, CDLS5, HD8, HDACL1, KDAC8, MRXS6, RPD3, WTS Definition (RefSeq) histone deacetylase 8   KO K11405   histone deacetylase 8 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis Disease H00631   Cornelia de Lange syndrome Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Mocetinostat (DG01404):  D09357 D09641 Nanatinostat:  D11442 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     55869 (HDAC8)   09165 Substance dependence    05034 Alcoholism     55869 (HDAC8)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     55869 (HDAC8) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      55869 (HDAC8) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class I HDACs      55869 (HDAC8) SSDB Motif Pfam:  Hist_deacetyl DNase-RNase Other DBs NCBI-GeneID:  55869 NCBI-ProteinID:  NP_060956 OMIM:  300269 HGNC:  13315 Ensembl:  ENSG00000147099 Vega:  OTTHUMG00000021814 Pharos:  Q9BY41(Tclin) UniProt:  Q9BY41 LinkDB Structure PDB:  5VI6 5DC8 5D1C 5DC6 5BWZ 4RN0 4QA5 3EW8 3MZ4 5THV 5THS 3MZ7 1T64 4QA1 5DC5 5THU 5FCW 4QA4 3SFF 3MZ6 2V5W 5D1D 4QA6 6HSK 3RQD 4RN1 1VKG 4QA0 2V5X 5DC7 4QA7 1T67 4QA2 4RN2 5THT 3EWF 3F0R 3F06 3EZP 3SFH 3EZT 4QA3 5D1B 1T69 3MZ3 3F07 1W22 Position Xq13.1 AA seq 377 aa MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH RIQQILNYIKGNLKHVV NT seq 1134 nt   +upstreamnt  +downstreamnt atggaggagccggaggaaccggcggacagtgggcagtcgctggtcccggtttatatctat agtcccgagtatgtcagtatgtgtgactccctggccaagatccccaaacgggccagtatg gtgcattctttgattgaagcatatgcactgcataagcagatgaggatagttaagcctaaa gtggcctccatggaggagatggccaccttccacactgatgcttatctgcagcatctccag aaggtcagccaagagggcgatgatgatcatccggactccatagaatatgggctaggttat gactgcccagccactgaagggatatttgactatgcagcagctataggaggggctacgatc acagctgcccaatgcctgattgacggaatgtgcaaagtagcaattaactggtctggaggg tggcatcatgcaaagaaagatgaagcatctggtttttgttatctcaatgatgctgtcctg ggaatattacgattgcgacggaaatttgagcgtattctctacgtggatttggatctgcac catggagatggtgtagaagacgcattcagtttcacctccaaagtcatgaccgtgtccctg cacaaattctccccaggatttttcccaggaacaggtgacgtgtctgatgttggcctaggg aagggacggtactacagtgtaaatgtgcccattcaggatggcatacaagatgaaaaatat taccagatctgtgaaagtgtactaaaggaagtataccaagcctttaatcccaaagcagtg gtcttacagctgggagctgacacaatagctggggatcccatgtgctcctttaacatgact ccagtgggaattggcaagtgtcttaagtacatccttcaatggcagttggcaacactcatt ttgggaggaggaggctataaccttgccaacacggctcgatgctggacatacttgaccggg gtcatcctagggaaaacactatcctctgagatcccagatcatgagtttttcacagcatat ggtcctgattatgtgctggaaatcacgccaagctgccggccagaccgcaatgagccccac cgaatccaacaaatcctcaactacatcaaagggaatctgaagcatgtggtctag

Homo sapiens (human): 79885 Entry 79885             CDS       T01001                                  Gene name HDAC11, HD11 Definition (RefSeq) histone deacetylase 11   KO K11418   histone deacetylase 11 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Mocetinostat (DG01404):  D09357 D09641 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     79885 (HDAC11)   09165 Substance dependence    05034 Alcoholism     79885 (HDAC11)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     79885 (HDAC11) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      79885 (HDAC11) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class IV HDACs      79885 (HDAC11) SSDB Motif Pfam:  Hist_deacetyl Other DBs NCBI-GeneID:  79885 NCBI-ProteinID:  NP_079103 OMIM:  607226 HGNC:  19086 Ensembl:  ENSG00000163517 Vega:  OTTHUMG00000129800 Pharos:  Q96DB2(Tclin) UniProt:  Q96DB2 A0A024R2I1 LinkDB Position 3p25.1 AA seq 347 aa MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP NT seq 1044 nt   +upstreamnt  +downstreamnt atgctacacacaacccagctgtaccagcatgtgccagagacacgctggccaatcgtgtac tcgccgcgctacaacatcaccttcatgggcctggagaagctgcatccctttgatgccgga aaatggggcaaagtgatcaatttcctaaaagaagagaagcttctgtctgacagcatgctg gtggaggcgcgggaggcctcggaggaggacctgctggtggtgcacacgaggcgctatctt aatgagctcaagtggtcctttgctgttgctaccatcacagaaatcccccccgttatcttc ctccccaacttccttgtgcagaggaaggtgctgaggccccttcggacccagacaggagga accataatggcggggaagctggctgtggagcgaggctgggccatcaacgtggggggtggc ttccaccactgctccagcgaccgtggcgggggcttctgtgcctatgcggacatcacgctc gccatcaagtttctgtttgagcgtgtggagggcatctccagggctaccatcattgatctt gatgcccatcagggcaatgggcatgagcgagacttcatggacgacaagcgtgtgtacatc atggatgtctacaaccgccacatctacccaggggaccgctttgccaagcaggccatcagg cggaaggtggagctggagtggggcacagaggatgatgagtacctggataaggtggagagg aacatcaagaaatccctccaggagcacctgcccgacgtggtggtatacaatgcaggcacc gacatcctcgagggggaccgccttggggggctgtccatcagcccagcgggcatcgtgaag cgggatgagctggtgttccggatggtccgtggccgccgggtgcccatccttatggtgacc tcaggcgggtaccagaagcgcacagcccgcatcattgctgactccatacttaatctgttt ggcctggggctcattgggcctgagtcacccagcgtctccgcacagaactcagacacaccg ctgcttccccctgcagtgccctga

Homo sapiens (human): 83933 Entry 83933             CDS       T01001                                  Gene name HDAC10, HD10 Definition (RefSeq) histone deacetylase 10   KO K18671   histone deacetylase 10 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Tucidinostat:  D10993 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     83933 (HDAC10)   09165 Substance dependence    05034 Alcoholism     83933 (HDAC10)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     83933 (HDAC10) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      83933 (HDAC10) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class II HDACs      83933 (HDAC10) SSDB Motif Pfam:  Hist_deacetyl Other DBs NCBI-GeneID:  83933 NCBI-ProteinID:  NP_114408 OMIM:  608544 HGNC:  18128 Ensembl:  ENSG00000100429 Vega:  OTTHUMG00000044647 Pharos:  Q969S8(Tclin) UniProt:  Q969S8 LinkDB Position 22q13.33 AA seq 669 aa MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM LQCHPHLVA NT seq 2010 nt   +upstreamnt  +downstreamnt atggggaccgcgcttgtgtaccatgaggacatgacggccacccggctgctctgggacgac cccgagtgcgagatcgagcgtcctgagcgcctgaccgcagccctggatcgcctgcggcag cgcggcctggaacagaggtgtctgcggttgtcagcccgcgaggcctcggaagaggagctg ggcctggtgcacagcccagagtatgtatccctggtcagggagacccaggtcctaggcaag gaggagctgcaggcgctgtccggacagttcgacgccatctacttccacccgagtaccttt cactgcgcgcggctggccgcaggggctggactgcagctggtggacgctgtgctcactgga gctgtgcaaaatgggcttgccctggtgaggcctcccgggcaccatggccagagggcggct gccaacgggttctgtgtgttcaacaacgtggccatagcagctgcacatgccaagcagaaa cacgggctacacaggatcctcgtcgtggactgggatgtgcaccatggccaggggatccag tatctctttgaggatgaccccagcgtcctttacttctcctggcaccgctatgagcatggg cgcttctggcctttcctgcgagagtcagatgcagacgcagtggggcggggacagggcctc ggcttcactgtcaacctgccctggaaccaggttgggatgggaaacgctgactacgtggct gccttcctgcacctgctgctcccactggcctttgagtttgaccctgagctggtgctggtc tcggcaggatttgactcagccatcggggaccctgaggggcaaatgcaggccacgccagag tgcttcgcccacctcacacagctgctgcaggtgctggccggcggccgggtctgtgccgtg ctggagggcggctaccacctggagtcactggcggagtcagtgtgcatgacagtacagacg ctgctgggtgacccggccccacccctgtcagggccaatggcgccatgtcagagtgcccta gagtccatccagagtgcccgtgctgcccaggccccgcactggaagagcctccagcagcaa gatgtgaccgctgtgccgatgagccccagcagccactccccagaggggaggcctccacct ctgctgcctgggggtccagtgtgtaaggcagctgcatctgcaccgagctccctcctggac cagccgtgcctctgccccgcaccctctgtccgcaccgctgttgccctgacaacgccggat atcacattggttctgccccctgacgtcatccaacaggaagcgtcagccctgagggaggag acagaagcctgggccaggccacacgagtccctggcccgggaggaggccctcactgcactt gggaagctcctgtacctcttagatgggatgctggatgggcaggtgaacagtggtatagca gccactccagcctctgctgcagcagccaccctggatgtggctgttcggagaggcctgtcc cacggagcccagaggctgctgtgcgtggccctgggacagctggaccggcctccagacctc gcccatgacgggaggagtctgtggctgaacatcaggggcaaggaggcggctgccctatcc atgttccatgtctccacgccactgccagtgatgaccggtggtttcctgagctgcatcttg ggcttggtgctgcccctggcctatggcttccagcctgacctggtgctggtggcgctgggg cctggccatggcctgcagggcccccacgctgcactcctggctgcaatgcttcgggggctg gcagggggccgagtcctggccctcctggaggagaactccacaccccagctagcagggatc ctggcccgggtgctgaatggagaggcacctcctagcctaggcccttcctctgtggcctcc ccagaggacgtccaggccctgatgtacctgagagggcagctggagcctcagtggaagatg ttgcagtgccatcctcacctggtggcttga

Homo sapiens (human): 8841 Entry 8841              CDS       T01001                                  Gene name HDAC3, HD3, KDAC3, RPD3, RPD3-2 Definition (RefSeq) histone deacetylase 3   KO K11404   histone deacetylase 3 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa04919   Thyroid hormone signaling pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Mocetinostat (DG01404):  D09357 D09641 Nanatinostat:  D11442 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Tinostamustine:  D11182 Tucidinostat:  D10993 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09152 Endocrine system    04919 Thyroid hormone signaling pathway     8841 (HDAC3)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     8841 (HDAC3)   09165 Substance dependence    05034 Alcoholism     8841 (HDAC3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     8841 (HDAC3) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      8841 (HDAC3) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class I HDACs      8841 (HDAC3) SSDB Motif Pfam:  Hist_deacetyl Other DBs NCBI-GeneID:  8841 NCBI-ProteinID:  NP_003874 OMIM:  605166 HGNC:  4854 Ensembl:  ENSG00000171720 Vega:  OTTHUMG00000129629 Pharos:  O15379(Tclin) UniProt:  O15379 LinkDB Structure PDB:  4A69 Position 5q31.3 AA seq 428 aa MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN DKESDVEI NT seq 1287 nt   +upstreamnt  +downstreamnt atggccaagaccgtggcctatttctacgaccccgacgtgggcaacttccactacggagct ggacaccctatgaagccccatcgcctggcattgacccatagcctggtcctgcattacggt ctctataagaagatgatcgtcttcaagccataccaggcctcccaacatgacatgtgccgc ttccactccgaggactacattgacttcctgcagagagtcagccccaccaatatgcaaggc ttcaccaagagtcttaatgccttcaacgtaggcgatgactgcccagtgtttcccgggctc tttgagttctgctcgcgttacacaggcgcatctctgcaaggagcaacccagctgaacaac aagatctgtgatattgccattaactgggctggtggtctgcaccatgccaagaagtttgag gcctctggcttctgctatgtcaacgacattgtgattggcatcctggagctgctcaagtac caccctcgggtgctctacattgacattgacatccaccatggtgacggggttcaagaagct ttctacctcactgaccgggtcatgacggtgtccttccacaaatacggaaattacttcttc cctggcacaggtgacatgtatgaagtcggggcagagagtggccgctactactgtctgaac gtgcccctgcgggatggcattgatgaccagagttacaagcaccttttccagccggttatc aaccaggtagtggacttctaccaacccacgtgcattgtgctccagtgtggagctgactct ctgggctgtgatcgattgggctgctttaacctcagcatccgagggcatggggaatgcgtt gaatatgtcaagagcttcaatatccctctactcgtgctgggtggtggtggttatactgtc cgaaatgttgcccgctgctggacatatgagacatcgctgctggtagaagaggccattagt gaggagcttccctatagtgaatacttcgagtactttgccccagacttcacacttcatcca gatgtcagcacccgcatcgagaatcagaactcacgccagtatctggaccagatccgccag acaatctttgaaaacctgaagatgctgaaccatgcacctagtgtccagattcatgacgtg cctgcagacctcctgacctatgacaggactgatgaggctgatgcagaggagaggggtcct gaggagaactatagcaggccagaggcacccaatgagttctatgatggagaccatgacaat gacaaggaaagcgatgtggagatttaa

Homo sapiens (human): 9734 Entry 9734              CDS       T01001                                  Gene name HDAC9, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR Definition (RefSeq) histone deacetylase 9   KO K11409   histone deacetylase 9 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     9734 (HDAC9)   09165 Substance dependence    05034 Alcoholism     9734 (HDAC9)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     9734 (HDAC9) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      9734 (HDAC9) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class II HDACs      9734 (HDAC9) SSDB Motif Pfam:  Hist_deacetyl HDAC4_Gln Other DBs NCBI-GeneID:  9734 NCBI-ProteinID:  NP_478056 OMIM:  606543 HGNC:  14065 Ensembl:  ENSG00000048052 Vega:  OTTHUMG00000152487 Pharos:  Q9UKV0(Tclin) UniProt:  Q9UKV0 LinkDB Position 7p21.1 AA seq 1011 aa MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS NT seq 3036 nt   +upstreamnt  +downstreamnt atgcacagtatgatcagctcagtggatgtgaagtcagaagttcctgtgggcctggagccc atctcacctttagacctaaggacagacctcaggatgatgatgcccgtggtggaccctgtt gtccgtgagaagcaattgcagcaggaattacttcttatccagcagcagcaacaaatccag aagcagcttctgatagcagagtttcagaaacagcatgagaacttgacacggcagcaccag gctcagcttcaggagcatatcaaggaacttctagccataaaacagcaacaagaactccta gaaaaggagcagaaactggagcagcagaggcaagaacaggaagtagagaggcatcgcaga gaacagcagcttcctcctctcagaggcaaagatagaggacgagaaagggcagtggcaagt acagaagtaaagcagaagcttcaagagttcctactgagtaaatcagcaacgaaagacact ccaactaatggaaaaaatcattccgtgagccgccatcccaagctctggtacacggctgcc caccacacatcattggatcaaagctctccaccccttagtggaacatctccatcctacaag tacacattaccaggagcacaagatgcaaaggatgatttcccccttcgaaaaactgcctct gagcccaacttgaaggtgcggtccaggttaaaacagaaagtggcagagaggagaagcagc cccttactcaggcggaaggatggaaatgttgtcacttcattcaagaagcgaatgtttgag gtgacagaatcctcagtcagtagcagttctccaggctctggtcccagttcaccaaacaat gggccaactggaagtgttactgaaaatgagacttcggttttgccccctacccctcatgcc gagcaaatggtttcacagcaacgcattctaattcatgaagattccatgaacctgctaagt ctttatacctctccttctttgcccaacattaccttggggcttcccgcagtgccatcccag ctcaatgcttcgaattcactcaaagaaaagcagaagtgtgagacgcagacgcttaggcaa ggtgttcctctgcctgggcagtatggaggcagcatcccggcatcttccagccaccctcat gttactttagagggaaagccacccaacagcagccaccaggctctcctgcagcatttatta ttgaaagaacaaatgcgacagcaaaagcttcttgtagctggtggagttcccttacatcct cagtctcccttggcaacaaaagagagaatttcacctggcattagaggtacccacaaattg ccccgtcacagacccctgaaccgaacccagtctgcacctttgcctcagagcacgttggct cagctggtcattcaacagcaacaccagcaattcttggagaagcagaagcaataccagcag cagatccacatgaacaaactgctttcgaaatctattgaacaactgaagcaaccaggcagt caccttgaggaagcagaggaagagcttcagggggaccaggcgatgcaggaagacagagcg ccctctagtggcaacagcactaggagcgacagcagtgcttgtgtggatgacacactggga caagttggggctgtgaaggtcaaggaggaaccagtggacagtgatgaagatgctcagatc caggaaatggaatctggggagcaggctgcttttatgcaacagcctttcctggaacccacg cacacacgtgcgctctctgtgcgccaagctccgctggctgcggttggcatggatggatta gagaaacaccgtctcgtctccaggactcactcttcccctgctgcctctgttttacctcac ccagcaatggaccgccccctccagcctggctctgcaactggaattgcctatgaccccttg atgctgaaacaccagtgcgtttgtggcaattccaccacccaccctgagcatgctggacga atacagagtatctggtcacgactgcaagaaactgggctgctaaataaatgtgagcgaatt caaggtcgaaaagccagcctggaggaaatacagcttgttcattctgaacatcactcactg ttgtatggcaccaaccccctggacggacagaagctggaccccaggatactcctaggtgat gactctcaaaagtttttttcctcattaccttgtggtggacttggggtggacagtgacacc atttggaatgagctacactcgtccggtgctgcacgcatggctgttggctgtgtcatcgag ctggcttccaaagtggcctcaggagagctgaagaatgggtttgctgttgtgaggccccct ggccatcacgctgaagaatccacagccatggggttctgcttttttaattcagttgcaatt accgccaaatacttgagagaccaactaaatataagcaagatattgattgtagatctggat gttcaccatggaaacggtacccagcaggccttttatgctgaccccagcatcctgtacatt tcactccatcgctatgatgaagggaactttttccctggcagtggagccccaaatgaggtt ggaacaggccttggagaagggtacaatataaatattgcctggacaggtggccttgatcct cccatgggagatgttgagtaccttgaagcattcaggaccatcgtgaagcctgtggccaaa gagtttgatccagacatggtcttagtatctgctggatttgatgcattggaaggccacacc cctcctctaggagggtacaaagtgacggcaaaatgttttggtcatttgacgaagcaattg atgacattggctgatggacgtgtggtgttggctctagaaggaggacatgatctcacagcc atctgtgatgcatcagaagcctgtgtaaatgcccttctaggaaatgagctggagccactt gcagaagatattctccaccaaagcccgaatatgaatgctgttatttctttacagaagatc attgaaattcaaagtatgtctttaaagttctcttaa

Homo sapiens (human): 9759 Entry 9759              CDS       T01001                                  Gene name HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA Definition (RefSeq) histone deacetylase 4   KO K11406   histone deacetylase 4/5 [EC:3.5.1.98] Organism hsa  Homo sapiens (human) Pathway hsa04371   Apelin signaling pathway hsa05034   Alcoholism hsa05203   Viral carcinogenesis hsa05206   MicroRNAs in cancer Disease H00561   Brachydactyly-mental retardation syndrome Drug target Abexinostat (DG01402):  D10060 D10084 Belinostat:  D08870 Entinostat:  D09338 Fimepinostat:  D11319 Panobinostat (DG01403):  D10019 D10319 Quisinostat (DG01407):  D10321 D10322 Remetinostat:  D10977 Romidepsin:  D06637 Vorinostat:  D06320 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     9759 (HDAC4)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     9759 (HDAC4)    05203 Viral carcinogenesis     9759 (HDAC4)   09165 Substance dependence    05034 Alcoholism     9759 (HDAC4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     9759 (HDAC4) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.98  histone deacetylase      9759 (HDAC4) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     Class II HDACs      9759 (HDAC4) SSDB Motif Pfam:  Hist_deacetyl HDAC4_Gln Other DBs NCBI-GeneID:  9759 NCBI-ProteinID:  NP_006028 OMIM:  605314 HGNC:  14063 Ensembl:  ENSG00000068024 Vega:  OTTHUMG00000133344 Pharos:  P56524(Tclin) UniProt:  P56524 LinkDB Structure PDB:  5ZOO 6FYZ 2VQO 2H8N 5A2S 5ZOP 4CBY 2O94 4CBT 2VQV 2VQW 2VQQ 2VQJ 2VQM Position 2q37.3 AA seq 1084 aa MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE EPPL NT seq 3255 nt   +upstreamnt  +downstreamnt atgagctcccaaagccatccagatggactttctggccgagaccagccagtggagctgctg aatcctgcccgcgtgaaccacatgcccagcacggtggatgtggccacggcgctgcctctg caagtggccccctcggcagtgcccatggacctgcgcctggaccaccagttctcactgcct gtggcagagccggccctgcgggagcagcagctgcagcaggagctcctggcgctcaagcag aagcagcagatccagaggcagatcctcatcgctgagttccagaggcagcacgagcagctc tcccggcagcacgaggcgcagctccacgagcacatcaagcaacaacaggagatgctggcc atgaagcaccagcaggagctgctggaacaccagcggaagctggagaggcaccgccaggag caggagctggagaagcagcaccgggagcagaagctgcagcagctcaagaacaaggagaag ggcaaagagagtgccgtggccagcacagaagtgaagatgaagttacaagaatttgtcctc aataaaaagaaggcgctggcccaccggaatctgaaccactgcatttccagcgaccctcgc tactggtacgggaaaacgcagcacagttcccttgaccagagttctccaccccagagcgga gtgtcgacctcctataaccacccggtcctgggaatgtacgacgccaaagatgacttccct cttaggaaaacagcttctgaaccgaatctgaaattacggtccaggctaaagcagaaagtg gccgaaagacggagcagccccctgttacgcaggaaagacgggccagtggtcactgctcta aaaaagcgtccgttggatgtcacagactccgcgtgcagcagcgccccaggctccggaccc agctcacccaacaacagctccgggagcgtcagcgcggagaacggtatcgcgcccgccgtc cccagcatcccggcggagacgagtttggcgcacagacttgtggcacgagaaggctcggcc gctccacttcccctctacacatcgccatccttgcccaacatcacgctgggcctgcctgcc accggcccctctgcgggcacggcgggccagcaggacgccgagagactcacccttcccgcc ctccagcagaggctctcccttttccccggcacccacctcactccctacctgagcacctcg cccttggagcgggacggaggggcagcgcacagccctcttctgcagcacatggtcttactg gagcagccgccggcacaagcacccctcgtcacaggcctgggagcactgcccctccacgca cagtccttggttggtgcagaccgggtgtccccctccatccacaagctgcggcagcaccgc ccactggggcggacccagtcggccccgctgccccagaacgcccaggctctgcagcacctg gtcatccagcagcagcatcagcagtttctggagaaacacaagcagcagttccagcagcag caactgcagatgaacaagatcatccccaagccaagcgagccagcccggcagccggagagc cacccggaggagacggaggaggagctccgtgagcaccaggctctgctggacgagccctac ctggaccggctgccggggcagaaggaggcgcacgcacaggccggcgtgcaggtgaagcag gagcccattgagagcgatgaggaagaggcagagcccccacgggaggtggagccgggccag cgccagcccagtgagcaggagctgctcttcagacagcaagccctcctgctggagcagcag cggatccaccagctgaggaactaccaggcgtccatggaggccgccggcatccccgtgtcc ttcggcggccacaggcctctgtcccgggcgcagtcctcacccgcgtctgccaccttcccc gtgtctgtgcaggagccccccaccaagccgaggttcacgacaggcctcgtgtatgacacg ctgatgctgaagcaccagtgcacctgcgggagtagcagcagccaccccgagcacgccggg aggatccagagcatctggtcccgcctgcaggagacgggcctccggggcaaatgcgagtgc atccgcggacgcaaggccaccctggaggagctacagacggtgcactcggaagcccacacc ctcctgtatggcacgaaccccctcaaccggcagaaactggacagtaagaaacttctaggc tcgctcgcctccgtgttcgtccggctcccttgcggtggtgttggggtggacagtgacacc atatggaacgaggtgcactcggcgggggcagcccgcctggctgtgggctgcgtggtagag ctggtcttcaaggtggccacaggggagctgaagaatggctttgctgtggtccgcccccct ggacaccatgcggaggagagcacgcccatgggcttttgctacttcaactccgtggccgtg gcagccaagcttctgcagcagaggttgagcgtgagcaagatcctcatcgtggactgggac gtgcaccatggaaacgggacccagcaggctttctacagcgaccccagcgtcctgtacatg tccctccaccgctacgacgatgggaacttcttcccaggcagcggggctcctgatgaggtg ggcacagggcccggcgtgggtttcaacgtcaacatggctttcaccggcggcctggacccc cccatgggagacgctgagtacttggcggccttcagaacggtggtcatgccgatcgccagc gagtttgccccggatgtggtgctggtgtcatcaggcttcgatgccgtggagggccacccc acccctcttgggggctacaacctctccgccagatgcttcgggtacctgacgaagcagctg atgggcctggctggcggccggattgtcctggccctcgagggaggccacgacctgaccgcc atttgcgacgcctcggaagcatgtgtttctgccttgctgggaaacgagcttgatcctctc ccagaaaaggttttacagcaaagacccaatgcaaacgctgtccgttccatggagaaagtc atggagatccacagcaagtactggcgctgcctgcagcgcacaacctccacagcggggcgt tctctgatcgaggctcagacttgcgagaacgaagaagccgagacggtcaccgccatggcc tcgctgtccgtgggcgtgaagcccgccgaaaagagaccagatgaggagcccatggaagag gagccgcccctgtag

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