KEGG   Homo sapiens (human): 3767
Entry
3767              CDS       T01001                                 

Gene name
KCNJ11, BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, PNDM2, TNDM3
Definition
(RefSeq) potassium inwardly rectifying channel subfamily J member 11
  KO
K05004  potassium inwardly-rectifying channel subfamily J member 11
Organism
hsa  Homo sapiens (human)
Pathway
hsa04911  Insulin secretion
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
Disease
H00409  Type 2 diabetes mellitus
H00410  Maturity onset diabetes of the young (MODY)
H00512  Permanent neonatal diabetes mellitus
H00513  Transient neonatal diabetes mellitus
H01267  Familial hyperinsulinemic hypoglycemia
Drug target
Amiodarone (DG00204): D00636<JP/US> D02910
Bepridil (DG00333): D00631<JP> D07520
Chlorpropamide: D00271<JP>
Diazoxide: D00294<JP/US>
Dronedarone (DG00207): D03914<US>
Glibenclamide: D00336<JP/US>
Glymidine: D01356
Levcromakalim: D02385 D02385
Linogliride (DG02893): D04739 D04740
Minoxidil: D00418<US>
Mitiglinide: D01854<JP>
Naminidil: D05114 D05114
Nateglinide: D01111<JP/US>
Nicorandil: D01810<JP> D01810<JP>
Pinacidil: D05482 D05482
Repaglinide: D00594<JP/US>
Tolazamide: D00379
Tolbutamide (DG00115): D00380<US> D06177
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3767 (KCNJ11)
   04929 GnRH secretion
    3767 (KCNJ11)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    3767 (KCNJ11)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3767 (KCNJ11)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, inwardly-rectifying (Kir)
   3767 (KCNJ11)
SSDB
Motif
Pfam: IRK_C IRK Ion_trans_2 Cupin_2
Other DBs
NCBI-GeneID: 3767
NCBI-ProteinID: NP_001159762
OMIM: 600937
HGNC: 6257
Ensembl: ENSG00000187486
Vega: OTTHUMG00000165914
Pharos: Q14654(Tclin)
UniProt: Q14654
LinkDB
Structure
PDB: 
6C3O 6C3P

Position
11p15.1
AA seq 303 aa
MAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAIL
ILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRK
SMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPL
YDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYS
VDYSKFGNTVKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPD
SLS
NT seq 912 nt   +upstreamnt  +downstreamnt
atggcctggtggctcatcgccttcgcccacggtgacctggcccccagcgagggcactgct
gagccctgtgtcaccagcatccactccttctcgtctgccttccttttctccattgaggtc
caagtgactattggctttggggggcgcatggtgactgaggagtgcccactggccatcctg
atcctcatcgtgcagaacatcgtggggctcatgatcaacgccatcatgcttggctgcatc
ttcatgaagactgcccaagcccaccgcagggctgagaccctcatcttcagcaagcatgcg
gtgatcgccctgcgccacggccgcctctgcttcatgctacgtgtgggtgacctccgcaag
agcatgatcatcagcgccaccatccacatgcaggtggtacgcaagaccaccagccccgag
ggcgaggtggtgcccctccaccaggtggacatccccatggagaacggcgtgggtggcaac
agcatcttcctggtggccccgctgatcatctaccatgtcattgatgccaacagcccactc
tacgacctggcacccagcgacctgcaccaccaccaggacctcgagatcatcgtcatcctg
gaaggcgtggtggaaaccacgggcatcaccacccaggcccgcacctcctacctggccgat
gagatcctgtggggccagcgctttgtgcccattgtagctgaggaggacggacgttactct
gtggactactccaagtttggcaacaccgtcaaagtgcccacaccactctgcacggcccgc
cagcttgatgaggaccacagcctactggaagctctgaccctcgcctcagcccgcgggccc
ctgcgcaagcgcagcgtgcccatggccaaggccaagcccaagttcagcatctctccagat
tccctgtcctga

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