KEGG   ORTHOLOGY: K04390
Entry
K04390                      KO                                     
Symbol
TNFRSF6, FAS, CD95
Name
tumor necrosis factor receptor superfamily member 6
Pathway
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04115  p53 signaling pathway
map04210  Apoptosis
map04217  Necroptosis
map04650  Natural killer cell mediated cytotoxicity
map04668  TNF signaling pathway
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map04940  Type I diabetes mellitus
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05142  Chagas disease
map05143  African trypanosomiasis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05320  Autoimmune thyroid disease
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05417  Lipid and atherosclerosis
Disease
H00005  Chronic lymphocytic leukemia
H00007  Hodgkin lymphoma
H00009  Adult T-cell leukemia
H00017  Esophageal cancer
H00108  Autoimmune lymphoproliferative syndromes
H01463  Mycosis fungoides
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   04668 TNF signaling pathway
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   04217 Necroptosis
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   04115 p53 signaling pathway
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05205 Proteoglycans in cancer
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05161 Hepatitis B
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05160 Hepatitis C
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05164 Influenza A
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05162 Measles
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05168 Herpes simplex virus 1 infection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05163 Human cytomegalovirus infection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05169 Epstein-Barr virus infection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05165 Human papillomavirus infection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05143 African trypanosomiasis
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05330 Allograft rejection
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05332 Graft-versus-host disease
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   05022 Pathways of neurodegeneration - multiple diseases
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   04936 Alcoholic liver disease
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   04932 Non-alcoholic fatty liver disease
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
   04090 CD molecules
    K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
Cytokine receptors [BR:ko04050]
 Tumor necrosis factor receptors
  TNF receptor superfamily
   K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
CD molecules [BR:ko04090]
 Proteins
  K04390  CD95, FAS; tumor necrosis factor receptor superfamily, member 6
Other DBs
GO: 0005031
Genes
HSA: 355(FAS)
PTR: 738331(FAS)
PPS: 100988526(FAS)
GGO: 101152441(FAS)
NLE: 100580318(FAS)
MCC: 574332(FAS)
CSAB: 103216224(FAS)
CATY: 105587157(FAS)
TGE: 112631569(FAS)
RRO: 104675147(FAS)
RBB: 108526609(FAS)
TFN: 117086221(FAS)
PTEH: 111551313(FAS)
CJC: 100397803(FAS)
SBQ: 101035635(FAS)
CSYR: 103273943(FAS)
MMUR: 105871657(FAS)
LCAT: 123649928(FAS)
OGA: 100957582(FAS)
MMU: 14102(Fas)
MCAL: 110285655(Fas)
MPAH: 110332797(Fas)
RNO: 246097(Fas)
MCOC: 116103761(Fas)
MUN: 110561521(Fas)
CGE: 100762537(Fas)
MAUA: 101823945(Fas)
MORG: 121454281(Fas)
AAMP: 119804936(Fas)
NGI: 103738053(Fas)
HGL: 101704746(Fas)
CPOC: 100726403(Fas)
CCAN: 109691142(Fas)
DORD: 105986214(Fas)
DSP: 122116005(Fas)
NCAR: 124984583
OCU: 100008609(FAS)
OPI: 101528938(FAS)
TUP: 102476587(FAS)
CFA: 486469(FAS)
VVP: 112931965(FAS)
VLG: 121475736
AML: 100473767(FAS)
UMR: 103661934(FAS)
UAH: 113258968(FAS)
UAR: 123795545(FAS)
ELK: 111144883
LLV: 125084890
MPUF: 101677976(FAS)
ORO: 101369551(FAS)
EJU: 114210338(FAS)
ZCA: 113921804(FAS)
MLX: 118012958(FAS)
FCA: 493881(FAS)
PYU: 121016588(FAS)
PBG: 122492668(FAS)
PTG: 102958442(FAS)
PPAD: 109255367(FAS)
AJU: 106980953(FAS)
HHV: 120223778(FAS)
BTA: 282488(FAS)
BOM: 102273906(FAS)
BIU: 109579171(FAS)
BBUB: 102408756(FAS)
CHX: 102180451(FAS)
OAS: 100144426(FAS)
ODA: 120873794(FAS)
CCAD: 122446181(FAS)
SSC: 396826(FAS)
CFR: 102518538(FAS)
CBAI: 105081852(FAS)
CDK: 105102832(FAS)
VPC: 102535267(FAS)
BACU: 103020508(FAS)
LVE: 103080104(FAS)
OOR: 101284022(FAS)
DLE: 111172519(FAS)
PCAD: 102985097(FAS)
PSIU: 116741753(FAS)
ECB: 100071639(FAS)
EPZ: 103558124(FAS)
EAI: 106822180(FAS)
MYB: 102259838(FAS)
MYD: 102760302(FAS)
MMYO: 118669989(FAS)
MLF: 102433075(FAS)
MNA: 107543257(FAS)
PKL: 118719270(FAS)
HAI: 109377126(FAS)
DRO: 112307358(FAS)
SHON: 118987956(FAS)
AJM: 119057762(FAS)
PDIC: 114497076(FAS)
PHAS: 123829139(FAS)
MMF: 118632575(FAS)
RFQ: 117035725(FAS)
PALE: 102879561(FAS)
PGIG: 120609345(FAS)
PVP: 105293104(FAS)
RAY: 107502212(FAS)
MJV: 108392867(FAS)
TOD: 119233895(FAS)
LAV: 100657715(FAS)
TMU: 101346704
DNM: 101413233(FAS)
SHR: 105749219(FAS)
PCW: 110198951(FAS)
OAA: 103165091(FAS)
GGA: 395274(FAS)
PCOC: 116238135(FAS)
MGP: 100550139(FAS)
CJO: 107315904(FAS)
NMEL: 110400542(FAS)
APLA: 101796331(FAS)
ACYG: 106030038(FAS)
AFUL: 116491656(FAS)
TGU: 100225721(FAS)
LSR: 110475612(FAS)
SCAN: 103814184(FAS)
PMOA: 120502034(FAS)
OTC: 121341716(FAS)
PRUF: 121350122(FAS)
GFR: 102033034(FAS)
FAB: 101806294(FAS)
PHI: 102102426(FAS)
PMAJ: 107206851(FAS)
CCAE: 111930915(FAS)
CCW: 104696515(FAS)
ETL: 114055892(FAS)
ZAB: 102068861(FAS)
FPG: 101911760(FAS)
FCH: 102048640(FAS)
CLV: 102087399(FAS)
EGZ: 104129042(FAS)
NNI: 104013978(FAS)
PLET: 104623743
ACUN: 113481795
TALA: 104363734(FAS)
PADL: 103913942(FAS)
ACHC: 115348644(FAS)
AAM: 106487830(FAS)
AROW: 112975229(FAS)
NPD: 112957695(FAS)
DNE: 112979760(FAS)
ASN: 102375471(FAS)
AMJ: 102562734(FAS)
CPOO: 109324296(FAS)
GGN: 109287468(FAS)
PSS: 102463316(FAS)
CMY: 102944566(FAS)
CPIC: 101938109(FAS)
TST: 117880159(FAS)
CABI: 116818982(FAS)
MRV: 120368627(FAS)
ACS: 100551688(fas)
PVT: 110083121(FAS)
SUND: 121926093(FAS)
PBI: 103050181
PGUT: 117673150(FAS)
VKO: 123018472(FAS)
PMUA: 114597296(FAS)
ZVI: 118096518(FAS)
GJA: 107121652(FAS)
STOW: 125438085(FAS)
XTR: 100124750(fas)
RTEM: 120910419(FAS)
BBUF: 121005536(FAS)
BGAR: 122940130
DRE: 768248(fas)
PPRM: 120467705(fas)
MAMB: 125268751(fas)
IPU: 100304627(fas)
PHYP: 113547709
SMEO: 124389817(fas)
AMEX: 103046657
EEE: 113590405
TRU: 101067230
LCO: 104929632
NCC: 104956661
CGOB: 115019686
ELY: 117247901
PLEP: 121954199(fas)
SLUC: 116055219(fas)
ECRA: 117960374
PFLV: 114572155
GAT: 120820559(fas)
CUD: 121511564(fas)
ALAT: 119034075(fas)
MZE: 101463633
ONL: 102083126
OAU: 116333649
OLA: 101172757
OML: 112161604(fas)
XMA: 102232209
XCO: 114137823
XHE: 116713079
PRET: 103476792
PFOR: 103133531
PLAI: 106947675
PMEI: 106907379
GAF: 122842973(fas)
CVG: 107088506
CTUL: 119790839(fas)
GMU: 124858714
NFU: 107376035
KMR: 108243471(fas)
ALIM: 106535067
AOCE: 111588573
CSEM: 103387676
POV: 109631170
SSEN: 122782299(fas)
HHIP: 117775348(fas)
LCF: 108897286(fas)
SDU: 111235178
SLAL: 111670053
XGL: 120796127(fas)
HCQ: 109528779
MALB: 109960379
BSPL: 114842188
SASA: 100380364(tnr6) 106577010
ELS: 105022722
SFM: 108939520(fas)
PKI: 111853643(fas)
AANG: 118221088(fas)
LOC: 107077336(fas)
PSPA: 121321385 121325159(fas)
ARUT: 117415262 117417998(fas)
LCM: 102349412(FAS)
CMK: 103180778
RTP: 109929457
BBEL: 109470305
GAE: 121392006
 » show all
Reference
PMID:1713127
  Authors
Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S
  Title
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
  Journal
Cell 66:233-43 (1991)
DOI:10.1016/0092-8674(91)90614-5
  Sequence
[hsa:355]
Reference
  Authors
Riccio M, Carnevale G, Cardinale V, Gibellini L, De Biasi S, Pisciotta A, Carpino G, Gentile R, Berloco PB, Brunelli R, Bastianelli C, Napoletano C, Cantafora A, Cossarizza A, Gaudio E, Alvaro D, De Pol A
  Title
The Fas/Fas ligand apoptosis pathway underlies immunomodulatory properties of human biliary tree stem/progenitor cells.
  Journal
J Hepatol 61:1097-105 (2014)
DOI:10.1016/j.jhep.2014.06.016
  Sequence
[hsa:355]
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