KEGG ORTHOLOGY: K08621

ORTHOLOGY: K08621

Entry

K08621                      KO

Symbol

ADAMTS6

Name

a disintegrin and metalloproteinase with thrombospondin motifs 6 [EC:3.4.24.-]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08621  ADAMTS6; a disintegrin and metalloproteinase with thrombospondin motifs 6
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M12: astacin/adamalysin family
   K08621  ADAMTS6; a disintegrin and metalloproteinase with thrombospondin motifs 6

Genes

HSA:	11174(ADAMTS6)

PTR:	471529(ADAMTS6)

PPS:	100981495(ADAMTS6)

GGO:	101138812(ADAMTS6)

PON:	100439086(ADAMTS6)

NLE:	100598465(ADAMTS6)

HMH:	116462546(ADAMTS6)

MCC:	696021(ADAMTS6)

MCF:	102126790(ADAMTS6)

MTHB:

126956637

MNI:	105499481(ADAMTS6)

CSAB:

103222308(ADAMTS6)

CATY:

105597622(ADAMTS6)

PANU:

101024212(ADAMTS6)

TGE:	112626251(ADAMTS6)

MLEU:

105529582(ADAMTS6)

RRO:	104666243(ADAMTS6)

RBB:	108532840(ADAMTS6)

TFN:	117065190(ADAMTS6)

PTEH:

111541585(ADAMTS6)

CANG:

105503261(ADAMTS6)

CJC:	100397718(ADAMTS6)

SBQ:	101029981(ADAMTS6)

CIMI:

108317885(ADAMTS6)

CSYR:

103251183(ADAMTS6)

MMUR:

105882015(ADAMTS6)

LCAT:

123648472(ADAMTS6)

PCOQ:

105826562(ADAMTS6)

OGA:	100944910(ADAMTS6)

MMU:	108154(Adamts6)

MCAL:

110307805(Adamts6)

MPAH:

110328989(Adamts6)

RNO:	361886(Adamts6)

MCOC:

116083866(Adamts6)

ANU:	117723995(Adamts6)

MUN:	110561499(Adamts6)

CGE:	100760416(Adamts6)

MAUA:

101823341(Adamts6)

PROB:

127220986(Adamts6)

PLEU:

114703220(Adamts6)

MORG:

121455926(Adamts6)

MFOT:

126512582

AAMP:

119810020(Adamts6)

NGI:	103752411(Adamts6)

HGL:	101715883(Adamts6)

CPOC:

100730230(Adamts6)

CCAN:

109687842(Adamts6)

DORD:

105992386(Adamts6)

DSP:	122117170(Adamts6)

PLOP:

125367484(Adamts6)

NCAR:

124986952

MMMA:

107139290(Adamts6)

OCU:

100355552

OPI:	101532283(ADAMTS6)

TUP:	102475543(ADAMTS6)

GVR:	103586473(ADAMTS6)

CFA:	478077(ADAMTS6)

CLUD:

112659903(ADAMTS6)

VVP:	112935681(ADAMTS6)

VLG:	121497620(ADAMTS6)

NPO:	129513956(ADAMTS6)

AML:	100467830(ADAMTS6)

UMR:

103663878

UAH:	113255284(ADAMTS6)

UAR:	123790151(ADAMTS6)

ELK:

111156970

LLV:

125100570

MPUF:

101693056(ADAMTS6)

MNP:	132028680(ADAMTS6)

MLK:	131832285(ADAMTS6)

NVS:	122919239(ADAMTS6)

ORO:	101370904(ADAMTS6)

EJU:	114224649(ADAMTS6)

ZCA:	113929615(ADAMTS6)

MLX:	118016839(ADAMTS6)

NSU:	110591303(ADAMTS6)

LWW:	102744005(ADAMTS6)

FCA:	101080862(ADAMTS6)

PYU:	121015256(ADAMTS6)

PCOO:

112860969(ADAMTS6)

PBG:	122489430(ADAMTS6)

PVIV:

125170766(ADAMTS6)

LRUF:

124517678

PTG:	102957775(ADAMTS6)

PPAD:

109246398(ADAMTS6)

PUC:	125916871 125917104 125935225

AJU:

106968868

HHV:	120247553(ADAMTS6) 120247563

BTA:	540722(ADAMTS6)

BOM:	102266556(ADAMTS6)

BIU:	109575008(ADAMTS6)

BBUB:

102401915(ADAMTS6)

BBIS:

104992595(ADAMTS6)

CHX:	102172391(ADAMTS6)

OAS:	101103840(ADAMTS6)

BTAX:

128066104(ADAMTS6)

ODA:	120879583(ADAMTS6)

CCAD:

122454200(ADAMTS6)

MBEZ:

129553222(ADAMTS6)

SSC:	100513765(ADAMTS6)

CFR:	102518531(ADAMTS6)

CBAI:

105064429

CDK:	105084745(ADAMTS6)

VPC:	102527788(ADAMTS6)

BACU:

103016412(ADAMTS6)

BMUS:

118893640(ADAMTS6)

LVE:	103076553(ADAMTS6)

OOR:	101280992(ADAMTS6)

DLE:	111186229(ADAMTS6)

PCAD:

102980411(ADAMTS6)

PSIU:

116752221(ADAMTS6)

NASI:

112404933(ADAMTS6)

ECB:	100050673(ADAMTS6) 111771761

EPZ:	103553149(ADAMTS6)

EAI:	106835908(ADAMTS6)

MYB:	102259053(ADAMTS6)

MYD:	102755927(ADAMTS6)

MMYO:

118656317(ADAMTS6)

MLF:	102435159(ADAMTS6)

PKL:	118703468(ADAMTS6)

EFUS:

103305152(ADAMTS6)

MNA:	107526335(ADAMTS6)

DRO:	112321084(ADAMTS6)

SHON:

118998607(ADAMTS6)

AJM:	119053316(ADAMTS6)

PDIC:

114504096(ADAMTS6)

PHAS:

123824977(ADAMTS6)

MMF:	118641882(ADAMTS6)

PPAM:

129074577(ADAMTS6)

HAI:	109388037(ADAMTS6)

RFQ:	117024458(ADAMTS6)

PALE:

102895337(ADAMTS6)

PGIG:

120608233

PVP:	105299393(ADAMTS6)

RAY:	107499404(ADAMTS6)

MJV:	108384907(ADAMTS6)

TOD:	119260675(ADAMTS6)

SARA:

101538182(ADAMTS6)

SETR:

126001549(ADAMTS6)

LAV:	100675457(ADAMTS6)

TMU:

101352875

ETF:	101660868(ADAMTS6)

DNM:	101427183(ADAMTS6)

MDO:	100018806(ADAMTS6)

GAS:	123237002(ADAMTS6)

SHR:	100922354(ADAMTS6)

PCW:	110222341(ADAMTS6)

OAA:	103169711(ADAMTS6)

GGA:	427160(ADAMTS6)

PCOC:

116238496

MGP:	104914924(ADAMTS6)

CJO:	107305919(ADAMTS6)

TPAI:

128074505(ADAMTS6)

LMUT:

125686537(ADAMTS6)

NMEL:

110389812(ADAMTS6)

APLA:

101795894(ADAMTS6)

ACYG:

106035643(ADAMTS6)

CATA:

118251433(ADAMTS6)

AFUL:

116501169(ADAMTS6)

TGU:	100222950(ADAMTS6)

LSR:	110472581(ADAMTS6)

SCAN:

103823136(ADAMTS6)

PMOA:

120502504(ADAMTS6)

OTC:	121341260(ADAMTS6)

PRUF:

121355384(ADAMTS6)

GFR:	102044765(ADAMTS6)

FAB:	101816481(ADAMTS6)

OMA:	130264709(ADAMTS6)

PHI:	102101795(ADAMTS6)

PMAJ:

107198369(ADAMTS6)

CCAE:

111924463 111941395(ADAMTS6)

CCW:	104686700(ADAMTS6)

CBRC:

103624315(ADAMTS6)

ETL:	114059375(ADAMTS6)

ZAB:	102065968(ADAMTS6)

ACHL:

103804624(ADAMTS6)

SVG:	106856223(ADAMTS6)

MMEA:

130588735(ADAMTS6)

HRT:	120765217(ADAMTS6)

FPG:	101923076(ADAMTS6)

FCH:	102057777(ADAMTS6)

CLV:	102095336(ADAMTS6)

EGZ:	104133471(ADAMTS6)

NNI:	104012373 104022295

ACUN:

113489732(ADAMTS6)

TALA:

104361206(ADAMTS6)

PADL:

103919725(ADAMTS6)

AFOR:

103893380(ADAMTS6)

ACHC:

121232867

HALD:

104325783(ADAMTS6)

HLE:	104839924(ADAMTS6)

AGEN:

126035436 126036051

GCL:	127027296 127029107

CCRI:

104160987

CSTI:

104560667(ADAMTS6)

BREG:

104642102(ADAMTS6)

FGA:

104077373

LDI:

104348339

MNB:	103771114(ADAMTS6)

OHA:	104337725(ADAMTS6)

SHAB:

115600915(ADAMTS6)

DPUB:

104302492(ADAMTS6)

PGUU:

104463125(ADAMTS6)

CPEA:

104395643(ADAMTS6)

AVIT:

104280386(ADAMTS6)

CVF:	104287393 104295732

RTD:	128901951 128903032(ADAMTS6)

CUCA:

104058121(ADAMTS6)

BRHI:

104489703

AROW:

112961360(ADAMTS6)

NPD:	112945398(ADAMTS6)

TGT:	104573949 104580724(ADAMTS6)

DNE:	112987045(ADAMTS6)

SCAM:

104146880(ADAMTS6)

ASN:	102370499(ADAMTS6)

AMJ:	102570710(ADAMTS6)

CPOO:

109307962(ADAMTS6)

GGN:	109297771(ADAMTS6)

PSS:	102460976(ADAMTS6)

CMY:	102942601(ADAMTS6)

CCAY:

125636963(ADAMTS6)

DCC:	119856081(ADAMTS6)

CPIC:

101945302(ADAMTS6)

TST:	117878922(ADAMTS6)

CABI:

116820902(ADAMTS6)

MRV:	120408583(ADAMTS6)

ACS:	100562338(adamts6)

ASAO:

132767023(ADAMTS6)

PVT:	110073963(ADAMTS6)

SUND:

121921627(ADAMTS6)

PBI:	103062257(ADAMTS6)

PMUR:

107284582(ADAMTS6)

CTIG:

120317894(ADAMTS6)

TSR:	106544625(ADAMTS6)

PGUT:

117679235(ADAMTS6)

APRI:

131191703(ADAMTS6)

PTEX:

113447191(ADAMTS6)

NSS:	113413924(ADAMTS6)

VKO:	123031180(ADAMTS6)

PMUA:

114606704(ADAMTS6)

PRAF:

128423105(ADAMTS6)

ZVI:	118077283(ADAMTS6)

HCG:	128345953(ADAMTS6)

GJA:	107109585(ADAMTS6)

STOW:

125436465(ADAMTS6)

EMC:	129334191(ADAMTS6)

XLA:	108704850(adamts6.S) 108718130

XTR:	100490362(adamts6)

NPR:	108797536(ADAMTS6)

RTEM:

120929054(ADAMTS6)

BBUF:

120992383(ADAMTS6)

BGAR:

122936221(ADAMTS6)

MUO:	115463020(ADAMTS6)

GSH:	117353843(ADAMTS6)

DRE:	569099(adamts6)

SRX:	107713302 107744255

SANH:

107658655 107685101

SGH:	107558663 107572006(adamts6)

CCAR:

109097592(adamts6)

CAUA:

113054050 113109629

CGIB:

127966260 128021516

PTET:

122352697(adamts6)

LROH:

127171555(adamts6)

OMC:	131547981(adamts6)

PPRM:

120482679(adamts6)

RKG:	130073525(adamts6)

MAMB:

125257964(adamts6)

CIDE:

127521628

MASI:

127432336 127433935

TROS:

130545749(adamts6)

TDW:	130412010(adamts6)

MANU:

129447303(adamts6)

IPU:

108276740

IFU:	128620081(adamts6)

PHYP:

113544045(adamts6)

SMEO:

124393482(adamts6)

TFD:	113653031(adamts6)

TVC:	132863338(adamts6)

TRN:	134332384(adamts6)

AMEX:

103021549(adamts6)

CMAO:

118825000(adamts6)

EEE:	113575857(adamts6)

CHAR:

105896651(adamts6)

TRU:	101065745(adamts6)

TFS:	130517382(adamts6)

TNG:	GSTEN00025249G001

LCO:	104937714(adamts6)

NCC:	104960880(adamts6)

TBEN:

117476317(adamts6)

CGOB:

115017163(adamts6)

PGEO:

117455789(adamts6)

GACU:

117561424(adamts6)

EMAC:

134868053(adamts6)

ELY:	117269290(adamts6)

EFO:	125878672(adamts6)

PLEP:

121960142(adamts6)

SLUC:

116062992(adamts6)

ECRA:

117959129(adamts6)

ESP:	116704081(adamts6)

PFLV:

114571579(adamts6)

GAT:	120831693(adamts6)

PPUG:

119227060(adamts6)

AFB:	129102494(adamts6)

CLUM:

117740503(adamts6)

PSWI:

130205081(adamts6)

MSAM:

119914750(adamts6)

SCHU:

122865790(adamts6)

CUD:	121524736(adamts6)

ALAT:

119030593(adamts6)

MZE:	101487420(adamts6)

ONL:	100701133(adamts6)

OAU:	116315927(adamts6)

OLA:	101172594(adamts6)

OML:	112162729(adamts6)

CSAI:

133455057(adamts6)

XMA:	102222443(adamts6)

XCO:	114150002(adamts6)

XHE:	116724852(adamts6)

PRET:

103473274(adamts6)

PFOR:

103151002(adamts6)

PLAI:

106963194(adamts6)

PMEI:

106926923(adamts6)

GAF:	122819751(adamts6)

PPRL:

129374170(adamts6)

CVG:	107095360(adamts6)

CTUL:

119795477(adamts6)

GMU:	124872829(adamts6)

NFU:	107374818(adamts6)

KMR:	108244758(adamts6)

ALIM:

106528712(adamts6)

NWH:	119425032(adamts6)

AOCE:

111566576(adamts6)

MCEP:

124997102(adamts6)

CSEM:

103389911(adamts6)

POV:	109626114(adamts6)

SSEN:

122758183(adamts6)

HHIP:

117772229(adamts6)

HSP:	118098028(adamts6)

PPLT:

128424875(adamts6)

SMAU:

118301361(adamts6)

LCF:

108873971

SDU:	111217862(adamts6)

SLAL:

111666776(adamts6)

XGL:	120806393(adamts6)

HCQ:	109529140(adamts6)

SSCV:

125979745

SBIA:

133491179(adamts6)

PEE:	133413353(adamts6)

PTAO:

133489822(adamts6)

BPEC:

110157543(adamts6)

MALB:

109967763(adamts6)

BSPL:

114867113(adamts6)

SJO:	128380285(adamts6)

SASA:

106562225 106568319

STRU:

115149323 115159229

OTW:	112219762 112257258

OMY:	110522946 110537061

OGO:	124000157 124048637(adamts6)

ONE:

115128750

OKI:	109868198 109893639

OKE:	118372715 118373438

SALP:

111962822 112069420(adamts6)

SNH:	120025618 120044797

CCLU:

121574156 121582789

ELS:	105005670(adamts6)

SFM:	108929863(adamts6)

PKI:	111836192(adamts6)

AANG:

118212235(adamts6)

LOC:	102698528(adamts6)

PSPA:

121300733 121316924 121330697

ARUT:

117403783 117411095

PSEX:

120532572(adamts6)

LCM:	102350447(ADAMTS6)

CMK:

103177863

RTP:	109933395(adamts6)

CPLA:

122549705(adamts6) 122565296

HOC:	132815073(adamts6) 132828835

LERI:

129696935(adamts6) 129711184

PMRN:

116941938

LRJ:

133358989

BFO:	118406011 118416136 118431655

BBEL:

109472795 109477637

CIN:

100187216

SCLV:

120337464

SPU:	100891561 115925222 579238 594564

LPIC:

129271192 129277231

APLC:

110977693

AJC:

117108757

SKO:	100375627(ADAMTS6)

DPA:

109540564

NVL:

108559510

HHAL:

106678859

CSCU:

111623285 111623286 111634827

LPOL:

106458225

LGI:	LOTGIDRAFT_126429

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:	105332571 105335682

CVN:	111118492 111132670

CANU:

OED:

MYI:

PMAX:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:	5499163 5505241 5505243 5505253 5505598 5506605 5506614 5507795 5517246 5517248 5519386

EPA:	110232569 110236350 110236351 110241983 110241987 110244938 110246044 110246122 110253639

ATEN:

116295494 116295495 116295498 116295527 116298938 116298940 116298941

ADF:	107338099 107338110 107340990 107347617 107347627 107348245

AMIL:

114950305 114950913 114957212 114958870 114958929 114963054

PDAM:

113668778 113668779 113671207 113678362 113681999 113682607 113682876

SPIS:

111331654 111331662 111335207 111336509 111342708 111342713

DGT:	114524401 114524402 114524450 114528547 114530310

XEN:	124433340 124443111

HMG:

HSY:

AQU:

Reference

PMID:15987500

Authors

Jones GC, Riley GP

Title

ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.

Journal

Arthritis Res Ther 7:160-9 (2005)
DOI:10.1186/ar1783

Reference

PMID:10464288

Authors

Hurskainen TL, Hirohata S, Seldin MF, Apte SS

Title

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.

Journal

J Biol Chem 274:25555-63 (1999)
DOI:10.1074/jbc.274.36.25555

Sequence

[hsa:11174]

LinkDB

DBGET integrated database retrieval system