Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.

Environmental Information Processing; Signal transduction
BRITE hierarchy

Mus pahari (shrew mouse) [GN:mpah]

PMID:21415026

Hilman D, Gat U

The evolutionary history of YAP and the hippo/YAP pathway.

Mol Biol Evol 28:2403-17 (2011)
DOI:10.1093/molbev/msr065

PMID:24715453

Varelas X

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.

Development 141:1614-26 (2014)
DOI:10.1242/dev.102376

PMID:21808241

Zhao B, Tumaneng K, Guan KL

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.

Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303

PMID:21138973

Halder G, Johnson RL

Hippo signaling: growth control and beyond.

Development 138:9-22 (2011)
DOI:10.1242/dev.045500

PMID:20951342

Pan D

The hippo signaling pathway in development and cancer.

Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011

PMID:20439427

Zhao B, Li L, Lei Q, Guan KL

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.

Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210

PMID:22830020

Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G

Hippo and rassf1a Pathways: A Growing Affair.

Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628

PMID:25966461

Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL

The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.

PLoS Biol 13:e1002146 (2015)
DOI:10.1371/journal.pbio.1002146

PMID:23396260

Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y

Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.

Exp Cell Res 319:931-45 (2013)
DOI:10.1016/j.yexcr.2013.01.020

PMID:23843471

Yang Z, Hata Y

What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?

J Biochem 154:207-9 (2013)
DOI:10.1093/jb/mvt060

PMID:24594661

Hotz M, Barral Y

The Mitotic Exit Network: new turns on old pathways.

Trends Cell Biol 24:145-52 (2014)
DOI:10.1016/j.tcb.2013.09.010

PMID:23579499

Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A

Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Science 340:871-5 (2013)
DOI:10.1126/science.1235822

PMID:22525225

Hergovich A, Hemmings BA

Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.

Semin Cell Dev Biol 23:794-802 (2012)
DOI:10.1016/j.semcdb.2012.04.001

PMID:19826484

Wang Y, Abu Irqeba A, Ayalew M, Suntay K

Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast.

PLoS One 4:e7456 (2009)
DOI:10.1371/journal.pone.0007456