Entry |
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Name |
Hippo signaling pathway - multiple species - Mus pahari (shrew mouse)
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Description |
Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.
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Class |
Environmental Information Processing; Signal transduction
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Pathway map |
mpah04392 | Hippo signaling pathway - multiple species |

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Other DBs |
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Organism |
Mus pahari (shrew mouse) [GN: mpah]
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Gene |
110327714 | Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850] |
110330820 | Rassf6; ras association domain-containing protein 6 isoform X1 [KO:K09854] |
110320091 | Wwtr1; WW domain-containing transcription regulator protein 1 isoform X1 [KO:K16820] |
110315959 | Tead4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448] |
110322324 | Tead1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448] |
110319868 | Tead2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448] |
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Reference |
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Authors |
Hilman D, Gat U |
Title |
The evolutionary history of YAP and the hippo/YAP pathway. |
Journal |
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Reference |
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Authors |
Varelas X |
Title |
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. |
Journal |
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Reference |
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Authors |
Zhao B, Tumaneng K, Guan KL |
Title |
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. |
Journal |
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Reference |
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Authors |
Halder G, Johnson RL |
Title |
Hippo signaling: growth control and beyond. |
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Reference |
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Authors |
Pan D |
Title |
The hippo signaling pathway in development and cancer. |
Journal |
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Reference |
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Authors |
Zhao B, Li L, Lei Q, Guan KL |
Title |
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. |
Journal |
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Reference |
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Authors |
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G |
Title |
Hippo and rassf1a Pathways: A Growing Affair. |
Journal |
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Reference |
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Authors |
Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL |
Title |
The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. |
Journal |
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Reference |
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Authors |
Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y |
Title |
Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. |
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Reference |
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Authors |
Yang Z, Hata Y |
Title |
What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans? |
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Reference |
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Authors |
Hotz M, Barral Y |
Title |
The Mitotic Exit Network: new turns on old pathways. |
Journal |
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Reference |
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Authors |
Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A |
Title |
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. |
Journal |
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Reference |
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Authors |
Hergovich A, Hemmings BA |
Title |
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. |
Journal |
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Reference |
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Authors |
Wang Y, Abu Irqeba A, Ayalew M, Suntay K |
Title |
Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. |
Journal |
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Related pathway |
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KO pathway |
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LinkDB |
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