KEGG   COMPOUND: C00752
Entry
C00752                      Compound                               
Name
Thrombin;
Coagulation factor IIa
Sequence
(A chain)
TFGSGEADCG LRPLFEKKSL EDKTERELLE SYIDGR
(B chain)
VEGSDAEIG MSPWQVMLFR KSPQELLCGA SLISDRWVLT AAHCLLYPPW DKNFTENDLL
VRIGKHSRTR YERNIEKISM LEKIYIHPRY NWRENLDRDI ALMKLKKPVA FSDYIHPVCL
PDRETAASLL QAGYKGRVTG WGNLKETWTA NVGKGQPSVL QVVNLPIVER PVCKDSTRIR
ITDNMFCAGY KPDEGKRGDA CEGDSGGPFV MKSPFNNRWY QMGIVSWGEG CDRDGKYGFY
THVFRLKKWI QKVIDQFGE
(Disulfide bridge: A9-B119)
  Organism
Homo sapiens [HSA:2147]
  Type
Peptide
Remark
Same as: D00090
Comment
active form [EC:3.4.21.5] of prothrombin [KO:K01313]
Pathway
map04610  Complement and coagulation cascades
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06514  Coagulation cascade
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC06 Thrombin
      D00090  Thrombin (JP18/USP/INN) <JP/US>
    B02BD Blood coagulation factors
     B02BD30 Thrombin
      D00090  Thrombin (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   332  Hemostatics
    3323  Hemostatics for organs
     D00090  Thrombin (JP18/USP/INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG00169  Thrombin
     D00090  Thrombin
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00090  Thrombin
Other DBs
CAS: 9002-04-4
PubChem: 4014
NIKKAJI: J247.643F
LinkDB

» Japanese version

KEGG   Homo sapiens (human): 4153
Entry
4153              CDS       T01001                                 
Symbol
MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD
Name
(RefSeq) mannose binding lectin 2
  KO
K03991  mannose-binding lectin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06513  Complement cascade
  Element
N01312  SARS-CoV-2 S to lectin pathway of complement cascade
N01315  Lectin pathway of coagulation cascade, prothrombin to thrombin
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation cascade
N01491  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
Disease
H00105  Mannose-binding lectin pathway component defects
H00342  Tuberculosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    4153 (MBL2)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    4153 (MBL2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    4153 (MBL2)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    4153 (MBL2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4153 (MBL2)
  09183 Protein families: signaling and cellular processes
   04091 Lectins [BR:hsa04091]
    4153 (MBL2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    4153 (MBL2)
Lectins [BR:hsa04091]
 C-Type lectins
  Collectins
   4153 (MBL2)
SSDB
Motif
Pfam: Lectin_C Collagen
Other DBs
NCBI-GeneID: 4153
NCBI-ProteinID: NP_000233
OMIM: 154545
HGNC: 6922
Ensembl: ENSG00000165471
UniProt: P11226
Structure
LinkDB
Position
10:complement(52765380..52772784)
AA seq 248 aa
MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKG
EPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMA
RIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKE
EAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSH
LAVCEFPI
NT seq 747 nt   +upstreamnt  +downstreamnt
atgtccctgtttccatcactccctctccttctcctgagtatggtggcagcgtcttactca
gaaactgtgacctgtgaggatgcccaaaagacctgccctgcagtgattgcctgtagctct
ccaggcatcaacggcttcccaggcaaagatgggcgtgatggcaccaagggagaaaagggg
gaaccaggccaagggctcagaggcttacagggcccccctggaaagttggggcctccagga
aatccagggccttctgggtcaccaggaccaaagggccaaaaaggagaccctggaaaaagt
ccggatggtgatagtagcctggctgcctcagaaagaaaagctctgcaaacagaaatggca
cgtatcaaaaagtggctcaccttctctctgggcaaacaagttgggaacaagttcttcctg
accaatggtgaaataatgacctttgaaaaagtgaaggccttgtgtgtcaagttccaggcc
tctgtggccacccccaggaatgctgcagagaatggagccattcagaatctcatcaaggag
gaagccttcctgggcatcactgatgagaagacagaagggcagtttgtggatctgacagga
aatagactgacctacacaaactggaacgagggtgaacccaacaatgctggttctgatgaa
gattgtgtattgctactgaaaaatggccagtggaatgacgtcccctgctccacctcccat
ctggccgtctgtgagttccctatctga

KEGG   Homo sapiens (human): 10584
Entry
10584             CDS       T01001                                 
Symbol
COLEC10, 3MC3, CL-10, CL-34, CLL1
Name
(RefSeq) collectin subfamily member 10
  KO
K10065  collectin sub-family member 10
Organism
hsa  Homo sapiens (human)
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06513  Complement cascade
  Element
N01315  Lectin pathway of coagulation cascade, prothrombin to thrombin
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation cascade
N01491  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
Disease
H01887  3MC syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04091 Lectins [BR:hsa04091]
    10584 (COLEC10)
Lectins [BR:hsa04091]
 C-Type lectins
  Collectins
   10584 (COLEC10)
SSDB
Motif
Pfam: Lectin_C Collagen
Other DBs
NCBI-GeneID: 10584
NCBI-ProteinID: NP_006429
OMIM: 607620
HGNC: 2220
Ensembl: ENSG00000184374
UniProt: Q9Y6Z7
LinkDB
Position
8:118952263..119108455
AA seq 277 aa
MNGFASLLRRNQFILLVLFLLQIQSLGLDIDSRPTAEVCATHTISPGPKGDDGEKGDPGE
EGKHGKVGRMGPKGIKGELGDMGDQGNIGKTGPIGKKGDKGEKGLLGIPGEKGKAGTVCD
CGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRETEEKFYYIVQEEKNYRESLTHCRIRG
GMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREGQYMFTDNTPLQNYSNWNEGEPS
DPYGHEDCVEMLSSGRWNDTECHLTMYFVCEFIKKKK
NT seq 834 nt   +upstreamnt  +downstreamnt
atgaatggctttgcatccttgcttcgaagaaaccaatttatcctcctggtactatttctt
ttgcaaattcagagtctgggtctggatattgatagccgtcctaccgctgaagtctgtgcc
acacacacaatttcaccaggacccaaaggagatgatggtgaaaaaggagatccaggagaa
gagggaaagcatggcaaagtgggacgcatggggccgaaaggaattaaaggagaactgggt
gatatgggagatcagggcaatattggcaagactgggcccattgggaagaagggtgacaaa
ggggaaaaaggtttgcttggaatacctggagaaaaaggcaaagcaggtactgtctgtgat
tgtggaagataccggaaatttgttggacaactggatattagtattgctcggctcaagaca
tctatgaagtttgtcaagaatgtgatagcagggattagggaaactgaagagaaattctac
tacatcgtgcaggaagagaagaactacagggaatccctaacccactgcaggattcggggt
ggaatgctagccatgcccaaggatgaagctgccaacacactcatcgctgactatgttgcc
aagagtggcttctttcgggtgttcattggcgtgaatgaccttgaaagggagggacagtac
atgttcacagacaacactccactgcagaactatagcaactggaatgagggggaacccagc
gacccctatggtcatgaggactgtgtggagatgctgagctctggcagatggaatgacaca
gagtgccatcttaccatgtactttgtctgtgagttcatcaagaagaaaaagtaa

KEGG   Homo sapiens (human): 78989
Entry
78989             CDS       T01001                                 
Symbol
COLEC11, 3MC2, CL-11, CL-K1-I, CL-K1-II, CL-K1-IIa, CL-K1-IIb, CLK1
Name
(RefSeq) collectin subfamily member 11
  KO
K10066  collectin sub-family member 11
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06513  Complement cascade
  Element
N01315  Lectin pathway of coagulation cascade, prothrombin to thrombin
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation cascade
N01491  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
Disease
H01887  3MC syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    78989 (COLEC11)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    78989 (COLEC11)
  09183 Protein families: signaling and cellular processes
   04091 Lectins [BR:hsa04091]
    78989 (COLEC11)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    78989 (COLEC11)
Lectins [BR:hsa04091]
 C-Type lectins
  Collectins
   78989 (COLEC11)
SSDB
Motif
Pfam: Lectin_C Collagen
Other DBs
NCBI-GeneID: 78989
NCBI-ProteinID: NP_076932
OMIM: 612502
HGNC: 17213
Ensembl: ENSG00000118004
UniProt: Q9BWP8
Structure
LinkDB
Position
2:3595112..3644644
AA seq 271 aa
MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGDAGEKGDKGAPGRPGR
VGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRK
AIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMP
KDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEE
DCVEMVASGGWNDVACHTTMYFMCEFDKENM
NT seq 816 nt   +upstreamnt  +downstreamnt
atgagggggaatctggccctggtgggcgttctaatcagcctggccttcctgtcactgctg
ccatctggacatcctcagccggctggcgatgacgcctgctctgtgcagatcctcgtccct
ggcctcaaaggggatgcgggagagaagggagacaaaggcgcccccggacggcctggaaga
gtcggccccacgggagaaaaaggagacatgggggacaaaggacagaaaggcagtgtgggt
cgtcatggaaaaattggtcccattggctctaaaggtgagaaaggagattccggtgacata
ggaccccctggtcctaatggagaaccaggcctcccatgtgagtgcagccagctgcgcaag
gccatcggggagatggacaaccaggtctctcagctgaccagcgagctcaagttcatcaag
aatgctgtcgccggtgtgcgcgagacggagagcaagatctacctgctggtgaaggaggag
aagcgctacgcggacgcccagctgtcctgccagggccgcgggggcacgctgagcatgccc
aaggacgaggctgccaatggcctgatggccgcatacctggcgcaagccggcctggcccgt
gtcttcatcggcatcaacgacctggagaaggagggcgccttcgtgtactctgaccactcc
cccatgcggaccttcaacaagtggcgcagcggtgagcccaacaatgcctacgacgaggag
gactgcgtggagatggtggcctcgggcggctggaacgacgtggcctgccacaccaccatg
tacttcatgtgtgagtttgacaaggagaacatgtga

KEGG   Homo sapiens (human): 2219
Entry
2219              CDS       T01001                                 
Symbol
FCN1, FCNM
Name
(RefSeq) ficolin 1
  KO
K10104  ficolin
Organism
hsa  Homo sapiens (human)
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06513  Complement cascade
  Element
N01315  Lectin pathway of coagulation cascade, prothrombin to thrombin
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation cascade
N01491  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04091 Lectins [BR:hsa04091]
    2219 (FCN1)
Lectins [BR:hsa04091]
 Ficolins
  2219 (FCN1)
SSDB
Motif
Pfam: Fibrinogen_C Collagen
Other DBs
NCBI-GeneID: 2219
NCBI-ProteinID: NP_001994
OMIM: 601252
HGNC: 3623
Ensembl: ENSG00000085265
UniProt: O00602
Structure
LinkDB
Position
9:complement(134903232..134917912)
AA seq 326 aa
MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP
GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD
LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG
SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV
GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY
ANGINWSAAKGYKYSYKVSEMKVRPA
NT seq 981 nt   +upstreamnt  +downstreamnt
atggagctgagtggagccaccatggcccgggggctcgctgtcctgctagtcttgttcctg
catatcaagaacctgcctgcccaggctgcggacacatgtccagaggtgaaggtggtgggc
ctggagggctctgacaagctcaccattctccgaggctgcccggggctgcccggggcccca
gggccaaagggagaggcaggtgtcattggagagagaggagaacgcggtctccctggagcc
cctggaaaggcaggaccagtggggcccaaaggagaccgaggagagaaggggatgcgtgga
gagaaaggagacgctgggcagtctcagtcgtgtgcgacaggcccacgcaactgcaaggac
ctgctagaccgggggtatttcctgagcggctggcacaccatctacctgcccgactgccgg
cccctgactgtgctctgtgacatggacacggacggagggggctggaccgttttccagcgg
aggatggatggctctgtggacttctatcgggactgggccgcatacaagcagggcttcggc
agtcagctgggggagttctggctggggaatgacaacatccacgccctgactgcccaggga
agcagcgagctccgtgtagacctggtggactttgagggcaaccaccagtttgctaagtac
aaatcattcaaggtggctgacgaggcagagaagtacaagctggtactgggagcctttgtc
gggggcagtgcgggtaattctctaacgggccacaacaacaacttcttctccaccaaagac
caagacaatgatgtgagttcttcgaattgtgctgagaagttccaaggagcctggtggtac
gccgactgtcatgcttcaaacctcaatggtctctacctcatgggaccccatgagagctat
gccaatggtatcaactggagtgcggcgaaggggtacaaatatagctacaaggtgtcagag
atgaaggtgcggcccgcctag

KEGG   Homo sapiens (human): 2220
Entry
2220              CDS       T01001                                 
Symbol
FCN2, EBP-37, FCNL, P35, ficolin-2
Name
(RefSeq) ficolin 2
  KO
K10104  ficolin
Organism
hsa  Homo sapiens (human)
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06513  Complement cascade
  Element
N01315  Lectin pathway of coagulation cascade, prothrombin to thrombin
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation cascade
N01491  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04091 Lectins [BR:hsa04091]
    2220 (FCN2)
Lectins [BR:hsa04091]
 Ficolins
  2220 (FCN2)
SSDB
Motif
Pfam: Fibrinogen_C Collagen
Other DBs
NCBI-GeneID: 2220
NCBI-ProteinID: NP_004099
OMIM: 601624
HGNC: 3624
Ensembl: ENSG00000160339
UniProt: Q15485
Structure
LinkDB
Position
9:134864144..134887523
AA seq 313 aa
MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSDKLTILRGCPGLPGAPG
PKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGPRTCKDLLDRGHFLSGWHT
IYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNI
HALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNN
QSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLNGRYLRGTHGSFANGINWKSGKGYN
YSYKVSEMKVRPA
NT seq 942 nt   +upstreamnt  +downstreamnt
atggagctggacagagctgtgggggtcctgggcgctgccaccctgctgctctctttcctg
ggcatggcctgggctctccaggcggcagacacctgtccagaggtgaagatggtgggcctg
gagggctctgacaagctcaccattctccgaggctgtccggggctgcctggggcccctggg
cccaagggagaggcaggcaccaatggaaagagaggagaacgtggcccccctggacctcct
gggaaggcaggaccacctgggcccaacggagcacctggggagccccagccgtgcctgaca
ggcccgcgtacctgcaaggacctgctagaccgagggcacttcctgagcggctggcacacc
atctacctgcccgactgccggcccctgactgtgctctgtgacatggacacggacggaggg
ggctggaccgttttccagcggagggtggatggctctgtggacttctaccgggactgggcc
acgtacaagcagggcttcggcagtcggctgggggagttctggctggggaatgacaacatc
cacgccctgaccgcccagggaaccagcgagctccgtgtagacctggtggactttgaggac
aactaccagtttgctaagtacagatcattcaaggtggccgacgaggcggagaagtacaat
ctggtcctgggggccttcgtggagggcagtgcgggagattccctgacgttccacaacaac
cagtccttctccaccaaagaccaggacaatgatcttaacaccggaaattgtgctgtgatg
tttcagggagcttggtggtacaaaaactgccatgtgtcaaacctgaatggtcgctacctc
agggggactcatggcagctttgcaaatggcatcaactggaagtcggggaaaggatacaat
tatagctacaaggtgtcagagatgaaggtgcgacctgcctag

KEGG   Homo sapiens (human): 8547
Entry
8547              CDS       T01001                                 
Symbol
FCN3, FCNH, HAKA1
Name
(RefSeq) ficolin 3
  KO
K10104  ficolin
Organism
hsa  Homo sapiens (human)
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06513  Complement cascade
  Element
N01315  Lectin pathway of coagulation cascade, prothrombin to thrombin
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation cascade
N01491  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
Disease
H00105  Mannose-binding lectin pathway component defects
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04091 Lectins [BR:hsa04091]
    8547 (FCN3)
Lectins [BR:hsa04091]
 Ficolins
  8547 (FCN3)
SSDB
Motif
Pfam: Fibrinogen_C Collagen
Other DBs
NCBI-GeneID: 8547
NCBI-ProteinID: NP_003656
OMIM: 604973
HGNC: 3625
Ensembl: ENSG00000142748
UniProt: O75636 Q6UY50
Structure
LinkDB
Position
1:complement(27369110..27374824)
AA seq 299 aa
MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPG
PQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGATLSGWYHLCLPEGRALPVF
CDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELR
VELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDS
SNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR
NT seq 900 nt   +upstreamnt  +downstreamnt
atggatctactgtggatcctgccctccctgtggcttctcctgcttggggggcctgcctgc
ctgaagacccaggaacaccccagctgcccaggacccagggaactggaagccagcaaagtt
gtcctcctgcccagttgtcccggagctccaggaagtcctggggagaagggagccccaggt
cctcaagggccacctggaccaccaggcaagatgggccccaagggtgagccaggagatcca
gtgaacctgctccggtgccaggaaggccccagaaactgccgggagctgttgagccagggc
gccaccttgagcggctggtaccatctgtgcctacctgagggcagggccctcccagtcttt
tgtgacatggacaccgaggggggcggctggctggtgtttcagaggcgccaggatggttct
gtggatttcttccgctcttggtcctcctacagagcaggttttgggaaccaagagtctgaa
ttctggctgggaaatgagaatttgcaccagcttactctccagggtaactgggagctgcgg
gtagagctggaagactttaatggtaaccgtactttcgcccactatgcgaccttccgcctc
ctcggtgaggtagaccactaccagctggcactgggcaagttctcagagggcactgcaggg
gattccctgagcctccacagtgggaggccctttaccacctatgacgctgaccacgattca
agcaacagcaactgtgcagtgattgtccacggtgcctggtggtatgcatcctgttaccga
tcaaatctcaatggtcgctatgcagtgtctgaggctgccgcccacaaatatggcattgac
tgggcctcaggccgtggtgtgggccacccctaccgcagggttcggatgatgcttcgatag

KEGG   Homo sapiens (human): 5648
Entry
5648              CDS       T01001                                 
Symbol
MASP1, 3MC1, CRARF, CRARF1, MAP-1, MAP1, MASP, MASP-3, MASP3, MAp44, PRSS5, RaRF
Name
(RefSeq) MBL associated serine protease 1
  KO
K03992  mannan-binding lectin serine protease 1 [EC:3.4.21.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06513  Complement cascade
nt06514  Coagulation cascade
  Element
N01312  SARS-CoV-2 S to lectin pathway of complement cascade
N01491  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
N01520  Regulation of fibrinolytic system, C1INH
Disease
H01887  3MC syndrome
Drug target
Zaltenibart: D12920
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5648 (MASP1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    5648 (MASP1)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    5648 (MASP1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5648 (MASP1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   5648 (MASP1)
SSDB
Motif
Pfam: Trypsin CUB Sushi FXa_inhibition CDCP1_CUB_6 EGF_CA cEGF Trypsin_2 CUB_M02D8_5_2nd DUF1986 Peptidase_S6
Other DBs
NCBI-GeneID: 5648
NCBI-ProteinID: NP_001870
OMIM: 600521
HGNC: 6901
Ensembl: ENSG00000127241
UniProt: P48740
Structure
LinkDB
Position
3:complement(187217282..187291737)
AA seq 699 aa
MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL
GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL
HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET
LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW
YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN
NT seq 2100 nt   +upstreamnt  +downstreamnt
atgaggtggctgcttctctattatgctctgtgcttctccctgtcaaaggcttcagcccac
accgtggagctaaacaatatgtttggccagatccagtcgcctggttatccagactcctat
cccagtgattcagaggtgacttggaatatcactgtcccagatgggtttcggatcaagctt
tacttcatgcacttcaacttggaatcctcctacctttgtgaatatgactatgtgaaggta
gaaactgaggaccaggtgctggcaaccttctgtggcagggagaccacagacacagagcag
actcccggccaggaggtggtcctctcccctggctccttcatgtccatcactttccggtca
gatttctccaatgaggagcgtttcacaggctttgatgcccactacatggctgtggatgtg
gacgagtgcaaggagagggaggacgaggagctgtcctgtgaccactactgccacaactac
attggcggctactactgctcctgccgcttcggctacatcctccacacagacaacaggacc
tgccgagtggagtgcagtgacaacctcttcactcaaaggactggggtgatcaccagccct
gacttcccaaacccttaccccaagagctctgaatgcctgtataccatcgagctggaggag
ggtttcatggtcaacctgcagtttgaggacatatttgacattgaggaccatcctgaggtg
ccctgcccctatgactacatcaagatcaaagttggtccaaaagttttggggcctttctgt
ggagagaaagccccagaacccatcagcacccagagccacagtgtcctgatcctgttccat
agtgacaactcgggagagaaccggggctggaggctctcatacagggctgcaggaaatgag
tgcccagagctacagcctcctgtccatgggaaaatcgagccctcccaagccaagtatttc
ttcaaagaccaagtgctcgtcagctgtgacacaggctacaaagtgctgaaggataatgtg
gagatggacacattccagattgagtgtctgaaggatgggacgtggagtaacaagattccc
acctgtaaaattgtagactgtagagccccaggagagctggaacacgggctgatcaccttc
tctacaaggaacaacctcaccacatacaagtctgagatcaaatactcctgtcaggagccc
tattacaagatgctcaacaataacacaggtatatatacctgttctgcccaaggagtctgg
atgaataaagtattggggagaagcctacccacctgccttccagtgtgtgggctccccaag
ttctcccggaagctgatggccaggatcttcaatggacgcccagcccagaaaggcaccact
ccctggattgccatgctgtcacacctgaatgggcagcccttctgcggaggctcccttcta
ggctccagctggatcgtgaccgccgcacactgcctccaccagtcactcgatccggaagat
ccgaccctacgtgattcagacttgctcagcccttctgacttcaaaatcatcctgggcaag
cattggaggctccggtcagatgaaaatgaacagcatctcggcgtcaaacacaccactctc
cacccccagtatgatcccaacacattcgagaatgacgtggctctggtggagctgttggag
agcccagtgctgaatgccttcgtgatgcccatctgtctgcctgagggaccccagcaggaa
ggagccatggtcatcgtcagcggctgggggaagcagttcttgcaaaggttcccagagacc
ctgatggagattgaaatcccgattgttgaccacagcacctgccagaaggcttatgccccg
ctgaagaagaaagtgaccagggacatgatctgtgctggggagaaggaagggggaaaggac
gcctgtgcgggtgactctggaggccccatggtgaccctgaatagagaaagaggccagtgg
tacctggtgggcactgtgtcctggggtgatgactgtgggaagaaggaccgctacggagta
tactcttacatccaccacaacaaggactggatccagagggtcaccggagtgaggaactga

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