KEGG   COMPOUND: C14818
Entry
C14818                      Compound                               
Name
Fe2+;
Fe(II);
Ferrous ion;
Iron(2+)
Formula
Fe
Exact mass
55.9349
Mol weight
55.85
Structure
Reaction
R00078 R00092 R00310 R00311 R02864 R04124 R05318 R07767
R09541 R09739 R10468 R10510 R11329 R11579 R11700 R11741
R11742 R11816 R11817 R12423 R12424 R13250 R13251 R13252
Pathway
map00860  Porphyrin metabolism
map02010  ABC transporters
map04066  HIF-1 signaling pathway
map04081  Hormone signaling
map04216  Ferroptosis
map04978  Mineral absorption
map05010  Alzheimer disease
Network
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06525  Ferroptosis
Enzyme
1.14.14.18      1.14.15.20      1.14.99.48      1.14.99.57      
1.14.99.58      1.16.1.7        1.16.1.9        1.16.2.1        
1.16.3.1        1.16.3.2        2.1.1.342       2.8.1.8         
4.98.1.1        4.99.1.4        4.99.1.9        7.2.1.3
Other DBs
PubChem: 17395816
PDB-CCD: FE2[PDBj]
NIKKAJI: J300.941F
LinkDB
KCF data

ATOM        1
            1   Z   Fe   24.6400  -20.3700 #2+
BOND        0

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KEGG   Homo sapiens (human): 5094
Entry
5094              CDS       T01001                                 
Symbol
PCBP2, HNRNPE2, HNRPE2, hnRNP-E2
Name
(RefSeq) poly(rC) binding protein 2
  KO
K13162  poly(rC)-binding protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04216  Ferroptosis
Network
nt06525  Ferroptosis
  Element
N01591  Fe2+ Ferroportin transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    5094 (PCBP2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5094 (PCBP2)
   03041 Spliceosome [BR:hsa03041]
    5094 (PCBP2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Other mRNA localization factors
     5094 (PCBP2)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     5094 (PCBP2)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   hnRNP proteins
    5094 (PCBP2)
SSDB
Motif
Pfam: KH_1 KH_2 KH-I_KHDC4-BBP KH_KhpA-B KH_5 MOEP19 Bac_chlorC
Other DBs
NCBI-GeneID: 5094
NCBI-ProteinID: NP_001122383
OMIM: 601210
HGNC: 8648
Ensembl: ENSG00000197111
UniProt: Q15366
Structure
LinkDB
Position
12:53452102..53481162
AA seq 365 aa
MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIIT
LAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKI
KEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLETLSQSPPKGVTI
PYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQ
PDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIG
CIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSETG
GMGSS
NT seq 1098 nt   +upstreamnt  +downstreamnt
atggacaccggtgtgattgaaggtggattaaatgtcactctcaccatccggctacttatg
catggaaaggaagttggcagtatcatcggaaagaaaggagaatcagttaagaagatgcgc
gaggagagtggtgcacgtatcaacatctcagaagggaattgtcctgagagaattatcact
ttggctggacccactaatgccatcttcaaagcctttgctatgatcattgacaaactggaa
gaggacataagcagctctatgaccaatagcacagctgccagtagacccccggtcaccctg
aggctggtggtccctgctagtcagtgtggctctctcattggaaaaggtggatgcaagatc
aaggaaatacgagagagtacaggggctcaggtccaggtggcaggggatatgctacccaac
tcaactgagcgggccatcactattgctggcattccacaatccatcattgagtgtgtcaaa
cagatctgcgtggtcatgttggagactctctcccagtcccccccgaagggcgtgaccatc
ccgtaccggcccaagccgtccagctctccggtcatctttgcaggtggtcaggacaggtac
agcacaggcagcgacagtgcgagctttccccacaccaccccgtccatgtgcctcaaccct
gacctggagggaccacctctagaggcctataccattcaaggacagtatgccattccacag
ccagatttgaccaagctgcaccagttggcaatgcaacagtctcattttcccatgacgcat
ggcaacaccggattcagtggcattgaatccagctctccagaggtgaaaggctattggggt
ttggatgcatctgctcagactacttctcatgaactcaccattccaaacgatttgattggc
tgcataatcgggcgtcaaggcgccaaaatcaatgagatccgtcagatgtctggggcgcag
atcaaaattgcgaacccagtggaaggatctactgataggcaggttaccatcactggatct
gctgccagcattagcctggctcaatatctaatcaatgtcaggctttcctcggagacgggt
ggcatggggagcagctag

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