 | | DRUG: Propranolol hydrochloride | |
| Entry |
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| Name |
Propranolol hydrochloride (JP18/USP);
Inderal (TN);
Innopran XL (TN) |
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| Product |
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| Generic |
PROPRANOLOL (Fresenius Kabi USA), PROPRANOLOL (Medical Purchasing Solutions), PROPRANOLOL HCL ER (Direct Rx), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (AMICI PHARMACEUTICALS LLC), PROPRANOLOL HYDROCHLORIDE (ANI Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Actavis Pharma), PROPRANOLOL HYDROCHLORIDE (Actavis Pharma), PROPRANOLOL HYDROCHLORIDE (American Health Packaging), PROPRANOLOL HYDROCHLORIDE (American Health Packaging), PROPRANOLOL HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), PROPRANOLOL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), PROPRANOLOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PROPRANOLOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PROPRANOLOL HYDROCHLORIDE (AvKARE), PROPRANOLOL HYDROCHLORIDE (AvPAK), PROPRANOLOL HYDROCHLORIDE (Breckenridge Pharmaceutical), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Cardinal Health 107), PROPRANOLOL HYDROCHLORIDE (DIRECT RX), PROPRANOLOL HYDROCHLORIDE (Denton Pharma), PROPRANOLOL HYDROCHLORIDE (Direct Rx), PROPRANOLOL HYDROCHLORIDE (Golden State Medical Supply), PROPRANOLOL HYDROCHLORIDE (HF Acquisition Co LLC), PROPRANOLOL HYDROCHLORIDE (Henry Schein), PROPRANOLOL HYDROCHLORIDE (Hikma Pharmaceuticals USA), PROPRANOLOL HYDROCHLORIDE (Hikma Pharmaceuticals USA), PROPRANOLOL HYDROCHLORIDE (Lannett Company), PROPRANOLOL HYDROCHLORIDE (Major Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Medical Purchasing Solutions), PROPRANOLOL HYDROCHLORIDE (Mylan Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (Nortec Development Associates), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Par Pharmaceutical), PROPRANOLOL HYDROCHLORIDE (Pharmaceutical Associates), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Quality Care Products), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), PROPRANOLOL HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROPRANOLOL HYDROCHLORIDE (Zydus Lifesciences Limited), PROPRANOLOL HYDROCHLORIDE (Zydus Pharmaceuticals USA) |
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| Formula |
C16H21NO2. HCl
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| Exact mass |
295.1339
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| Mol weight |
295.8044
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03231 Antihypertensive
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
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| Remark |
| Product (DG00305): | D00483<JP/US> |
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| Efficacy |
Antiarrhythmic, Antihypertensive, Vasodilator, beta-Adrenergic receptor antagonist |
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| Disease |
Hypertension [DS: H01633] Angina pectoris due to coronary atherosclerosis [DS: H01632] Atrial fibrillation [DS: H00731] Myocardial infarction [DS: H01730] Essential tremor [DS: H01577] Infantile hemangioma [DS: H01482] |
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| Comment |
Class II antiarrhythmic agent
Propranolol derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP1A2 [HSA: 1544], CYP2C19 [HSA: 1557]
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| Interaction |
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| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA05 Propranolol
D00483 Propranolol hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antimigraine Agents
Antimigraine Agents, Other
Propranolol
D00483 Propranolol hydrochloride (JP18/USP)
Cardiovascular Agents
Antiarrhythmics
Vaughn Williams-Class II
Propranolol
D00483 Propranolol hydrochloride (JP18/USP)
Beta-adrenergic Blocking Agents
Non-Selective
Propranolol
D00483 Propranolol hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2123 Beta blockers
D00483 Propranolol hydrochloride (JP18/USP)
214 Antihypertensives
2149 Others
D00483 Propranolol hydrochloride (JP18/USP)
29 Other agents affecting individual organs
290 Other agents affecting individual organs
2900 Other agents affecting individual organs
D00483 Propranolol hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00305 Propranolol
D00483 Propranolol hydrochloride
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00305 Propranolol
D00483 Propranolol hydrochloride
DG03231 Antihypertensive
DG00305 Propranolol
D00483 Propranolol hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00305 Propranolol
D00483 Propranolol hydrochloride
DG01639 CYP2C19 substrate
DG00305 Propranolol
D00483 Propranolol hydrochloride
DG01644 CYP2D6 substrate
DG00305 Propranolol
D00483 Propranolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D00483 Propranolol hydrochloride
DG01653 Antiarrhythmics
D00483 Propranolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D00483 Propranolol hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00483 Propranolol hydrochloride
D00483 Propranolol hydrochloride tablets
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00483
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00483
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00483
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00305 Propranolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00305 Propranolol
DG03231 Antihypertensive
DG00305 Propranolol
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00305 Propranolol
DG01639 CYP2C19 substrate
DG00305 Propranolol
DG01644 CYP2D6 substrate
DG00305 Propranolol
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 C8x C 7.6300 -12.9500
2 C8x C 7.6300 -14.3500
3 C8x C 8.8424 -15.0500
4 C8y C 10.0549 -14.3500
5 C8y C 10.0549 -12.9500
6 C8x C 8.8424 -12.2500
7 C8x C 11.2673 -15.0500
8 C8x C 12.4797 -14.3500
9 C8x C 12.4797 -12.9500
10 C8y C 11.2673 -12.2500
11 O2a O 11.2673 -10.8500
12 C1b C 12.4818 -10.1488
13 C1c C 13.6783 -10.8398
14 C1b C 14.8651 -10.1546
15 O1a O 13.6784 -12.2497
16 N1b N 16.0566 -10.8428
17 C1c C 17.2460 -10.1561
18 C1a C 18.4362 -10.8435
19 C1a C 17.2462 -8.7502
20 X Cl 18.7600 -14.2800
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 10 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 13 15 1
17 14 16 1
18 16 17 1
19 17 18 1
20 17 19 1
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