KEGG   DRUG: MirtazapineHelp
Entry
D00563                      Drug                                   

Name
Mirtazapine (JAN/USAN/INN);
Remeron (TN);
Reflex (TN)
Product
  Generic
MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (Actavis Pharma), MIRTAZAPINE (Actavis Pharma), MIRTAZAPINE (Aidarex Pharmaceuticals LLC), MIRTAZAPINE (Aidarex Pharmaceuticals LLC), MIRTAZAPINE (American Health Packaging), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Apotex Corp.), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurolife Pharma LLC), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Cadila Healthcare Limited), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Clinical Solutions Wholesale), MIRTAZAPINE (Clinical Solutions Wholesale), MIRTAZAPINE (Contract Pharmacy Services-PA), MIRTAZAPINE (Contract Pharmacy Services-PA), MIRTAZAPINE (Contract Pharmacy Services-PA), MIRTAZAPINE (DIRECT RX), MIRTAZAPINE (Direct Rx), MIRTAZAPINE (DirectRX), MIRTAZAPINE (Eon Labs), MIRTAZAPINE (H.J. Harkins Company), MIRTAZAPINE (Impax Generics), MIRTAZAPINE (KAISER FOUNDATION HOSPITALS), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical Medical DBA Quality Care Products LLC), MIRTAZAPINE (Major Pharmaceuticals), MIRTAZAPINE (McKesson Corporation), MIRTAZAPINE (Medsource Pharmaceuitcals), MIRTAZAPINE (Medsource Pharmaceuticals), MIRTAZAPINE (Mylan Institutional), MIRTAZAPINE (Mylan Pharmaceuticals), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (Northstar Rx LLC), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (PD-Rx Pharmaceuticals), MIRTAZAPINE (PD-Rx Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (RPK Pharmaceuticals), MIRTAZAPINE (RPK Pharmaceuticals), MIRTAZAPINE (Rebel Distributors Corp), MIRTAZAPINE (Rebel Distributors Corp), MIRTAZAPINE (Rebel Distributors Corp.), MIRTAZAPINE (Rising Health), MIRTAZAPINE (Rising Health), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (Sun Pharmaceutical Industries), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (Teva Pharmaceuticals USA), MIRTAZAPINE (Unit Dose Services), MIRTAZAPINE (Zydus Pharmaceuticals (USA))
Formula
C17H19N3
Exact mass
265.1579
Mol weight
265.3529
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01729  Tetracyclic antidepressant
Other
 DG01489  5-HT3-receptor antagonist
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Same as: C07570
Therapeutic category: 1179
ATC code: N06AX11
Chemical structure group: DG02838
Product (DG02838): D00563<JP/US>
Efficacy
Antidepressant, Serotonin receptor antagonist
Comment
NaSSA: Noradrenergic and specific serotonergic antidepressant
Target
HTR2 [HSA:3356 3357 3358] [KO:K04157]
HTR3 [HSA:3359 9177 170572 200909 285242] [KO:K04819]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX11 Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  Antidepressants, Other
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00563  Mirtazapine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D00563  Mirtazapine (JAN/USAN/INN) <JP/US>
   Serotonin
    HTR2
     D00563  Mirtazapine (JAN/USAN/INN) <JP/US>
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D00563  Mirtazapine (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00563
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00563
BRITE hierarchy
Other DBs
CAS: 85650-52-8
PubChem: 7847629
ChEBI: 6950
ChEMBL: CHEMBL654
DrugBank: DB00370
LigandBox: D00563
NIKKAJI: J327.434I
LinkDB All DBs
KCF data Show

ATOM        20
            1   C1y C     9.7476   -8.2180
            2   N1y N    11.1496   -8.2180
            3   C8y C    11.9909   -7.1665
            4   C8y C    11.7105   -5.7644
            5   C8y C     8.9064   -7.1665
            6   C1x C    10.4486   -5.2036
            7   C8y C     9.1868   -5.7644
            8   C8x C     7.5744   -7.5871
            9   C8x C     6.5229   -6.6056
            10  C8x C     6.8033   -5.2737
            11  C8x C     8.1353   -4.8531
            12  C8x C    12.6919   -4.8531
            13  C8x C    14.0238   -5.2737
            14  C8x C    14.3743   -6.6056
            15  N5x N    13.3228   -7.5170
            16  C1x C    11.8507   -9.4097
            17  C1x C    11.1496  -10.6715
            18  N1y N     9.8177  -10.6715
            19  C1x C     9.0466   -9.4798
            20  C1a C     9.1167  -11.9334
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 2
            6     1   2 1
            7     6   7 1
            8     5   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12    7  11 1
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    3  15 2
            18    2  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22    1  19 1
            23   18  20 1

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