| Entry |
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| Name |
Methylprednisolone sodium succinate (JAN/USP);
A-methapred (TN);
Solu-medrol (TN) |
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| Product |
SOLU-MEDROL (A-S Medication Solutions), SOLU-MEDROL (Cardinal Health 107), SOLU-MEDROL (Cardinal Health 107), SOLU-MEDROL (Cardinal Health 107), SOLU-MEDROL (HF Acquisition Co. LLC), SOLU-MEDROL (HF Acquisition Co. LLC), SOLU-MEDROL (Henry Schein), SOLU-MEDROL (Henry Schein), SOLU-MEDROL (Medical Purchasing Solutions), SOLU-MEDROL (Medical Purchasing Solutions), SOLU-MEDROL (Medical Purchasing Solutions), SOLU-MEDROL (Pharmacia & Upjohn Company LLC), SOLU-MEDROL (Pharmacia & Upjohn Company LLC), SOLU-MEDROL (ProPharma Distribution), SOLU-MEDROL (ProPharma Distribution), SOLU-MEDROL (REMEDYREPACK), SOLU-MEDROL(R) METHYLPREDNISOLONE SODIUM SUCCINAT (HF Acquisition Co LLC) |
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| Generic |
METHYLPREDNISOLONE SODIUM SUCCINATE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE SODIUM SUCCINATE (Civica), METHYLPREDNISOLONE SODIUM SUCCINATE (Dr. Reddy's Laboratories), METHYLPREDNISOLONE SODIUM SUCCINATE (Eugia US LLC), METHYLPREDNISOLONE SODIUM SUCCINATE (Fresenius Kabi USA), METHYLPREDNISOLONE SODIUM SUCCINATE (Hikma Pharmaceuticals USA), METHYLPREDNISOLONE SODIUM SUCCINATE (Hikma Pharmaceuticals USA), METHYLPREDNISOLONE SODIUM SUCCINATE (Hikma Pharmaceuticals USA), METHYLPREDNISOLONE SODIUM SUCCINATE (REMEDYREPACK), METHYLPREDNISOLONE SODIUM SUCCINATE (REMEDYREPACK), METHYLPREDNISOLONE SODIUM SUCCINATE (Tianjin Kingyork Pharmaceuticals) |
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| Formula |
C26H33O8. Na
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| Exact mass |
496.2073
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| Mol weight |
496.52
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2456 |
| Product (DG00410): | D00407<JP/US> D00751<JP/US> D00979<JP/US> |
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| Efficacy |
Anti-inflammatory, Immunosuppressant, Glucocorticoid receptor agonist |
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| Disease |
Asthma [DS: H00079] Atopic dermatitis [DS: H01358] Contact dermatitis [DS: H01357] Allergic rhinitis [DS: H01360] Dermatitis herpetiformis [DS: H01362] Mycosis fungoides [DS: H01463] Pemphigus [DS: H01648] Erythema multiforme [DS: H01695] Stevens-Johnson syndrome [DS: H01694] Congenital adrenal hyperplasia [DS: H00216] Ulcerative colitis [DS: H01466] Acquired (autoimmune) hemolytic anemia [DS: H01585] Congenital (erythroid) hypoplastic anemia; Diamond-Blackfan anemia [DS: H00237] Idiopathic thrombocytopenic purpura [DS: H01240] Pure red cell aplasia [DS: H01586] Multiple sclerosis [DS: H01490] Ankylosing spondylitis [DS: H01674] Psoriatic arthritis [DS: H01507] Rheumatoid arthritis [DS: H00630] Juvenile idiopathic arthritis [DS: H01672] Dermatomyositis [DS: H01604] Temporal arteritis [DS: H01698] Polymyositis [DS: H01604] Systemic lupus erythematosus [DS: H00080] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA01 Methylprednisolone
D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA02 Methylprednisolone
D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB04 Methylprednisolone
D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Methylprednisolone
D00751 Methylprednisolone sodium succinate (JAN/USP)
Inflammatory Bowel Disease Agents
Glucocorticoids
Methylprednisolone
D00751 Methylprednisolone sodium succinate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2456 Prednisolones
D00751 Methylprednisolone sodium succinate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
D00751 Methylprednisolone sodium succinate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
D00751 Methylprednisolone sodium succinate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00751 Methylprednisolone sodium succinate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00751
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 35
1 C2x C 26.6700 -18.6900
2 C5x C 26.6700 -20.0900
3 C2x C 27.8600 -20.7900
4 C2y C 29.1200 -20.0900
5 C1z C 29.1200 -18.6900
6 C2x C 27.8600 -17.9900
7 C1y C 30.3100 -20.7900
8 C1x C 31.5000 -20.0900
9 C1y C 31.5000 -18.6900
10 C1y C 30.3100 -17.9900
11 C1y C 32.7600 -17.9900
12 C1z C 32.7600 -16.5900
13 C1x C 31.5000 -15.8900
14 C1y C 30.3100 -16.5900
15 C1x C 35.1400 -17.9900
16 C1x C 35.1400 -16.5900
17 C1z C 33.9500 -15.8900
18 O5x O 25.4800 -20.7900
19 C1a C 29.1200 -17.2900
20 O1a O 29.1200 -15.8900
21 C1a C 32.7600 -15.1900
22 C5a C 33.9500 -14.2100
23 C1a C 30.3100 -22.1900
24 O1a O 35.1400 -15.1900
25 C1b C 35.1400 -13.5100
26 O5a O 32.7600 -13.5100
27 O7a O 36.3300 -14.2100
28 C7a C 37.5200 -13.5100
29 C1b C 38.7100 -14.2100
30 O6a O 37.5200 -12.1100
31 C1b C 39.9281 -13.5199
32 C6a C 41.1095 -14.2150
33 O6a O 42.3149 -13.5320 #-
34 O6a O 41.0981 -15.6100
35 Z Na 43.7500 -13.5100 #+
BOND 37
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 14 20 1 #Up
24 12 21 1 #Up
25 17 22 1 #Up
26 7 23 1 #Down
27 17 24 1 #Down
28 22 25 1
29 22 26 2
30 25 27 1
31 27 28 1
32 28 29 1
33 28 30 2
34 29 31 1
35 31 32 1
36 32 33 1
37 32 34 2
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