 | | DRUG: Amitriptyline hydrochloride | |
| Entry |
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| Name |
Amitriptyline hydrochloride (JP18/USP);
Elavil (TN) |
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| Product |
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| Generic |
AMITRIPTYLINE HCL (Advanced Rx Pharmacy of Tennessee), AMITRIPTYLINE HCL (Advanced Rx Pharmacy of Tennessee), AMITRIPTYLINE HCL (Advanced Rx Pharmacy of Tennessee), AMITRIPTYLINE HCL (Direct Rx), AMITRIPTYLINE HCL (Direct_Rx), AMITRIPTYLINE HCL (Direct_Rx), AMITRIPTYLINE HCL (Direct_Rx), AMITRIPTYLINE HCL (Direct_Rx), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), AMITRIPTYLINE HYDROCHLORIDE (Accord Healthcare), AMITRIPTYLINE HYDROCHLORIDE (Advagen Pharma), AMITRIPTYLINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Advanced Rx of Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Advanced Rx of Tennessee), AMITRIPTYLINE HYDROCHLORIDE (American Health Packaging), AMITRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Asclemed USA), AMITRIPTYLINE HYDROCHLORIDE (Asclemed USA), AMITRIPTYLINE HYDROCHLORIDE (AvPAK), AMITRIPTYLINE HYDROCHLORIDE (AvPAK), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Centaur Pharmaceuticals Private Limited), AMITRIPTYLINE HYDROCHLORIDE (DIRECT RX), AMITRIPTYLINE HYDROCHLORIDE (DIRECT RX), AMITRIPTYLINE HYDROCHLORIDE (Direct Rx), AMITRIPTYLINE HYDROCHLORIDE (DirectRx), AMITRIPTYLINE HYDROCHLORIDE (Direct_Rx), AMITRIPTYLINE HYDROCHLORIDE (Direct_Rx), AMITRIPTYLINE HYDROCHLORIDE (Direct_Rx), AMITRIPTYLINE HYDROCHLORIDE (Direct_Rx), AMITRIPTYLINE HYDROCHLORIDE (Direct_Rx), AMITRIPTYLINE HYDROCHLORIDE (Doc Rx), AMITRIPTYLINE HYDROCHLORIDE (Golden State Medical Supply), AMITRIPTYLINE HYDROCHLORIDE (Graviti Pharmaceuticals Private Limited), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lifestar Pharma LLC), AMITRIPTYLINE HYDROCHLORIDE (Major Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Major Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Medsource Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Medsource Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Medsource Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Medsource Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Northstar Rx LLC.), AMITRIPTYLINE HYDROCHLORIDE (Northstar RxLLC), AMITRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Northwind Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharamaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), AMITRIPTYLINE HYDROCHLORIDE (Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Quality Care Products), AMITRIPTYLINE HYDROCHLORIDE (Quality Care Products), AMITRIPTYLINE HYDROCHLORIDE (Quality Care Products), AMITRIPTYLINE HYDROCHLORIDE (Quality Care Products), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (RPK Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (RPK Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (RPK Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (RPK Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (RedPharm Drug), AMITRIPTYLINE HYDROCHLORIDE (Rising Pharma Holdings), AMITRIPTYLINE HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), AMITRIPTYLINE HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), AMITRIPTYLINE HYDROCHLORIDE (Sandoz), AMITRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), AMITRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), AMITRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), AMITRIPTYLINE HYDROCHLORIDE (Sun Pharmaceutical Industries), AMITRIPTYLINE HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), AMITRIPTYLINE HYDROCHLORIDE (Westminster Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Zydus Lifesciences Limited), AMITRIPTYLINE HYDROCHLORIDE (Zydus Pharmaceuticals USA) |
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| Formula |
C20H23N. HCl
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| Exact mass |
313.1597
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| Mol weight |
313.86
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00934): | D00809<JP/US> |
| Product (mixture): | D10207<US> D10294<US> |
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| Efficacy |
Antidepressant |
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| Disease |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576], CYP2C19 [HSA: 1557]
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| Interaction |
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA09 Amitriptyline
D00809 Amitriptyline hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
Tricyclics
Amitriptyline
D00809 Amitriptyline hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00809 Amitriptyline hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00934 Amitriptyline
D00809 Amitriptyline hydrochloride
DG01728 Tricyclic antidepressant
DG00934 Amitriptyline
D00809 Amitriptyline hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00934 Amitriptyline
D00809 Amitriptyline hydrochloride
DG01639 CYP2C19 substrate
DG00934 Amitriptyline
D00809 Amitriptyline hydrochloride
DG01644 CYP2D6 substrate
DG00934 Amitriptyline
D00809 Amitriptyline hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00934 Amitriptyline
D00809 Amitriptyline hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D00809 Amitriptyline hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D00809 Amitriptyline hydrochloride (JP18/USP) <JP/US>
SLC6A4 (HTT)
D00809 Amitriptyline hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00809 Amitriptyline hydrochloride
D00809 Amitriptyline hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00809
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00809
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00934 Amitriptyline
DG01728 Tricyclic antidepressant
DG00934 Amitriptyline
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00934 Amitriptyline
DG01639 CYP2C19 substrate
DG00934 Amitriptyline
DG01644 CYP2D6 substrate
DG00934 Amitriptyline
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00934 Amitriptyline
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C1x C 22.3053 -18.3173
2 C8y C 21.4609 -17.2047
3 C8y C 21.7970 -15.8442
4 C2y C 23.0615 -15.2645
5 C1x C 23.7149 -18.3426
6 C8y C 24.3184 -15.8885
7 C8y C 24.6057 -17.2610
8 C8x C 20.7871 -14.8731
9 C8x C 19.4414 -15.2623
10 C8x C 19.1053 -16.6228
11 C8x C 20.1152 -17.5936
12 C8x C 25.9405 -17.6993
13 C8x C 26.9876 -16.7623
14 C8x C 26.7005 -15.3898
15 C8x C 25.3654 -14.9515
16 C2b C 23.0132 -13.8858
17 C1b C 24.2405 -13.2028
18 C1b C 25.4121 -13.9042
19 N1c N 26.6376 -13.2223
20 C1a C 27.8757 -13.9629
21 C1a C 26.6597 -11.8503
22 X Cl 29.9627 -16.4829
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 19 21 1
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