KEGG   DRUG: Cenobamate
Entry
D11150                      Drug                                   

Name
Cenobamate (USAN/INN);
Xcopri (TN)
Product
Formula
C10H10ClN5O2
Exact mass
267.0523
Mol weight
267.6717
Structure
Remark
Product: D11150<US>
Efficacy
Analgesic, Antiepileptic
Comment
Treatment of partial-onset seizures
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: UGT2B7 [HSA:7364], CYP2E1 [HSA:1571], CYP2A6 [HSA:1548], CYP2B6 [HSA:1555]; UGT2B4 [HSA:7363], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D11150  Cenobamate (USAN/INN) <US>
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D11150  Cenobamate (USAN/INN) <US>
    SCN2A
     D11150  Cenobamate (USAN/INN) <US>
    SCN3A
     D11150  Cenobamate (USAN/INN) <US>
    SCN4A
     D11150  Cenobamate (USAN/INN) <US>
    SCN5A
     D11150  Cenobamate (USAN/INN) <US>
    SCN8A
     D11150  Cenobamate (USAN/INN) <US>
    SCN9A
     D11150  Cenobamate (USAN/INN) <US>
    SCN10A
     D11150  Cenobamate (USAN/INN) <US>
    SCN11A
     D11150  Cenobamate (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11150
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11150
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11150
Other DBs
CAS: 913088-80-9
PubChem: 376219074
ChEMBL: CHEMBL3989949
LinkDB
KCF data

ATOM        18
            1   C8x C    10.6400  -26.0400
            2   C8x C    10.6400  -27.4400
            3   C8x C    11.8524  -28.1400
            4   C8y C    13.0649  -27.4400
            5   C8y C    13.0649  -26.0400
            6   C8x C    11.8524  -25.3400
            7   X   Cl   14.2960  -28.1510
            8   C1c C    14.2960  -25.3290
            9   O7a O    15.5012  -26.0247
            10  C1b C    14.2957  -23.9401
            11  C7a C    16.6835  -25.3419
            12  N1a N    17.8775  -26.0312
            13  O6a O    16.6835  -23.9402
            14  N4y N    13.0714  -23.2334
            15  N5x N    13.0557  -21.8404
            16  C8x C    11.7275  -21.4260
            17  N5x N    10.9229  -22.5612
            18  N5x N    11.7539  -23.6772
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     5   8 1
            9     8   9 1 #Down
            10    8  10 1
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   10  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   14  18 1

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