KEGG   DRUG: Desvenlafaxine succinate anhydrous
Entry
D11619                      Drug                                   

Name
Desvenlafaxine succinate anhydrous;
Desvenlafaxine succinate (TN)
Product
  Generic
Formula
C16H25NO2. C4H6O4
Exact mass
381.2151
Mol weight
381.4632
Structure
Remark
ATC code: N06AX23
Chemical structure group: DG00963
Product (DG00963): D07793<US> D02570<US> D11619<US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Major depressive disorder [DS:H01646]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Metabolism
Enzyme: UGT [KO:K00699]; CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX23 Desvenlafaxine
      D11619  Desvenlafaxine succinate anhydrous <US>
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D11619  Desvenlafaxine succinate anhydrous <US>
    SLC6A4 (HTT)
     D11619  Desvenlafaxine succinate anhydrous <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11619
Other DBs
CAS: 448904-47-0
PubChem: 405226486
ChEMBL: CHEMBL1201728
LinkDB
KCF data

ATOM        27
            1   O6a O    20.7242  -16.6806
            2   C6a C    21.9752  -15.9856
            3   C1b C    23.1567  -16.6806
            4   C1b C    24.3382  -15.9856
            5   C6a C    25.5197  -16.6806
            6   O6a O    26.7707  -15.9856
            7   O6a O    21.9752  -14.5956
            8   O6a O    25.5197  -18.0707
            9   C8x C    11.7586  -17.1671
            10  C8y C    11.7586  -18.6267
            11  C8x C    12.9401  -19.3217
            12  C8x C    14.1216  -18.6267
            13  C8y C    14.1216  -17.1671
            14  C8x C    12.9401  -16.4721
            15  C1x C    16.6236  -18.6267
            16  C1z C    16.6236  -17.1671
            17  C1c C    15.3031  -16.4721
            18  C1x C    17.8051  -19.3217
            19  C1x C    18.9866  -18.6267
            20  C1x C    18.9866  -17.1671
            21  C1x C    17.8051  -16.4721
            22  O1a O    10.5771  -19.3217
            23  O1a O    16.6236  -15.7771
            24  C1b C    15.3031  -15.0821
            25  N1c N    14.1216  -14.4566
            26  C1a C    12.8706  -15.1516
            27  C1a C    14.1216  -12.9971
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     5   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14   15  16 1
            15   16  17 1
            16   13  17 1
            17   15  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   16  21 1
            22   10  22 1
            23   16  23 1
            24   17  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 1

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