KEGG ORTHOLOGY: K04635

ORTHOLOGY: K04635

Entry

K04635                      KO

Symbol

GNA11

Name

guanine nucleotide-binding protein subunit alpha-11

Pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04081

Hormone signaling

map04082

Neuroactive ligand signaling

map04270

Vascular smooth muscle contraction

map04540

Gap junction

map04725

Cholinergic synapse

map04730

Long-term depression

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04928

Parathyroid hormone synthesis, secretion and action

map04929

GnRH secretion

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05142

Chagas disease

map05146

Amoebiasis

map05163

Human cytomegalovirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

Disease

H02026

Familial hypocalciuric hypercalcemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04022 cGMP-PKG signaling pathway
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04081 Hormone signaling
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04929 GnRH secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04912 GnRH signaling pathway
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04935 Growth hormone synthesis, secretion and action
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04928 Parathyroid hormone synthesis, secretion and action
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04925 Aldosterone synthesis and secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04927 Cortisol synthesis and secretion
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09156 Nervous system
   04725 Cholinergic synapse
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04730 Long-term depression
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   05163 Human cytomegalovirus infection
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   05142 Chagas disease
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
   04031 GTP-binding proteins
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
  Exosomal proteins of melanoma cells
   K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
GTP-binding proteins [BR:ko04031]
Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 3 (Gq/11) [OT]
    K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11

Genes

HSA:	2767(GNA11)

PTR:	100611153(GNA11)

PPS:	100972605(GNA11)

GGO:	101129671(GNA11) 101149632 129531713

PON:	100460338(GNA11)

PPYG:

129020216(GNA11)

NLE:	100584446(GNA11)

HMH:	116483096(GNA11)

SSYN:

129465309(GNA11)

MCC:	721649(GNA11)

MCF:	102123885(GNA11)

MTHB:

126942698

MNI:	105485659(GNA11)

CSAB:

103233670(GNA11)

CATY:

105591769(GNA11)

PANU:

101019734(GNA11)

TGE:	112612879(GNA11)

MLEU:

105530008(GNA11)

RRO:	104665456(GNA11)

RBB:	108512657(GNA11)

TFN:	117074394(GNA11)

PTEH:

111520693(GNA11)

CANG:

105527658(GNA11)

CJC:	100386734(GNA11)

SBQ:	101032578(GNA11)

CIMI:

108288490(GNA11)

ANAN:

105706181(GNA11)

CSYR:

103252789

MMUR:

105873966(GNA11)

LCAT:

123633418(GNA11)

ERUF:

138401943(GNA11)

PCOQ:

105811873(GNA11)

OGA:	100949562(GNA11)

MMU:	14672(Gna11)

MCAL:

110303103(Gna11)

MPAH:

110326239(Gna11)

RNO:	81662(Gna11)

MCOC:

116075890(Gna11)

ANU:	143435772(Gna11)

ASYL:

127670814(Gna11)

MUN:	110548534(Gna11)

CGE:	100689065(Gna11)

MAUA:

101839416(Gna11)

PROB:

127216566(Gna11)

PLEU:

114688160(Gna11)

PMAV:

143270227(Gna11)

MORG:

121459559(Gna11)

MFOT:

126489320

AAMP:

119827968(Gna11)

CNL:	130876042 130876087

NGI:	103737243(Gna11)

HGL:	101722520(Gna11)

CPOC:

100715351(Gna11)

CCAN:

109691040(Gna11)

DORD:

105990272(Gna11)

DSP:	122099338(Gna11)

DMER:

138807567 138813917(Gna11)

PLOP:

125348648(Gna11)

NCAR:

124968563

MMMA:

107157430(Gna11)

ITI:	101964680(Gna11)

OPI:	101518174(GNA11)

OCZ:	121163178(GNA11)

TUP:	102479071(GNA11)

GVR:

103604359

CFA:	403914(GNA11)

CLUD:

112666259(GNA11)

VVP:	112935541(GNA11)

VLG:	121495327(GNA11)

NPO:	129522061(GNA11)

AML:	100469689(GNA11)

UMR:	103681813(GNA11)

UAH:	113242780(GNA11)

UAR:	123793965(GNA11)

ELK:

111161857

LLV:

125087086

MPUF:

101681131(GNA11)

MNP:	132010764(GNA11)

MLK:	131823276(GNA11)

NVS:	122909893(GNA11)

ORO:	101385358(GNA11)

EJU:	114226318(GNA11)

ZCA:	113917830(GNA11)

MLX:	118005532(GNA11)

MANO:

123834266(GNA11)

NSU:	110594139(GNA11)

LWW:	102732710(GNA11)

FCA:	101086541(GNA11)

PYU:	121021509(GNA11)

PBG:	122486676(GNA11)

PVIV:

125155799(GNA11)

LRUF:

124524235

LGF:	123605082(GNA11)

AJU:

106982140

PTG:	107181018(GNA11)

PPAD:

109255970(GNA11)

PUC:

125930520

PLEZ:

122213746(GNA11)

HHV:	120242104(GNA11)

CCRU:

144218920(GNA11)

BTA:	281788(GNA11)

BOM:	102287661(GNA11)

BIU:	109561778(GNA11)

BJV:	133250903(GNA11)

BBUB:

102391819(GNA11)

BKE:	129627878(GNA11)

BBIS:

104979885(GNA11)

CHX:	102177328(GNA11)

OAS:	101119215(GNA11)

OCAN:

138441068(GNA11)

BTAX:

128050674(GNA11)

CSUM:

138086072(GNA11)

ODA:	120864791(GNA11)

CCAD:

122440204(GNA11)

MREE:

136155883(GNA11)

OVR:	110138312(GNA11)

MBEZ:

129558678(GNA11)

SSC:	733588(GNA11)

CFR:	102508599(GNA11)

CBAI:

105078179(GNA11)

CDK:	105106041(GNA11)

VPC:	116276519(GNA11)

BACU:

103000262(GNA11)

BMUS:

118892955(GNA11)

LVE:	103076924(GNA11)

OOR:	101269696(GNA11)

LALB:

132517779(GNA11)

GMF:	115846684(GNA11)

DDP:	132422614(GNA11)

DLE:	111166066(GNA11)

PCAD:

102995887(GNA11)

PSIU:

116751212(GNA11)

PPHC:

136120669(GNA11)

NASI:

112396330(GNA11)

ECB:	100067327(GNA11)

EPZ:	103543382(GNA11)

EAI:	106832309(GNA11)

MYB:	102259944(GNA11)

MYD:	102771954(GNA11)

MMYO:

118658361(GNA11)

MLF:	102424028(GNA11)

MDT:	132235217(GNA11)

MYUM:

139010817(GNA11)

PKL:	118731318(GNA11)

EFUS:

103294255(GNA11)

MNA:	107544328(GNA11)

DRO:	112312418(GNA11)

SHON:

118984473(GNA11)

AJM:	119063760(GNA11)

PDIC:

114502886(GNA11)

PHAS:

123813822(GNA11)

MMF:	118615876(GNA11)

PPAM:

129074308(GNA11)

HAI:	109388624(GNA11)

RFQ:	117037515(GNA11)

PALE:

102888619(GNA11)

PGIG:

120583757(GNA11)

PVP:	105300436(GNA11)

RAY:	107520124(GNA11)

MJV:	108403596(GNA11)

TOD:	119240551(GNA11)

SARA:

101544809(GNA11)

SFUM:

130022142(GNA11)

SETR:

126030452(GNA11)

LAV:

100675896

TMU:

101345890

ETF:	101648105(GNA11)

MDO:	100009763(GNA11)

GAS:

123244152

SHR:	100920179(GNA11)

AFZ:

127545247

PCW:	110223412(GNA11)

TVP:	118848739(GNA11)

PBRV:

138174016(GNA11)

MLAO:

141501168(GNA11)

OAA:	100084804(GNA11) 114808753

TACU:

119919420(GNA11) 119946744

GGA:	374077(GNA11)

PCOC:

116236152

MGP:	100151748(GNA11)

CJO:	107325609(GNA11)

TPAI:

128090368(GNA11)

LMUT:

125685047

NMEL:

110388935

APLA:

101802177(GNA11)

AACU:

137844792(GNA11)

OJA:

118179114

ACYG:

106049557(GNA11)

CATA:

118260042(GNA11)

AFUL:

116498997(GNA11)

TGU:	100219505(GNA11)

LSR:	110475762(GNA11)

VMC:	128819250(GNA11)

VCHA:

128800526(GNA11)

AIB:	137463049(GNA11)

SCAN:

103821936

PMOA:

120498075(GNA11)

OTC:	121341550(GNA11)

PRUF:

121360852

ATRC:

139602113(GNA11)

MATE:

118696895(GNA11)

MAEN:

136567082(GNA11)

GFR:	102043661(GNA11)

FAB:	101818273(GNA11)

OMA:	130264470(GNA11)

PHI:	102102102(GNA11)

PMAJ:

107215591(GNA11)

CCAE:

111940370

CCW:	104697002(GNA11)

CBRC:

103622123

ACOE:

138099555(GNA11)

ETL:

114066350

ZAB:

102068726

ZLE:	135458744(GNA11)

ACHL:

103800863

SVG:	106857133(GNA11)

MMEA:

130580238(GNA11)

HRT:	120763365(GNA11)

SATI:

136371876(GNA11)

CFAI:

136302419(GNA11)

CCIC:

134054398(GNA11)

NNT:

104406567

SHAB:

115618049

POCC:

134166916(GNA11)

FPG:	101923890(GNA11)

FCH:

102051778

FRS:	119146601(GNA11)

CCRI:

104157544(GNA11)

ACUN:

113489339

ANOC:

141971113(GNA11)

SURA:

141935219

TALA:

104358520(GNA11)

ACHC:

115349102(GNA11)

HALD:

104323367(GNA11)

HLE:	104829070(GNA11)

AGEN:

126041819

HHAR:

128147957(GNA11)

BBUT:

142035547(GNA11)

GCL:

CSTI:

LDI:

MNB:

DPUB:

104300262(GNA11)

PPUS:

135191997(GNA11)

IIN:	128978338(GNA11)

AVIT:

104270213(GNA11)

BRHI:

104492235(GNA11)

EGZ:

104124382

NNI:	104016271(GNA11)

PCRI:

104025944(GNA11)

PCAO:

104044867(GNA11)

PARX:

142049234(GNA11)

PADL:

103923466(GNA11)

AFOR:

103899343

FGA:	104071101(GNA11)

CBOR:

142093889(GNA11)

GSTE:

104258204(GNA11)

CBOY:

140643428(GNA11)

MAME:

142420207(GNA11)

CLV:	102092243(GNA11)

CNIC:

135998962(GNA11)

MUI:	104542203(GNA11)

PGUU:

104465457(GNA11)

PLET:

104615213(GNA11)

EHS:	104507746(GNA11)

CMAC:

104483865

CUCA:

104064195(GNA11)

PCUR:

138731882(GNA11)

TEO:	104376190(GNA11)

BREG:

104633747

GAME:

129197434(GNA11)

OHA:	104335025(GNA11)

ACAR:

104518533

CPEA:

104397500(GNA11)

CVF:	104294373(GNA11)

RTD:	128900713(GNA11)

CRID:

134526176(GNA11)

LMIC:

141734107(GNA11)

NARQ:

141475428(GNA11)

AAM:	106486396(GNA11)

AROW:

112973885(GNA11)

NPD:

112946801

TGT:	104580087(GNA11)

DNE:

112988073

SCAM:

104151006(GNA11)

ASN:	102385893(GNA11)

AMJ:	102565314(GNA11)

CPOO:

109320468(GNA11)

GGN:	109294697(GNA11)

PSS:	102455465(GNA11)

CIZ:	142002082(GNA11)

CMY:	102945827(GNA11)

LKP:	140903378(GNA11)

NDS:	141977885(GNA11)

DCC:	119848260(GNA11)

CPIC:

101946431

TST:

117869019

EOB:	135894246(GNA11)

CABI:

116824631(GNA11)

MRV:	120391557(GNA11)

EMQ:	137160216(GNA11)

ACS:	100566521(gna11)

ASAO:

132781065(GNA11)

PVT:	110079229(GNA11)

SUND:

121936291

PBI:

103050016

PMUR:

107295332(GNA11)

CTIG:

120297072(GNA11)

TSR:

106556348

PGUT:

117668645(GNA11)

PCAE:

139317428(GNA11)

APRI:

131188349(GNA11)

PTEX:

113434991(GNA11)

NSS:

113426434

VKO:	123035340(GNA11)

PMUA:

114588282

PRAF:

128405531(GNA11)

ZVI:

118086473

HCG:	128344392(GNA11)

GJA:

107120591

STOW:

125433216(GNA11)

EMC:	129330695(GNA11)

XLA:	380535(gna11.S) 779103(gna11.L)

XTR:	394755(gna11)

NPR:	108791250(GNA11)

RTEM:

120909973 120935206

ACAT:

141103824

PADS:

140326282(GNA11)

BBUF:

120989414

BGAR:

122920385

DTC:	141050812(GNA11)

HSQ:	130268847(GNA11)

PCOB:

134903265

PWL:	138267964(GNA11)

MUO:

115479534

GSH:	117365265(GNA11)

DRE:	493613(gna11b)

DAES:

130213995(gna11b)

SRX:	107717982 107719558 107729972 107750923

SANH:

107667855 107676956 107696027 107699416

SGH:	107558284 107600186

CCAR:

109105347 109109034(gna11b) 109110238

CAUA:

113040036 113079298 113082387 113112706 113113987

CGIB:

127937615 127950782 127987912

PTET:

122327736(gna11a) 122335667(gna11b)

LROH:

127153994 127176505(gna11b)

GRF:	141339253 141344685(gna11b)

OMC:	131529876 131554152(gna11b)

PPRM:

120487915(gna11b) 120495270(gna11a)

RKG:	130071973(gna11a) 130105591(gna11b)

MAMB:

125249962(gna11b) 125263822(gna11a)

CIDE:

127520230 127522861

CERY:

137003897(gna11b)

MASI:

127439306 127440684 127443198

TROS:

130548375 130553984(gna11b)

TDW:	130418195(gna11b) 130429531

MANU:

129443147 129453546(gna11a) 141351010

PDAB:

135729303 135744324(gna11b)

IPU:	108271202 108280682(gna11b)

IFU:	128614279 128623927(gna11b)

PHYP:

113527868 113533313

SMEO:

124390834 124403004(gna11b)

TFD:	113645165(gna11b) 113657743

TVC:	132845898(gna11b) 132853215

CGAR:

128513066(gna11b) 128542703

NGRA:

132871747(gna11b) 132899520

TRN:	134302773(gna11b) 134331788

AMEX:

103033252(gna11b) 125782213

CMAO:

118796732(gna11b) 118818804

EEE:

113583372

CHAR:

105889474(gna11b)

SPIL:

134072252(gna11b)

ASAD:

121708911(gna11b)

TRU:

101064679

TFS:	130540421(gna11b)

TNG:	GSTEN00028786G001 GSTEN00031921G001

NCC:

104967393

CGOB:

115006572 115027534

PGEO:

117445871 117467600(gna11b)

GACU:

117540532(gna11b) 117550896

EMAC:

134882003(gna11b)

ELY:	117253564 117267243(gna11b)

EFO:	125900696(gna11b)

PLEP:

121938034 121953479(gna11b)

SLUC:

116055441 116057356(gna11b)

ECRA:

117935998(gna11b) 117951130

ESP:	116670588 116695435

PFLV:

114547460 114561099

GAT:	120823903 120833304(gna11b)

PPUG:

119216773 119227252(gna11b)

AFB:	129094874 129103986(gna11b)

CLUM:

117751460(gna11b)

PSWI:

130201190(gna11b)

CANA:

137794408 137803009

CVE:	137866451(gna11b) 137870218

MSAM:

119889655 119900765

EARM:

139287981 139297904

SPUL:

138591760(gna11b) 138607007

LMIX:

132959914 132993522(gna11b)

HTC:	141789689 141806860(gna11b)

ALAT:

119028320 119034345(gna11b)

ASTR:

PKLU:

LCO:

MZE:

ONL:	100709052 100710383

OAU:	116317322 116318011(gna11b)

OLA:	101158934 101161353

OML:	112143250(gna11b) 112150368

CSAI:

133458368 133462577(gna11b)

XMA:

102238377

XCO:

114133767

XHE:	116708893 116725378

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122838816 122846253(gna11b)

PPRL:

129371651

CVG:

107100829

CTUL:

119775695(gna11b) 119794270

GMU:	124855443(gna11b) 124873810

NFU:

107393186

KMR:	108230762 108235078(gna11b)

ALIM:

106521552 106528393

NWH:	119427143(gna11b) 119430669

LTU:	140269908 140311977

MCEP:

125009101 125023161

AOCE:

111564939 111567721(gna11b)

EJA:	138198767 138200134(gna11b)

BFRE:

138621147 138627925(gna11b)

LCF:	108874918(gna11b)

CSEM:

103379958

SSEN:

122780589 122782615

SSOE:

131444331 131465237

HHIP:

117755958(gna11b) 117760645

HSP:	118116483(gna11b) 118120798

PPLT:

SMAU:

SDU:

SLAL:

XGL:

HCQ:	109517351 109532023

SSCV:

125965761 125981040

PEE:	133406857 133413257

BPEC:

110160176

ENY:	140353999 140370828

MALB:

109952059 109964012

BSPL:

114848961(gna11b)

SJO:	128361278 128375275

SSCO:

133984855 134001393(gna11b)

TTY:

137187855

GMH:	115544135 115555099

SASA:

106574495 106575390 106584406 106613802

STRU:

115158280 115179716 115192595 115196175

OTW:	112235116 112250892 112266387

OMY:	110495735 110521465 110528895

OGO:	124007768 124010445

ONE:	115108339 115120284 115129805 115144916

OKI:	109879717 109890384 109897876

OKE:	118363868 118390019 127916701

OMM:	135512808 135542674 135543416 135556498

OCLA:

139373114 139406548 139409193 139412952

SALP:

111953718 111972124 111975535

SNH:	120033549 120051355 120052454 120054794

SFON:

129810678 129840361 129855136(gna11b) 129859739

CCLU:

121533502 121540335 121560172

ELS:	105011594 105019863

OEP:	134013127 134027092

SFM:

108919906

PKI:	111836597 111860249

AANG:

AROT:

LOC:

PSPA:

ARUT:

PSEX:

CPLA:

HOC:

PMRN:

SCLV:

RZE:

LSQ:	119612549 119614530

AFRA:

TCF:

HAME:

OOT:

VDE:

VJA:

PMEO:

PVUL:

BARL:

YBA:

RPHI:

CCLM:

Reference

PMID:1902575

Authors

Jiang M, Pandey S, Tran VT, Fong HK

Title

Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.

Journal

Proc Natl Acad Sci U S A 88:3907-11 (1991)
DOI:10.1073/pnas.88.9.3907

Sequence

[hsa:2767]

Reference

PMID:16183910

Authors

Wettschureck N, Offermanns S.

Title

Mammalian G proteins and their cell type specific functions.

Journal

Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

LinkDB

DBGET integrated database retrieval system