KEGG ORTHOLOGY: K04943

ORTHOLOGY: K04943

Entry

K04943                      KO

Symbol

KCNN2, KCA2.2

Name

potassium intermediate/small conductance calcium-activated channel subfamily N member 2

Pathway

map04726

Serotonergic synapse

map04911

Insulin secretion

map04929

GnRH secretion

map04976

Bile secretion

Disease

H00831

Primary dystonia

H02397

Neurodevelopmental disorder with movement abnormalities or hypotonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04943  KCNN2, KCA2.2; potassium intermediate/small conductance calcium-activated channel subfamily N member 2
   04929 GnRH secretion
    K04943  KCNN2, KCA2.2; potassium intermediate/small conductance calcium-activated channel subfamily N member 2
  09154 Digestive system
   04976 Bile secretion
    K04943  KCNN2, KCA2.2; potassium intermediate/small conductance calcium-activated channel subfamily N member 2
  09156 Nervous system
   04726 Serotonergic synapse
    K04943  KCNN2, KCA2.2; potassium intermediate/small conductance calcium-activated channel subfamily N member 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04943  KCNN2, KCA2.2; potassium intermediate/small conductance calcium-activated channel subfamily N member 2
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   K04943  KCNN2, KCA2.2; potassium intermediate/small conductance calcium-activated channel subfamily N member 2

Other DBs

GO:

0016286

TC:	1.A.1.16.1 1.A.1.16.5

Genes

HSA:	3781(KCNN2)

GGO:	101143462(KCNN2)

PPYG:

129037232(KCNN2)

NLE:	100589687(KCNN2)

HMH:	116470927(KCNN2)

SSYN:

129492939(KCNN2)

MCC:	695374(KCNN2)

MTHB:

126956223

MNI:	105499979(KCNN2)

CSAB:

103244350(KCNN2)

CATY:

105590682(KCNN2)

TGE:	112626284(KCNN2)

MLEU:

105532893(KCNN2)

RRO:	104672367(KCNN2)

RBB:	108544087(KCNN2)

TFN:	117066009(KCNN2)

PTEH:

111527783(KCNN2)

CANG:

105527355(KCNN2)

CJC:	100413033(KCNN2)

SBQ:	101052280(KCNN2)

CIMI:

108315528(KCNN2)

ANAN:

105729384(KCNN2)

CSYR:

103269198(KCNN2)

MMUR:

105870846(KCNN2)

LCAT:

123648299(KCNN2)

ERUF:

138398408(KCNN2)

PCOQ:

105822561(KCNN2)

OGA:	100947450(KCNN2)

MMU:	140492(Kcnn2)

MCAL:

110284513(Kcnn2)

MPAH:

110332888(Kcnn2)

RNO:	54262(Kcnn2)

MCOC:

116087124(Kcnn2)

ANU:	117719969(Kcnn2)

ASYL:

127663645

MUN:	110540397(Kcnn2)

CGE:

100761590

MAUA:

101835309(Kcnn2)

PROB:

127234062(Kcnn2)

PLEU:

114710065(Kcnn2)

PMAV:

102919374(Kcnn2)

MORG:

121445762 121453374(Kcnn2)

MFOT:

126505982

AAMP:

119814055(Kcnn2)

CNL:	130886647(Kcnn2)

NGI:	103727441(Kcnn2)

HGL:	101725711(Kcnn2)

CPOC:

100734732(Kcnn2)

CCAN:

109687969(Kcnn2)

DORD:

105985459(Kcnn2)

DSP:	122101981(Kcnn2)

PLOP:

125342084(Kcnn2)

NCAR:

124974405 124975662 124987171

ITI:	101964369(Kcnn2)

OCU:

100342605

OPI:	101527560(KCNN2)

OCZ:	121154197(KCNN2)

TUP:	102485167(KCNN2)

GVR:

103601927

CFA:	474640(KCNN2)

CLUD:

112659635(KCNN2)

VVP:	112932427(KCNN2)

VLG:	121494966(KCNN2)

NPO:	129495296(KCNN2)

AML:	100476146(KCNN2)

UMR:	103679964(KCNN2)

UAH:	113261595(KCNN2)

UAR:	123790456(KCNN2)

ELK:

111158908

LLV:

125100516

MPUF:

101693473(KCNN2)

MNP:	132027392(KCNN2)

MLK:	131832612(KCNN2)

NVS:	122916068(KCNN2)

ORO:	101374769(KCNN2)

EJU:	114200734(KCNN2)

ZCA:	113929116(KCNN2)

MLX:	118016531(KCNN2)

NSU:	110591043(KCNN2)

LWW:	102727764(KCNN2)

FCA:	101099926(KCNN2)

PYU:	121010546(KCNN2)

PCOO:

112860966(KCNN2)

PBG:	122486509(KCNN2)

PVIV:

125167284(KCNN2)

LRUF:

124521591

LGF:	123601986(KCNN2)

AJU:

106970052

PTG:	102956767(KCNN2)

PPAD:

109278931(KCNN2)

PUC:

125935122

PLEZ:

122200084(KCNN2)

HHV:	120246976(KCNN2)

BTA:	404177(KCNN2)

BOM:	102270681(KCNN2)

BIU:	109564611(KCNN2)

BBUB:

102390288(KCNN2)

BKE:	129620800(KCNN2)

BBIS:

104989318

CHX:	102185838(KCNN2)

OAS:	101105660(KCNN2)

BTAX:

128054239(KCNN2)

CSUM:

138073676(KCNN2)

ODA:	120852643 120860996

CCAD:

122442950(KCNN2)

MREE:

136171843(KCNN2)

OVR:	110122315(KCNN2)

MBEZ:

129562943(KCNN2)

SSC:	100519705(KCNN2)

CFR:	102504426(KCNN2)

CBAI:

105082037

CDK:	105095376(KCNN2)

VPC:	102530274(KCNN2)

BACU:

103003546(KCNN2)

BMUS:

118893438(KCNN2)

LVE:	103085041(KCNN2)

OOR:	101277663(KCNN2)

LALB:

132516998(KCNN2)

GMF:	115860240(KCNN2)

DDP:	132423362(KCNN2)

DLE:	111183549(KCNN2)

PCAD:

102974029(KCNN2)

PSIU:

116751365(KCNN2)

PPHC:

136120003(KCNN2)

NASI:

112398677(KCNN2)

ECB:	100064342(KCNN2)

EPZ:	103546976(KCNN2)

EAI:	106832185(KCNN2)

MYB:	102242910(KCNN2)

MYD:	102760784(KCNN2)

MMYO:

118656781(KCNN2)

MLF:	102435562(KCNN2)

MDT:	132233348(KCNN2)

MYUM:

139008817(KCNN2)

PKL:	118703293(KCNN2)

EFUS:

103288714(KCNN2)

MNA:	107546518(KCNN2)

DRO:	112307200(KCNN2)

SHON:

118977287(KCNN2)

AJM:	119065112(KCNN2)

PDIC:

114507800(KCNN2)

PHAS:

123818139(KCNN2)

MMF:	118641908(KCNN2)

PPAM:

129083902(KCNN2)

HAI:	109376519(KCNN2)

RFQ:	117025279(KCNN2)

PALE:

102881903(KCNN2)

PGIG:

120590832(KCNN2)

PVP:	105308549(KCNN2)

RAY:	107512127(KCNN2)

MJV:	108392736(KCNN2)

TOD:	119243580(KCNN2)

SARA:

101554587(KCNN2)

SFUM:

130026046(KCNN2)

SETR:

126027843(KCNN2)

LAV:

100663280

TMU:

101360667

ETF:	101658994(KCNN2)

DNM:	101431308(KCNN2)

MDO:	100016183(KCNN2)

GAS:	123231350(KCNN2)

SHR:	100931280(KCNN2)

AFZ:

127560128

PCW:	110223768(KCNN2)

TVP:	118835698(KCNN2)

PBRV:

138161356(KCNN2)

MLAO:

141502769(KCNN2)

OAA:	100074996(KCNN2)

TACU:

119948155(KCNN2)

GGA:	395579(KCNN2)

PCOC:

116236215(KCNN2)

MGP:	100546930(KCNN2)

CJO:	107306691(KCNN2)

TPAI:

128089742(KCNN2)

LMUT:

125687197(KCNN2)

NMEL:

110389660(KCNN2)

APLA:

101802567(KCNN2)

AACU:

137847812(KCNN2)

ACYG:

106046537(KCNN2)

CATA:

118255965(KCNN2)

AFUL:

116500425(KCNN2)

TGU:	100230275(KCNN2)

LSR:	110467739(KCNN2)

SCAN:

103821477(KCNN2)

PMOA:

120513562(KCNN2)

OTC:	121332723(KCNN2)

PRUF:

121362573(KCNN2)

ATRC:

139588745(KCNN2)

GFR:	102043417(KCNN2)

FAB:	101806088(KCNN2)

OMA:	130265373(KCNN2)

PHI:	102106253(KCNN2)

PMAJ:

107198221(KCNN2)

CCAE:

111941213(KCNN2)

CCW:	104690508(KCNN2)

CBRC:

103611638(KCNN2) 103612944

ACOE:

138102919 138103378(KCNN2)

ETL:	114069549(KCNN2) 114070112 114072709

ZAB:	102066333(KCNN2)

ZLE:	135459792(KCNN2)

SVG:	106852002(KCNN2)

MMEA:

130583399(KCNN2)

HRT:	120765303(KCNN2)

SATI:

136374611(KCNN2)

CFAI:

136288366(KCNN2)

CCIC:

134056422(KCNN2)

FPG:	101916724(KCNN2)

FCH:	102052215(KCNN2)

SHAB:

115600580(KCNN2) 115619017 115619018

ACUN:

113489746(KCNN2)

SURA:

141937910(KCNN2)

TALA:

104364312(KCNN2)

ACHC:

115336828(KCNN2) 121232920 121232921

HLE:	104832319(KCNN2)

AGEN:

126035855 126037380

HHAR:

128136074 128136077 128137091(KCNN2)

BBUT:

142027392(KCNN2)

GCL:	127027537 127027895

CSTI:

104556892

LDI:

104351447

DPUB:

104308093(KCNN2)

PPUS:

135193100(KCNN2)

EGZ:	104124254(KCNN2)

NNI:	104016335(KCNN2)

PCRI:

104036467

PARX:

142050333(KCNN2)

PADL:

103914456(KCNN2)

CBOR:

142074657 142074689 142075408(KCNN2)

CBOY:

140650599(KCNN2) 140651515 140651517

MAME:

142402619(KCNN2) 142403051 142403053

CLV:	102098776(KCNN2)

CNIC:

136002517(KCNN2)

EHS:

104505840

CMAC:

104480968

CUCA:

104056285(KCNN2) 128850216

TEO:

104378941

GAME:

129199784(KCNN2)

OHA:	104327304(KCNN2)

CPEA:

104394006

CVF:	104294223(KCNN2)

RTD:	128902272(KCNN2)

CRID:

134508956(KCNN2)

LMIC:

141735999(KCNN2)

NARQ:

141476975(KCNN2)

AROW:

112963128(KCNN2)

NPD:	112958895(KCNN2)

TGT:	104571555(KCNN2)

DNE:	112985811(KCNN2)

SCAM:

104150984(KCNN2)

ASN:	102379931(KCNN2)

AMJ:	102575299(KCNN2)

CPOO:

109307706(KCNN2)

GGN:	109298056(KCNN2)

PSS:	102452777(KCNN2)

CIZ:	142013605(KCNN2)

CMY:	102946385(KCNN2)

CCAY:

125637007(KCNN2)

LKP:	140911511(KCNN2)

NDS:	141987544(KCNN2)

DCC:	119856147(KCNN2)

CPIC:

101947976(KCNN2)

TST:	117879506(KCNN2)

CABI:

116829160

MRV:	120408048(KCNN2)

ACS:	100555736(kcnn2)

ASAO:

132767211(KCNN2)

PVT:	110072039(KCNN2)

SUND:

121924181(KCNN2)

PBI:	103051373(KCNN3) 103056598(KCNN2)

PMUR:

107296867(KCNN2)

CTIG:

120317732(KCNN2)

TSR:

106545479

PGUT:

117674652(KCNN2)

PCAE:

139311315(KCNN2)

APRI:

131189804(KCNN2)

PTEX:

113449087(KCNN2)

NSS:	113414475(KCNN2)

VKO:	123031412(KCNN2)

PMUA:

114606388(KCNN2)

PRAF:

128423471(KCNN2)

ZVI:	118076932(KCNN2)

HCG:	128344084(KCNN2)

GJA:

107115580

STOW:

125436195(KCNN2)

EMC:	129334277(KCNN2)

XLA:	100861589(kcnn2.S) 108717345(kcnn2.L)

XTR:	100145581(kcnn2)

NPR:	108789757(KCNN2)

RTEM:

120931810(KCNN2)

ACAT:

141138048(KCNN2)

PADS:

140334012(KCNN2)

BBUF:

120992581(KCNN2)

BGAR:

122935408(KCNN2)

DTC:	141055530(KCNN2)

HSQ:	130288637(KCNN2)

PWL:	138286350(KCNN2)

MUO:	115462314(KCNN2)

GSH:	117352574(KCNN2)

DRE:	564698(kcnn2)

SRX:	107713286 107744127 107744128

SANH:

107686472 107687918

SGH:	107555526 107567448

CCAR:

109097240 109097428

CAUA:

113054122 113059733 113074626 113076112 113109699

CGIB:

127965943 128021346

PTET:

122352990(kcnn2)

LROH:

127172501(kcnn2)

GRF:	141299244(kcnn2)

OMC:	131548095(kcnn2)

PPRM:

120482662(kcnn2)

RKG:	130087084(kcnn2)

MAMB:

125256893(kcnn2)

CIDE:

127521653

CERY:

137029751(kcnn2)

MASI:

127432749 127434012

TROS:

130546516(kcnn2)

TDW:	130411539(kcnn2)

MANU:

129447173(kcnn2)

PDAB:

135779662(kcnn2)

IPU:	108276576(kcnn2)

IFU:	128620363(kcnn2)

PHYP:

113543953

SMEO:

124393097(kcnn2)

TFD:	113661355(kcnn2)

TVC:	132863101(kcnn2)

CGAR:

128505474(kcnn2)

NGRA:

132873580(kcnn2)

TRN:	134332864(kcnn2)

AMEX:

103042004(kcnn2)

CMAO:

118824638(kcnn2)

EEE:

113575107

CHAR:

105888958(kcnn2)

SPIL:

134100988(kcnn2) 134102731(kcnn1b)

ASAD:

121680351(kcnn2)

TRU:	101066337(kcnn2)

TFS:	130516898(kcnn2)

TNG:	GSTEN00017335G001

LCO:	104923390(kcnn2)

NCC:	104961025(kcnn2)

TBEN:

117476733(kcnn2)

CGOB:

115016656(kcnn2)

PGEO:

117455820(kcnn2)

GACU:

117539242(kcnn2)

EMAC:

134868091(kcnn2)

ELY:	117269674(kcnn2)

EFO:	125878567(kcnn2)

PLEP:

121959983(kcnn2)

SLUC:

116035147(kcnn2)

ECRA:

117959304(kcnn2)

ESP:

116704471

PFLV:

114571435

GAT:	120832237(kcnn2)

PPUG:

119226516(kcnn2)

AFB:	129102522(kcnn2)

CLUM:

117740573(kcnn2)

PSWI:

130205617(kcnn2)

CANA:

137784166(kcnn2)

CVE:	137868821(kcnn2)

MSAM:

119915147(kcnn2)

SCHU:

122866054(kcnn2)

EARM:

139301258(kcnn2)

CUD:	121525497(kcnn2)

SPUL:

138601840(kcnn2)

LMIX:

132992343(kcnn2)

HTC:	141805606(kcnn2)

ALAT:

119030302(kcnn2)

ASTR:

137608675(kcnn2)

PKLU:

139218947(kcnn2)

MZE:

101487107

ONL:

100705317

OAU:	116322535 120441247(kcnn2)

OLA:

101174204

OML:	112163420(kcnn2)

CSAI:

133454670(kcnn2)

XMA:	102224881(kcnn2)

XCO:	114150202(kcnn2)

XHE:

116725011

PRET:

103473677(kcnn2)

PFOR:

103148368(kcnn2)

PLAI:

106958401

PMEI:

106927954

GAF:	122846901(kcnn2)

PPRL:

129366623(kcnn2)

CVG:	107092668(kcnn2)

CTUL:

119771603(kcnn2)

GMU:	124873116(kcnn2)

NFU:	107372790(kcnn2)

KMR:	108232541(kcnn2)

ALIM:

106514520(kcnn2)

NWH:	119424545(kcnn2)

AOCE:

111568359(kcnn2)

EJA:	138207067(kcnn2)

BFRE:

138623369(kcnn2)

MCEP:

124997084(kcnn2)

CSEM:

103389126(kcnn2)

POV:

109625918

SSEN:

122781860(kcnn2)

SSOE:

131446591(kcnn2)

HHIP:

117771575(kcnn2)

HSP:	118125381(kcnn2)

PPLT:

128424965(kcnn2)

SMAU:

118285271(kcnn2)

LCF:

108879302

SDU:

111234228

SLAL:

111668098

XGL:	120806436(kcnn2)

HCQ:

109517054

SSCV:

125980055(kcnn2)

SBIA:

133491102(kcnn2)

PEE:	133413849(kcnn2)

PTAO:

133464994(kcnn2)

BPEC:

110174209

ENY:	140368378(kcnn2)

MALB:

109963429

BSPL:

114866787(kcnn2)

SJO:	128380235(kcnn2)

SSCO:

133995723(kcnn2)

TTY:	137171140(kcnn2)

GMH:

115541693

SASA:

106563202 106564970

STRU:

115159456 115204174

OTW:	112219399(kcnn2) 112231081

OMY:	100135971 110509890

OGO:	124007245 124048858

ONE:	115101251 115124140

OKI:	109868132 109873802

OKE:	118385209 118387624(kcnn2)

OMM:	135517890 135544381

OCLA:

139387936 139408706

SALP:

111961518 111964104

SNH:	120021303 120026373(kcnn2)

SFON:

129818554(kcnn2) 129864042

CCLU:

121541756 121582411

ELS:	105014982(kcnn2)

OEP:	134034209(kcnn2)

SFM:

108933664

PKI:

111849923

AANG:

118212234(kcnn2)

AROT:

135239558(kcnn2)

CCOG:

133142318(kcnn2)

LOC:	102699124(kcnn2)

PSPA:

121302819 121315157

ARUT:

117406716 117973660

PSEX:

120532678(kcnn2)

LCM:

102364416

CMK:

103181140

CPLA:

122560288

CPUN:

140485628(kcnn2)

HOC:

132827770

SCAU:

119953337 119970451(kcnn2)

STOZ:

140429452

LERI:

129695829

HAKA:

140739953

PMRN:

116940030 116953540(KCNN1) 116954943

LRJ:	133345534 133350704 133359075

BFO:

BBEL:

CIN:

SCLV:

CLEP:

LPIC:

LVG:

APLC:

ARUN:

AAMU:

AFIL:

PFLL:

PPYR:

RSAN:

TUT:

UDV:	129219212 129222074

LPOL:

106458375

LGI:	LOTGIDRAFT_94219

PVUL:

126814594 126814598 126818092

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105328596 105344664

CANU:

128188734

CVN:	111108178 111133635

OED:	125666235 125683433 130046304

MYI:

110443725

DPOL:

127845380 127872478

OSN:	115216392 115220952

LJP:

LLON:

EPA:

PDAM:

SPIS:

Reference

PMID:22794265

Authors

Ohtsuki G, Piochon C, Adelman JP, Hansel C

Title

SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells.

Journal

Neuron 75:108-20 (2012)
DOI:10.1016/j.neuron.2012.05.025

Sequence

[mmu:140492]

Reference

PMID:10991935

Authors

Desai R, Peretz A, Idelson H, Lazarovici P, Attali B

Title

Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization.

Journal

J Biol Chem 275:39954-63 (2000)
DOI:10.1074/jbc.M001562200

Sequence

[hsa:3781]

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