ORTHOLOGY: K06856
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Entry
K06856 KO
Symbol
IGH
Name
immunoglobulin heavy chain
Pathway
map04020
Calcium signaling pathway
map04064
NF-kappa B signaling pathway
map04072
Phospholipase D signaling pathway
map04145
Phagosome
map04151
PI3K-Akt signaling pathway
map04613
Neutrophil extracellular trap formation
map04640
Hematopoietic cell lineage
map04650
Natural killer cell mediated cytotoxicity
map04662
B cell receptor signaling pathway
map04664
Fc epsilon RI signaling pathway
map04666
Fc gamma R-mediated phagocytosis
map04672
Intestinal immune network for IgA production
map05130
Pathogenic Escherichia coli infection
map05135
Yersinia infection
map05140
Leishmaniasis
map05143
African trypanosomiasis
map05146
Amoebiasis
map05150
Staphylococcus aureus infection
map05152
Tuberculosis
map05169
Epstein-Barr virus infection
map05171
Coronavirus disease - COVID-19
map05202
Transcriptional misregulation in cancer
map05310
Asthma
map05320
Autoimmune thyroid disease
map05322
Systemic lupus erythematosus
map05323
Rheumatoid arthritis
map05330
Allograft rejection
map05340
Primary immunodeficiency
map05414
Dilated cardiomyopathy
map05416
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
K06856 IGH; immunoglobulin heavy chain
04020 Calcium signaling pathway
K06856 IGH; immunoglobulin heavy chain
04072 Phospholipase D signaling pathway
K06856 IGH; immunoglobulin heavy chain
04151 PI3K-Akt signaling pathway
K06856 IGH; immunoglobulin heavy chain
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
K06856 IGH; immunoglobulin heavy chain
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
K06856 IGH; immunoglobulin heavy chain
04613 Neutrophil extracellular trap formation
K06856 IGH; immunoglobulin heavy chain
04650 Natural killer cell mediated cytotoxicity
K06856 IGH; immunoglobulin heavy chain
04662 B cell receptor signaling pathway
K06856 IGH; immunoglobulin heavy chain
04664 Fc epsilon RI signaling pathway
K06856 IGH; immunoglobulin heavy chain
04666 Fc gamma R-mediated phagocytosis
K06856 IGH; immunoglobulin heavy chain
04672 Intestinal immune network for IgA production
K06856 IGH; immunoglobulin heavy chain
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
K06856 IGH; immunoglobulin heavy chain
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
K06856 IGH; immunoglobulin heavy chain
05169 Epstein-Barr virus infection
K06856 IGH; immunoglobulin heavy chain
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
K06856 IGH; immunoglobulin heavy chain
05135 Yersinia infection
K06856 IGH; immunoglobulin heavy chain
05150 Staphylococcus aureus infection
K06856 IGH; immunoglobulin heavy chain
05152 Tuberculosis
K06856 IGH; immunoglobulin heavy chain
09174 Infectious disease: parasitic
05146 Amoebiasis
K06856 IGH; immunoglobulin heavy chain
05140 Leishmaniasis
K06856 IGH; immunoglobulin heavy chain
05143 African trypanosomiasis
K06856 IGH; immunoglobulin heavy chain
09163 Immune disease
05310 Asthma
K06856 IGH; immunoglobulin heavy chain
05322 Systemic lupus erythematosus
K06856 IGH; immunoglobulin heavy chain
05323 Rheumatoid arthritis
K06856 IGH; immunoglobulin heavy chain
05320 Autoimmune thyroid disease
K06856 IGH; immunoglobulin heavy chain
05330 Allograft rejection
K06856 IGH; immunoglobulin heavy chain
05340 Primary immunodeficiency
K06856 IGH; immunoglobulin heavy chain
09166 Cardiovascular disease
05414 Dilated cardiomyopathy
K06856 IGH; immunoglobulin heavy chain
05416 Viral myocarditis
K06856 IGH; immunoglobulin heavy chain
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K06856 IGH; immunoglobulin heavy chain
Membrane trafficking [BR:
ko04131
]
Endocytosis
Phagocytosis
Opsonins
K06856 IGH; immunoglobulin heavy chain
BRITE hierarchy
Genes
HSA:
102723407
(IGH)
PTR:
100608894
104002200
104002202
PPS:
117975722
GGO:
101133851
109023156
115930553
115930559
PON:
100431520
100939054
100939231
100939294
NLE:
100592223
MCC:
106996003
106999628
114675805
114679736
714419
720452
720904
720935
720985
721002
721083
722278
MCF:
102122532
102124047
107130290
123574606
CSAB:
103224088
103229820
103229828
103229838
103229839
103229845
103229849
103229850
103229864
103229935
103229939
103229942
103229943
103247608
CATY:
105574042
105574050
105574052
105574060
105574071
105574077
105574081
105574082
105574084
105575920
105575923
105575925
105576625
105576626
105577130
105577139
105577141
105577142
105577143
105577144
105577151
105594283
PANU:
101004461
RRO:
104664696
104674294
104677074
RBB:
108511997
108512001
108519975
108519976
108519983
108519992
108520828
108522153
108524775
TFN:
117069568
117069583
117069585
117069725
117069765
117084140
CJC:
100386440
100388240
103793556
SBQ:
101033685
101040997
101041646
101054381
MMUR:
105862892
105883149
CGE:
113831730
113831736
113838236
NGI:
103726091
103751925
HGL:
101696611
101722770
CCAN:
109677916
OCU:
100009097
(IGGC)
100351810
100352996
(IGHM)
100353328
100353656
103345968
103345969
103345989
(IGH)
103346899
103347021
103347112
103347220
(IGHM)
TUP:
102473679
102498935
106733485
VVP:
112912798
UAH:
113267145
ORO:
101370467
PBG:
122469619
BTA:
100300716
100300806
104968484
524810
BOM:
102268126
102283173
BBUB:
112582609
112582881
OAS:
101113211
SSC:
100038328
396781
CDK:
105102978
116151844
116153639
BACU:
103002153
103002419
103003240
103004077
LVE:
103075075
103075361
OOR:
101270770
101287043
ECB:
100146643
EPZ:
103562621
103562625
EAI:
106827306
MYB:
102251188
102253571
106724953
106725385
106725568
106726103
106726515
106726783
MYD:
102754308
107181583
107182802
RFQ:
117024085
PALE:
102892050
RAY:
107507577
SARA:
101546778
101553484
101557492
LAV:
104847364
TMU:
111820845
DNM:
101423469
MDO:
100015122
100015252
100015424
100015499
100015641
103098203
SHR:
100918091
100925503
100935579
PCW:
110214297
110214304
OAA:
100076770
103166088
103166634
103169821
GGA:
101750160
CJO:
107324947
NMEL:
110391159
110391511
110392057
APLA:
101791674
101804340
ACYG:
106029527
106043396
106045966
106049912
106049915
AFUL:
116493723
TGU:
115490733
116807070
LSR:
110481636
110481639
SCAN:
103824581
103825246
PMOA:
120512175
GFR:
102042769
FAB:
101807300
101808393
PHI:
102099602
102099978
102107391
CCAE:
111943573
111945990
ETL:
114056381
114073587
FCH:
114015671
CLV:
102088834
102091146
110365047
EGZ:
104127473
104130344
ACUN:
113485949
PADL:
103925773
ASN:
102370271
AMJ:
109283745
109285747
PSS:
102462069
106731800
112545842
112545843
112547828
CMY:
102948108
CPIC:
103306831
TST:
117885463
117885490
MRV:
120380730
120380736
120380831
120380857
ACS:
100553338
103280740
PVT:
110070582
110071048
PBI:
103051937
PMUR:
107295545
107296524
107296529
107299668
107300454
TSR:
106542010
106547028
106547029
106548383
106550511
106550514
106553678
106553680
106555890
PGUT:
117656916
VKO:
123020118
PMUA:
114583543
114589776
GJA:
107116422
XLA:
101027262
108695616
XTR:
100135349
101734149
548369
RTEM:
120940874
DRE:
100535958
(ighv4-5)
SRX:
107710248
CCAR:
109113479
109113498
CAUA:
113072693
PHYP:
113546930
AMEX:
111190154
111190155
111190159
TRU:
101067887
101075124
105416433
TNG:
GSTEN00006728G001
GSTEN00009859G001
PFLV:
114551742
PPUG:
119219964
119219978
119220538
MSAM:
119887406
MZE:
101465001
101470821
111500991
ONL:
100700235
102076453
106096470
OLA:
101175656
105354605
XMA:
111611614
XCO:
114159462
PRET:
103468640
103468641
PMEI:
106912570
GAF:
122822394
CVG:
107103927
CTUL:
119772640
119781709
NFU:
107376166
KMR:
108236236
112450705
ALIM:
106516944
106526304
AOCE:
111585549
111585983
111586137
111587120
LCF:
108879259
SDU:
111229939
111229958
SNH:
120033925
120034032
ELS:
105008121
105009319
SFM:
108930865
114910223
PKI:
111837245
111842004
111842377
AANG:
118220452
LOC:
107080089
LCM:
102348584
102354443
102356544
RTP:
109921871
» show all
Taxonomy
UniProt
Reference
PMID:
17560275
Authors
Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW
Title
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
Journal
Adv Immunol 94:157-214 (2007)
DOI:
10.1016/S0065-2776(06)94006-1
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