KEGG   ORTHOLOGY: K06856
Entry
K06856                      KO                                     
Symbol
IGH
Name
immunoglobulin heavy chain
Pathway
map04020  Calcium signaling pathway
map04064  NF-kappa B signaling pathway
map04072  Phospholipase D signaling pathway
map04145  Phagosome
map04151  PI3K-Akt signaling pathway
map04613  Neutrophil extracellular trap formation
map04640  Hematopoietic cell lineage
map04650  Natural killer cell mediated cytotoxicity
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04672  Intestinal immune network for IgA production
map05130  Pathogenic Escherichia coli infection
map05135  Yersinia infection
map05140  Leishmaniasis
map05143  African trypanosomiasis
map05146  Amoebiasis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05202  Transcriptional misregulation in cancer
map05310  Asthma
map05320  Autoimmune thyroid disease
map05322  Systemic lupus erythematosus
map05323  Rheumatoid arthritis
map05330  Allograft rejection
map05340  Primary immunodeficiency
map05414  Dilated cardiomyopathy
map05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04020 Calcium signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04072 Phospholipase D signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04151 PI3K-Akt signaling pathway
    K06856  IGH; immunoglobulin heavy chain
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06856  IGH; immunoglobulin heavy chain
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06856  IGH; immunoglobulin heavy chain
   04613 Neutrophil extracellular trap formation
    K06856  IGH; immunoglobulin heavy chain
   04650 Natural killer cell mediated cytotoxicity
    K06856  IGH; immunoglobulin heavy chain
   04662 B cell receptor signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04664 Fc epsilon RI signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04666 Fc gamma R-mediated phagocytosis
    K06856  IGH; immunoglobulin heavy chain
   04672 Intestinal immune network for IgA production
    K06856  IGH; immunoglobulin heavy chain
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06856  IGH; immunoglobulin heavy chain
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K06856  IGH; immunoglobulin heavy chain
   05169 Epstein-Barr virus infection
    K06856  IGH; immunoglobulin heavy chain
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K06856  IGH; immunoglobulin heavy chain
   05135 Yersinia infection
    K06856  IGH; immunoglobulin heavy chain
   05150 Staphylococcus aureus infection
    K06856  IGH; immunoglobulin heavy chain
   05152 Tuberculosis
    K06856  IGH; immunoglobulin heavy chain
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K06856  IGH; immunoglobulin heavy chain
   05140 Leishmaniasis
    K06856  IGH; immunoglobulin heavy chain
   05143 African trypanosomiasis
    K06856  IGH; immunoglobulin heavy chain
  09163 Immune disease
   05310 Asthma
    K06856  IGH; immunoglobulin heavy chain
   05322 Systemic lupus erythematosus
    K06856  IGH; immunoglobulin heavy chain
   05323 Rheumatoid arthritis
    K06856  IGH; immunoglobulin heavy chain
   05320 Autoimmune thyroid disease
    K06856  IGH; immunoglobulin heavy chain
   05330 Allograft rejection
    K06856  IGH; immunoglobulin heavy chain
   05340 Primary immunodeficiency
    K06856  IGH; immunoglobulin heavy chain
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K06856  IGH; immunoglobulin heavy chain
   05416 Viral myocarditis
    K06856  IGH; immunoglobulin heavy chain
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06856  IGH; immunoglobulin heavy chain
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Opsonins
    K06856  IGH; immunoglobulin heavy chain
Genes
HSA: 102723407(IGH)
GGO: 101133851 109023154 115930559
PON: 100939054 100939231
NLE: 100592223
MCC: 106996003 106999628 114675805 114679736 714419 720452 720904 720935 720985 721002 721083 722278
MCF: 102122532 107128638 107130290 123574606 135971582
MNI: 105489886
CSAB: 103224088 103229820 103229828 103229838 103229839 103229845 103229849 103229850 103229864 103229935 103229939 103229942 103229943 103247608
CATY: 105574042 105574050 105574052 105574060 105574071 105574077 105574081 105574082 105574084 105575920 105575923 105575925 105576625 105576626 105577130 105577139 105577141 105577142 105577143 105577144 105577151 105594283
PANU: 101004461
MLEU: 105532929 105532934 105535254 105535256 105536925 105537275 105537413 105538227 105548664
RRO: 104664696 104674294 104677074
RBB: 108511997 108512001 108519975 108519976 108519983 108519992 108520828 108522153 108524775
TFN: 117069568 117069583 117069585 117069725 117069765 117084140
CANG: 105509184 105525086 105525098 105525110 105525116
CJC: 103793556
SBQ: 101033685 101040997 101041646 101054381
MMUR: 105862892 105883149
LCAT: 123643379 123643441 123643449 123643456 123643464
PCOQ: 105822769 105825941
CGE: 113831730 113831736 113838236
MORG: 121438466
NGI: 103726091 103751925
HGL: 101696611 101722770
CCAN: 109677916
NCAR: 124974743
OCU: 100009097 100352996 100353328 103347220
TUP: 102473679 102498935 106733485
GVR: 103583500 103606671 103607357 103609769
CFA: 111097183
CLUD: 125755517
VVP: 112912798
MNP: 131999471 131999488
ORO: 101370467
PBG: 122469619
PVIV: 125168154 125168156
BTA: 100300716 100300806 104968484 524810
BBUB: 112582609 112582664
OAS: 101113211
SSC: 100038328 396781
CDK: 105102978 116151844 116153639
VPC: 102533497 102538064 116278391
BACU: 103002153 103002419 103003240 103004077
BMUS: 118905421
LVE: 103075075 103075361
ECB: 100146643
EPZ: 103562621 103562625
EAI: 106827306
MYB: 102251188 102253571 106724953 106725385 106725568 106726103 106726515 106726783
MYD: 102754308 107181583 107182802
MDT: 132225700
EFUS: 129148251
PPAM: 129064951
RFQ: 117024085
PALE: 102892050
RAY: 107507577
SARA: 101546778 101553484 101557492
SETR: 126015875
LAV: 104847364
TMU: 111820845
DNM: 101423469
MDO: 100015122 100015252 100015424 100015499 100015641 103098203
SHR: 100918091 100925503 100935579
PCW: 110214297 110214304
PBRV: 138156917
OAA: 103166634
GGA: 101750160
NMEL: 110391511
APLA: 101791674 119712955
ACYG: 106043396
CATA: 118251967
AFUL: 116493723
TGU: 116807070
LSR: 110481636 110481639
SCAN: 103825246
PMOA: 120512175
FAB: 101807300 101808393
OMA: 130263285
PHI: 102099602 102099978 102107391
CCAE: 111943573 111945990
ETL: 114056381 114073587
ACUN: 113485949
EGZ: 104127473 104130344
PCAO: 104049738
PADL: 103925773
CLV: 102088834 102091146
MUI: 104539979
PLET: 104627864
CMAC: 104481964
BREG: 104640155
CPEA: 104394762
ASN: 102370271
AMJ: 109283745 109285747
PSS: 102462069 112545842 112545843 112547828
CCAY: 125629493 125629520
CPIC: 103306831
TST: 117885463 117885490
MRV: 120380730 120380800 120380831 120380857
ACS: 100553338 103280740
ASAO: 132779199
PVT: 110071048
PBI: 103051937
PMUR: 107295545 107296524 107296529 107299668 107300454
CTIG: 120300339 120300372 120300425 120300484 120302124 120303619 120303624 120303627
TSR: 106542010 106547028 106547029 106548383 106550511 106550514 106553678 106553680 106555890
APRI: 131197116 131197844 131197859
PMUA: 114583543 114589776
PRAF: 128399161 128399227
HCG: 128329564
GJA: 107116422
STOW: 125444351
EMC: 129339922
XLA: 101027262
XTR: 100135349 101734149 548369
SRX: 107710248
CCAR: 109113479 109113498
CAUA: 113072693
LROH: 127157711
CERY: 137004602(ighv4-2)
IPU: 108275153
IFU: 128616901 128616964
PHYP: 113546930
TFD: 113640836 113645932 125138849
TVC: 132861629 132861639
TRN: 134300380
AMEX: 111190157 125784505 125784512
CMAO: 118801283 118802799
CHAR: 122129008 122132339
TRU: 101067887 105416433
TNG: GSTEN00006728G001 GSTEN00009859G001
TBEN: 117492134 117492937
EFO: 125878736
PFLV: 114551742
PPUG: 119219964 119219978 119220538
CANA: 137787144
CVE: 137885712
MSAM: 119887406
SCHU: 122868508
SPUL: 138602498 138602618 138602765 138602767
ALAT: 119013783 119013995 119013998
ASTR: 137609110
MZE: 101465001 101470821 111500991
ONL: 100700235 102076453 106096470
OLA: 101175656 105354605
CSAI: 133456195 133456801
XMA: 111611614
XCO: 114159462
PRET: 103468640 103468641
PMEI: 106912570
GAF: 122822394
PPRL: 129363471
CTUL: 119772640 119781709
GMU: 124864921
NFU: 107376166
KMR: 112450705
ALIM: 106516944 106526304
AOCE: 111585549 111585983 111586137 111587120
EJA: 138198112
BFRE: 138622365(ighd) 138622368
MCEP: 124998206
SDU: 111229939 111229958
SJO: 128378802
SSCO: 133999392 133999963 133999974 133999979 133999995
SNH: 120033925 120034032
ELS: 105008121 105009319
SFM: 108930865
PKI: 111837245 111842004 111842377
AANG: 118220452
CCOG: 133121409
CPLA: 122543728
HOC: 132807342 132807757 132808131 132808133 132808234 132808242 132808251 132808260
LERI: 129716386
 » show all
Reference
PMID:17560275
  Authors
Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW
  Title
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
  Journal
Adv Immunol 94:157-214 (2007)
DOI:10.1016/S0065-2776(06)94006-1
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