KEGG   ORTHOLOGY: K13085
Entry
K13085                      KO                                     
Symbol
ipgD, sopB
Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
Pathway
map05100  Bacterial invasion of epithelial cells
map05131  Shigellosis
map05132  Salmonella infection
Network
nt06110  MAPK signaling (viruses and bacteria)
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
  Element
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01130  Salmonella SopB to RhoA signaling pathway
N01133  Salmonella SopB to RhoG signaling pathway
N01134  Salmonella SopB to CDC42 signaling pathway
N01303  Salmonella SopB to Early endosomal fusion
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
   05131 Shigellosis
    K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
   05100 Bacterial invasion of epithelial cells
    K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.78  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
     K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Other DBs
RN: R08981
Genes
EMA: C1192_24285
STY: STY1121(sigD)
STT: t1828(sigD)
SEX: STBHUCCB_19440
SENT: TY21A_09295
STM: STM1091(sopB)
SEO: STM14_1237(sopB)
SEV: STMMW_11031
SEY: SL1344_1030(sopB)
SEM: STMDT12_C11120
SEJ: STMUK_1060(sopB)
SEB: STM474_1083(sopB)
SEF: UMN798_1133(sigD)
SETC: CFSAN001921_11720(sopB)
SENR: STMDT2_10271(sigD)
SEND: DT104_10731(sopB)
SENI: CY43_05575(sopB)
SEEN: SE451236_11305(sopB)
SPT: SPA1759(sigD)
SEK: SSPA1634
SEI: SPC_2659(sigD)
SEC: SCH_1043(sopB)
SHB: SU5_01724
SENH: CFSAN002069_03565(sopB)
SENS: Q786_04870(sopB)
SED: SeD_A1167
SEG: SG0980(sopB)
SEL: SPUL_1966(sopB)
SEGA: SPUCDC_1952(sopB)
SET: SEN0955(sopB)
SENA: AU38_04930(sopB)
SENO: AU37_04920(sopB)
SENV: AU39_04920(sopB)
SENQ: AU40_05535(sopB)
SENL: IY59_05020(sopB)
SEEC: CFSAN002050_11850(sopB)
SEEB: SEEB0189_014115(sopB)
SEEP: I137_08940(sopB)
SENE: IA1_05370(sopB)
SENC: SEET0819_12115(sopB)
SBG: SBG_0939(sopB)
SBZ: A464_1030
SBV: N643_04465(sopB)
SFL: CP0133(ipgD)
SFE: SFxv_4976(ipgD)
SSN: SSON_P095(ipgD)
SBC: SbBS512_A0166(ipgD)
SDY: SDY_P171(ipgD)
YAL: AT01_2850(sopB)
SOD: Sant_3206(sigD) Sant_3209(sigD2)
PAY: PAU_01919
PSI: S70_12925
PSX: DR96_586(sopB)
ANS: ArsFIN_43100(sopB)
VAN: VAA_02157
CHAE: CH06BL_40220(sopB_sigD)
IFL: C1H71_17665(sopB)
PPNO: DA70_11385
PPNM: LV28_19660
PVAC: HC248_01669(ipgD)
PSF: PSE_2750(ipgD)
PNL: PNK_0614(ipgD)
 » show all
Reference
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO J 21:5069-78 (2002)
DOI:10.1093/emboj/cdf522
  Sequence
[sfl:CP0133]
LinkDB

KEGG   ORTHOLOGY: K13741
Entry
K13741                      KO                                     
Symbol
sopE
Name
guanine nucleotide exchange factor SopE
Pathway
map05100  Bacterial invasion of epithelial cells
map05132  Salmonella infection
Network
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06139  NLR signaling (viruses and bacteria)
  Element
N01112  Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01127  Salmonella SopE to Inflammasome signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01131  Salmonella SopE/E2 to RhoA signaling pathway
N01132  Salmonella SopE/E2 to RhoG signaling pathway
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K13741  sopE; guanine nucleotide exchange factor SopE
   05100 Bacterial invasion of epithelial cells
    K13741  sopE; guanine nucleotide exchange factor SopE
Genes
STY: STY4609(sopE)
STT: t4303(sopE)
SEX: STBHUCCB_10950 STBHUCCB_45570
SENT: TY21A_05210 TY21A_21915
STM: STM1855(sopE2)
SEO: STM14_2244(sopE2)
SEV: STMMW_18441
SEY: SL1344_1784(sopE2) SL1344_2674(sopE)
SEM: STMDT12_C18770(sopE)
SEJ: STMUK_1829(sopE2)
SEF: UMN798_1953(sopE2) UMN798_2922(sopE)
SENR: STMDT2_17751(sopE2)
SEND: DT104_18201(sopE2)
SENI: CY43_09470
SPT: SPA1018(sopE2) SPA2564(sopE)
SEI: SPC_1874
SEC: SCH_1852(sopE2)
SENS: Q786_05915
SEG: SG1233 SG1261(sopE2)
SEL: SPUL_1675(sopE2) SPUL_1705
SEGA: SPUCDC_1675(sopE2)
SET: SEN1155 SEN1182(sopE2)
SENE: IA1_09210
SBG: SBG_1707(sopE2)
SBZ: A464_1954
HDE: HDEF_2312
PSTW: DSJ_23980
CVI: CV_0296
BMA: BMAA1523(bopE)
BML: BMA10229_2078(bopE)
BMN: BMA10247_A0761(bopE)
BMAL: DM55_4856(bopE)
BMAE: DM78_4102(bopE)
BMAQ: DM76_3809(bopE)
BMAI: DM57_08330
BMAF: DM51_3229(bopE)
BMAZ: BM44_4985(bopE)
BMAB: BM45_3886(bopE)
BPS: BPSS1525(bopE)
BPM: BURPS1710b_A0564(bopE)
BPL: BURPS1106A_A2067(sopE)
BPD: BURPS668_A2155(sopE)
BPSE: BDL_4834(bopE)
BPSM: BBQ_4625(bopE)
BPSU: BBN_4968(bopE)
BPSD: BBX_3996(bopE)
BPZ: BP1026B_II1621(bopE)
BPK: BBK_4134(bopE)
BPSH: DR55_3751(bopE)
BPSA: BBU_4510(bopE)
BPSO: X996_3537(bopE)
BUT: X994_5592(bopE)
BTQ: BTQ_4135(bopE)
BTJ: BTJ_5167(bopE)
BTZ: BTL_3638(bopE)
BTD: BTI_4004(bopE)
BTV: BTHA_4250(bopE)
BTHE: BTN_5621(bopE)
BTHM: BTRA_3629(bopE)
BTHA: DR62_3387
BTHL: BG87_3591(bopE)
BOK: DM82_5832(bopE)
BOC: BG90_4799(bopE)
BUL: BW21_5998(bopE)
 » show all
Reference
  Authors
Mirold S, Rabsch W, Rohde M, Stender S, Tschape H, Russmann H, Igwe E, Hardt WD
  Title
Isolation of a temperate bacteriophage encoding the type III effector protein SopE from an epidemic Salmonella typhimurium strain.
  Journal
Proc Natl Acad Sci U S A 96:9845-50 (1999)
DOI:10.1073/pnas.96.17.9452
  Sequence
[sty:STY4609]
Reference
  Authors
Stender S, Friebel A, Linder S, Rohde M, Mirold S, Hardt WD
  Title
Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell.
  Journal
Mol Microbiol 36:1206-21 (2000)
DOI:10.1046/j.1365-2958.2000.01933.x
  Sequence
[stm:STM1855]
Reference
  Authors
Huang FC, Werne A, Li Q, Galyov EE, Walker WA, Cherayil BJ
  Title
Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection.
  Journal
Infect Immun 72:5052-62 (2004)
DOI:10.1128/IAI.72.9.5052-5062.2004
  Sequence
[stm:STM1855]
LinkDB

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