| Entry |
|
|---|
| Name |
Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
|
|---|
| Definition |
SopB -> (PIK3CA/B/G/D,PIK3C2B) -> PIP3 -> ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1) |
|---|
| Expanded |
K13085 -> ((5290,5291,5294,5293),5287) -> C05981 -> (27128,9265,9266,9267) -> 382 -> 375 -> ((10163,10810,8936)+10006+55845+(23191,26999)+10787) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71) |
|---|
| Class |
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
|
|---|
| Disease |
|
|---|
| Gene |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5294 | PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 5287 | PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta |
| 382 | ARF6; ADP ribosylation factor 6 |
| 375 | ARF1; ADP ribosylation factor 1 |
| 10163 | WASF2; WASP family member 2 |
| 10810 | WASF3; WASP family member 3 |
| 8936 | WASF1; WASP family member 1 |
| 10006 | ABI1; abl interactor 1 |
| 55845 | BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex |
| 23191 | CYFIP1; cytoplasmic FMR1 interacting protein 1 |
| 26999 | CYFIP2; cytoplasmic FMR1 interacting protein 2 |
| 10787 | NCKAP1; NCK associated protein 1 |
| 10097 | ACTR2; actin related protein 2 |
| 10096 | ACTR3; actin related protein 3 |
| 10552 | ARPC1A; actin related protein 2/3 complex subunit 1A |
| 10095 | ARPC1B; actin related protein 2/3 complex subunit 1B |
| 10109 | ARPC2; actin related protein 2/3 complex subunit 2 |
| 10094 | ARPC3; actin related protein 2/3 complex subunit 3 |
| 10093 | ARPC4; actin related protein 2/3 complex subunit 4 |
| 10092 | ARPC5; actin related protein 2/3 complex subunit 5 |
| 81873 | ARPC5L; actin related protein 2/3 complex subunit 5 like |
|
|---|
| Perturbant |
| K13085 (SopB) | ipgD; phosphatidylinositol-4,5-bisphosphate 4-phosphatase |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Humphreys D, Davidson A, Hume PJ, Koronakis V |
|---|
| Title |
Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Roppenser B, Kwon H, Canadien V, Xu R, Devreotes PN, Grinstein S, Brumell JH |
|---|
| Title |
Multiple host kinases contribute to Akt activation during Salmonella infection. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Van Acker T, Tavernier J, Peelman F |
|---|
| Title |
The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host(-)Pathogen Interactions and Innate Immunity. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
