KEGG   ORTHOLOGY: K14271
Entry
K14271                      KO                                     
Symbol
NAAT
Name
nicotianamine aminotransferase [EC:2.6.1.80]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00953  Mugineic acid biosynthesis, methionine => 3-epihydroxymugineic acid
Reaction
R07277  nicotianamine:2-oxoglutarate aminotransferase; nicotianamine transaminase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K14271  NAAT; nicotianamine aminotransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K14271  NAAT; nicotianamine aminotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.80  nicotianamine aminotransferase
     K14271  NAAT; nicotianamine aminotransferase
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Others
   K14271  NAAT; nicotianamine aminotransferase
Other DBs
GO: 0033855
Genes
OSA: 9267778(NAAT1)
OBR: 102711499
OGL: 127764751
BDI: 100831451
ATS: 109747034 109747035
TDC: 119283036 119283052 119348169 119348182
TAES: 123059564 123093828 123136500 123154591 123182310 123182311
TUA: 125521156 125536048
LPER: 127318045 127334708
LRD: 124678253 124705925
SBI: 110433086 8081150
ZMA: 100191283 100193424
SITA: 101775023
SVS: 117847656
PVIR: 120655531 120655609 120699474
PHAI: 112878152
AG: BAA87052(NAAT-A) BAA87053(NAAT-B)
 » show all
Reference
PMID:18034312
  Authors
Inoue H, Takahashi M, Kobayashi T, Suzuki M, Nakanishi H, Mori S, Nishizawa NK
  Title
Identification and localisation of the rice nicotianamine aminotransferase gene OsNAAT1 expression suggests the site of phytosiderophore synthesis in rice.
  Journal
Plant Mol Biol 66:193-203 (2008)
DOI:10.1007/s11103-007-9262-8
Reference
PMID:10557244
  Authors
Takahashi M, Yamaguchi H, Nakanishi H, Shioiri T, Nishizawa NK, Mori S
  Title
Cloning two genes for nicotianamine aminotransferase, a critical enzyme in iron acquisition (Strategy II) in graminaceous plants.
  Journal
Plant Physiol 121:947-56 (1999)
DOI:10.1104/pp.121.3.947
  Sequence
[ag:BAA87052 BAA87053]
LinkDB

KEGG   ENZYME: 2.6.1.80
Entry
EC 2.6.1.80                 Enzyme                                 
Name
nicotianamine aminotransferase;
NAAT;
NAAT-I;
NAAT-II;
NAAT-III;
nicotianamine transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
nicotianamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate [RN:R07277]
Reaction(KEGG)
R07277
Substrate
nicotianamine [CPD:C05324];
2-oxoglutarate [CPD:C00026]
Product
3''-deamino-3''-oxonicotianamine [CPD:C15486];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. This enzyme is produced by grasses. They secrete both the nicotianamine and the transaminated product into the soil around them. Both compounds chelate iron(II) and iron(III); these chelators, called mugineic acid family phytosiderophores, are taken up by the grass, which is thereby supplied with iron.
History
EC 2.6.1.80 created 2005
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14271  nicotianamine aminotransferase
Genes
OSA: 9267778(NAAT1)
OBR: 102711499
OGL: 127764751
BDI: 100831451
ATS: 109747034 109747035
TDC: 119283036 119283052 119348169 119348182
TAES: 123059564 123093828 123136500 123154591 123182310 123182311
TUA: 125521156 125536048
LPER: 127318045 127334708
LRD: 124678253 124705925
SBI: 110433086 8081150
ZMA: 100191283 100193424
SITA: 101775023
SVS: 117847656
PVIR: 120655531 120655609 120699474
PHAI: 112878152
 » show all
Reference
1
  Authors
Kanazawa K, Higuchi K, Nishizawa N-K, Fushiya S, Chino M, Mori S.
  Title
Nicotianamine aminotransferase activities are correlated with the phytosiderophore secretions under Fe-deficient conditions in Gramineae.
  Journal
J Exp Bot 45:1903-1906 (1994)
Reference
2  [PMID:10557244]
  Authors
Takahashi M, Yamaguchi H, Nakanishi H, Shioiri T, Nishizawa NK, Mori S
  Title
Cloning two genes for nicotianamine aminotransferase, a critical enzyme in iron acquisition (Strategy II) in graminaceous plants.
  Journal
Plant Physiol 121:947-56 (1999)
DOI:10.1104/pp.121.3.947
  Sequence
[ag:BAA87052 BAA87053]
Reference
3  [PMID:14699112]
  Authors
Schaaf G, Ludewig U, Erenoglu BE, Mori S, Kitahara T, von Wiren N.
  Title
ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals.
  Journal
J Biol Chem 279:9091-6 (2004)
DOI:10.1074/jbc.M311799200
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.80
IUBMB Enzyme Nomenclature: 2.6.1.80
ExPASy - ENZYME nomenclature database: 2.6.1.80
BRENDA, the Enzyme Database: 2.6.1.80
CAS: 154907-64-9
LinkDB

KEGG   REACTION: R07277
Entry
R07277                      Reaction                               
Name
nicotianamine:2-oxoglutarate aminotransferase; nicotianamine transaminase
Definition
Nicotianamine + 2-Oxoglutarate <=> 3''-Deamino-3''-oxonicotianamine + L-Glutamate
Equation
C05324 + C00026 <=> C15486 + C00025
Reaction class
RC00006  C00025_C00026  C05324_C15486
Enzyme
2.6.1.80
Pathway
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00953  Mugineic acid biosynthesis, methionine => 3-epihydroxymugineic acid
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.80
     R07277  Nicotianamine + 2-Oxoglutarate <=> 3''-Deamino-3''-oxonicotianamine + L-Glutamate
Orthology
K14271  nicotianamine aminotransferase [EC:2.6.1.80]
Other DBs
RHEA: 22107
LinkDB

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