| Entry |
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| Name |
Fumagillin biosynthesis, farnesyl-PP => fumagillin
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| Definition |
K22569 K21295 K22570 K22571 K22572
K22573
K22574 K22575
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| Diagram |
| M00969 | Fumagillin biosynthesis, farnesyl-PP => fumagillin |
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| Class |
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
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| Pathway |
| map00998 | Biosynthesis of various antibiotics |
| map01110 | Biosynthesis of secondary metabolites |
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| Orthology |
AF390-400; 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase [EC: 2.1.1.387] [RN: R13123] AF370; fumagillin biosynthesis polyketide synthase [EC:2.3.1.-] [RN: R13145] AF380; fumagillin biosynthesis transferase [RN: R13146] AF470; fumagillin biosynthesis monooxygenase [RN: R13147] |
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| Complete |
| afm | Aspergillus fumigatus |
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| Reaction |
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| Compound |
| C00448 | trans,trans-Farnesyl diphosphate |
| C22617 | (+)-exo-beta-Bergamotene |
| C22629 | 5-Dehydro-6-demethoxyfumagillol |
| C22631 | 5-Dehydro-6-demethoxy-6-hydroxyfumagillol |
| C22651 | Dodecapentaenoyl-[acyl-carrier protein] |
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| Reference |
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| Authors |
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y |
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| Title |
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. |
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| Journal |
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| Reference |
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| Authors |
Guruceaga X, Perez-Cuesta U, Abad-Diaz de Cerio A, Gonzalez O, Alonso RM, Hernando FL, Ramirez-Garcia A, Rementeria A. |
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| Title |
Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications. |
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| Journal |
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| LinkDB |
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