KEGG   MODULE: M00980
Entry
M00980            Pathway   Module                                 
Name
Strychnine biosynthesis, geissoschizine => strychnine
Definition
K27780 K27781 K27782 K27783 K27784
Diagram
M00980  Strychnine biosynthesis, geissoschizine => strychnine
M00980

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K27780  
(19E)-geissoschizine oxidase [EC:1.14.19.80] [RN:R13342 R13329]
K27781  
dehydropreakuammicine esterase [EC:3.1.1.123] [RN:R13330]
K27782  
norfluorocurarine oxidase [RN:R13332]
K27783  
Wieland-Gumlich aldehyde synthase [RN:R13333]
K27784  
17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase [EC:2.3.1.325] [RN:R13334]
Complete
28545  Strychnos nux-vomica
Reaction
Compound
C02151  Geissoschizine
C22936  3,17-Didehydrostemmadenine
C22922  17-Dehydropreakuammicine
C22923  Norfluorocurarine
C22924  18-Hydroxynorfluorocurarine
C22925  Wieland-Gumlich aldehyde
C22927  Prestrychnine
C06522  Strychnine
Reference
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
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