| Entry |
|
|---|
| Name |
Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
|
|---|
| Definition |
FLT3* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
|---|
| Expanded |
(2322v2,2322v1) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
|
|---|
| Gene |
| 2322 | FLT3; fms related tyrosine kinase 3 |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
|
|---|
| Variant |
2322v2 (FLT3*) FLT3 internal tandem duplication (ITD)
2322v1 (FLT3*) FLT3 kinase domain mutation
|
|---|
| Reference |
|
|---|
| Authors |
Stirewalt DL, Radich JP. |
|---|
| Title |
The role of FLT3 in haematopoietic malignancies. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Doepfner KT, Boller D, Arcaro A |
|---|
| Title |
Targeting receptor tyrosine kinase signaling in acute myeloid leukemia. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H. |
|---|
| Title |
The molecular pathogenesis of acute myeloid leukemia. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Stirewalt DL, Meshinchi S, Radich JP |
|---|
| Title |
Molecular targets in acute myelogenous leukemia. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
