| Entry |
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| Name |
Mutation-activated KRAS/NRAS to ERK signaling pathway
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| Definition |
(KRAS*,NRAS*) -> RAF -> MEK -> ERK -> CCND1 |
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| Expanded |
(3845v1,4893v1) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595 |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Variant |
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| Reference |
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| Authors |
Schubbert S, Shannon K, Bollag G |
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| Title |
Hyperactive Ras in developmental disorders and cancer. |
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| Journal |
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| Reference |
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| Authors |
Adjei AA. |
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| Title |
Blocking oncogenic Ras signaling for cancer therapy. |
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| Journal |
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| Reference |
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| Authors |
Janssen KP. |
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| Title |
Murine models of colorectal cancer: studying the role of oncogenic K-ras. |
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| Journal |
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| Reference |
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| Authors |
Ryan AJ, Susil B, Jobling TW, Oehler MK. |
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| Title |
Endometrial cancer. |
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| Journal |
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| Reference |
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| Authors |
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H. |
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| Title |
The molecular pathogenesis of acute myeloid leukemia. |
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| Journal |
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| Reference |
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| Authors |
Chin L. |
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| Title |
The genetics of malignant melanoma: lessons from mouse and man. |
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| Journal |
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| LinkDB |
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