| Entry |
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| Name |
Mutation-activated EGFR to RAS-ERK signaling pathway
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| Definition |
EGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1 |
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| Expanded |
(1956v2,1956v3) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 1956 | EGFR; epidermal growth factor receptor |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Variant |
1956v2 (EGFR*) EGFR mutation in non-small cell lung cancer
1956v3 (EGFR*) First generation TKI-resistant EGFR mutation
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| Reference |
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| Authors |
Osada H, Takahashi T. |
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| Title |
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
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| Journal |
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| Reference |
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| Authors |
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA. |
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| Title |
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies. |
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| Journal |
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| LinkDB |
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