| Entry |
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| Name |
IGF1R-overexpression to RAS-ERK signaling pathway
|
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| Definition |
IGF2 -> IGF1R* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
3481 -> 3480v1 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Variant
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| Pathway |
|
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| Disease |
| H00048 | Hepatocellular carcinoma |
|
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| Gene |
| 3481 | IGF2; insulin like growth factor 2 |
| 3480 | IGF1R; insulin like growth factor 1 receptor |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
|
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| Variant |
3480v1 (IGF1R*) IGF1R overexpression
|
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| Reference |
|
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| Authors |
Whittaker S, Marais R, Zhu AX |
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| Title |
The role of signaling pathways in the development and treatment of hepatocellular carcinoma. |
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| Journal |
|
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| Reference |
|
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| Authors |
Kudo M |
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| Title |
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM |
|---|
| Title |
Pathogenesis of hepatocellular carcinoma and molecular therapies. |
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| Journal |
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| LinkDB |
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