KEGG   NETWORK: N01408
Entry
N01408                      Network                                
Name
Metals to RAS-ERK signaling pathway
Definition
Metals -> ROS -> RAS -> RAF -> MEK -> ERK -> AP1
  Expanded
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (2353,3725)
Class
nt06210 ERK signaling (cancer)
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00021  Renal cell carcinoma
H00024  Prostate cancer
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
H00048  Hepatocellular carcinoma
H00054  Nasopharyngeal cancer
Gene
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Perturbant
C06269 (Metals)  Arsenic
C01413 (Metals)  Cadmium
C19171 (Metals)  Cobalt
C06268 (Metals)  Chromium
C06696 (Metals)  Lead
C00023 (Metals)  Iron
C00291 (Metals)  Nickel
Metabolite
C22381  Reactive oxygen species
Reference
PMID:22705365
  Authors
Lee JC, Son YO, Pratheeshkumar P, Shi X
  Title
Oxidative stress and metal carcinogenesis.
  Journal
Free Radic Biol Med 53:742-57 (2012)
DOI:10.1016/j.freeradbiomed.2012.06.002
Reference
PMID:16430879
  Authors
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M
  Title
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
  Journal
Chem Biol Interact 160:1-40 (2006)
DOI:10.1016/j.cbi.2005.12.009
Reference
PMID:15544913
  Authors
Leonard SS, Harris GK, Shi X
  Title
Metal-induced oxidative stress and signal transduction.
  Journal
Free Radic Biol Med 37:1921-42 (2004)
DOI:10.1016/j.freeradbiomed.2004.09.010
Reference
PMID:32358622
  Authors
Kirtonia A, Sethi G, Garg M
  Title
The multifaceted role of reactive oxygen species in tumorigenesis.
  Journal
Cell Mol Life Sci 77:4459-4483 (2020)
DOI:10.1007/s00018-020-03536-5
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