KEGG   PATHWAY: aaa00260
Entry
aaa00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paracidovorax avenae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aaa00260  Glycine, serine and threonine metabolism
aaa00260

Module
aaa_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aaa00260]
aaa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aaa00260]
aaa_M00621  Glycine cleavage system [PATH:aaa00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paracidovorax avenae [GN:aaa]
Gene
Acav_2806  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Acav_1234  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Acav_1256  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Acav_0021  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Acav_3238  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Acav_1257  threonine synthase [KO:K01733] [EC:4.2.3.1]
Acav_0188  Threonine synthase [KO:K01733] [EC:4.2.3.1]
Acav_0609  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Acav_2305  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Acav_2961  Glyoxylate reductase (NADP(+)) [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Acav_4250  Hydroxypyruvate reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Acav_1950  Glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Acav_1110  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Acav_3766  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
Acav_4115  Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Acav_2148  Phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Acav_2100  Phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Acav_3568  Phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Acav_1974  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Acav_1623  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Acav_2115  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Acav_2117  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Acav_2752  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Acav_2783  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Acav_2002  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Acav_2116  glycine cleavage system H protein [KO:K02437]
Acav_0156  CDP-diacylglycerol/serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Acav_2174  CDP-diacylglycerol/serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Acav_0362  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Acav_0177  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
Acav_3709  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01754] [EC:4.3.1.19]
Acav_4335  Threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Acav_0881  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
Acav_2788  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
Acav_1229  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
Acav_1230  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Acav_4093  2,4-diaminobutyrate 4-transaminase [KO:K00836] [EC:2.6.1.76]
Acav_4094  Diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aaa00010  Glycolysis / Gluconeogenesis
aaa00020  Citrate cycle (TCA cycle)
aaa00230  Purine metabolism
aaa00250  Alanine, aspartate and glutamate metabolism
aaa00270  Cysteine and methionine metabolism
aaa00290  Valine, leucine and isoleucine biosynthesis
aaa00300  Lysine biosynthesis
aaa00330  Arginine and proline metabolism
aaa00460  Cyanoamino acid metabolism
aaa00470  D-Amino acid metabolism
aaa00564  Glycerophospholipid metabolism
aaa00620  Pyruvate metabolism
aaa00630  Glyoxylate and dicarboxylate metabolism
aaa00640  Propanoate metabolism
aaa00680  Methane metabolism
aaa00860  Porphyrin metabolism
aaa00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system