KEGG   PATHWAY: abd00260
Entry
abd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Acinetobacter baumannii TCDC-AB0715
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
abd00260  Glycine, serine and threonine metabolism
abd00260

Module
abd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:abd00260]
abd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:abd00260]
abd_M00555  Betaine biosynthesis, choline => betaine [PATH:abd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Acinetobacter baumannii TCDC-AB0715 [GN:abd]
Gene
ABTW07_1340  aspartate kinase [KO:K00928] [EC:2.7.2.4]
ABTW07_0468  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ABTW07_1959  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ABTW07_0292  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ABTW07_3654  homoserine kinase [KO:K02204] [EC:2.7.1.39]
ABTW07_3245  thrH; phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
ABTW07_0291  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
ABTW07_2698  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ABTW07_2641  lactate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ABTW07_3107  glycerate kinase [KO:K00865] [EC:2.7.1.165]
ABTW07_0285  gpmI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
ABTW07_3565  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ABTW07_2107  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ABTW07_3082  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
ABTW07_3793  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ABTW07_2964  putative L-allo-threonine dehydrogenase, NADP+-dependent (other substrates include L-serine, D-serine, D-threonine and 3-hydroxyisobutyrate) [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ABTW07_2178  tyramine oxidase [KO:K00276] [EC:1.4.3.21]
ABTW07_3400  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ABTW07_1951  pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component [KO:K00382] [EC:1.8.1.4]
ABTW07_3176  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ABTW07_1795  gcvH; glycine cleavage system protein H [KO:K02437]
ABTW07_3432  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
ABTW07_1017  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
ABTW07_1018  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ABTW07_1298  NAD-dependent aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ABTW07_1505  Iron-sulfur-dependent L-serine dehydratase single chain form [KO:K01752] [EC:4.3.1.17]
ABTW07_3263  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ABTW07_2239  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ABTW07_1064  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
ABTW07_3337  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
ABTW07_3342  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
ABTW07_1941  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
ABTW07_2906  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
ABTW07_2905  glutamate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
abd00010  Glycolysis / Gluconeogenesis
abd00020  Citrate cycle (TCA cycle)
abd00230  Purine metabolism
abd00250  Alanine, aspartate and glutamate metabolism
abd00270  Cysteine and methionine metabolism
abd00290  Valine, leucine and isoleucine biosynthesis
abd00300  Lysine biosynthesis
abd00330  Arginine and proline metabolism
abd00460  Cyanoamino acid metabolism
abd00470  D-Amino acid metabolism
abd00564  Glycerophospholipid metabolism
abd00600  Sphingolipid metabolism
abd00620  Pyruvate metabolism
abd00630  Glyoxylate and dicarboxylate metabolism
abd00640  Propanoate metabolism
abd00680  Methane metabolism
abd00860  Porphyrin metabolism
abd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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