KEGG   PATHWAY: adl00260
Entry
adl00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Auricularia subglabra
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
adl00260  Glycine, serine and threonine metabolism
adl00260

Module
adl_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:adl00260]
adl_M00621  Glycine cleavage system [PATH:adl00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Auricularia subglabra [GN:adl]
Gene
AURDEDRAFT_114713  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AURDEDRAFT_111139  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AURDEDRAFT_115989  aspartate kinase homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AURDEDRAFT_179092  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AURDEDRAFT_181431  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K01733] [EC:4.2.3.1]
AURDEDRAFT_109768  hypothetical protein [KO:K01620] [EC:4.1.2.48]
AURDEDRAFT_109769  hypothetical protein [KO:K01620] [EC:4.1.2.48]
AURDEDRAFT_107338  hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AURDEDRAFT_113262  PLP-dependent transferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AURDEDRAFT_185600  hypothetical protein [KO:K00049] [EC:1.1.1.79 1.1.1.81]
AURDEDRAFT_135947  hypothetical protein [KO:K00049] [EC:1.1.1.79 1.1.1.81]
AURDEDRAFT_60343  hypothetical protein [KO:K00049] [EC:1.1.1.79 1.1.1.81]
AURDEDRAFT_170060  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AURDEDRAFT_112514  P-loop containing nucleoside triphosphate hydrolase protein [KO:K15918] [EC:2.7.1.31]
AURDEDRAFT_51013  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AURDEDRAFT_110867  PLP-dependent transferase [KO:K00831] [EC:2.6.1.52]
AURDEDRAFT_114376  NAD(P)-binding protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AURDEDRAFT_110589  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
AURDEDRAFT_72211  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AURDEDRAFT_115401  amine oxidase catalytic domain-containing protein [KO:K00276] [EC:1.4.3.21]
AURDEDRAFT_111483  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AURDEDRAFT_89993  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
AURDEDRAFT_109677  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AURDEDRAFT_141107  glycine cleavage system H protein [KO:K02437]
AURDEDRAFT_115921  nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
AURDEDRAFT_161209  FAD dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
AURDEDRAFT_184116  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
AURDEDRAFT_75112  nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
AURDEDRAFT_81053  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AURDEDRAFT_82786  succinate-semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
AURDEDRAFT_116268  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AURDEDRAFT_111724  hypothetical protein [KO:K01758] [EC:4.4.1.1]
AURDEDRAFT_105999  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
AURDEDRAFT_89462  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
AURDEDRAFT_115027  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
AURDEDRAFT_91309  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AURDEDRAFT_184100  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AURDEDRAFT_116588  hypothetical protein [KO:K20498] [EC:4.3.1.18]
AURDEDRAFT_145185  bifunctional tryptophan synthase TRP1 [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
adl00010  Glycolysis / Gluconeogenesis
adl00020  Citrate cycle (TCA cycle)
adl00230  Purine metabolism
adl00250  Alanine, aspartate and glutamate metabolism
adl00270  Cysteine and methionine metabolism
adl00290  Valine, leucine and isoleucine biosynthesis
adl00300  Lysine biosynthesis
adl00330  Arginine and proline metabolism
adl00460  Cyanoamino acid metabolism
adl00470  D-Amino acid metabolism
adl00564  Glycerophospholipid metabolism
adl00600  Sphingolipid metabolism
adl00620  Pyruvate metabolism
adl00630  Glyoxylate and dicarboxylate metabolism
adl00640  Propanoate metabolism
adl00680  Methane metabolism
adl00860  Porphyrin metabolism
adl00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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