KEGG   PATHWAY: amam00260
Entry
amam00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Actinomyces marmotae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
amam00260  Glycine, serine and threonine metabolism
amam00260

Module
amam_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:amam00260]
amam_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:amam00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Actinomyces marmotae [GN:amam]
Gene
HPC72_00500  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HPC72_00505  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HPC72_07890  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HPC72_07885  homoserine kinase [KO:K00872] [EC:2.7.1.39]
HPC72_09960  threonine synthase [KO:K01733] [EC:4.2.3.1]
HPC72_02995  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HPC72_05980  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HPC72_07610  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HPC72_00930  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
HPC72_05815  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
HPC72_09920  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HPC72_09925  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HPC72_04480  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HPC72_06740  hypothetical protein [KO:K00605] [EC:2.1.2.10]
HPC72_05745  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HPC72_00875  serine/threonine protein kinase [KO:K00613] [EC:2.1.4.1]
HPC72_08305  aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HPC72_08740  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HPC72_04280  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HPC72_04285  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HPC72_04305  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
amam00010  Glycolysis / Gluconeogenesis
amam00020  Citrate cycle (TCA cycle)
amam00230  Purine metabolism
amam00250  Alanine, aspartate and glutamate metabolism
amam00270  Cysteine and methionine metabolism
amam00290  Valine, leucine and isoleucine biosynthesis
amam00300  Lysine biosynthesis
amam00330  Arginine and proline metabolism
amam00460  Cyanoamino acid metabolism
amam00470  D-Amino acid metabolism
amam00564  Glycerophospholipid metabolism
amam00600  Sphingolipid metabolism
amam00620  Pyruvate metabolism
amam00630  Glyoxylate and dicarboxylate metabolism
amam00640  Propanoate metabolism
amam00680  Methane metabolism
amam00860  Porphyrin metabolism
amam00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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