KEGG   PATHWAY: ath00999
Entry
ath00999                    Pathway                                
Name
Biosynthesis of various plant secondary metabolites - Arabidopsis thaliana (thale cress)
  Including
Crocin biosynthesis, Ginsenoside biosynthesis, Saponin adjuvant biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ath00999  Biosynthesis of various plant secondary metabolites
ath00999

Organism
Arabidopsis thaliana (thale cress) [GN:ath]
Gene
AT1G78950  BAS; Terpenoid cyclases family protein [KO:K15813] [EC:5.4.99.39]
AT5G36110  CYP716A1; cytochrome P450, family 716, subfamily A, polypeptide 1 [KO:K20667] [EC:1.14.14.126]
AT5G36140  CYP716A2; cytochrome P450, family 716, subfamily A, polypeptide 2 [KO:K20667] [EC:1.14.14.126]
AT5G36130  Cytochrome P450 superfamily protein [KO:K20667] [EC:1.14.14.126]
AT2G36880  MAT3; methionine adenosyltransferase 3 [KO:K00789] [EC:2.5.1.6]
AT3G17390  MTO3; S-adenosylmethionine synthetase family protein [KO:K00789] [EC:2.5.1.6]
AT4G01850  SAM-2; S-adenosylmethionine synthetase 2 [KO:K00789] [EC:2.5.1.6]
AT1G02500  SAM1; S-adenosylmethionine synthetase 1 [KO:K00789] [EC:2.5.1.6]
AT5G04950  NAS1; nicotianamine synthase 1 [KO:K05953] [EC:2.5.1.43]
AT5G56080  NAS2; nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
AT1G09240  NAS3; nicotianamine synthase 3 [KO:K05953] [EC:2.5.1.43]
AT1G56430  NAS4; nicotianamine synthase 4 [KO:K05953] [EC:2.5.1.43]
AT1G59960  NAD(P)-linked oxidoreductase superfamily protein [KO:K22374] [EC:1.1.1.285]
AT1G59950  NAD(P)-linked oxidoreductase superfamily protein [KO:K22374] [EC:1.1.1.285]
AT3G06350  MEE32; dehydroquinate dehydratase, putative / shikimate dehydrogenase [KO:K13832] [EC:4.2.1.10 1.1.1.25]
AT5G42260  BGLU12; beta glucosidase 12 [KO:K01188] [EC:3.2.1.21]
AT5G44640  BGLU13; beta glucosidase 13 [KO:K01188] [EC:3.2.1.21]
AT2G44450  BGLU15; beta glucosidase 15 [KO:K01188] [EC:3.2.1.21]
AT1G26560  BGLU40; beta glucosidase 40 [KO:K01188] [EC:3.2.1.21]
AT2G44480  BGLU17; beta glucosidase 17 [KO:K01188] [EC:3.2.1.21]
AT3G47050  Glycosyl hydrolase family protein [KO:K01188] [EC:3.2.1.21]
AT1G75940  ATA27; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
AT1G66280  BGLU22; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
AT1G66270  BGLU21; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
AT3G09260  PYK10; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
AT5G28510  BGLU24; beta glucosidase 24 [KO:K01188] [EC:3.2.1.21]
AT5G36890  BGLU42; beta glucosidase 42 [KO:K01188] [EC:3.2.1.21]
AT5G54570  BGLU41; beta glucosidase 41 [KO:K01188] [EC:3.2.1.21]
AT2G32860  BGLU33; beta glucosidase 33 [KO:K01188] [EC:3.2.1.21]
AT3G03640  BGLU25; beta glucosidase 25 [KO:K01188] [EC:3.2.1.21]
AT3G21370  BGLU19; beta glucosidase 19 [KO:K01188] [EC:3.2.1.21]
AT3G60130  BGLU16; beta glucosidase 16 [KO:K01188] [EC:3.2.1.21]
AT2G25630  BGLU14; beta glucosidase 14 [KO:K01188] [EC:3.2.1.21]
AT3G60140  DIN2; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
AT2G44470  BGLU29; beta glucosidase 29 [KO:K01188] [EC:3.2.1.21]
AT2G44460  BGLU28; beta glucosidase 28 [KO:K01188] [EC:3.2.1.21]
AT2G44490  PEN2; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
AT5G24550  BGLU32; beta glucosidase 32 [KO:K01188] [EC:3.2.1.21]
AT5G24540  BGLU31; beta glucosidase 31 [KO:K01188] [EC:3.2.1.21]
AT3G60120  BGLU27; beta glucosidase 27 [KO:K01188] [EC:3.2.1.21]
AT1G02850  BGLU11; beta glucosidase 11 [KO:K01188] [EC:3.2.1.21]
AT1G45191  BGLU1; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
AT4G22100  BGLU3; beta glucosidase 2 [KO:K01188] [EC:3.2.1.21]
AT4G27830  BGLU10; beta glucosidase 10 [KO:K01188] [EC:3.2.1.21]
AT3G62750  BGLU8; beta glucosidase 8 [KO:K01188] [EC:3.2.1.21]
AT5G16580  BGLU2; beta glucosidase 2 [KO:K01188] [EC:3.2.1.21]
AT1G60270  BGLU6; beta glucosidase 6 [KO:K01188] [EC:3.2.1.21]
AT3G62740  BGLU7; beta glucosidase 7 [KO:K01188] [EC:3.2.1.21]
AT4G27820  BGLU9; beta glucosidase 9 [KO:K01188] [EC:3.2.1.21]
AT1G60260  BGLU5; beta glucosidase 5 [KO:K01188] [EC:3.2.1.21]
AT1G60090  BGLU4; beta glucosidase 4 [KO:K01188] [EC:3.2.1.21]
AT3G47000  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
AT5G20950  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
AT5G20940  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
AT3G47040  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
AT5G04885  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
AT3G47010  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
AT3G18080  BGLU44; B-S glucosidase 44 [KO:K05350] [EC:3.2.1.21]
AT1G61820  BGLU46; beta glucosidase 46 [KO:K05350] [EC:3.2.1.21]
AT4G21760  BGLU47; beta-glucosidase 47 [KO:K05350] [EC:3.2.1.21]
AT1G61810  BGLU45; beta-glucosidase 45 [KO:K05350] [EC:3.2.1.21]
AT3G18070  BGLU43; beta glucosidase 43 [KO:K05350] [EC:3.2.1.21]
AT3G13610  2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [KO:K06892] [EC:1.14.11.61]
AT1G55290  2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [KO:K06892] [EC:1.14.11.61]
AT3G12900  2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [KO:K23145] [EC:1.14.11.60]
AT4G31940  CYP82C4; cytochrome P450, family 82, subfamily C, polypeptide 4 [KO:K23136] [EC:1.14.14.164]
AT4G31970  CYP82C2; cytochrome P450, family 82, subfamily C, polypeptide 2 [KO:K23137] [EC:1.14.14.165]
AT1G32100  PRR1; pinoresinol reductase 1 [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
AT4G13660  PRR2; pinoresinol reductase 2 [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
AT5G61160  AACT1; anthocyanin 5-aromatic acyltransferase 1 [KO:K14329] [EC:2.3.1.64 2.3.1.-]
Compound
C00019  S-Adenosyl-L-methionine
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00049  L-Aspartate
C00073  L-Methionine
C00074  Phosphoenolpyruvate
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00108  Anthranilate
C00179  Agmatine
C00223  p-Coumaroyl-CoA
C00251  Chorismate
C00254  Prephenate
C00323  Caffeoyl-CoA
C00353  Geranylgeranyl diphosphate
C00406  Feruloyl-CoA
C00423  trans-Cinnamate
C00448  trans,trans-Farnesyl diphosphate
C00463  Indole
C00493  Shikimate
C00590  Coniferyl alcohol
C00751  Squalene
C00758  Bergaptol
C00841  Xanthotoxol
C01054  (S)-2,3-Epoxysqualene
C01158  1-O-Galloyl-beta-D-glucose
C01198  3-(2-Hydroxyphenyl)propanoate
C01424  Gallate
C01527  Scopolin
C01557  Bergapten
C01752  Scopoletin
C01772  trans-2-Hydroxycinnamate
C01864  Xanthotoxin
C02162  Isopimpinellin
C02274  Dihydrocoumarin
C02637  3-Dehydroshikimate
C02951  5-Hydroxyxanthotoxin
C03506  Indoleglycerol phosphate
C04498  p-Coumaroylagmatine
C04576  Pentagalloylglucose
C04831  DIMBOA-glucoside
C05158  trans-beta-D-Glucosyl-2-hydroxycinnamate
C05324  Nicotianamine
C05366  (+)-Pinoresinol
C05838  cis-2-Hydroxycinnamate
C05839  cis-beta-D-Glucosyl-2-hydroxycinnamate
C05851  Coumarin
C06098  Zeaxanthin
C06972  Dronabinol
C07578  Cannabidiol
C08304  Gramine
C08307  Hordatine A
C08308  Hordatine B
C08588  Crocetin
C08589  Crocin
C08616  beta-Amyrin
C08942  Echinocystic acid
C08946  Ginsenoside Rg1
C08972  Quillaic acid
C09060  Angelicin
C09263  Esculetin
C09265  Fraxetin
C09276  Marmesin
C09305  Psoralen
C09311  Scoparone
C09315  Umbelliferone
C10556  Deoxypodophyllotoxin
C10557  Dihydroanhydropodorhizol
C10646  Lariciresinol
C10682  Matairesinol
C10784  Cannabidiolic acid
C10874  Podophyllotoxin
C11130  3-Hydroxyindolin-2-one
C12312  Indolin-2-one
C15485  2'-Deoxymugineic acid
C15486  3''-Deamino-3''-oxonicotianamine
C15500  Mugineic acid
C15501  3-Epihydroxymugineic acid
C15502  3-Epihydroxy-2'-deoxymugineic acid
C15769  HBOA
C15770  DIBOA
C15772  DIBOA-glucoside
C17055  Picrocrocin
C17062  Safranal
C17148  Oleanolic acid
C17513  trans-Crocetin (beta-D-glucosyl) (beta-D-gentibiosyl) ester
C18062  TRIBOA-glucoside
C18079  Isoscopoletin
C18080  Osthenol
C18083  Demethylsuberosin
C18167  Secoisolariciresinol
C18325  Feruloylagmatine
C19707  (+)-Columbianetin
C19730  Crocetin dialdehyde
C19731  (3S)-3-Hydroxycyclocitral
C19829  Dammarenediol-II
C19867  beta-D-Glucosyl crocetin
C19868  Bis(beta-D-glucosyl) crocetin
C19869  beta-D-Gentiobiosyl crocetin
C20406  Cannabigerolate
C20413  3,5,7-Trioxododecanoyl-CoA
C20417  2,4-Dihydroxy-6-pentylbenzoate
C20454  (-)-Lariciresinol
C20455  (-)-Pinoresinol
C20456  (+)-Secoisolariciresinol
C20713  Ginsenoside Rb1
C20715  Protopanaxadiol
C20716  Protopanaxatriol
C20725  Ginsenoside Rd
C20778  Ginsenoside Rg3
C20779  Ginsenoside F2
C20780  Ginsenoside F1
C20894  beta-Citraurin
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C21191  Pluviatolide
C21459  6-Hydroxyferuloyl-CoA
C21601  3-(Aminomethyl)indole
C21602  (1H-Indol-3-yl)-N-methylmethanamine
C21903  Delta9-Tetrahydrocannabinolate
C22007  Sideretin
C22070  2,4-Dihydroxycinnamoyl-CoA
C22127  Ginsenoside C-K
C22128  (20S)-Ginsenoside Rh2
C22129  Ginsenoside Rh1
C22152  Bergamottin
C22153  Epoxybergamottin
C22156  6',7'-Dihydroxybergamottin
C22438  3,5-Dehydroshikimate
C22444  5,8-Dihydroxypsoralen
C22445  8-Hydroxybergapten
C22452  6,7,8-Trihydroxycoumarin
C22652  Quillaic acid 3-O-beta-D-glucuronide
C22653  Quillaic acid 3-O-beta-D-galactosyl-1,2-beta-D-glucuronide
C22654  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22655  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22656  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22657  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22658  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22659  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22660  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22661  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22662  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22663  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22664  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22665  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22666  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide 28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-(beta-D-glucosyl-1,3)-alpha-L-rhamnosyl-1,2-(alpha-L-rhamnosyl-1,3)-4-O-acetyl-beta-D-fucoside
Reference
  Authors
Nagatoshi M, Terasaka K, Owaki M, Sota M, Inukai T, Nagatsu A, Mizukami H
  Title
UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
  Journal
FEBS Lett 586:1055-61 (2012)
DOI:10.1016/j.febslet.2012.03.003
Reference
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS Lett 581:2929-34 (2007)
DOI:10.1016/j.febslet.2007.05.043
Reference
PMID:9952442
  Authors
Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S
  Title
Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores.
  Journal
Plant Physiol 119:471-80 (1999)
DOI:10.1104/pp.119.2.471
Reference
PMID:7622460
  Authors
Ma JF, Shinada T, Matsuda C, Nomoto K
  Title
Biosynthesis of phytosiderophores, mugineic acids, associated with methionine cycling.
  Journal
J Biol Chem 270:16549-54 (1995)
DOI:10.1074/jbc.270.28.16549
Reference
  Authors
Tahara K, Nishiguchi M, Funke E, Miyazawa SI, Miyama T, Milkowski C
  Title
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis.
  Journal
Planta 253:3 (2020)
DOI:10.1007/s00425-020-03516-w
Reference
  Authors
Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, Bourgaud F.
  Title
The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways.
  Journal
PLoS One 10:e0142757 (2015)
DOI:10.1371/journal.pone.0142757
Reference
  Authors
Hehmann M, Lukacin R, Ekiert H, Matern U
  Title
Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.
  Journal
Eur J Biochem 271:932-40 (2004)
DOI:10.1111/j.1432-1033.2004.03995.x
Reference
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Reference
  Authors
Reed J, Orme A, El-Demerdash A, Owen C, Martin LBB, Misra RC, Kikuchi S, Rejzek M, Martin AC, Harkess A, Leebens-Mack J, Louveau T, Stephenson MJ, Osbourn A.
  Title
Elucidation of the pathway for biosynthesis of saponin adjuvants from the soapbark tree.
  Journal
Science 379:1252-1264 (2023)
DOI:10.1126/science.adf3727
Related
pathway
ath00010  Glycolysis / Gluconeogenesis
ath00020  Citrate cycle (TCA cycle)
ath00270  Cysteine and methionine metabolism
ath00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ath00900  Terpenoid backbone biosynthesis
ath00940  Phenylpropanoid biosynthesis
KO pathway
ko00999   
LinkDB

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