KEGG   PATHWAY: bamn00260
Entry
bamn00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus velezensis UCMB5113
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bamn00260  Glycine, serine and threonine metabolism
bamn00260

Module
bamn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bamn00260]
bamn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bamn00260]
bamn_M00555  Betaine biosynthesis, choline => betaine [PATH:bamn00260]
bamn_M00621  Glycine cleavage system [PATH:bamn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus velezensis UCMB5113 [GN:bamn]
Gene
BASU_0016  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
BASU_0229  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BASU_0361  yclM; aspartate kinase III [KO:K00928] [EC:2.7.2.4]
BASU_0421  racD; Putative aspartate racemase [KO:K25316]
BASU_0502  racX; putative amino-acid racemase [KO:K25316]
BASU_0784  acoL; Dihydrolipoamide dehydrogenase (acetoin dehydrogenase E3 component) [KO:K00382] [EC:1.8.1.4]
BASU_0965  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BASU_1407  pdhD; dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes [KO:K00382] [EC:1.8.1.4]
BASU_1524  sdaAB; L-serine dehydratase (beta chain) [KO:K01752] [EC:4.3.1.17]
BASU_1525  sdaAA; L-serine dehydratase (alpha chain) [KO:K01752] [EC:4.3.1.17]
BASU_1615  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BASU_1616  dapG; aspartokinase I (alpha and beta subunits) [KO:K00928] [EC:2.7.2.4]
BASU_1639  tdh; threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BASU_1640  kbl; 2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase) [KO:K00639] [EC:2.3.1.29]
BASU_1825  yoaD; putative 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BASU_1923  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BASU_2007  trpA; tryptophan synthase (alpha subunit) [KO:K01695] [EC:4.2.1.20]
BASU_2008  trpB; tryptophan synthase (beta subunit) [KO:K01696] [EC:4.2.1.20]
BASU_2049  serA; 3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BASU_2116  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BASU_2159  lpdV; branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase) [KO:K00382] [EC:1.8.1.4]
BASU_2212  gcvPB; Probable glycine dehydrogenase [decarboxylating] subunit 2 [KO:K00283] [EC:1.4.4.2]
BASU_2213  gcvPA; Probable glycine dehydrogenase [decarboxylating] subunit 1 [KO:K00282] [EC:1.4.4.2]
BASU_2214  gcvT; aminomethyltransferase (glycine cleavage system protein T) [KO:K00605] [EC:2.1.2.10]
BASU_2340  nrpsC; Glycine-serine hydroxymethyltransferase like protein [KO:K00600] [EC:2.1.2.1]
BASU_2378  mccB; cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BASU_2497  lysC; aspartokinase II alpha subunit (aa 1->408) and beta subunit (aa 246->408) [KO:K00928] [EC:2.7.2.4]
BASU_2541  ysaA; putative phosphatase [KO:K25528]
BASU_2731  gbsB; choline dehydrogenase [KO:K11440] [EC:1.1.1.1]
BASU_2732  gbsA; glycine betaine aldehyde dehydrogenase,NAD+-dependent [KO:K00130] [EC:1.2.1.8]
BASU_2856  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
BASU_2857  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BASU_2858  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BASU_2909  gcvH; glycine cleavage system protein H [KO:K02437]
BASU_3043  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase/phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BASU_3107  yvcT; putative 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BASU_3318  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bamn00010  Glycolysis / Gluconeogenesis
bamn00020  Citrate cycle (TCA cycle)
bamn00230  Purine metabolism
bamn00250  Alanine, aspartate and glutamate metabolism
bamn00270  Cysteine and methionine metabolism
bamn00290  Valine, leucine and isoleucine biosynthesis
bamn00300  Lysine biosynthesis
bamn00330  Arginine and proline metabolism
bamn00460  Cyanoamino acid metabolism
bamn00470  D-Amino acid metabolism
bamn00564  Glycerophospholipid metabolism
bamn00600  Sphingolipid metabolism
bamn00620  Pyruvate metabolism
bamn00630  Glyoxylate and dicarboxylate metabolism
bamn00640  Propanoate metabolism
bamn00680  Methane metabolism
bamn00860  Porphyrin metabolism
bamn00920  Sulfur metabolism
KO pathway
ko00260   

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