KEGG   PATHWAY: bard00260
Entry
bard00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus arachidis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bard00260  Glycine, serine and threonine metabolism
bard00260

Module
bard_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bard00260]
bard_M00621  Glycine cleavage system [PATH:bard00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus arachidis [GN:bard]
Gene
QRY57_18655  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
QRY57_10255  aspartate kinase [KO:K00928] [EC:2.7.2.4]
QRY57_18660  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
QRY57_11115  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
QRY57_13980  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
QRY57_26535  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
QRY57_11125  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
QRY57_11120  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
QRY57_15720  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
QRY57_26530  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
QRY57_26110  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
QRY57_24125  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
QRY57_02600  glycerate kinase [KO:K00865] [EC:2.7.1.165]
QRY57_13250  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
QRY57_15175  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
QRY57_15740  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
QRY57_24525  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
QRY57_09960  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
QRY57_13070  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
QRY57_25080  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
QRY57_15615  3-phosphoglycerate dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QRY57_15620  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
QRY57_04935  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
QRY57_11315  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
QRY57_07475  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
QRY57_20895  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit 1 [KO:K00282] [EC:1.4.4.2]
QRY57_03400  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
QRY57_20890  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
QRY57_03405  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
QRY57_20900  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
QRY57_19620  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QRY57_20615  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QRY57_24635  gcvH; glycine cleavage system protein GcvH [KO:K02437]
QRY57_14605  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
QRY57_17345  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
QRY57_08850  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
QRY57_17285  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
QRY57_08540  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
QRY57_21565  bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
QRY57_20480  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
QRY57_20485  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
QRY57_03875  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
QRY57_10400  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
QRY57_10125  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
QRY57_12455  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
QRY57_23415  amino acid racemase [KO:K25316] [EC:5.1.1.10]
QRY57_07925  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
QRY57_13955  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
QRY57_07920  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bard00010  Glycolysis / Gluconeogenesis
bard00020  Citrate cycle (TCA cycle)
bard00230  Purine metabolism
bard00250  Alanine, aspartate and glutamate metabolism
bard00270  Cysteine and methionine metabolism
bard00290  Valine, leucine and isoleucine biosynthesis
bard00300  Lysine biosynthesis
bard00330  Arginine and proline metabolism
bard00460  Cyanoamino acid metabolism
bard00470  D-Amino acid metabolism
bard00564  Glycerophospholipid metabolism
bard00600  Sphingolipid metabolism
bard00620  Pyruvate metabolism
bard00630  Glyoxylate and dicarboxylate metabolism
bard00640  Propanoate metabolism
bard00680  Methane metabolism
bard00860  Porphyrin metabolism
bard00920  Sulfur metabolism
KO pathway
ko00260   
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