KEGG   PATHWAY: bdg00260
Entry
bdg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bradyrhizobium daqingense
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bdg00260  Glycine, serine and threonine metabolism
bdg00260

Module
bdg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bdg00260]
bdg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bdg00260]
bdg_M00621  Glycine cleavage system [PATH:bdg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bradyrhizobium daqingense [GN:bdg]
Gene
LPJ38_06165  aspartate kinase [KO:K00928] [EC:2.7.2.4]
LPJ38_25255  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LPJ38_05040  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LPJ38_23665  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
LPJ38_08815  homoserine kinase [KO:K02204] [EC:2.7.1.39]
LPJ38_25695  threonine synthase [KO:K01733] [EC:4.2.3.1]
LPJ38_01315  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
LPJ38_30705  threonine aldolase family protein [KO:K01620] [EC:4.1.2.48]
LPJ38_27210  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LPJ38_32100  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
LPJ38_32105  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
LPJ38_05675  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
LPJ38_11920  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
LPJ38_00615  glycerate kinase [KO:K11529] [EC:2.7.1.165]
LPJ38_04095  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
LPJ38_13430  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LPJ38_14640  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LPJ38_17620  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LPJ38_18810  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LPJ38_08375  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LPJ38_11000  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LPJ38_12420  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LPJ38_10995  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
LPJ38_14835  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
LPJ38_33430  SDR family oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LPJ38_01210  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
LPJ38_04835  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
LPJ38_24580  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
LPJ38_30920  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
LPJ38_30910  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
LPJ38_19845  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LPJ38_25700  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LPJ38_05315  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LPJ38_30915  gcvH; glycine cleavage system protein GcvH [KO:K02437]
LPJ38_21165  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
LPJ38_25495  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
LPJ38_31530  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
LPJ38_03780  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
LPJ38_03785  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
LPJ38_35575  ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bdg00010  Glycolysis / Gluconeogenesis
bdg00020  Citrate cycle (TCA cycle)
bdg00230  Purine metabolism
bdg00250  Alanine, aspartate and glutamate metabolism
bdg00270  Cysteine and methionine metabolism
bdg00290  Valine, leucine and isoleucine biosynthesis
bdg00300  Lysine biosynthesis
bdg00330  Arginine and proline metabolism
bdg00460  Cyanoamino acid metabolism
bdg00470  D-Amino acid metabolism
bdg00564  Glycerophospholipid metabolism
bdg00620  Pyruvate metabolism
bdg00630  Glyoxylate and dicarboxylate metabolism
bdg00640  Propanoate metabolism
bdg00680  Methane metabolism
bdg00860  Porphyrin metabolism
bdg00920  Sulfur metabolism
KO pathway
ko00260   
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