KEGG   PATHWAY: bsep00260
Entry
bsep00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bradyrhizobium septentrionale
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bsep00260  Glycine, serine and threonine metabolism
bsep00260

Module
bsep_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bsep00260]
bsep_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bsep00260]
bsep_M00621  Glycine cleavage system [PATH:bsep00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bradyrhizobium septentrionale [GN:bsep]
Gene
HAP48_0040115  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HAP48_0017590  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HAP48_0038810  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HAP48_0014440  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HAP48_0037130  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HAP48_0020325  homoserine kinase [KO:K02204] [EC:2.7.1.39]
HAP48_0040040  threonine synthase [KO:K01733] [EC:4.2.3.1]
HAP48_0011690  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HAP48_0013915  threonine synthase [KO:K01733] [EC:4.2.3.1]
HAP48_0044380  beta-eliminating lyase-related protein [KO:K01620] [EC:4.1.2.48]
HAP48_0046150  threonine aldolase family protein [KO:K01620] [EC:4.1.2.48]
HAP48_0039165  hypothetical protein [KO:K00600] [EC:2.1.2.1]
HAP48_0041380  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HAP48_0005505  hypothetical protein [KO:K00600] [EC:2.1.2.1]
HAP48_0010135  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HAP48_0047760  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HAP48_0047770  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HAP48_0013775  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HAP48_0033340  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
HAP48_0020835  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
HAP48_0007850  glycerate kinase [KO:K11529] [EC:2.7.1.165]
HAP48_0019080  glycerate kinase [KO:K11529] [EC:2.7.1.165]
HAP48_0015675  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
HAP48_0029075  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0030490  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0032070  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0033270  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0038095  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0002565  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0007170  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0008625  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0008755  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HAP48_0008765  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
HAP48_0002415  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HAP48_0011615  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
HAP48_0028610  NAD(P)/FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
HAP48_0014705  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
HAP48_0032820  tyramine oxidase [KO:K00276] [EC:1.4.3.21]
HAP48_0013500  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
HAP48_0046450  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HAP48_0046440  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HAP48_0040045  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HAP48_0008200  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HAP48_0014150  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HAP48_0046445  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HAP48_0034095  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HAP48_0047180  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
HAP48_0002400  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
HAP48_0016705  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
HAP48_0016085  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HAP48_0016080  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bsep00010  Glycolysis / Gluconeogenesis
bsep00020  Citrate cycle (TCA cycle)
bsep00230  Purine metabolism
bsep00250  Alanine, aspartate and glutamate metabolism
bsep00270  Cysteine and methionine metabolism
bsep00290  Valine, leucine and isoleucine biosynthesis
bsep00300  Lysine biosynthesis
bsep00330  Arginine and proline metabolism
bsep00460  Cyanoamino acid metabolism
bsep00470  D-Amino acid metabolism
bsep00564  Glycerophospholipid metabolism
bsep00620  Pyruvate metabolism
bsep00630  Glyoxylate and dicarboxylate metabolism
bsep00640  Propanoate metabolism
bsep00680  Methane metabolism
bsep00860  Porphyrin metabolism
bsep00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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