KEGG   PATHWAY: bta05217
Entry
bta05217                    Pathway                                
Name
Basal cell carcinoma - Bos taurus (cow)
Description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
Class
Human Diseases; Cancer: specific types
Pathway map
bta05217  Basal cell carcinoma
bta05217

Disease
H00039  Basal cell carcinoma
Organism
Bos taurus (cow) [GN:bta]
Gene
100337066  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
280730  BAX; apoptosis regulator BAX [KO:K02159]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
286821  SHH; sonic hedgehog protein [KO:K11988]
407216  BMP4; bone morphogenetic protein 4 precursor [KO:K04662]
445416  FZD4; frizzled-4 precursor [KO:K02354]
445417  FZD1; frizzled-1 [KO:K02432]
445418  FZD6; frizzled-6 [KO:K02376]
445419  FZD3; frizzled-3 precursor [KO:K02329]
445420  WNT2B; protein Wnt-2b [KO:K00182]
493729  WNT2; protein Wnt-2 precursor [KO:K00182]
504357  AXIN1; axin-1 [KO:K02157]
504939  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
505075  WNT6; protein Wnt-6 precursor [KO:K00445]
505463  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
507948  PTCH2; protein patched homolog 2 isoform X2 [KO:K11101]
508008  WNT5B; protein Wnt-5b precursor [KO:K00444]
510255  GLI2; zinc finger protein GLI2 [KO:K16798]
511308  WNT9A; protein Wnt-9a [KO:K01064]
511619  AXIN2; axin-2 [KO:K04385]
513497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
514090  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
515303  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
515323  FZD10; frizzled-10 precursor [KO:K02842]
517588  GLI1; zinc finger protein GLI1 [KO:K16797]
519357  DDB2; DNA damage-binding protein 2 [KO:K10140]
520994  PTCH1; protein patched homolog 1 [KO:K06225]
521364  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
522467  WNT3A; protein Wnt-3a [KO:K00312]
523325  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
524255  FZD7; frizzled-7 precursor [KO:K02432]
526572  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
530005  WNT5A; protein Wnt-5a [KO:K00444]
533233  APC; adenomatous polyposis coli protein [KO:K02085]
533782  WNT7A; protein Wnt-7a [KO:K00572]
535067  SUFU; suppressor of fused homolog [KO:K06229]
535399  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
537330  WNT10A; protein Wnt-10a precursor [KO:K01357]
538507  FZD2; frizzled-2 [KO:K02235]
538536  FZD5; frizzled-5 [KO:K02375]
538627  WNT16; protein Wnt-16 precursor [KO:K01558]
538720  WNT8B; protein Wnt-8b [KO:K00714]
538808  KIF7; kinesin-like protein KIF7 isoform X4 [KO:K18806]
539003  CTNNB1; catenin beta-1 [KO:K02105]
539203  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
539308  SMO; protein smoothened precursor [KO:K06226]
539337  WNT10B; protein Wnt-10b [KO:K01357]
540199  WNT8A; protein Wnt-8a [KO:K00714]
540481  TCF7L2; transcription factor 7-like 2 [KO:K04491]
540662  WNT1; proto-oncogene Wnt-1 precursor [KO:K03209]
540753  WNT3; proto-oncogene Wnt-3 precursor [KO:K00312]
540830  HHIP; hedgehog-interacting protein precursor [KO:K06231]
541218  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
541243  WNT9B; protein Wnt-9b [KO:K01064]
613288  WNT11; protein Wnt-11 [KO:K01384]
614312  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
615037  BMP2; bone morphogenetic protein 2 precursor [KO:K21283]
616913  FZD8; frizzled-8 [KO:K02375]
618405  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
782690  TCF7; transcription factor 7 [KO:K02620]
785371  GLI3; transcriptional activator GLI3 isoform X3 [KO:K06230]
789600  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
Compound
C00187  Cholesterol
Reference
PMID:15948971
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
PMID:12588368
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
PMID:15978322
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
PMID:15468170
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
PMID:16881963
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
PMID:16306523
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
PMID:11276000
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
Reference
PMID:15270885
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
PMID:14737121
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
PMID:15656799
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:11736900
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
PMID:16054233
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
PMID:11130178
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
PMID:28286127
  Authors
Wu F, Zhang Y, Sun B, McMahon AP, Wang Y
  Title
Hedgehog Signaling: From Basic Biology to Cancer Therapy.
  Journal
Cell Chem Biol 24:252-280 (2017)
DOI:10.1016/j.chembiol.2017.02.010
Reference
PMID:25766766
  Authors
Otsuka A, Levesque MP, Dummer R, Kabashima K
  Title
Hedgehog signaling in basal cell carcinoma.
  Journal
J Dermatol Sci 78:95-100 (2015)
DOI:10.1016/j.jdermsci.2015.02.007
Related
pathway
bta04110  Cell cycle
bta04115  p53 signaling pathway
bta04310  Wnt signaling pathway
bta04340  Hedgehog signaling pathway
bta04350  TGF-beta signaling pathway
KO pathway
ko05217   

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