KEGG PATHWAY: bxe00621

PATHWAY: bxe00621

Entry

bxe00621                    Pathway

Name

Dioxin degradation - Paraburkholderia xenovorans LB400

Description

Dioxins and dioxin-like compounds, including PCDDs, PCDFs and PCBs, are persistent organic pollutants (POPs) that are resistant to environmental degradation. However, POPs can be degraded by certain microorganisms with acquisition of a novel set of enzymes, such as biphenyl degradation by Paraburkholderia xenovorans LB400 involving four novel enzymes encoded in operon-like structures [MD:M00543]. DDT, another POP, and carbazol are also known to be degraded in similar pathways.

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

bxe00621

Dioxin degradation

Module

bxe_M00543

Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate [PATH:bxe00621]

Other DBs

UMBBD:

dpd dbf bph cbp car ddt

Organism

Paraburkholderia xenovorans LB400 [GN:bxe]

Gene

Bxe_C0717

Conserved hypothetical protein [KO:K01821] [EC:5.3.2.6]

Bxe_A2694

Putative tautomerase [KO:K01821] [EC:5.3.2.6]

Bxe_A1150

amnE; 4-oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]

Bxe_A3548

2-hydroxypenta-2,4-dienoate hydratase (CmtF) [KO:K02554] [EC:4.2.1.80]

Bxe_A1149

amnF; 2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]

Bxe_B2327

Putative 2-hydroxypenta-2,4-dienoate hydratase(MhpD) [KO:K02554] [EC:4.2.1.80]

Bxe_C1189

bphH; 2-hydroxypenta-2,4-dienoate hydratase (BphH) [KO:K18364] [EC:4.2.1.80 4.2.1.132]

Bxe_A1152

amnG; 4-hydroxy 2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]

Bxe_B2325

4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]

Bxe_A3546

4-hydroxy-2-ketovalerate aldolase (CmtG) [KO:K01666] [EC:4.1.3.39]

Bxe_C1187

bphI; 4-hydroxy-2-oxovalerate aldolase [KO:K18365] [EC:4.1.3.39 4.1.3.43]

Bxe_A3547

acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]

Bxe_B2326

acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]

Bxe_A1151

amnH; acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]

Bxe_C1188

bphJ; acetaldehyde dehydrogenase [KO:K18366] [EC:1.2.1.10 1.2.1.87]

Bxe_C1197

bphA1; Biphenyl 2,3-dioxygenase alpha subunit (BphA1) [KO:K08689] [EC:1.14.12.18]

Bxe_C1196

bphA2; Biphenyl 2,3-dioxygenase small subunit (BphA2) [KO:K15750] [EC:1.14.12.18]

Bxe_C1194

bphA3; Biphenyl 2,3-dioxygenase ferredoxin subunit (BphA3) [KO:K18087]

Bxe_C1193

bphA4; Biphenyl 2,3-dioxygenase ferredoxin reductase subunit (BphA4) [KO:K18088] [EC:1.18.1.3]

Bxe_C1192

bphB; Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (BphB) [KO:K08690] [EC:1.3.1.56]

Bxe_C1191

bphC; 2,3-Dihydroxybiphenyl-1,2-dioxygenase (BphC) [KO:K00462] [EC:1.13.11.39]

Bxe_C1186

bphD; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (BphD) [KO:K10222] [EC:3.7.1.8]

Compound

C00022

Pyruvate

C00024

Acetyl-CoA

C00084

Acetaldehyde

C00090

Catechol

C00108

Anthranilate

C00180

Benzoate

C00596

2-Hydroxy-2,4-pentadienoate

C00805

Salicylate

C01273

2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate

C02370

4-Chlorobenzoate

C02501

2-Hydroxymuconate

C02526

Biphenyl-2,3-diol

C03077

4-Chlorophenylacetate

C03453

gamma-Oxalocrotonate

C03569

2,2',3-Trihydroxybiphenyl

C03589

4-Hydroxy-2-oxopentanoate

C04596

1,1-Dichloro-2,2-bis(4-chlorophenyl)ethylene

C04623

DDT

C06584

4-Chlorobiphenyl

C06585

cis-2,3-Dihydro-2,3-dihydroxy-4'-chlorobiphenyl

C06586

2,3-Dihydroxy-4'-chlorobiphenyl

C06587

2-Hydroxy-6-oxo-6-(4'-chlorophenyl)-hexa-2,4-dienoate

C06588

Biphenyl

C06589

cis-2,3-Dihydro-2,3-dihydroxybiphenyl

C06644

1,1-Dichloro-2-(dihydroxy-4'-chlorophenyl)-2-(4'-chlorophenyl)ethylene

C06645

6-Oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate

C06646

2-(4'-Chlorophenyl)-3,3-dichloropropenoate

C07557

2,3,7,8-Tetrachlorodibenzodioxin

C07729

Dibenzofuran

C07731

2-Hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate

C07732

Dibenzo-p-dioxin

C07733

2,2',3-Trihydroxydiphenylether

C07734

2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate

C08060

Carbazole

C08061

2'-Aminobiphenyl-2,3-diol

C08062

2-Hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate

C11057

3,4,3',4'-Tetrachlorobiphenyl

C11353

2-Hydroxy-3-chloropenta-2,4-dienoate

C14573

3,3',4,4',5-Pentachlorobiphenyl

C18099

1,2,3,7,8-Pentachlorodibenzodioxin

C18100

1,2,3,4,7,8-Hexachlorodibenzodioxin

C18101

1,2,3,6,7,8-Hexachlorodibenzodioxin

C18102

1,2,3,7,8,9-Hexachlorodibenzodioxin

C18103

1,2,3,4,6,7,8-Heptachlorodibenzodioxin

C18104

2,3,7,8-Tetrachlorodibenzofuran

C18105

1,2,3,7,8-Pentachlorodibenzofuran

C18106

2,3,4,7,8-Pentachlorodibenzofuran

C18107

1,2,3,4,7,8-Hexachlorodibenzofuran

C18108

1,2,3,7,8,9-Hexachlorodibenzofuran

C18109

1,2,3,6,7,8-Hexachlorodibenzofuran

C18110

2,3,4,6,7,8-Hexachlorodibenzofuran

C18111

1,2,3,4,6,7,8-Heptachlorodibenzofuran

C18112

1,2,3,4,7,8,9-Heptachlorodibenzofuran

C18113

1,2,3,4,6,7,8,9-Octachlorodibenzofuran

C18114

3,4,4',5-Tetrachlorobiphenyl

C18115

3,4,5,3',4',5'-Hexachlorobiphenyl

C18116

2,3,4,3',4'-Pentachlorobiphenyl

C18117

2,3,4,4',5-Pentachlorobiphenyl

C18118

2,3',4,4',5-Pentachlorobiphenyl

C18119

2,3',4,4',5'-Pentachlorobiphenyl

C18120

2,3,3',4,4',5-Hexachlorobiphenyl

C18121

2,3,3',4,4',5'-Hexachlorobiphenyl

C18122

2,3',4,4',5,5'-Hexachlorobiphenyl

C18123

2,3,3',4,4',5,5'-Heptachlorobiphenyl

C18180

1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin

C21859

cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol

Reference

PMID:12450109

Authors

Nojiri H, Omori T.

Title

Molecular bases of aerobic bacterial degradation of dioxins: involvement of angular dioxygenation.

Journal

Biosci Biotechnol Biochem 66:2001-16 (2002)
DOI:10.1271/bbb.66.2001

Reference

PMID:16775784

Authors

Jin S, Zhu T, Xu X, Xu Y.

Title

Biodegradation of dibenzofuran by Janibacter terrae strain XJ-1.

Journal

Curr Microbiol 53:30-6 (2006)
DOI:10.1007/s00284-005-0180-1

Reference

PMID:12483604

Authors

Nojiri H, Habe H, Omori T.

Title

Bacterial degradation of aromatic compounds via angular dioxygenation.

Journal

J Gen Appl Microbiol 47:279-305 (2001)
DOI:10.2323/jgam.47.279

Reference

PMID:11322788

Authors

Kasuga K, Habe H, Chung JS, Yoshida T, Nojiri H, Yamane H, Omori T.

Title

Isolation and characterization of the genes encoding a novel oxygenase component of angular dioxygenase from the gram-positive dibenzofuran-degrader Terrabacter sp. strain DBF63.

Journal

Biochem Biophys Res Commun 283:195-204 (2001)
DOI:10.1006/bbrc.2001.4763

Reference

PMID:17142386

Authors

Vezina J, Barriault D, Sylvestre M

Title

Family shuffling of soil DNA to change the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase.

Journal

J Bacteriol 189:779-88 (2007)
DOI:10.1128/JB.01267-06

Reference

PMID:12501294

Authors

Ouchiyama N, Miyachi S, Omori T

Title

Cloning and nucleotide sequence of carbazole catabolic genes from Pseudomonas stutzeri strain OM1, isolated from activated sludge.

Journal

J Gen Appl Microbiol 44:57-63 (1998)
DOI:10.2323/jgam.44.57

Reference

PMID:9244273

Authors

Sato SI, Ouchiyama N, Kimura T, Nojiri H, Yamane H, Omori T

Title

Cloning of genes involved in carbazole degradation of Pseudomonas sp. strain CA10: nucleotide sequences of genes and characterization of meta-cleavage enzymes and hydrolase.

Journal

J Bacteriol 179:4841-9 (1997)
DOI:10.1128/JB.179.15.4841-4849.1997

Reference

PMID:23415487

Authors

Nguyen PA, Trinh TH, Fukumitsu Y, Shimodaira J, Miyauchi K, Tokuda M, Kasai D, Masai E, Fukuda M

Title

Gene cluster and regulation system for 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE) degradation in Janibacter sp. TYM3221.

Journal

J Biosci Bioeng 116:91-100 (2013)
DOI:10.1016/j.jbiosc.2013.01.007

Related
pathway

bxe00020