KEGG   PATHWAY: bxe00622
Entry
bxe00622                    Pathway                                
Name
Xylene degradation - Paraburkholderia xenovorans LB400
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
bxe00622  Xylene degradation
bxe00622

Module
bxe_M00419  Cymene degradation, p-cymene => p-cumate [PATH:bxe00622]
bxe_M00539  Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate [PATH:bxe00622]
bxe_M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:bxe00622]
Other DBs
GO: 0042184
UMBBD: mxy oxy pxy pcy tol
Organism
Paraburkholderia xenovorans LB400 [GN:bxe]
Gene
Bxe_C0302  benzaldehyde dehydrogenase (NAD+) [KO:K00141] [EC:1.2.1.28]
Bxe_B0915  benA; benzoate 1,2-dioxygenase, alpha subunit [KO:K05549] [EC:1.14.12.10 1.14.12.-]
Bxe_B0914  benB; benzoate 1,2-dioxygenase, beta subunit [KO:K05550] [EC:1.14.12.10 1.14.12.-]
Bxe_B0913  benC; Benzoate 1,2-dioxygenase, electron transfer subunit (benC) [KO:K05784] [EC:1.18.1.-]
Bxe_B0912  benD; 1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [KO:K05783] [EC:1.3.1.25 1.3.1.-]
Bxe_A1147  amnC; 2-hydroxymuconate semialdehyde dehydrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
Bxe_C0717  Conserved hypothetical protein [KO:K01821] [EC:5.3.2.6]
Bxe_A2694  Putative tautomerase [KO:K01821] [EC:5.3.2.6]
Bxe_A1150  amnE; 4-oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]
Bxe_C1189  bphH; 2-hydroxypenta-2,4-dienoate hydratase (BphH) [KO:K18364] [EC:4.2.1.80 4.2.1.132]
Bxe_C1187  bphI; 4-hydroxy-2-oxovalerate aldolase [KO:K18365] [EC:4.1.3.39 4.1.3.43]
Bxe_C1188  bphJ; acetaldehyde dehydrogenase [KO:K18366] [EC:1.2.1.10 1.2.1.87]
Bxe_A3561  p-cymene monooxygenase, hydroxylase subunit(CymAa) [KO:K10616] [EC:1.14.15.25]
Bxe_A3559  xylene monooxygenase electron transfer component [KO:K18293] [EC:1.18.1.3]
Bxe_A3563  p-cumic alcohol dehydrogenase (CymB) [KO:K10617]
Bxe_A3562  aldehyde dehydrogenase (acceptor) [KO:K10618]
Bxe_A3556  p-cumate dioxygenase large subunit (CmtAb) [KO:K10619] [EC:1.14.12.25]
Bxe_A3555  p-cumate dioxygenase small subunit (CmtAc) [KO:K16303] [EC:1.14.12.25]
Bxe_A3552  p-cumate dioxygenase ferredoxin subunit (CmtAd) [KO:K16304]
Bxe_A3557  p-cumate dioxygenase ferredoxin reductase subunit (CmtAa) [KO:K18227] [EC:1.18.1.3]
Bxe_A3553  2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase(CmtB) [KO:K10620] [EC:1.3.1.58]
Bxe_A3554  2,3-dihydroxy-p-cumate-3,4-dioxygenase (CmtC) [KO:K10621] [EC:1.13.11.- 1.13.11.14]
Bxe_A3551  HCOMODA decarboxylase (CmtD) [KO:K10622] [EC:4.1.1.-]
Bxe_A3549  HOMODA hydrolase (CmtE) [KO:K10623] [EC:3.7.1.-]
Bxe_A3548  2-hydroxypenta-2,4-dienoate hydratase (CmtF) [KO:K02554] [EC:4.2.1.80]
Bxe_A1149  amnF; 2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]
Bxe_B2327  Putative 2-hydroxypenta-2,4-dienoate hydratase(MhpD) [KO:K02554] [EC:4.2.1.80]
Bxe_A1152  amnG; 4-hydroxy 2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
Bxe_B2325  4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
Bxe_A3546  4-hydroxy-2-ketovalerate aldolase (CmtG) [KO:K01666] [EC:4.1.3.39]
Bxe_A3547  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
Bxe_B2326  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
Bxe_A1151  amnH; acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00084  Acetaldehyde
C00100  Propanoyl-CoA
C00479  Propanal
C00596  2-Hydroxy-2,4-pentadienoate
C01454  Toluate
C02923  2,3-Dihydroxytoluene
C03589  4-Hydroxy-2-oxopentanoate
C06210  2-Hydroxy-6-keto-2,4-heptadienoate
C06575  p-Cymene
C06576  p-Cumic alcohol
C06577  4-Isopropylbenzaldehyde
C06578  p-Cumate
C06579  cis-2,3-Dihydroxy-2,3-dihydro-p-cumate
C06580  2,3-Dihydroxy-p-cumate
C06581  2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate
C06582  2-Hydroxy-6-oxo-7-methylocta-2,4-dienoate
C06720  1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate
C06729  cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate
C06730  4-Methylcatechol
C06731  1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate
C06756  p-Xylene
C06757  4-Methylbenzyl alcohol
C06758  p-Tolualdehyde
C06760  2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde
C06762  4-Hydroxy-2-oxohexanoic acid
C07208  m-Xylene
C07209  3-Methylbenzaldehyde
C07211  m-Methylbenzoate
C07212  o-Xylene
C07213  2-Methylbenzyl alcohol
C07214  2-Methylbenzaldehyde
C07215  o-Toluate
C07216  3-Methylbenzyl alcohol
C07478  2-Hydroxy-5-methyl-cis,cis-muconate
C07479  2-Oxo-5-methyl-cis-muconate
C11354  2-Hydroxy-cis-hex-2,4-dienoate
Reference
PMID:11375157
  Authors
Haddad S, Eby DM, Neidle EL.
  Title
Cloning and expression of the benzoate dioxygenase genes from Rhodococcus sp. strain 19070.
  Journal
Appl Environ Microbiol 67:2507-14 (2001)
DOI:10.1128/AEM.67.6.2507-2514.2001
Reference
PMID:7768806
  Authors
Kim E, Zylstra GJ
  Title
Molecular and biochemical characterization of two meta-cleavage dioxygenases involved in biphenyl and m-xylene degradation by Beijerinckia sp. strain B1.
  Journal
J Bacteriol 177:3095-103 (1995)
DOI:10.1128/JB.177.11.3095-3103.1995
Reference
PMID:15127183
  Authors
Morasch B, Schink B, Tebbe CC, Meckenstock RU
  Title
Degradation of o-xylene and m-xylene by a novel sulfate-reducer belonging to the genus Desulfotomaculum.
  Journal
Arch Microbiol 181:407-17 (2004)
DOI:10.1007/s00203-004-0672-6
Reference
PMID:9150211
  Authors
Eaton RW.
  Title
p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and characterization of DNA encoding conversion of p-cymene to p-cumate.
  Journal
J Bacteriol 179:3171-80 (1997)
DOI:10.1128/JB.179.10.3171-3180.1997
Reference
PMID:8631713
  Authors
Eaton RW.
  Title
p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon.
  Journal
J Bacteriol 178:1351-62 (1996)
DOI:10.1128/JB.178.5.1351-1362.1996
Related
pathway
bxe00010  Glycolysis / Gluconeogenesis
bxe00020  Citrate cycle (TCA cycle)
bxe00623  Toluene degradation
bxe00640  Propanoate metabolism
KO pathway
ko00622   
LinkDB

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