PATHWAY: ko00622 Help
Entry Name Xylene degradation
Class Metabolism; Xenobiotics biodegradation and metabolismBRITE hierarchy
Pathway map Module M00537 Xylene degradation, xylene => methylbenzoate [PATH:ko00622 ]
M00539 Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate [PATH:ko00622 ]
M00551 Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:ko00622 ]
M00569 Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:ko00622 ]
Other DBs Orthology K01617 dmpH, xylI, nahK; 2-oxo-3-hexenedioate decarboxylase [EC:4.1.1.77 ]
K05549 benA-xylX; benzoate/toluate 1,2-dioxygenase subunit alpha [EC:1.14.12.10 1.14.12.-]
K05550 benB-xylY; benzoate/toluate 1,2-dioxygenase subunit beta [EC:1.14.12.10 1.14.12.-]
K05783 benD-xylL; dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.25 1.3.1.-]
K05784 benC-xylZ; benzoate/toluate 1,2-dioxygenase reductase component [EC:1.18.1.-]
K10216 dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9 ]
K10217 dmpC, xylG, praB; aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.32 1.2.1.85 ]
K10617 cymB; p-cumic alcohol dehydrogenase
K10618 cymC; p-cumic aldehyde dehydrogenase
K10620 cmtB; 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase [EC:1.3.1.58 ]
K10621 cmtC, dhbA; 2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase [EC:1.13.11.- 1.13.11.14 ]
K10622 cmtD, dhbB; HCOMODA/2-hydroxy-3-carboxy-muconic semialdehyde decarboxylase [EC:4.1.1.-]
K10623 cmtE; HOMODA hydrolase [EC:3.7.1.-]
K10702 todF; 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase [EC:3.7.1.25 ]
K15758 xylA; toluene methyl-monooxygenase electron transfer component [EC:1.18.1.3 ]
K16270 todE; 3-methylcatechol 2,3-dioxygenase [EC:1.13.11.-]
K16304 cmtAd; p-cumate 2,3-dioxygenase ferredoxin component
K18227 cmtAa; p-cumate 2,3-dioxygenase ferredoxin reductase component [EC:1.18.1.3 ]
K18293 cymAb; p-cymene methyl-monooxygenase electron transfer component [EC:1.18.1.3 ]
K18365 bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43 ]
Compound C00596 2-Hydroxy-2,4-pentadienoate
C03589 4-Hydroxy-2-oxopentanoate
C06210 2-Hydroxy-6-keto-2,4-heptadienoate
C06577 4-Isopropylbenzaldehyde
C06579 cis-2,3-Dihydroxy-2,3-dihydro-p-cumate
C06581 2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate
C06582 2-Hydroxy-6-oxo-7-methylocta-2,4-dienoate
C06720 1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate
C06729 cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate
C06731 1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate
C06760 2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde
C06762 4-Hydroxy-2-oxohexanoic acid
C07478 2-Hydroxy-5-methyl-cis,cis-muconate
C07479 2-Oxo-5-methyl-cis-muconate
C11354 2-Hydroxy-cis-hex-2,4-dienoate
Reference Authors Haddad S, Eby DM, Neidle EL.
Title Cloning and expression of the benzoate dioxygenase genes from Rhodococcus sp. strain 19070.
Journal Reference Authors Kim E, Zylstra GJ
Title Molecular and biochemical characterization of two meta-cleavage dioxygenases involved in biphenyl and m-xylene degradation by Beijerinckia sp. strain B1.
Journal Reference Authors Morasch B, Schink B, Tebbe CC, Meckenstock RU
Title Degradation of o-xylene and m-xylene by a novel sulfate-reducer belonging to the genus Desulfotomaculum.
Journal Reference Authors Eaton RW.
Title p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and characterization of DNA encoding conversion of p-cymene to p-cumate.
Journal Reference Authors Eaton RW.
Title p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon.
Journal Related ko00010 Glycolysis / Gluconeogenesis
