KEGG   PATHWAY: cace00260
Entry
cace00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Clostridium aceticum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cace00260  Glycine, serine and threonine metabolism
cace00260

Module
cace_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cace00260]
cace_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cace00260]
cace_M00621  Glycine cleavage system [PATH:cace00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Clostridium aceticum [GN:cace]
Gene
CACET_c03840  dapG1; aspartate kinase DapG [KO:K00928] [EC:2.7.2.4]
CACET_c04390  trpB1; tryptophan synthase beta chain TrpB [KO:K01696] [EC:4.2.1.20]
CACET_c04400  trpA; tryptophan synthase alpha chain TrpA [KO:K01695] [EC:4.2.1.20]
CACET_c05010  pdhD; dihydrolipoyl dehydrogenase PdhD [KO:K00382] [EC:1.8.1.4]
CACET_c06810  ltaE; low specificity L-threonine aldolase LtaE [KO:K01620] [EC:4.1.2.48]
CACET_c06910  trpB2; tryptophan synthase beta chain TrpB [KO:K01696] [EC:4.2.1.20]
CACET_c07110  [KO:K00928] [EC:2.7.2.4]
CACET_c07200  ilvA1; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
CACET_c09010  asd; aspartate-semialdehyde dehydrogenase Asd [KO:K00133] [EC:1.2.1.11]
CACET_c09050  dapG2; aspartate kinase DapG [KO:K00928] [EC:2.7.2.4]
CACET_c09440  [KO:K00639] [EC:2.3.1.29]
CACET_c10270  lpdA; dihydrolipoamide dehydrogenase LpdA [KO:K00382] [EC:1.8.1.4]
CACET_c10330  gcvH; glycine cleavage system H protein GcvH [KO:K02437]
CACET_c11130  apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApgM [KO:K15635] [EC:5.4.2.12]
CACET_c11470  ttuD; hydroxypyruvate reductase TtuD [KO:K11529] [EC:2.7.1.165]
CACET_c11950  dsdA; D-serine dehydratase DsdA [KO:K01753] [EC:4.3.1.18]
CACET_c12380  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GpmI [KO:K15633] [EC:5.4.2.12]
CACET_c13050  [KO:K01733] [EC:4.2.3.1]
CACET_c16700  sdaAB; L-serine dehydratase, beta chain [KO:K01752] [EC:4.3.1.17]
CACET_c16710  sdaAA; L-serine dehydratase, alpha chain [KO:K01752] [EC:4.3.1.17]
CACET_c17460  glyA1; serine hydroxymethyltransferase GlyA [KO:K00600] [EC:2.1.2.1]
CACET_c19520  [KO:K22305] [EC:3.1.3.3]
CACET_c22030  [KO:K00274] [EC:1.4.3.4]
CACET_c28080  [KO:K17103] [EC:2.7.8.8]
CACET_c28590  tdcB; threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
CACET_c28990  gck; glycerate 2-kinase Gck [KO:K11529] [EC:2.7.1.165]
CACET_c29930  gcvT; aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
CACET_c33560  serA2; D-3-phosphoglycerate dehydrogenase SerA [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CACET_c34470  mttB; trimethylamine methyltransferase MttB [KO:K25220]
CACET_c34740  serC; phosphoserine aminotransferase SerC [KO:K00831] [EC:2.6.1.52]
CACET_c37370  thrB; homoserine kinase ThrB [KO:K00872] [EC:2.7.1.39]
CACET_c37380  thrC; threonine synthase ThrC [KO:K01733] [EC:4.2.3.1]
CACET_c37390  hom; homoserine dehydrogenase Hom [KO:K00003] [EC:1.1.1.3]
CACET_c37920  gcvPB; glycine dehydrogenase [decarboxylating] subunit 2 [KO:K00283] [EC:1.4.4.2]
CACET_c37930  gcvPA; glycine dehydrogenase [decarboxylating] subunit 1 [KO:K00282] [EC:1.4.4.2]
CACET_c38010  glyA2; serine hydroxymethyltransferase GlyA [KO:K00600] [EC:2.1.2.1]
CACET_c38080  [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cace00010  Glycolysis / Gluconeogenesis
cace00020  Citrate cycle (TCA cycle)
cace00230  Purine metabolism
cace00250  Alanine, aspartate and glutamate metabolism
cace00270  Cysteine and methionine metabolism
cace00290  Valine, leucine and isoleucine biosynthesis
cace00300  Lysine biosynthesis
cace00330  Arginine and proline metabolism
cace00460  Cyanoamino acid metabolism
cace00470  D-Amino acid metabolism
cace00564  Glycerophospholipid metabolism
cace00620  Pyruvate metabolism
cace00630  Glyoxylate and dicarboxylate metabolism
cace00640  Propanoate metabolism
cace00680  Methane metabolism
cace00860  Porphyrin metabolism
cace00920  Sulfur metabolism
KO pathway
ko00260   

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