KEGG   PATHWAY: ccaj00260
Entry
ccaj00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Cajanus cajan (pigeon pea)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ccaj00260  Glycine, serine and threonine metabolism
ccaj00260

Module
ccaj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ccaj00260]
ccaj_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ccaj00260]
ccaj_M00555  Betaine biosynthesis, choline => betaine [PATH:ccaj00260]
ccaj_M00621  Glycine cleavage system [PATH:ccaj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cajanus cajan (pigeon pea) [GN:ccaj]
Gene
109814628  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
109807968  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
109807745  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
109803603  uncharacterized protein LOC109803603 [KO:K00133] [EC:1.2.1.11]
109819277  homoserine kinase [KO:K00872] [EC:2.7.1.39]
109808088  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
109806656  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
109793729  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
109818199  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
109819146  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
109808109  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
109818644  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
109803507  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
109803560  serine hydroxymethyltransferase 7 isoform X1 [KO:K00600] [EC:2.1.2.1]
109797011  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
109807918  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
109804881  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
109796697  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
109796136  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
109798262  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
109816372  uncharacterized protein LOC109816372 [KO:K01834] [EC:5.4.2.11]
109791894  uncharacterized protein LOC109791894 [KO:K01834] [EC:5.4.2.11]
109810761  uncharacterized protein LOC109810761 isoform X1 [KO:K01834] [EC:5.4.2.11]
109792874  uncharacterized protein LOC109792874 [KO:K01834] [EC:5.4.2.11]
109803817  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
109804569  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
109818417  2,3-bisphosphoglycerate-independent phosphoglycerate mutase isoform X1 [KO:K15633] [EC:5.4.2.12]
109805485  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
109795032  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109812684  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109807040  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109801192  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
109798642  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
109815964  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
109807288  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
109813419  uncharacterized protein LOC109813419 isoform X1 [KO:K00276] [EC:1.4.3.21]
109797957  uncharacterized protein LOC109797957 isoform X1 [KO:K00276] [EC:1.4.3.21]
109812868  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
109807660  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
109797299  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
109791767  primary amine oxidase 2 [KO:K00276] [EC:1.4.3.21]
109800880  uncharacterized protein LOC109800880 isoform X1 [KO:K00276] [EC:1.4.3.21]
109797368  uncharacterized protein LOC109797368 [KO:K00276] [EC:1.4.3.21]
109805761  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
109811124  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
109796115  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
109808775  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
109804187  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
109811008  leghemoglobin reductase [KO:K00382] [EC:1.8.1.4]
109808086  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X2 [KO:K00382] [EC:1.8.1.4]
109793046  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
109805426  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
109807757  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
109800868  glycine cleavage system H protein, mitochondrial [KO:K02437]
109813650  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109816349  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109816350  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109800924  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
109811005  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
109789025  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
109815177  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
109817465  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
109790248  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
109793745  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
109800959  serine racemase [KO:K12235] [EC:5.1.1.18]
109809372  tryptophan synthase alpha chain isoform X1 [KO:K01695] [EC:4.2.1.20]
109805060  tryptophan synthase beta chain 2, chloroplastic [KO:K01696] [EC:4.2.1.20]
109805245  tryptophan synthase beta chain 1 isoform X2 [KO:K01696] [EC:4.2.1.20]
109818793  uncharacterized protein LOC109818793 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ccaj00010  Glycolysis / Gluconeogenesis
ccaj00020  Citrate cycle (TCA cycle)
ccaj00230  Purine metabolism
ccaj00250  Alanine, aspartate and glutamate metabolism
ccaj00270  Cysteine and methionine metabolism
ccaj00290  Valine, leucine and isoleucine biosynthesis
ccaj00300  Lysine biosynthesis
ccaj00330  Arginine and proline metabolism
ccaj00460  Cyanoamino acid metabolism
ccaj00470  D-Amino acid metabolism
ccaj00564  Glycerophospholipid metabolism
ccaj00600  Sphingolipid metabolism
ccaj00620  Pyruvate metabolism
ccaj00630  Glyoxylate and dicarboxylate metabolism
ccaj00640  Propanoate metabolism
ccaj00860  Porphyrin metabolism
ccaj00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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