KEGG   PATHWAY: cie00260
Entry
cie00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Citrobacter sp. CRE-46
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cie00260  Glycine, serine and threonine metabolism
cie00260

Module
cie_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cie00260]
cie_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cie00260]
cie_M00621  Glycine cleavage system [PATH:cie00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Citrobacter sp. CRE-46 [GN:cie]
Gene
AN232_16580  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
AN232_02740  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
AN232_00165  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
AN232_03245  metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
AN232_06060  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AN232_00160  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AN232_00155  threonine synthase [KO:K01733] [EC:4.2.3.1]
AN232_13435  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
AN232_10830  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AN232_20495  glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AN232_05415  glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AN232_23715  glxK; glycerate 3-kinase [KO:K00865] [EC:2.7.1.165]
AN232_07640  garK; glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
AN232_09495  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AN232_22570  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AN232_00215  phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
AN232_05135  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AN232_08775  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AN232_21865  3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
AN232_00255  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AN232_18205  bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AN232_05110  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AN232_05115  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AN232_08830  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
AN232_08820  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
AN232_25885  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AN232_08825  gcvH; glycine cleavage system protein H [KO:K02437]
AN232_10635  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
AN232_18850  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AN232_07680  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AN232_16220  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AN232_09435  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AN232_04155  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
AN232_04535  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
AN232_09185  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
AN232_16885  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AN232_16890  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AN232_16585  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
AN232_16590  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cie00010  Glycolysis / Gluconeogenesis
cie00020  Citrate cycle (TCA cycle)
cie00230  Purine metabolism
cie00250  Alanine, aspartate and glutamate metabolism
cie00270  Cysteine and methionine metabolism
cie00290  Valine, leucine and isoleucine biosynthesis
cie00300  Lysine biosynthesis
cie00330  Arginine and proline metabolism
cie00460  Cyanoamino acid metabolism
cie00470  D-Amino acid metabolism
cie00564  Glycerophospholipid metabolism
cie00600  Sphingolipid metabolism
cie00620  Pyruvate metabolism
cie00630  Glyoxylate and dicarboxylate metabolism
cie00640  Propanoate metabolism
cie00680  Methane metabolism
cie00860  Porphyrin metabolism
cie00920  Sulfur metabolism
KO pathway
ko00260   
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