KEGG   PATHWAY: cqu03420
Entry
cqu03420                    Pathway                                
Name
Nucleotide excision repair - Culex quinquefasciatus (southern house mosquito)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
cqu03420  Nucleotide excision repair
cqu03420

Other DBs
GO: 0006289
Organism
Culex quinquefasciatus (southern house mosquito) [GN:cqu]
Gene
CpipJ_CPIJ000126  [KO:K10756]
CpipJ_CPIJ000302  [KO:K10755]
CpipJ_CPIJ000358  [KO:K03143]
CpipJ_CPIJ001219  [KO:K03015]
CpipJ_CPIJ001399  [KO:K10755]
CpipJ_CPIJ001565  [KO:K10842]
CpipJ_CPIJ001855  [KO:K03017]
CpipJ_CPIJ001914  [KO:K10756]
CpipJ_CPIJ002381  [KO:K07466]
CpipJ_CPIJ002930  [KO:K03009]
CpipJ_CPIJ003130  [KO:K10740]
CpipJ_CPIJ003591  [KO:K10838]
CpipJ_CPIJ003592  [KO:K10838]
CpipJ_CPIJ003593  [KO:K10838]
CpipJ_CPIJ004184  [KO:K10846]
CpipJ_CPIJ004241  [KO:K03142]
CpipJ_CPIJ004242  [KO:K03142]
CpipJ_CPIJ004313  [KO:K10848] [EC:3.1.-.-]
CpipJ_CPIJ004855  [KO:K06634]
CpipJ_CPIJ005206  [KO:K03016]
CpipJ_CPIJ005256  [KO:K03144]
CpipJ_CPIJ005304  [KO:K03008]
CpipJ_CPIJ005859  [KO:K03007]
CpipJ_CPIJ006417  [KO:K10739]
CpipJ_CPIJ006481  [KO:K10843] [EC:5.6.2.4]
CpipJ_CPIJ006691  [KO:K10739]
CpipJ_CPIJ006734  [KO:K03012]
CpipJ_CPIJ006890  [KO:K10847]
CpipJ_CPIJ007365  [KO:K21987]
CpipJ_CPIJ007655  [KO:K03010] [EC:2.7.7.6]
CpipJ_CPIJ008666  [KO:K02324] [EC:2.7.7.7]
CpipJ_CPIJ008667  [KO:K02325] [EC:2.7.7.7]
CpipJ_CPIJ009046  [KO:K04802]
CpipJ_CPIJ010026  [KO:K02328]
CpipJ_CPIJ010574  [KO:K10609]
CpipJ_CPIJ010897  [KO:K03506] [EC:2.7.7.7]
CpipJ_CPIJ012084  [KO:K03504]
CpipJ_CPIJ012886  [KO:K03868] [EC:2.3.2.32]
CpipJ_CPIJ013742  [KO:K10610]
CpipJ_CPIJ013903  [KO:K10849]
CpipJ_CPIJ014481  [KO:K10756]
CpipJ_CPIJ014629  [KO:K10845]
CpipJ_CPIJ015285  [KO:K03013]
CpipJ_CPIJ015737  [KO:K10838]
CpipJ_CPIJ015824  [KO:K03141]
CpipJ_CPIJ016568  [KO:K02326] [EC:2.7.7.7]
CpipJ_CPIJ016666  [KO:K03006] [EC:2.7.7.6]
CpipJ_CPIJ016774  [KO:K10843] [EC:5.6.2.4]
CpipJ_CPIJ017892  [KO:K10754]
CpipJ_CPIJ018287  [KO:K02327] [EC:2.7.7.7]
CpipJ_CPIJ018296  [KO:K02202] [EC:2.7.11.22 2.7.11.23]
CpipJ_CPIJ018444  [KO:K03014]
CpipJ_CPIJ018569  [KO:K03016]
CpipJ_CPIJ018703  [KO:K10844] [EC:5.6.2.3]
CpipJ_CPIJ019384  [KO:K21987]
CpipJ_CPIJ020000  [KO:K02326] [EC:2.7.7.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
cqu03020  RNA polymerase
cqu04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

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